Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
penicillin-binding protein 2X
Overview
| Candidate |
| M339F | - | - | Streptococcus pneumoniae | cefotaxime | Reslit | Candidate |
| I366M | - | - | Streptococcus pneumoniae | cefotaxime | Reslit | Candidate |
| M400T | - | - | Streptococcus pneumoniae | cefotaxime | Reslit | Candidate |
| F395L | - | reduced penicillin susceptibility | Streptococcus agalactiae, Group B | penicillin | Reslit | Candidate |
| Q557E | - | - | Streptococcus agalactiae | penicillin|cefotaxime|cefoxitin|cefazolin | Reslit | Candidate |
Analysis of penicillin-binding protein genes of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to amoxicillin.
The study identifies mutations in penicillin-binding protein genes (pbp2x, pbp2b, pbp1a) and the murMN resistance determinant as contributors to amoxicillin and penicillin resistance in Streptococcus pneumoniae isolates.
Single-step capsular transformation and acquisition of penicillin resistance in Streptococcus pneumoniae.
The study demonstrates that a single transformation event can lead to the acquisition of penicillin resistance and a new capsular type in Streptococcus pneumoniae, highlighting the role of pbp2x and pbp1a mutations in this process.
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