Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| E183A | - | Target protection, D-alanyl-D-alanine carboxypeptidase PBP4 | Staphylococcus aureus | Cefazolin,Ceftriaxone,CeftarolineCEPHALOSPORINCeftaroline|Ceftobiprole+2 more | Reference Gene CatalogResFinder DatabaseReslit | Confirmed |
| Y605H | - | - | Enterococcus faecalis | Ampicillin|Imipenem | Reslit |
| E218K | - | increased survival in the presence of the β-lactams nafcillin and cefoxitin, D-alanyl-D-alanine carboxypeptidase PBP4 | Staphylococcus aureus | Nafcillin|CefoxitinCEPHALOSPORIN | Reference Gene CatalogReslit | Confirmed |
| R200L | - | increased survival in the presence of the β-lactams nafcillin and cefoxitin, D-alanyl-D-alanine carboxypeptidase PBP4 | Staphylococcus aureus | Nafcillin|CefoxitinCeftarolineCEPHALOSPORIN | Reference Gene CatalogReslit | Confirmed |
| F241R | - | D-alanyl-D-alanine carboxypeptidase PBP4, Target protection | Staphylococcus aureus | CEPHALOSPORINCefazolin,Ceftriaxone,CeftarolineCeftobiprole|Ceftaroline+1 more | Reference Gene CatalogResFinder DatabaseReslit | Confirmed |
| P520S | - | - | Enterococcus faecalis | Ampicillin|Imipenem | Reslit | Candidate |
| E297K | - | - | Staphylococcus aureus | Oxacillin|Penicillin|Amoxicillin/clavulanic acid|Ceftaroline | Reslit | Candidate |
| G105R | - | - | Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis | Cefepime | Reslit | Candidate |
| N138I | - | - | Staphylococcus aureus | Ceftaroline | Reslit | Candidate |
| N138K | - | - | Staphylococcus aureus | Ceftaroline | Reslit | Candidate |
| F241L | - | - | Staphylococcus aureus | Ceftaroline | Reslit | Candidate |
| T201A | - | - | Staphylococcus aureus | Ceftaroline | Reslit | Candidate |
| H270L | - | - | Staphylococcus aureus | Ceftaroline | Reslit | Candidate |
| T189S | - | Staphylococcus aureus | Oxacillin | Reslit | Candidate |
| T25A | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| S395C | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| T253P | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| E398A | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| D98E | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| A409T | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| Q283A | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| P220S | - | - | Staphylococcus aureus | Cefoxitin|Penicillin|Cephalosporin|Carbapenem | Reslit | Candidate |
| L307I | - | - | Staphylococcus aureus | Vancomycin | Reslit | Candidate |
| - | D-alanyl-D-alanine carboxypeptidase PBP4 promoter region | Staphylococcus aureus | CEPHALOSPORIN | Reference Gene Catalog | Established |
| - | - | Staphylococcus aureus | - | Reslit | Candidate |
PBP4 activity and its overexpression are necessary for PBP4-mediated high-level β-lactam resistance.
Mechanisms of resistance to imipenem and ampicillin in Enterococcus faecalis.
PBP4-mediated β-lactam resistance among clinical strains of Staphylococcus aureus.
mutations in pbp4 promoter and gene mediate β-lactam resistance
pbp4
A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level β-lactam resistance contains mutations in three genes.
pbp4
In Vitro Selection of High-Level Beta-Lactam Resistance in Methicillin-Susceptible Staphylococcus aureus.
Detected in both strains after 5th and 30th passages
De novo acquisition of antibiotic resistance in six species of bacteria.
Whole-Genome Sequencing of Methicillin-Resistant Staphylococcus aureus Resistant to Fifth-Generation Cephalosporins Reveals Potential Non-mecA Mechanisms of Resistance.
Mutations in pbp4 and its promoter are associated with resistance to ceftaroline.
PBP 4 Mediates High-Level Resistance to New-Generation Cephalosporins in Staphylococcus aureus.
Mutations in pbp4 contribute to high-level resistance to ceftaroline and ceftobiprole.
Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus.
Mutations in pbp4 contribute to β-lactam resistance in S. aureus.
Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility.
Mutation in PBP4 contributes to reduced oxacillin susceptibility.
Genomic insights on heterogeneous resistance to vancomycin and teicoplanin in Methicillin-resistant Staphylococcus aureus: A first report from South India.
novel mutation
Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus.
missense mutation
Genomic characterization of two community-acquired methicillin-resistant Staphylococcus aureus with novel sequence types in Kenya.
Single-nucleotide polymorphisms in a vancomycin-resistant Staphylococcus aureus strain based on whole-genome sequencing.
Comparative Genomics of Borderline Oxacillin-Resistant Staphylococcus aureus Detected during a Pseudo-outbreak of Methicillin-Resistant S. aureus in a Neonatal Intensive Care Unit.
A Nonclassical Mechanism of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus and Its Effect on Virulence.
Promoter mutations in pbp4 lead to overexpression and beta-lactam resistance.
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