Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
penicillin-binding protein 4
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| P520S | - | - | Enterococcus faecalis | ampicillinimipenem | Reslit | Candidate |
| Y605H | - | - | Enterococcus faecalis | ampicillinimipenem | Reslit | Candidate |
| E218K | - | increased survival in the presence of the β-lactams nafcillin and cefoxitin, D-alanyl-D-alanine carboxypeptidase PBP4 | Staphylococcus aureus | nafcillincefoxitincephalosporins | Reference Gene CatalogReslit | Confirmed |
| R200L | - | increased survival in the presence of the β-lactams nafcillin and cefoxitin, D-alanyl-D-alanine carboxypeptidase PBP4 | Staphylococcus aureus | nafcillincefoxitinceftaroline+1 more | Reference Gene CatalogReslit | Confirmed |
| E297K | - | - | Staphylococcus aureus | oxacillinpenicillinamoxicillin clavulanic acid+1 more | Reslit | Candidate |
| G105R | - | - | Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis | cefepime | Reslit | Candidate |
| N138K | - | - | Staphylococcus aureus | ceftaroline | Reslit | Candidate |
| N138I | - | - | Staphylococcus aureus | ceftaroline | Reslit | Candidate |
| T201A | - | - | Staphylococcus aureus | ceftaroline | Reslit | Candidate |
| F241L | - | - | Staphylococcus aureus | ceftaroline | Reslit | Candidate |
| H270L | - | - | Staphylococcus aureus | ceftaroline | Reslit | Candidate |
| E183A | - | Target protection, D-alanyl-D-alanine carboxypeptidase PBP4 | Staphylococcus aureus | ceftarolineceftobiprolenafcillin+4 more | Reference Gene CatalogResFinder DatabaseReslit | Confirmed |
| F241R | - | Target protection, D-alanyl-D-alanine carboxypeptidase PBP4 | Staphylococcus aureus | ceftobiproleceftarolinenafcillin+4 more | Reference Gene CatalogResFinder DatabaseReslit | Confirmed |
| T189S | - | Staphylococcus aureus | oxacillin | Reslit | Candidate | |
| D98E | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| T253P | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| E398A | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| T25A | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| Q283A | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| S395C | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| A409T | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| P220S | - | - | Staphylococcus aureus | cefoxitinpenicillincephalosporins+1 more | Reslit | Candidate |
| L307I | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| - | D-alanyl-D-alanine carboxypeptidase PBP4 promoter region | Staphylococcus aureus | cephalosporins | Reference Gene Catalog | Established |
Mechanisms of resistance to imipenem and ampicillin in Enterococcus faecalis.
Research Article
PBP4-mediated β-lactam resistance among clinical strains of Staphylococcus aureus.
Research Article
mutations in pbp4 promoter and gene mediate β-lactam resistance
pbp4
In Vitro Selection of High-Level Beta-Lactam Resistance in Methicillin-Susceptible Staphylococcus aureus.
Research Article
Detected in both strains after 5th and 30th passages
De novo acquisition of antibiotic resistance in six species of bacteria.
Research Article
Whole-Genome Sequencing of Methicillin-Resistant Staphylococcus aureus Resistant to Fifth-Generation Cephalosporins Reveals Potential Non-mecA Mechanisms of Resistance.
Research Article
Mutations in pbp4 and its promoter are associated with resistance to ceftaroline.
PBP 4 Mediates High-Level Resistance to New-Generation Cephalosporins in Staphylococcus aureus.
Research Article
Mutations in pbp4 contribute to high-level resistance to ceftaroline and ceftobiprole.
Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus.
Research Article
Mutations in pbp4 contribute to β-lactam resistance in S. aureus.
Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility.
Research Article
Mutation in PBP4 contributes to reduced oxacillin susceptibility.
Genomic insights on heterogeneous resistance to vancomycin and teicoplanin in Methicillin-resistant Staphylococcus aureus: A first report from South India.
Research Article
novel mutation
Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus.
Research Article
missense mutation
Genomic characterization of two community-acquired methicillin-resistant Staphylococcus aureus with novel sequence types in Kenya.
Research Article
Single-nucleotide polymorphisms in a vancomycin-resistant Staphylococcus aureus strain based on whole-genome sequencing.
Research Article
PBP4 activity and its overexpression are necessary for PBP4-mediated high-level β-lactam resistance.
Research Article
A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level β-lactam resistance contains mutations in three genes.
Research Article
pbp4
Comparative Genomics of Borderline Oxacillin-Resistant Staphylococcus aureus Detected during a Pseudo-outbreak of Methicillin-Resistant S. aureus in a Neonatal Intensive Care Unit.
Research Article