Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
penicillin-binding protein
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| E629V | - | Target modification, penicillin-binding protein 5 | Enterococcus faecalis, Enterococcus faecium | ampicillinbeta lactams | Reference Gene CatalogResFinder DatabaseReslit | Confirmed |
| M485A | - | Target modification, penicillin-binding protein 5 | Enterococcus faecium, Enterococcus faecalis | penicillinampicillinbeta lactams | Reference Gene CatalogResFinder DatabaseReslit | Confirmed |
| A111G | - | - | - | penicillin | Reslit | Candidate |
| A192V | - | - | - | ampicillin | Reslit | Candidate |
| S39T | - | - | Enterococcus faecium | ampicillin | Reslit | Candidate |
| D644N | - | - | Enterococcus faecium | ampicillin | Reslit | Candidate |
| D434A | - | penicillin-binding protein 5 | Enterococcus faecium | ampicillinbeta lactams | Reference Gene CatalogReslit | Confirmed |
| V24A | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| S27G | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| R34Q | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| G66E | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| A68T | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| E85D | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| E100Q | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| K144Q | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| T172A | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| L177I | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| D204G | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| A216S | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| T324A | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| M485T | - | Target modification, penicillin-binding protein 5 | Enterococcus faecium | ampicillinbeta lactams | Reference Gene CatalogResFinder Database | Confirmed |
| N496K | - | Target modification, penicillin-binding protein 5 | Enterococcus faecium | ampicillinbeta lactams | Reference Gene CatalogResFinder Database | Confirmed |
| A499T | - | Target modification, penicillin-binding protein 5 | Enterococcus faecium | ampicillinbeta lactams | Reference Gene CatalogResFinder Database | Confirmed |
| A499I | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| E525D | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| V586L | - | Target modification, penicillin-binding protein 5 | Enterococcus faecium | ampicillinbeta lactams | Reference Gene CatalogResFinder Database | Confirmed |
| P667S | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| ins466S | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| ins466D | - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
| D325E | - | penicillin-binding protein 5 | Enterococcus faecium | beta lactams | Reference Gene Catalog | Established |
| A401S | - | penicillin-binding protein 5 | Enterococcus faecium | beta lactams | Reference Gene Catalog | Established |
| M426I | - | penicillin-binding protein 5 | Enterococcus faecium | beta lactams | Reference Gene Catalog | Established |
| S466SS | - | penicillin-binding protein 5 | Enterococcus faecium | beta lactams | Reference Gene Catalog | Established |
| D467DD | - | penicillin-binding protein 5 | Enterococcus faecium | beta lactams | Reference Gene Catalog | Established |
| L610I | - | penicillin-binding protein 5 | Enterococcus faecium | beta lactams | Reference Gene Catalog | Established |
| - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established | |
| - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established | |
| - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established | |
| - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established | |
| - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established | |
| - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established | |
| - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established | |
| - | Target modification | Enterococcus faecium | ampicillin | ResFinder Database | Established |
The ionophore resistance genes narA and narB are geographically widespread and linked to resistance to medically important antibiotics.
Research Article
Global epidemiological insights on the antimicrobial resistance of Enterococcus faecium and a genomic analysis framework.
Research Article
Optimizing Nanopore Sequencing for Rapid Detection of Microbial Species and Antimicrobial Resistance in Patients at Risk of Surgical Site Infections.
Research Article
Detected in Enterococcus faecium
Mechanisms of antibiotic resistance in enterococci.
Review
Mutation in Pbp5 leading to high-level ampicillin resistance
Characterization of a new transferable MDR plasmid carrying the pbp5 gene from a clade B commensal Enterococcus faecium.
Research Article
The PBP5 amino acid sequence differed from the C46 variant by two mutations (S39T and D644N).
Diversification and Evolution of Vancomycin-Resistant Enterococcus faecium during Intestinal Domination.
Research Article
A nonsynonymous mutation in the gene for penicillin-binding protein 5 (pbp5) became fixed in the population by day 49.
pbp5
Enterococcus faecium PBP5-S/R, the missing link between PBP5-S and PBP5-R.
Research Article
The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
Not essential for resistance phenotype
[The artificial feeding of tumor patients at home. Collaboration by the nutritional team and the community nursing service].
Research Article
The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
Not essential for resistance phenotype
Genotyping using whole-genome sequencing is a realistic alternative to surveillance based on phenotypic antimicrobial susceptibility testing.
Research Article
pbp5
Modification of penicillin-binding protein 5 associated with high-level ampicillin resistance in Enterococcus faecium.
Research Article
pbp5
Antibiotic resistance determination using Enterococcus faecium whole-genome sequences: a diagnostic accuracy study using genotypic and phenotypic data.
Research Article
pbp5
Whole-genome sequencing based characterization of antimicrobial resistance in Enterococcus.
Research Article
pbp5
Prediction of Antimicrobial Resistance in Clinical Enterococcus faecium Isolates Using a Rules-Based Analysis of Whole-Genome Sequences.
Research Article
pbp5
Molecular characterization of ampicillin-resistant Enterococcus faecium isolates from hospitalized patients in Norway.
Research Article
pbp5
Structure of the low-affinity penicillin-binding protein 5 PBP5fm in wild-type and highly penicillin-resistant strains of Enterococcus faecium.
Research Article
pbp5