pbpA

penicillin-binding protein

Validation StatusCandidate

Overview

Validation Method: transformation and penicillin binding assays
Drug Classes: Amoxicillin, Ceftriaxone, Ampicillin, Penicillin, Amoxicillin|Ceftriaxone
Organisms: Helicobacter cinaedi, Staphylococcus aureus ST692, Staphylococcus aureus
Geographic Location: Japan
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S314A	-	-	Staphylococcus aureus	Penicillin	Reslit	Candidate
S423R	-	-	Helicobacter cinaedi	Amoxicillin\|Ceftriaxone	Reslit	Candidate

Papers3

Mutations in Genes Encoding Penicillin-Binding Proteins and Efflux Pumps Play a Role in β-Lactam Resistance in Helicobacter cinaedi.

PMID 29203490 · 2018

Mutations in pbpA and ftsI genes were identified as key determinants of β-lactam resistance in Helicobacter cinaedi, with pbpA mutations being the primary factor. Additionally, efflux pump components cmeB and cmeD were found to contribute to resistance.

Gene Information

Gene Name: pbpA
Allele: pbpA
Encodes: penicillin-binding protein
Source Database: Reslit
Confers Resistance To: AmoxicillinCeftriaxone
Organisms Tested In: • Helicobacter cinaedi
Geographic Location: Japan
Validation Method: transformation and penicillin binding assays
Sequence Accession: AP017374|DRA005701

Significant increase in the secretion of extracellular vesicles and antibiotics resistance from methicillin-resistant Staphylococcus aureus induced by ampicillin stress.

PMID 33273518 · 2020

The study identifies β-lactamase (blaZ and SA1529) and penicillin-binding proteins (pbpA, pbp2, pbp3) in EVs from MRSA that contribute to β-lactam antibiotic resistance by degrading antibiotics and altering cell wall synthesis.

Gene Information

Gene Name: pbpA
Allele: pbpA
Encodes: Penicillin-binding protein 1
Source Database: Reslit
Confers Resistance To: AmpicillinAmoxicillin
Organisms Tested In: • Staphylococcus aureus ST692
Validation Method: proteomic analysis

Browse AMR Genes

pbpA

Mutations

Gene Information

Gene Information