Browse AMR Genes

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pbpC

penicillin-binding protein 3

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to pbpC

Browse AMR rules for pbpC

Validation StatusSupported

Overview

Mechanism: confers resistance to beta-lactam antibiotics by functioning as a penicillin-binding protein
Validation Method: insertional inactivation and complementation experiments
Drug Classes: Beta-lactams, Imipenem, Meropenem, Ampicillin, Ceftriaxone, Cefepime
Organisms: Staphylococcus aureus, Pseudomonas spp., Enterococcus faecalis, Bacillus subtilis, Morganella morganii
Geographic Location: Norway|China
Papers: 5
Databases: Reslit
Mutations: 26

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G105R	-	-	Enterococcus faecalis, Bacillus subtilis, Staphylococcus aureus	Cefepime	Reslit	Candidate
A345V	-	-	Morganella morganii	Imipenem	Reslit	Candidate
V280I	-	-	Morganella morganii	Imipenem	Reslit

Papers5

1

Cloning, characterization, and inactivation of the gene pbpC, encoding penicillin-binding protein 3 of Staphylococcus aureus.

PMID 10648534 · 2000

The study identifies and characterizes the pbpC gene, which encodes penicillin-binding protein 3 (PBP 3) in Staphylococcus aureus. Inactivation of pbpC resulted in decreased autolysis rates and minor effects on growth, but did not significantly alter methicillin resistance in the MRSA strain COL. However, reintroducing pbpC in a mutant strain led to a twofold decrease in methicillin MIC.

Gene Information

Gene Name: pbpC
Allele: pbpC
Encodes: penicillin-binding protein 3
Source Database: Reslit
Mechanism: confers resistance to beta-lactam antibiotics by functioning as a penicillin-binding protein
Confers Resistance To: Beta-lactams
Organisms Tested In: • Staphylococcus aureus
Validation Method: insertional inactivation and complementation experiments
Sequence Accession: AJ243120

2

Antibiotic Resistance and Phylogeny of Pseudomonas spp. Isolated over Three Decades from Chicken Meat in the Norwegian Food Chain.

PMID 33498315 · 2021

The study identified several AMR genes and mutations in Pseudomonas spp. isolated from chicken meat in Norway, including beta-lactamases, efflux pumps, and genes involved in resistance to aminoglycosides, fluoroquinolones, and colistin.

Gene Information

Gene Name: pbpC
Allele: pbpC
Encodes: penicillin-binding protein
Source Database: Reslit
Mechanism: reduced affinity for beta-lactam antibiotics
Confers Resistance To: ImipenemMeropenem
Organisms Tested In: • Pseudomonas spp.
Geographic Location: Norway|China
Validation Method: whole-genome sequencing
Sequence Accession: PRJNA685056

3

Arginine impacts aggregation, biofilm formation, and antibiotic susceptibility in Enterococcus faecalis.

PMID 39524554 · 2024

Arginine metabolism in Enterococcus faecalis leads to increased aggregation, decreased biofilm formation, and altered antibiotic susceptibility, particularly to ampicillin and ceftriaxone.

Gene Information

Gene Name: pbpC
Allele: pbpC
Encodes: penicillin-binding protein
Source Database: Reslit
Confers Resistance To: AmpicillinCeftriaxone
Organisms Tested In: • Enterococcus faecalis
Validation Method: RNAseq and disc diffusion assay
Sequence Accession: GSE268264