pbpG

d-Alanyl-d-alanine endopeptidase

Validation StatusCandidate

Overview

Mechanism: peptidoglycan synthesis
Validation Method: transposon insertion and MIC testing
Drug Classes: Ampicillin, Piperacillin, Ceftazidime, Imipenem, Vancomycin, Carbapenem
Organisms: Acinetobacter baylyi, Acinetobacter baumannii
Papers: 2
Databases: Reslit

Papers2

Genes involved in intrinsic antibiotic resistance of Acinetobacter baylyi.

PMID 16940057 · 2006

The study identifies 11 genes in Acinetobacter baylyi whose disruption leads to antibiotic hypersusceptibility, including genes involved in efflux pumps, peptidoglycan synthesis, and other metabolic pathways.

Gene Information

Gene Name: pbpG
Allele: pbpG
Encodes: d-Alanyl-d-alanine endopeptidase
Source Database: Reslit
Mechanism: peptidoglycan synthesis
Confers Resistance To: AmpicillinPiperacillinCeftazidimeImipenemVancomycin
Organisms Tested In: • Acinetobacter baylyi
Validation Method: transposon insertion and MIC testing

Peptidoglycan Recycling Promotes Outer Membrane Integrity and Carbapenem Tolerance in Acinetobacter baumannii.

PMID 35638738 · 2022

The study identifies pbpG and elsL as key contributors to meropenem tolerance in Acinetobacter baumannii through their roles in peptidoglycan recycling and maintaining outer membrane integrity.

Gene Information

Gene Name: pbpG
Allele: pbpG
Encodes: penicillin-binding protein 7
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Acinetobacter baumannii
Validation Method: genetic knockout and meropenem killing assay
Sequence Accession: GSE190441

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pbpG

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