pbpX

putative carboxypeptidase

Validation StatusSupported

Overview

Mechanism: binding to penicillin
Validation Method: disk diffusion assay
Drug Classes: Penicillin, Beta-lactams, Cefepime
Organisms: Listeria monocytogenes, Streptococcus pneumoniae, Lactobacillus helveticus D75, Lactobacillus helveticus D76, Acinetobacter pittii, Enterococcus faecalis, Staphylococcus aureus
Geographic Location: Netherlands|USA|Thailand, Russia
Papers: 4
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G105R	-	-	Acinetobacter pittii, Enterococcus faecalis, Staphylococcus aureus	Cefepime	Reslit	Candidate

Papers4

Listeria monocytogenes Is Resistant to Lysozyme through the Regulation, Not the Acquisition, of Cell Wall-Modifying Enzymes.

PMID 25157076 · 2014

The study identifies pgdA, pbpX, degU, and rli31 as key players in Listeria monocytogenes resistance to lysozyme, highlighting the importance of gene regulation rather than the acquisition of new enzymes.

Gene Information

Gene Name: pbpX
Allele: pbpX
Encodes: putative carboxypeptidase
Source Database: Reslit
Organisms Tested In: • Listeria monocytogenes
Validation Method: disk diffusion assay

Deciphering the distance to antibiotic resistance for the pneumococcus using genome sequencing data.

PMID 28205635 · 2017

The study identifies numerous genes and mutations associated with antibiotic resistance in Streptococcus pneumoniae through genome-wide association studies, highlighting the genetic basis of resistance to penicillin, trimethoprim, cotrimoxazole, erythromycin, and fluoroquinolones.

Gene Information

Gene Name: pbpX
Allele: pbpX
Encodes: penicillin-binding protein X
Source Database: Reslit
Confers Resistance To: Penicillin
Organisms Tested In: • Streptococcus pneumoniae
Geographic Location: Netherlands|USA|Thailand
Validation Method: genome-wide association study

Whole-Genome Sequencing of Lactobacillus helveticus D75 and D76 Confirms Safety and Probiotic Potential.

PMID 32111071 · 2020

The study identified eight genes associated with moderate antibiotic resistance and resistance against xenobiotics in Lactobacillus helveticus D75 and D76, including blaZ, pbpX, mprF, and had.

Gene Information

Gene Name: pbpX
Allele: pbpX
Encodes: penicillin-binding protein
Source Database: Reslit
Mechanism: binding to penicillin
Confers Resistance To: Beta-lactams
Organisms Tested In: • Lactobacillus helveticus D75
• Lactobacillus helveticus D76
Geographic Location: Russia
Validation Method: genomic analysis
Sequence Accession: CP020029|CP16827

Browse AMR Genes

pbpX

Mutations

Gene Information

Gene Information

Gene Information