pbpb
penicillin-binding protein 2
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to pbpb
AMR Rules
Browse AMR rules for pbpb
Validation StatusCandidate
Overview
- Mechanism
- mutation in the transpeptidase domain leading to reduced affinity for ceftizoxime and altered cell wall cross-linking
- Validation Method
- allelic replacement experiments and site-directed mutagenesis
- Drug Classes
- ceftizoxime
- Organisms
- Staphylococcus aureus
- Papers
- 1
- Databases
- Reslit
Papers1
1
Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A.
Gene Information
- Gene Name
- pbpb
- Allele
- pbpB
- Encodes
- penicillin-binding protein 2
- Source Database
- Reslit
- Mechanism
- mutation in the transpeptidase domain leading to reduced affinity for ceftizoxime and altered cell wall cross-linking
- Confers Resistance To
- ceftizoxime
- Organisms Tested In
- • Staphylococcus aureus
- Validation Method
- allelic replacement experiments and site-directed mutagenesis
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