penA
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
AMR Rules
Browse AMR rules for penA
Validation StatusCandidate
Overview
- Papers
- 2
- Mutations
- 5
Mutations
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| A501V | - | increased resistance | Neisseria gonorrhoeae | cefixime|ceftriaxoneceftriaxone|cefixime | Reslit | Candidate |
| I312M | - | decreased susceptibility | Neisseria gonorrhoeae | ceftriaxone|cefixime | Reslit | Candidate |
| V316T | - | decreased susceptibility | Neisseria gonorrhoeae | ceftriaxone|cefixime | Reslit | Candidate |
| G545S | - | decreased susceptibility | Neisseria gonorrhoeae | ceftriaxone|cefixime | Reslit | Candidate |
| N512Y | - | decreased susceptibility | Neisseria gonorrhoeae | ceftriaxone|cefixime | Reslit | Candidate |
Papers2
1
Various penA mutations together with mtrR, porB and ponA mutations in Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime or ceftriaxone.
PenA mutations including deletion of A leading to Ala-501→Val substitution are associated with reduced susceptibility to cefixime and ceftriaxone.
Mutation Information
- Protein Change
- A501V
- Organisms
- Neisseria gonorrhoeae
- Confers Resistance To
- cefixime|ceftriaxone
- Source Database
- Reslit
2
Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations.
Mutations in penA are critical for intermediate resistance to expanded-spectrum cephalosporins in Neisseria gonorrhoeae.
Mutation Information
- Protein Change
- I312M, V316T, G545S, N512Y, A501V
- Organisms
- Neisseria gonorrhoeae
- Confers Resistance To
- ceftriaxone|cefixime
- Effect on Function
- decreased susceptibility; increased resistance
- Source Database
- Reslit