Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Xaa-Pro aminopeptidase
Overview
| Candidate |
| - | - | - | Bedaquiline | Reslit | Candidate |
| - | - | - | Bedaquiline | Reslit | Candidate |
| - | - | - | Bedaquiline | Reslit | Candidate |
| - | - | - | Bedaquiline | Reslit | Candidate |
| - | - | - | Bedaquiline | Reslit | Candidate |
| - | - | - | Bedaquiline | Reslit | Candidate |
| - | - | - | Bedaquiline | Reslit | Candidate |
| - | - | - | Bedaquiline | Reslit | Candidate |
| E177* | - | Mycobacterium tuberculosis | Bedaquiline|Clofazimine | Reslit | Candidate |
| - | - | - | Bedaquiline | Reslit | Candidate |
| - | - | - | Bedaquiline | Reslit | Candidate |
| - | - | - | Bedaquiline | Reslit | Candidate |
Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.
This study identifies numerous mutations in genes associated with resistance to bedaquiline, clofazimine, linezolid, delamanid, and pretomanid in Mycobacterium tuberculosis, highlighting the genetic basis of resistance to these drugs.
Treatment of Highly Drug-Resistant Pulmonary Tuberculosis
The study identified mutations in the pepQ gene that confer low-level resistance to bedaquiline and clofazimine in Mycobacterium tuberculosis.
Nontuberculous Mycobacterial Resistance to Antibiotics and Disinfectants: Challenges Still Ahead.
The paper discusses various AMR mechanisms in non-tuberculous mycobacteria (NTM), focusing on resistance to antibiotics such as ethambutol, macrolides, rifampin, bedaquiline, and clofazimine. Key genes and mutations identified include embB, erm, rpoB, atpE, mmpT5, pepQ, mmpL5, rplC, 23S rRNA, 16S rRNA, gyrA, and gyrB.
Bedaquiline Resistance and Molecular Characterization of Rifampicin-Resistant Mycobacterium Tuberculosis Isolates in Zhejiang, China.
The study identified Rv0678 and pepQ mutations as the primary mechanisms of bedaquiline resistance in rifampicin-resistant Mycobacterium tuberculosis isolates from Zhejiang, China.
Speeding up drug susceptibility testing in Mycobacterium tuberculosis using RNA biomarkers.
The study introduces TRACeR-TB, a rapid drug susceptibility testing method for Mycobacterium tuberculosis that uses RNA biomarkers to detect resistance. It identifies specific mRNA biomarkers for different antibiotics and demonstrates improved sensitivity and specificity compared to traditional methods.
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