pgm

Phosphoglucomutase

Validation StatusCandidate

Overview

Mechanism: Other functions
Validation Method: Gene knockout and MIC testing
Drug Classes: Tilmicosin, Erythromycin, Azithromycin, Rifampin, Ceftriaxone
Organisms: Escherichia coli ETEC5621, Escherichia coli K-12 MG1655, Staphylococcus aureus, Escherichia coli
Geographic Location: Denmark, Europe
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
F266L	-	-	Escherichia coli	Ceftriaxone	Reslit	Candidate
P121L	-	-	Escherichia coli	Ceftriaxone	Reslit	Candidate

Papers3

The intrinsic macrolide resistome of Escherichia coli.

PMID 38940570 · 2024

The study identified several genes involved in intrinsic macrolide resistance in E. coli, including surA, waaG, acrA, acrB, tolC, lptC, bamB, lpp, tolA, tolB, tolR, waaQ, gmhB, galU, waaP, lapC, prc, nlpI, hrpA, and pgm. These genes are associated with outer membrane integrity, efflux pumps, LPS biosynthesis, and peptidoglycan metabolism.

Gene Information

Gene Name: pgm
Allele: pgm
Encodes: Phosphoglucomutase
Source Database: Reslit
Mechanism: Other functions
Confers Resistance To: TilmicosinErythromycinAzithromycin
Organisms Tested In: • Escherichia coli ETEC5621
• Escherichia coli K-12 MG1655
Geographic Location: Denmark
Validation Method: Gene knockout and MIC testing
Sequence Accession: U00096.3

A Study of Antibiotic Tolerance to Levofloxacin and Rifampin in Staphylococcus aureus Isolates Causing Prosthetic Joint Infections: Clinical Relevance and Treatment Challenges.

PMID 41594048 · 2025

The study identified sspA and leuS as genes associated with increased levofloxacin tolerance in biofilm-forming S. aureus isolates, and prs and pgm as genes linked to rifampin tolerance in non-biofilm isolates.

Gene Information

Gene Name: pgm
Allele: pgm
Encodes: phosphoglucomutase
Source Database: Reslit
Confers Resistance To: Rifampin
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Europe
Validation Method: genomic analysis and TDtest
Sequence Accession: JAJHMK000000000|JAJHNB000000000|JAJHMI000000000|JAJHNN000000000|JAJHMB000000000|JAJHLP000000000|JAJHLR000000000|JAJHLS000000000|JAJHLQ000000000|JAJHMV000000000|JAJHNG000000000|JAJHNF000000000

Browse AMR Genes

pgm

Mutations

Gene Information

Gene Information