Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G147D | - | abolishing phosphatidylglycerophosphate synthase activity | Corynebacterium striatum | Daptomycin | Reslit | Candidate |
| T33N | - | - | Staphylococcus aureus | Daptomycin | Reslit | Candidate |
| A64V | - | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA, single resistance variant | Staphylococcus aureus | Daptomycin |
Card DatabaseReference Gene CatalogReslit |
| Confirmed |
| K65R | - | - | Staphylococcus aureus | Daptomycin | Reslit | Candidate |
| V59N | - | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA, single resistance variant | Staphylococcus aureus | DaptomycinDAPTOMYCIN | Card DatabaseReference Gene CatalogReslit | Confirmed |
| V44P | - | - | Escherichia coli | Gentamicin | Reslit | Candidate |
| G52S | - | - | Streptococcus mitis, S. oralis | Daptomycin | Reslit | Candidate |
| G122D | - | - | Staphylococcus capitis | Daptomycin | Reslit | Candidate |
| K135E | - | - | Staphylococcus aureus | Daptomycin | Reslit | Candidate |
| S177F | - | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA, single resistance variant | Staphylococcus aureus | DaptomycinDAPTOMYCIN | Card DatabaseReference Gene CatalogReslit | Confirmed |
| G170D | - | - | Staphylococcus aureus | Daptomycin | Reslit | Candidate |
| R579L | - | - | Staphylococcus aureus | Daptomycin | Reslit | Candidate |
| T70P | - | decreased PgsA activity | Enterococcus faecium | Daptomycin | Reslit | Candidate |
| K66R | - | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA, single resistance variant | Staphylococcus aureus | DAPTOMYCINDaptomycin | Card DatabaseReference Gene Catalog | Confirmed |
Rapid acquisition of daptomycin resistance in a Corynebacterium striatum osteoarticular infection: case report and discussion on antimicrobial resistance.
The G147D mutation introduces a premature stop codon in the active site of the PgsA enzyme, abolishing phosphatidylglycerophosphate synthase activity.
Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus.
Staphylococcus aureus pgsA mutations conferring resistance to daptomycin; CARD accession: CARD:3003323
Metabolic mutations reduce antibiotic susceptibility of E. coli by pathway-specific bottlenecks.
Resistant to gentamicin with at least twofold higher MIC.
Mutations in cdsA and pgsA Correlate with Daptomycin Resistance in Streptococcus mitis and S. oralis.
Emergence of daptomycin non-susceptible coagulase-negative Staphylococci in patients with cardiovascular device infections: Two cases report investigated by whole genome analysis.
Insights Into the Evolution of Staphylococcus aureus Daptomycin Resistance From an in vitro Bioreactor Model.
Adaptive Laboratory Evolution of Staphylococcus aureus Resistance to Vancomycin and Daptomycin: Mutation Patterns and Cross-Resistance.
Mutations detected in derivatives selected for daptomycin.
Evolution of Enterococcus faecium in Response to a Combination of Daptomycin and Fosfomycin Reveals Distinct and Diverse Adaptive Strategies.
The mutation pgsA T70P was observed in DAP-resistant isolates and is associated with decreased PgsA activity, leading to reduced phosphatidylglycerol (PG) levels and contributing to DAP resistance.
Reduction in membrane phosphatidylglycerol content leads to daptomycin resistance in Bacillus subtilis.
Bacillus subtilis pgsA with mutation conferring resistance to daptomycin; CARD accession: CARD:3003788
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