Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R117L | - | single resistance variant, two-component system response regulator PhoP | Pseudomonas aeruginosa | ColistinCOLISTIN | Card DatabaseReference Gene Catalog | Confirmed |
| H14R | - | - | Pseudomonas aeruginosa | Gentamicin|Cefotaxime | Reslit | Candidate |
| D191Y | - | single resistance variant, two-component system response regulator PhoP |
| Klebsiella pneumoniae, Enterobacterales |
ColistinCOLISTIN |
Card DatabaseReference Gene CatalogReslit |
| Confirmed |
| V30A | - | - | Pseudomonas aeruginosa | Polymyxin | Reslit | Candidate |
| L12Q | - | deleterious | Klebsiella pneumoniae | Colistin | Reslit | Supported |
| R114A | - | - | - | Colistin | Reslit | Candidate |
| A416T | - | - | Escherichia coli | Colistin | Reslit | Candidate |
| C58A | - | - | Enterobacter xiangfangensis | Colistin | Reslit | Candidate |
| D191N | - | - | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| H188P | - | - | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| T151A | - | - | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| H6R | - | - | E. coli | Colistin | Reslit | Candidate |
| D86G | - | affects protein function | E. coli | Colistin | Reslit | Candidate |
| A482T | - | affects protein function | E. coli | Colistin | Reslit | Candidate |
| V260G | - | - | Pseudomonas aeruginosa | Colistin | Reslit | Candidate |
| D46V | - | - | Enterobacter spp. | Colistin | Reslit | Candidate |
| N188Y | - | two-component system response regulator PhoP | Pseudomonas aeruginosa | COLISTIN | Reference Gene Catalog | Established |
| N188H | - | two-component system response regulator PhoP | Pseudomonas aeruginosa | COLISTIN | Reference Gene Catalog | Established |
| A110V | - | single resistance variant, two-component system response regulator PhoP | Pseudomonas aeruginosa | ColistinCOLISTIN | Card DatabaseReference Gene Catalog | Confirmed |
| K199M | - | - | Polymyxin | Reslit | Candidate |
| R81S | - | - | Stenotrophomonas maltophilia | Ciprofloxacin|Ceftazidime | Reslit | Candidate |
| G72D | - | - | Pseudomonas aeruginosa | Polymyxin b | Reslit | Candidate |
| V108M | - | - | Escherichia coli | Colistin | Reslit | Candidate |
| A217V | - | - | - | Colistin | Reslit | Candidate |
| R13C | - | - | - | Colistin | Reslit | Candidate |
| I44L | - | - | Escherichia coli | Colistin | Reslit | Candidate |
| I175F | - | - | Escherichia coli | Colistin | Reslit | Candidate |
| V386L | - | - | Escherichia coli | Colistin | Reslit | Candidate |
| G123D | - | - | Pseudomonas aeruginosa | Colistin | Reslit | Candidate |
| M175K | - | neutral | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| E22K | - | neutral | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| D434N | - | - | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| A21S | - | - | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| T104A | - | - | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| E82K | - | effect on function of PhoP | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| G121A | - | - | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| L26Q | - | - | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| Q317K | - | - | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| Q426L | - | - | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| L4F | - | - | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| V3F | - | two-component system response regulator PhoP | Klebsiella pneumoniae | ColistinCOLISTIN | Reference Gene CatalogReslit | Confirmed |
| V5R | - | strain-specific and were considered as mutations affecting protein function | Enterobacter hormaechei | Colistin | Reslit | Candidate |
| D191A | - | - | Klebsiella pneumoniae | Polymyxin | Reslit | Candidate |
| I201N | - | two-component system response regulator PhoP | Klebsiella pneumoniae | COLISTIN | Reference Gene Catalog | Established |
| - | - | Klebsiella pneumoniae | Colistin | Reslit | Candidate |
| - | - | Klebsiella pneumoniae | Polymyxin b | Reslit | Candidate |
| - | - | Pseudomonas aeruginosa | Polymyxin | Reslit | Candidate |
Mutations and expression of PmrAB and PhoPQ related with colistin resistance in Pseudomonas aeruginosa clinical isolates.
Pseudomonas mutant PhoP conferring resistance to colistin; CARD accession: CARD:3003895
phoP
Phenotypic and genome-wide analysis of an antibiotic-resistant small colony variant (SCV) of Pseudomonas aeruginosa.
Heteroresistance to Colistin in Klebsiella pneumoniae Associated with Alterations in the PhoPQ Regulatory System.
The wild-type PhoP protein is part of the PhoPQ regulatory system that activates pmrHFIJKLM expression responsible for l-aminoarabinose synthesis and polymyxin resistance.
Klebsiella mutant PhoP conferring antibiotic resistance to colistin; CARD accession: CARD:3003585
phoP
Hypermutator Pseudomonas aeruginosa Exploits Multiple Genetic Pathways To Develop Multidrug Resistance during Long-Term Infections in the Airways of Cystic Fibrosis Patients.
Risk factors for acquisition of colistin-resistant Klebsiella pneumoniae and expansion of a colistin-resistant ST307 epidemic clone in hospitals in Marseille, France, 2014 to 2017.
Predicted to modify protein function by PROVEAN analysis.
A Molecular Perspective on Colistin and Klebsiella pneumoniae: Mode of Action, Resistance Genetics, and Phenotypic Susceptibility.
Mutations in PhoP/PhoQ lead to constitutive activation of the arnBCADTEF operon and pmrC.
Molecular Epidemiology and Colistin-Resistant Mechanism of mcr-Positive and mcr-Negative Escherichia coli Isolated From Animal in Sichuan Province, China.
Mutation in PhoP was found in mcr-negative colistin-resistant E. coli isolates.
Colistin heteroresistance in Enterobacter due to base heterozygosity at certain phoP and phoQ locations.
Mutation in phoP gene was found to confer colistin resistance.
Evolution of Colistin Resistance in the Klebsiella pneumoniae Complex Follows Multiple Evolutionary Trajectories with Variable Effects on Fitness and Virulence Characteristics.
A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition.
Colistin Resistance Among Multiple Sequence Types of Klebsiella pneumoniae Is Associated With Diverse Resistance Mechanisms: A Report From India.
Acquisition of the mcr-1 Gene Lowers the Target Mutation to Impede the Evolution of a High-Level Colistin-Resistant Mutant in Escherichia coli.
Antibiotic Heteroresistance in Klebsiella pneumoniae.
Mutations in PhoP are associated with colistin heteroresistance.
The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions.
Global colistin use: a review of the emergence of resistant Enterobacterales and the impact on their genetic basis.
Mutations in PhoP contribute to colistin resistance.
Emergence of colistin resistance in Pseudomonas aeruginosa ST235 clone in South Korea.
phoP
Mutant prevention concentrations of colistin for Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae clinical isolates.
phoP
Clonal transmission and species-specific mechanisms of polymyxin resistance in carbapenem-resistant Enterobacteriaceae from Southwest China.
PhoP Lys199Met mutation contributes to polymyxin resistance.
Predictive Studies Suggest that the Risk for the Selection of Antibiotic Resistance by Biocides Is Likely Low in Stenotrophomonas maltophilia.
Mutation in phoP was associated with reduced susceptibility to certain antibiotics.
Production of Norspermidine Contributes to Aminoglycoside Resistance in pmrAB Mutants of Pseudomonas aeruginosa.
mutation in phoP leads to polymyxin B resistance
Characterization Of Chromosome-Mediated Colistin Resistance In Escherichia coli Isolates From Livestock In Korea.
observed in CL-18 isolate
Pathogenomics and Evolutionary Epidemiology of Multi-Drug Resistant Clinical Klebsiella pneumoniae Isolated from Pretoria, South Africa.
Clinical and Microbiological Risk Factors for 30-Day Mortality of Bloodstream Infections Caused by OXA-48-Producing Klebsiella pneumoniae.
associated with colistin resistance
Whole-genome sequence analysis of clinically isolated carbapenem resistant Escherichia coli from Iran.
Identification of mcr-1 Genes and Characterization of Resistance Mechanisms to Colistin in Escherichia coli Isolates from Colombian Hospitals.
The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research.
Mutations in phoP lead to resistance to colistin.
Heteroresistance to colistin in wild-type Klebsiella pneumoniae isolates from clinical origin.
Mutations in phoP were associated with colistin resistance.
Proteomic Investigation of the Signal Transduction Pathways Controlling Colistin Resistance in Klebsiella pneumoniae.
Specific mutations in PhoPQ were found to activate arn operon transcription and confer colistin resistance.
Colistin Heteroresistance among Extended Spectrum β-lactamases-Producing Klebsiella pneumoniae.
High prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be overcome by colistin-EDTA combination therapy.
mutation in phoP contributes to colistin resistance
Polymyxin Resistance in Clinical Isolates of K. pneumoniae in Brazil: Update on Molecular Mechanisms, Clonal Dissemination and Relationship With KPC-Producing Strains.
mutations in PhoP contribute to polymyxin resistance
Characterization of Carbapenemase-Producing Klebsiella pneumoniae Isolates from Two Romanian Hospitals Co-Presenting Resistance and Heteroresistance to Colistin.
Mutations in phoP were observed in multiple strains and are associated with colistin resistance
Colistin Resistance Mechanism in Enterobacter hormaechei subsp. steigerwaltii Isolated from Wild Boar (Sus scrofa) in France.
High prevalence of polymyxin-heteroresistant carbapenem-resistant Klebsiella pneumoniae and its within-host evolution to resistance among critically ill scenarios.
Mutation in phoP contributes to polymyxin resistance
Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan.
phoP
Delta sleep-inducing peptide response to human corticotropin-releasing hormone (CRH) in major depressive disorder. Comparison with CRH-induced corticotropin and cortisol secretion.
phoP
Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.
associated with colistin resistance
Lipid A in outer membrane vesicles shields bacteria from polymyxins.
Mutation in the promoter region of phoP leads to increased expression and contributes to polymyxin B resistance.
PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients.
phoP24 allele
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