Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
two-component sensor kinase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| V260G | - | increased susceptibility to colistin, single resistance variant, two-component system sensor histidine kinase PhoQ | Pseudomonas aeruginosa, E. coli | polymyxin bcolistin | Card DatabaseReference Gene CatalogReslit | Confirmed |
| D434N | - | mutation in the cytoplasmic GHKL domain (ATP-lid loop) | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| L26P | - | two-component system sensor histidine kinase PhoQ | Klebsiella pneumoniae | colistin | Reference Gene CatalogReslit | Confirmed |
| A21S | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| N346K | - | - | - | colistin | Reslit | Candidate |
| T156A | - | - | Escherichia coli | colistin | Reslit | Candidate |
| Y85F | - | - | Pseudomonas aeruginosa | amikacingentamicin | Reslit | Candidate |
| R16C | - | two-component system sensor histidine kinase PhoQ | Klebsiella pneumoniae | colistin | Reference Gene CatalogReslit | Confirmed |
| D150G | - | - | Klebsiella pneumoniae | colistinpolymyxin b | Reslit | Supported |
| V206G | - | - | Klebsiella pneumoniae | polymyxin b | Reslit | Candidate |
| K46T | - | deleterious | Escherichia coli | colistin | Reslit | Candidate |
| A466T | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| G1375T | - | - | Enterobacter xiangfangensis | colistin | Reslit | Candidate |
| T749A | - | - | Enterobacter xiangfangensis | colistin | Reslit | Candidate |
| G1175A | - | - | Enterobacter xiangfangensis | colistin | Reslit | Candidate |
| G1154A | - | - | Enterobacter xiangfangensis | colistin | Reslit | Candidate |
| G881A | - | - | Enterobacter xiangfangensis | colistin | Reslit | Candidate |
| L396Q | - | two-component system sensor histidine kinase PhoQ | Klebsiella pneumoniae | colistin | Reference Gene CatalogReslit | Confirmed |
| G385S | - | two-component system sensor histidine kinase PhoQ | Klebsiella pneumoniae | colistin | Reference Gene CatalogReslit | Confirmed |
| L30Q | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| A351D | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| L52V | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| E41D | - | - | Escherichia coli | aztreonamclavulanic acid | Reslit | Candidate |
| R423C | - | - | Enterobacter cloacae | colistin | Reslit | Candidate |
| N90D | - | - | Enterobacter cloacae | colistin | Reslit | Candidate |
| N150D | - | - | Enterobacter cloacae | colistin | Reslit | Candidate |
| R220C | - | - | Pseudomonas aeruginosa | carbenicillincefuroximedoripenem | Reslit | Candidate |
| L10R | - | - | - | colistin | Reslit | Candidate |
| Y89H | - | - | polymyxins | Reslit | Candidate | |
| L348Q | - | two-component system sensor histidine kinase PhoQ | Klebsiella pneumoniae | carbapenemspolymyxin bcolistin | Reference Gene CatalogReslit | Confirmed |
| F76Y | - | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| G39S | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| L239P | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| N253T | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| N253P | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| D438H | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| T439P | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| V446G | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| C340F | - | - | - | polymyxin b | Reslit | Candidate |
| D101E | - | - | Escherichia coli | colistin | Reslit | Candidate |
| S138T | - | - | Escherichia coli | colistin | Reslit | Candidate |
| I175F | - | - | Escherichia coli | colistin | Reslit | Candidate |
| V386L | - | - | Escherichia coli | colistin | Reslit | Candidate |
| E464D | - | - | Escherichia coli | colistin | Reslit | Candidate |
| T348N | - | - | Escherichia coli | colistin | Reslit | Candidate |
| D553V | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| M234V | - | - | Klebsiella pneumoniae | polymyxin b | Reslit | Candidate |
| G365R | - | - | Pseudomonas putida | aminoglycosides | Reslit | Candidate |
| K46Q | - | disrupts the phosphatase domain, allowing continuous PhoP activation of downstream genes such as those that modify lipid A, thereby providing colistin resistance | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| L467M | - | - | Escherichia coli | colistin | Reslit | Candidate |
| P142S | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| L322Q | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| Q435H | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| V456A | - | - | - | colistin | Reslit | Candidate |
| V24G | - | deleterious, single resistance variant, two-component system sensor histidine kinase PhoQ | Klebsiella pneumoniae | colistin | Card DatabaseReference Gene CatalogReslit | Confirmed |
| L105Q | - | deleterious | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| K46E | - | neutral | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| Q155R | - | - | Pseudomonas aeruginosa | aztreonam | Reslit | Candidate |
| T281M | - | - | Klebsiella pneumoniae | polymyxin bcolistin | Reslit | Candidate |
| G385C | - | - | Klebsiella pneumoniae | polymyxin bcolistin | Reslit | Candidate |
| A351N | - | deleterious | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| I88N | - | - | - | colistin | Reslit | Candidate |
| T276C | - | - | - | colistin | Reslit | Candidate |
| Y265C | - | - | - | colistin | Reslit | Candidate |
| Y265T | - | - | - | colistin | Reslit | Candidate |
| E397G | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| L26Q | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| L224Q | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| L96R | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| L257P | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| K123Q | - | single resistance variant, two-component system sensor histidine kinase PhoQ | Pseudomonas aeruginosa | colistin | Card DatabaseReference Gene Catalog | Confirmed |
| A20P | - | two-component system sensor histidine kinase PhoQ | Klebsiella pneumoniae | colistin | Reference Gene Catalog | Established |
| A20S | - | two-component system sensor histidine kinase PhoQ | Klebsiella pneumoniae | colistin | Reference Gene Catalog | Established |
| S56R | two-component system sensor histidine kinase PhoQ | Klebsiella pneumoniae | colistin | Reference Gene CatalogReslit | Confirmed | |
| L96P | - | two-component system sensor histidine kinase PhoQ | Klebsiella pneumoniae | colistin | Reference Gene Catalog | Established |
| S174N | - | two-component system sensor histidine kinase PhoQ | Klebsiella pneumoniae | colistin | Reference Gene Catalog | Established |
| D266DD | - | two-component system sensor histidine kinase PhoQ | Klebsiella pneumoniae | colistin | Reference Gene Catalog | Established |
| D438N | - | two-component system sensor histidine kinase PhoQ | Klebsiella pneumoniae | colistin | Reference Gene Catalog | Established |
| N104I | - | two-component system sensor histidine kinase PhoQ | Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Established |
| V152* | - | two-component system sensor histidine kinase PhoQ | Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Established |
| LG364del | - | two-component system sensor histidine kinase PhoQ | Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Established |
| I421* | - | two-component system sensor histidine kinase PhoQ | Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Established |
| D433* | - | two-component system sensor histidine kinase PhoQ | Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Established |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| Q457E | - | - | colistin | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| A23V | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| - | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate | |
| - | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate | |
| L87P | - | - | colistin | Reslit | Candidate |
Differential Role of Two-Component Regulatory Systems (phoPQ and pmrAB) in Polymyxin B Susceptibility of Pseudomonas aeruginosa.
Research Article
phoQ
Genomic and transcriptomic analyses of colistin-resistant clinical isolates of Klebsiella pneumoniae reveal multiple pathways of resistance.
Research Article
Colistin Resistance Mechanisms in Klebsiella pneumoniae Strains from Taiwan.
Research Article
phoQ
Genomic Characterization of Colistin Heteroresistance in Klebsiella pneumoniae during a Nosocomial Outbreak.
Research Article
phoQ
Molecular Epidemiology and Colistin Resistant Mechanism of mcr-Positive and mcr-Negative Clinical Isolated Escherichia coli.
Research Article
found in high-MIC isolates
Molecular and genome characterization of colistin-resistant Escherichia coli isolates from wild sea lions (Zalophus californianus).
Research Article
Mutations in pmrB and phoQ were identified but not confirmed to contribute to colistin resistance.
Novel Molecular Markers Linked to Pseudomonas aeruginosa Epidemic High-Risk Clones.
Research Article
associated with high-risk clones
A Molecular Perspective on Colistin and Klebsiella pneumoniae: Mode of Action, Resistance Genetics, and Phenotypic Susceptibility.
Review
Mutations in PhoP/PhoQ lead to constitutive activation of the arnBCADTEF operon and pmrC.
Genotyping of paired KPC-producing Klebsiella pneumoniae isolates with and without divergent polymyxin B susceptibility profiles.
Research Article
Substitution in PhoQ was associated with polymyxin B resistance.
Molecular Epidemiology and Colistin-Resistant Mechanism of mcr-Positive and mcr-Negative Escherichia coli Isolated From Animal in Sichuan Province, China.
Research Article
Mutation in PhoQ was found in mcr-negative colistin-resistant E. coli isolates.
Molecular characterization of colistin resistance in carbapenem-resistant Klebsiella pneumoniae from a tertiary hospital in China.
Research Article
Colistin heteroresistance in Enterobacter due to base heterozygosity at certain phoP and phoQ locations.
Research Article
Mutations in phoQ gene were found to confer colistin resistance.
Emergence and clonal spread of colistin resistance due to multiple mutational mechanisms in carbapenemase-producing Klebsiella pneumoniae in London.
Research Article
Mutation in phoQ contributes to colistin resistance.
Evolution of Colistin Resistance in the Klebsiella pneumoniae Complex Follows Multiple Evolutionary Trajectories with Variable Effects on Fitness and Virulence Characteristics.
Research Article
Colistin Resistance Among Multiple Sequence Types of Klebsiella pneumoniae Is Associated With Diverse Resistance Mechanisms: A Report From India.
Research Article
Resistance evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11 during treatment with tigecycline and polymyxin.
Research Article
Emergence of polymyxin B-heteroresistant hypervirulent Klebsiella pneumoniae from an individual in the community with asymptomatic bacteriuria.
Research Article
The D150G substitution in phoQ is known to confer polymyxin B resistance.
Prevalence and genetic characterization of clinically relevant extended-spectrum β-lactamase-producing Enterobacterales in the Gulf Cooperation Council countries.
Review
The impact of aztreonam-clavulanic acid exposure on gene expression and mutant selection using a multidrug-resistant E. coli.
Research Article
part of the PhoP–PhoQ TCS
Clinical characteristics, molecular epidemiology and mechanisms of colistin heteroresistance in Enterobacter cloacae complex.
Research Article
Mutations in phoQ contribute to colistin heteroresistance.
Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa.
Research Article
The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions.
Research Article
High potency of sequential therapy with only β-lactam antibiotics.
Research Article
Global colistin use: a review of the emergence of resistant Enterobacterales and the impact on their genetic basis.
Review
Mutations in PhoQ contribute to colistin resistance.
Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.
Research Article
Clonal transmission and species-specific mechanisms of polymyxin resistance in carbapenem-resistant Enterobacteriaceae from Southwest China.
Research Article
PhoQ Tyr89His mutation contributes to polymyxin resistance.
In Vivo Evolution of Bacterial Resistance in Two Cases of Enterobacter aerogenes Infections during Treatment with Imipenem.
Research Article
Genomic islands 1 and 2 play key roles in the evolution of extensively drug-resistant ST235 isolates of Pseudomonas aeruginosa.
Research Article
Mutation in phoQ contributes to colistin resistance
Multifaceted mechanisms of colistin resistance revealed by genomic analysis of multidrug-resistant Klebsiella pneumoniae isolates from individual patients before and after colistin treatment.
Research Article
Multiple missense mutations in phoQ were identified in colistin-susceptible and -resistant isolates.
Production of Norspermidine Contributes to Aminoglycoside Resistance in pmrAB Mutants of Pseudomonas aeruginosa.
Research Article
mutation in phoQ leads to polymyxin B resistance
Characterization Of Chromosome-Mediated Colistin Resistance In Escherichia coli Isolates From Livestock In Korea.
Research Article
first detected in CL-17 isolate
Pathogenomics and Evolutionary Epidemiology of Multi-Drug Resistant Clinical Klebsiella pneumoniae Isolated from Pretoria, South Africa.
Research Article
Lipid A in outer membrane vesicles shields bacteria from polymyxins.
Research Article
Single nucleotide polymorphism in phoQ leads to amino acid change and contributes to polymyxin B resistance.
Antibiotic resistance determinants in a Pseudomonas putida strain isolated from a hospital.
Research Article
Morphological, genomic and transcriptomic responses of Klebsiella pneumoniae to the last-line antibiotic colistin.
Research Article
Prevalence of Mutated Colistin-Resistant Klebsiella pneumoniae: A Systematic Review and Meta-Analysis.
Review
Whole-genome sequence analysis of clinically isolated carbapenem resistant Escherichia coli from Iran.
Research Article
Clonal transmission of polymyxin B-resistant hypervirulent Klebsiella pneumoniae isolates coharboring bla(NDM-1) and bla(KPC-2) in a tertiary hospital in China.
Research Article
From Farm to Fork: Persistence of Clinically Relevant Multidrug-Resistant and Copper-Tolerant Klebsiella pneumoniae Long after Colistin Withdrawal in Poultry Production.
Research Article
associated with colistin resistance
Genomic characterization of colistin-resistant Klebsiella pneumoniae isolated from intensive care unit patients in Egypt.
Research Article
mutations in phoQ lead to colistin resistance
The PitA protein contributes to colistin susceptibility in Pseudomonas aeruginosa.
Research Article
The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research.
Review
Mutations in phoQ lead to resistance to colistin.
Heteroresistance to colistin in wild-type Klebsiella pneumoniae isolates from clinical origin.
Research Article
Mutations in phoQ were associated with colistin resistance.
Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa.
Research Article
Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae.
Research Article
missense mutations
Exploring the success of Brazilian endemic clone Pseudomonas aeruginosa ST277 and its association with the CRISPR-Cas system type I-C.
Research Article
Colistin Heteroresistance among Extended Spectrum β-lactamases-Producing Klebsiella pneumoniae.
Research Article
Polymyxin Resistance in Clinical Isolates of K. pneumoniae in Brazil: Update on Molecular Mechanisms, Clonal Dissemination and Relationship With KPC-Producing Strains.
Research Article
mutations in PhoQ contribute to polymyxin resistance
Characterization of Carbapenemase-Producing Klebsiella pneumoniae Isolates from Two Romanian Hospitals Co-Presenting Resistance and Heteroresistance to Colistin.
Research Article
PhoQ mutations were detected in multiple strains and are associated with colistin resistance
Identification of a novel mutation involved in colistin resistance in Klebsiella pneumoniae through Next-Generation Sequencing (NGS) based approaches.
Research Article
Klebsiella pneumoniae mutant PhoQ conferring resistance to colistin; CARD accession: CARD:3007203
phoQ
Mutations and expression of PmrAB and PhoPQ related with colistin resistance in Pseudomonas aeruginosa clinical isolates.
Research Article
Pseudomonas mutant PhoQ conferring resistance to colistin; CARD accession: CARD:3003896
phoQ
A Retrospective Whole-Genome Sequencing Analysis of Carbapenem and Colistin-Resistant Klebsiella Pneumoniae Nosocomial Strains Isolated during an MDR Surveillance Program.
Research Article
phoQ
Worldwide emergence of colistin resistance in Klebsiella pneumoniae from healthy humans and patients in Lao PDR, Thailand, Israel, Nigeria and France owing to inactivation of the PhoP/PhoQ regulator mgrB: an epidemiological and molecular study.
Research Article
phoQ
Mutant prevention concentrations of colistin for Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae clinical isolates.
Research Article
phoQ
Emergence of Polymyxin Resistance in Clinical Klebsiella pneumoniae Through Diverse Genetic Adaptations: A Genomic, Retrospective Cohort Study.
Research Article
phoQ
PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients.
Research Article
phoQ
Colistin Resistance and Extensive Genetic Variations in PmrAB and PhoPQ in Klebsiella Pneumoniae Isolates from South Korea.
Research Article
New amphiphilic neamine derivatives active against resistant Pseudomonas aeruginosa and their interactions with lipopolysaccharides.
Research Article
Mutation in phoQ contributes to colistin resistance
Efficacy of colistin-based combinations against pandrug-resistant whole-genome-sequenced Klebsiella pneumoniae isolated from hospitalized patients in Egypt: an in vitro/vivo comparative study.
Research Article
Amino acid substitution affecting phosphorylation
Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa.
Research Article