pilq

Type IV pilus secretin

Validation StatusCandidate

Overview

Mechanism: Alters porin-mediated penicillin entry
Validation Method: Site-directed mutagenesis and MIC testing
Drug Classes: penicillin
Organisms: Neisseria gonorrhoeae FA19, Neisseria gonorrhoeae PR100
Papers: 1
Databases: Reslit

Papers1

The penC mutation conferring antibiotic resistance in Neisseria gonorrhoeae arises from a mutation in the PilQ secretin that interferes with multimer stability.

PMID 16101998 · 2005

The penC mutation in Neisseria gonorrhoeae, which confers resistance to penicillin and tetracycline, is caused by a point mutation in the pilQ gene (Glu-666 to Lys) that disrupts the formation of the SDS-resistant high-molecular-mass PilQ secretin complex.

Gene Information

Gene Name: pilq
Allele: pilQ
Encodes: Type IV pilus secretin
Source Database: Reslit
Mechanism: Alters porin-mediated penicillin entry
Confers Resistance To: penicillin
Organisms Tested In: • Neisseria gonorrhoeae FA19
• Neisseria gonorrhoeae PR100
Validation Method: Site-directed mutagenesis and MIC testing

Comments (0)

No comments yet. Be the first to comment!

Browse AMR Genes

pilq

Gene Information