pilq2

secretin

Validation StatusCandidate

Overview

Mechanism: point mutation (Glu-666 to Lys) in the pilQ gene that interferes with the formation of the SDS-resistant high-molecular-mass PilQ secretin complex
Validation Method: cloning and transformation experiments showing increased resistance in strains with the pilQ2 mutation
Drug Classes: penicillin, tetracycline
Organisms: Neisseria gonorrhoeae
Papers: 1
Databases: Reslit

Papers1

The penC mutation conferring antibiotic resistance in Neisseria gonorrhoeae arises from a mutation in the PilQ secretin that interferes with multimer stability.

PMID 16101998 · 2005

The penC mutation in Neisseria gonorrhoeae, which confers resistance to penicillin and tetracycline, is caused by a point mutation in the pilQ gene (Glu-666 to Lys) that disrupts the formation of the SDS-resistant high-molecular-mass PilQ secretin complex.

Gene Information

Gene Name: pilq2
Allele: pilQ2
Encodes: secretin
Source Database: Reslit
Mechanism: point mutation (Glu-666 to Lys) in the pilQ gene that interferes with the formation of the SDS-resistant high-molecular-mass PilQ secretin complex
Confers Resistance To: penicillintetracycline
Organisms Tested In: • Neisseria gonorrhoeae
Validation Method: cloning and transformation experiments showing increased resistance in strains with the pilQ2 mutation

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pilq2

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