Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

pirA

ferric enterobactin transporter

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to pirA

AMR Rules

Browse AMR rules for pirA

Validation StatusSupported

Overview

Mechanism: disruption
Validation Method: whole-genome sequencing and MIC testing
Drug Classes: Cefiderocol
Organisms: Acinetobacter baumannii, Pseudomonas aeruginosa
Geographic Location: Europe, United States, Vietnam
Papers: 7
Databases: Reslit
Mutations: 4

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Y636*	-	premature termination of the protein translation and alters the structure of the β-barrel	Pseudomonas aeruginosa	Cefiderocol	Reslit	Candidate
M1A	-	-	-	Cefiderocol	Reslit	Candidate
I262V	-	-	-	Cefiderocol	Reslit

Papers7

Evolution and Transmission of Cefiderocol-Resistant Acinetobacter baumannii During an Outbreak in the Burn Intensive Care Unit.

PMID 35974429 · 2023

The study identifies disruptions in the piuA and pirA genes as mechanisms of cefiderocol resistance in Acinetobacter baumannii during an outbreak in a burn intensive care unit.

Gene Information

Gene Name: pirA
Allele: pirA
Encodes: ferric enterobactin transporter
Source Database: Reslit
Mechanism: disruption
Confers Resistance To: Cefiderocol
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: United States
Validation Method: whole-genome sequencing and MIC testing
Sequence Accession: PRJNA823680

Cefiderocol and Sulbactam-Durlobactam against Carbapenem-Resistant Acinetobacter baumannii.

PMID 38136764 · 2023

The study characterizes several AMR genes and mutations involved in resistance to cefiderocol in Acinetobacter baumannii, including blaPER-1, blaNDM-1, blaADC-25, blaADC-33, pirA, piuA, BaeS, BaeR, and specific mutations in PirA and PBP3.

Gene Information

Gene Name: pirA
Allele: pirA
Encodes: siderophore receptor
Source Database: Reslit
Mechanism: reduced expression of the siderophore receptor pirA and piuA genes in several A. baumannii strains
Confers Resistance To: Cefiderocol
Organisms Tested In: • Acinetobacter baumannii
Validation Method: reduced expression of the siderophore receptor pirA and piuA genes

Transmission cluster of cefiderocol-non-susceptible carbapenem-resistant Acinetobacter baumannii in cefiderocol-naïve individuals.

PMID 39614286 · 2024

The study identifies a transmission cluster of cefiderocol-non-susceptible carbapenem-resistant Acinetobacter baumannii (CRAB) in cefiderocol-naïve individuals, characterized by a premature stop codon and amino acid deletion in the PirA protein, leading to reduced cefiderocol susceptibility.

Gene Information

Gene Name: pirA
Allele: pirA
Encodes: siderophore-drug receptor
Source Database: Reslit
Mechanism: premature stop codon and amino acid deletion
Confers Resistance To: Cefiderocol
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Europe
Validation Method: whole genome sequencing and antimicrobial susceptibility testing
Sequence Accession: SAMN43144136|SAMN43144137|SAMN43144138|SAMN43144139

Susceptibility toward cefiderocol and sulbactam-durlobactam in extensively drug-resistant Acinetobacter baumannii detected from ICU admission screening in Hanoi, Vietnam, 2023.

PMID 40488459 · 2025

The study identified bla OXA-23, bla OXA-91, and bla NDM-1 as key resistance genes in extensively drug-resistant Acinetobacter baumannii isolates. Mutations in fstI (A515V and T526S) were associated with reduced susceptibility to sulbactam-durlobactam. Additionally, alterations in pirA and piuA genes were linked to cefiderocol resistance.

Gene Information

Gene Name: pirA
Allele: pirA
Encodes: iron transporter
Source Database: Reslit
Confers Resistance To: Cefiderocol
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Vietnam
Validation Method: genomic analysis and antimicrobial susceptibility testing
Sequence Accession: PRJNA1195824