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ResLit

piuA

TonB-dependent siderophore receptor

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to piuA

AMR Rules

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Validation StatusSupported

Overview

Mechanism: disruption
Validation Method: whole-genome sequencing and MIC testing
Drug Classes: Cefiderocol, CEFIDEROCOL/CEPHALOSPORIN
Organisms: Acinetobacter baumannii, Burkholderia cenocepacia, Pseudomonas aeruginosa
Geographic Location: United States, Vietnam
Papers: 7
Databases: Reslit
Mutations: 4

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Q34H	-	-	Pseudomonas aeruginosa	Cefiderocol	Reslit	Candidate
Q38H	-	-	Pseudomonas aeruginosa	Cefiderocol	Reslit	Candidate
Q548Ter	-	TonB-dependent siderophore receptor PiuA	Pseudomonas aeruginosa	CEFIDEROCOL/CEPHALOSPORIN

Papers7

Evolution and Transmission of Cefiderocol-Resistant Acinetobacter baumannii During an Outbreak in the Burn Intensive Care Unit.

PMID 35974429 · 2023

The study identifies disruptions in the piuA and pirA genes as mechanisms of cefiderocol resistance in Acinetobacter baumannii during an outbreak in a burn intensive care unit.

Gene Information

Gene Name: piuA
Allele: piuA
Encodes: TonB-dependent siderophore receptor
Source Database: Reslit
Mechanism: disruption
Confers Resistance To: Cefiderocol
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: United States
Validation Method: whole-genome sequencing and MIC testing
Sequence Accession: PRJNA823680

Profiling cell envelope-antibiotic interactions reveals vulnerabilities to β-lactams in a multidrug-resistant bacterium.

PMID 37558695 · 2023

The study identifies bla_penB and K562_RS32470 as β-lactamase targets of avibactam in Burkholderia cenocepacia, and piuA as a key receptor for cefiderocol uptake.

Gene Information

Gene Name: piuA
Allele: piuA
Encodes: TonB-dependent receptor
Source Database: Reslit
Confers Resistance To: Cefiderocol
Organisms Tested In: • Burkholderia cenocepacia
Validation Method: CRISPRi knockdown

Mutant prevention concentrations and phenotypic and genomic profiling of first-step resistance mechanisms to classical and novel β-lactams in Pseudomonas aeruginosa.

PMID 40067045 · 2025

Gene Information

Gene Name: piuA
Allele: piuA
Encodes: iron transporter
Source Database: Reslit
Confers Resistance To: Cefiderocol
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: whole-genome sequencing

Susceptibility toward cefiderocol and sulbactam-durlobactam in extensively drug-resistant Acinetobacter baumannii detected from ICU admission screening in Hanoi, Vietnam, 2023.

PMID 40488459 · 2025

The study identified bla OXA-23, bla OXA-91, and bla NDM-1 as key resistance genes in extensively drug-resistant Acinetobacter baumannii isolates. Mutations in fstI (A515V and T526S) were associated with reduced susceptibility to sulbactam-durlobactam. Additionally, alterations in pirA and piuA genes were linked to cefiderocol resistance.

Gene Information

Gene Name: piuA
Allele: piuA
Encodes: iron transporter
Source Database: Reslit
Confers Resistance To: Cefiderocol
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Vietnam
Validation Method: genomic analysis and antimicrobial susceptibility testing
Sequence Accession: PRJNA1195824