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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
PiuC iron-dependent oxygenase (a TonB-dependent transporter)
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S116F | - | entailing a switch from an amino acid with polar uncharged side chain (serine) to one with a hydrophobic side chain (phenylalanine), which could be involved in the binding of the siderophore | Pseudomonas aeruginosa | cefiderocol | Reslit | Candidate |
| R201H | - | - | Pseudomonas aeruginosa, Acinetobacter spp. | cefiderocol | Reslit | Candidate |
| M1V | - | - | Acinetobacter baumannii | cefiderocol | Reslit | Candidate |
Novel PiuC, PirA, and PiuA mutations leading to in vivo cefiderocol resistance progression in IMP-16- and KPC-2-producing Pseudomonas aeruginosa from a leukemic patient.
Research Article
Mutation in the Fe2OG dioxygenase domain of PiuC
In vitro activity of cefiderocol against European Pseudomonas aeruginosa and Acinetobacter spp., including isolates resistant to meropenem and recent β-lactam/β-lactamase inhibitor combinations.
Research Article
Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis With Sulbactam-Durlobactam.
Research Article