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Explore antimicrobial resistance genes from the literature

pmrC

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to pmrC

Browse AMR rules for pmrC

Overview

Drug Classes: COLISTIN, Colistin, Polymyxin b
Organisms: Acinetobacter baumannii, Klebsiella pneumoniae, Acinetobacter pittii, Acinetobacter junii, Enterobacter cloacae, Klebsiella quasipneumoniae
Papers: 17
Mutations: 39

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R125P	-	phosphoethanolamine--lipid A transferase PmrC	Acinetobacter baumannii	COLISTINColistin	Reference Gene CatalogReslit	Confirmed
F27C	-	-	Klebsiella pneumoniae	Colistin	Reslit	Candidate
Q143L	-	mutations in the pmrC gene including Q143L, L146F, Q148K, I171V, and L258S were detected in strain 17-84 and whether these mutations contributed to the colistin resistance phenotype remined to be studied

Papers17

1

Trajectory of genetic alterations associated with colistin resistance in Acinetobacter baumannii during an in-hospital outbreak of infection.

PMID 34609499 · 2021

pmrC

Mutation Information

Protein Change: R125P
Organisms: Acinetobacter baumannii
Confers Resistance To: COLISTIN
Effect on Function: phosphoethanolamine--lipid A transferase PmrC
Source Database: Reference Gene Catalog

2

A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition.

PMID 33298160 · 2020

Mutation Information

Protein Change: F27C
Organisms: Klebsiella pneumoniae
Confers Resistance To: Colistin
Source Database: Reslit

3

Emergence of ST63 Pandrug-Resistant Acinetobacter pittii Isolated From an AECOPD Patient in China.

PMID 34722334 · 2021

Mutation Information

pmrC: p.Q143L pmrC: p.L146F pmrC: p.L258S pmrC: p.I171V pmrC: p.Q148K

Protein Change: Q143L, L146F, L258S, I171V, Q148K
Organisms: Acinetobacter pittii
Confers Resistance To: Colistin
Effect on Function: mutations in the pmrC gene including Q143L, L146F, Q148K, I171V, and L258S were detected in strain 17-84 and whether these mutations contributed to the colistin resistance phenotype remined to be studied
Source Database: Reslit

4

Polymyxin Resistance Among XDR ST1 Carbapenem-Resistant Acinetobacter baumannii Clone Expanding in a Teaching Hospital.

PMID 33897637 · 2021

mutations in pmrC are associated with polymyxin resistance

Mutation Information

Protein Change: R125H
Organisms: Acinetobacter baumannii
Confers Resistance To: Polymyxin b
Source Database: Reslit

5

Genomic Characterization of Extensively Drug-Resistant NDM-Producing Acinetobacter baumannii Clinical Isolates With the Emergence of Novel bla (ADC-257).

PMID 34880837 · 2021

Mutation Information

Protein Change: I42V
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Source Database: Reslit

6

Analysis of colistin resistance in carbapenem-resistant Enterobacterales and XDR Klebsiella pneumoniae.

PMID 35237435 · 2022

Mutation Information

pmrC: p.Q319R pmrC: p.F27C pmrC: p.S25G

Protein Change: Q319R, F27C, S25G
Organisms: Klebsiella pneumoniae
Confers Resistance To: Colistin
Source Database: Reslit

7

Rapid dissemination of colistin and carbapenem resistant Acinetobacter baumannii in Central Greece: mechanisms of resistance, molecular identification and epidemiological data.

PMID 26653099 · 2015

Mutation Information

Protein Change: R109H
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Source Database: Reslit

8

Emergence of Colistin-Resistant Acinetobacter junii in China.

PMID 36551350 · 2022

Mutation Information

pmrC: p.V286L pmrC: p.G228V pmrC: p.L70F pmrC: p.L269I pmrC: p.S500N pmrC: p.V54A pmrC: p.T232S pmrC: p.A332V pmrC: p.V61I pmrC: p.T233A pmrC: p.Q346K pmrC: p.L67I pmrC: p.E268D pmrC: p.L418Q pmrC: p.I2T pmrC: p.D230E pmrC: p.S304R

Protein Change: V286L, G228V, L70F, L269I, S500N, V54A, T232S, A332V, V61I, T233A, Q346K, L67I, E268D, L418Q, I2T, D230E, S304R
Organisms: Acinetobacter junii
Confers Resistance To: Colistin
Source Database: Reslit

9

Bacteremia by colistin-resistant Acinetobacter baumannii isolate: a case report.

PMID 31064407 · 2019

Mutations in pmrC may contribute to colistin resistance

Mutation Information

Protein Change: A178G
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Source Database: Reslit

10

Characterization of a carbapenem- and colistin-resistant Enterobacter cloacae carrying Tn6901 in bla (NDM-1) genomic context.

PMID 31118694 · 2019

Mutation Information

Protein Change: F515S
Organisms: Enterobacter cloacae
Confers Resistance To: Colistin
Source Database: Reslit

11

Comparative genomics and molecular epidemiology of colistin-resistant Acinetobacter baumannii.

PMID 36659926 · 2023

Mutations in pmrC were associated with colistin resistance.

Mutation Information

pmrC: p.R125P pmrC: p.R230Q pmrC: p.L128I

Protein Change: R125P, R230Q, L128I
Confers Resistance To: Colistin
Source Database: Reslit

12

Colistin Resistance in Acinetobacter baumannii: Molecular Mechanisms and Epidemiology.

PMID 36978383 · 2023

Mutations in pmrC contribute to colistin resistance via lipid A modification

Mutation Information

pmrC: p.R125P pmrC: p.L150F pmrC: p.R109H pmrC: p.I42V

Protein Change: R125P, L150F, R109H, I42V
Confers Resistance To: Colistin
Source Database: Reslit

13

Acinetobacter baumannii Global Clone-Specific Resistomes Explored in Clinical Isolates Recovered from Egypt.

PMID 37508245 · 2023

Mutation Information

Protein Change: N268Y
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Source Database: Reslit

14

Genomic characterization of colistin-resistant Klebsiella pneumoniae isolated from intensive care unit patients in Egypt.

PMID 37689686 · 2023

mutation in pmrC leads to colistin resistance

Mutation Information

Protein Change: S257L
Organisms: Klebsiella pneumoniae
Confers Resistance To: Colistin
Source Database: Reslit

15

Genomic investigation unveils colistin resistance mechanism in carbapenem-resistant Acinetobacter baumannii clinical isolates.

PMID 38214512 · 2024

Detected in colistin-resistant isolate AB06.

Mutation Information

pmrC: p.T7I pmrC: p.V383I

Protein Change: T7I, V383I
Organisms: Acinetobacter baumannii
Confers Resistance To: Colistin
Effect on Function: destabilizing
Source Database: Reslit

16

Genomic analysis of carbapenem- and colistin-resistant Klebsiella pneumoniae complex harbouring mcr-8 and mcr-9 from individuals in Thailand.

PMID 39039157 · 2024

Mutation Information

Protein Change: T224K
Organisms: Klebsiella pneumoniae, Klebsiella quasipneumoniae
Confers Resistance To: Colistin
Source Database: Reslit

17

Efficacy of colistin-based combinations against pandrug-resistant whole-genome-sequenced Klebsiella pneumoniae isolated from hospitalized patients in Egypt: an in vitro/vivo comparative study.

PMID 39627871 · 2024

Amino acid substitution in the lipopolysaccharide modification enzyme

Mutation Information

pmrC: p.S257L / c.T770C

Protein Change: S257L
Nucleotide Change: T770C
Organisms: Klebsiella pneumoniae
Confers Resistance To: Colistin
Source Database: Reslit