Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
regulatory protein
Overview
| Candidate |
| N11D | - | - | Escherichia coli | Colistin | Reslit | Candidate |
| M20K | - | - | Escherichia coli | Colistin | Reslit | Candidate |
| A27T | - | - | Escherichia coli | Colistin | Reslit | Candidate |
| A52V | - | - | Escherichia coli | Colistin | Reslit | Candidate |
| V83S | - | - | Escherichia coli | Colistin | Reslit | Candidate |
| K82Q | - | - | Escherichia coli | Colistin | Reslit | Candidate |
Phenotypic differences between Salmonella and Escherichia coli resulting from the disparate regulation of homologous genes.
The study identifies the pmrD gene as a key factor in the differential regulation of polymyxin B resistance between Salmonella and E. coli. The Salmonella pmrD gene enables E. coli to transcribe the pbgP gene and display resistance to polymyxin B in response to low Mg2+.
Evolution and dynamics of regulatory architectures controlling polymyxin B resistance in enteric bacteria.
The study identifies a novel regulatory architecture called the feedforward connector loop (FCL) in Klebsiella pneumoniae, which involves the pmrD gene and regulates polymyxin B resistance through a combination of direct and indirect signaling pathways.
An allele of an ancestral transcription factor dependent on a horizontally acquired gene product.
A single amino acid difference in the PmrA transcription factor from S. paratyphi B compared to S. typhimurium leads to differential dependence on the PmrD protein for polymyxin B resistance. The pmrA(E211) allele exhibits reduced DNA binding affinity and requires PmrD for effective gene expression, while the pmrA(G211) allele functions independently of PmrD.
Signal-specific temporal response by the Salmonella PhoP/PhoQ regulatory system.
The study identifies mgtA, pmrD, and ugtL as genes involved in Salmonella's resistance to polymyxin B through the PhoP/PhoQ regulatory system.
PmrD is required for modifications to Escherichia coli endotoxin that promote antimicrobial resistance.
The study identifies pmrD as essential for lipid A modifications in E. coli under low Mg2+ conditions, which confer resistance to polymyxin B. pmrD facilitates the addition of pEtN and l-Ara4N to lipid A, enhancing bacterial resistance.
Heteroresistance Is Associated With in vitro Regrowth During Colistin Treatment in Carbapenem-Resistant Klebsiella pneumoniae.
The study found that colistin heteroresistance in carbapenem-resistant K. pneumoniae (CR-KP) is associated with in vitro regrowth during treatment. Overexpression of phoPQ and pmrD was identified as a key mechanism of colistin resistance.
Antibiotic Resistance Diagnosis in ESKAPE Pathogens-A Review on Proteomic Perspective.
This review discusses proteomic approaches for diagnosing antibiotic resistance in ESKAPE pathogens, highlighting the importance of proteomic techniques in understanding resistance mechanisms and improving diagnostic accuracy.
No comments yet. Be the first to comment!
© 2026 ResLit. Data sourced from PubMed literature analysis.
Built for antimicrobial resistance research