Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
penicillin-binding protein 1
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| L421P | increased MIC, decreases penicillin acylation of PBP1 and increases penicillin resistance, reduces penicillin acylation of PBP1 ~3- to 4-fold, penicillin-binding protein 1 PonA | Neisseria gonorrhoeae | cefiximeceftriaxonepenicillin+4 more | Reference Gene CatalogResFinder DatabaseReslit | Confirmed | |
| A375T | - | - | Neisseria gonorrhoeae | penicillin | Reslit | Candidate |
Various penA mutations together with mtrR, porB and ponA mutations in Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime or ceftriaxone.
Research Article
ponA mutations including Leu-421→Pro are associated with reduced susceptibility to cefixime and ceftriaxone.
The antimicrobial resistance landscape of Neisseria gonorrhoeae in New Zealand from November 2018 to March 2019 and the role of sexual orientation in transmission.
Research Article
Mutation in ponA contributes to reduced susceptibility to ceftriaxone and cefixime.
WGS to predict antibiotic MICs for Neisseria gonorrhoeae.
Research Article
Genomic surveillance of Neisseria gonorrhoeae in the Philippines, 2013-2014.
Research Article
Reliability of Genetic Alterations in Predicting Ceftriaxone Resistance in Neisseria gonorrhoeae Globally.
Research Article
Global concerns, local challenges: the alarming spread of FC428-related gonococcal strains in Nanchang City, 2021.
Research Article
single nucleotide polymorphism
Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains.
Research Article
The use of cephalosporins for gonorrhea: the impending problem of resistance.
Review
The L421P substitution in ponA may contribute to ceftriaxone resistance.
Molecular Typing of Neisseria gonorrhoeae Clinical Isolates in Russia, 2018-2019: A Link Between penA Alleles and NG-MAST Types.
Research Article
Hydrogel Droplet Microarray for Genotyping Antimicrobial Resistance Determinants in Neisseria gonorrhoeae Isolates.
Research Article
Neisseria gonorrhoeae FC428 Subclone, Vietnam, 2019-2020.
Research Article
associated with penicillin resistance
Genetic identification of mutations and MLST types associated with decreased susceptibility to ceftriaxone in Neisseria gonorrhoeae.
Research Article
Mutation in ponA is associated with ceftriaxone resistance.
Neisseria gonorrhoeae Resistant to Ceftriaxone and Cefixime, Argentina.
Research Article
Amino acid substitution in the ponA gene
Equations To Predict Antimicrobial MICs in Neisseria gonorrhoeae Using Molecular Antimicrobial Resistance Determinants.
Research Article
Antimicrobial resistance genetic factor identification from whole-genome sequence data using deep feature selection.
Research Article
Genomic evolution of Neisseria gonorrhoeae since the preantibiotic era (1928-2013): antimicrobial use/misuse selects for resistance and drives evolution.
Research Article
Antimicrobial resistance and heterogeneity of Neisseria gonorrhoeae isolated from patients attending sexually transmitted infection clinics in Lusaka, Zambia.
Research Article
Antibiotic Targets in Gonococcal Cell Wall Metabolism.
Review
Antimicrobial resistance prediction and phylogenetic analysis of Neisseria gonorrhoeae isolates using the Oxford Nanopore MinION sequencer.
Research Article
Identification of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain FC428, China
Research Article
PonA1 variant
Dissemination of Neisseria gonorrhoeae with decreased susceptibility to extended-spectrum cephalosporins in Southern China, 2021: a genome-wide surveillance from 20 cities.
Research Article
Phenotypic and genotypic characterization of Neisseria gonorrhoeae isolates from Yaoundé, Cameroon, 2019 to 2020.
Research Article
Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future.
Review
Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand.
Research Article
Phylogeny and antimicrobial resistance in Neisseria gonorrhoeae isolates from Rio de Janeiro, Brazil.
Research Article
Whole-genome sequencing reveals transmission of gonococcal antibiotic resistance among men who have sex with men: an observational study.
Research Article
Cephalosporin-Resistant Neisseria gonorrhoeae Clone, China
Research Article
Molecular Algorithms Accurately Predict Decreased Susceptibility to Ceftriaxone in Neisseria gonorrhoeae.
Research Article
Whole-genome sequence analysis of high-level penicillin-resistant strains and antimicrobial susceptibility of Neisseria gonorrhoeae clinical isolates from Thailand.
Research Article
The A375T substitution in ponA contributes to penicillin resistance.
Molecular Mechanisms of Drug Resistance and Epidemiology of Multidrug-Resistant Variants of Neisseria gonorrhoeae.
Review
mutations in ponA contribute to resistance by reducing penicillin binding
Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.
Research Article
Mediates transformation of intermediate-level penicillin-resistant transformants to high-level penicillin resistance
ponA
Molecular Assay for Detection of Genetic Markers Associated with Decreased Susceptibility to Cephalosporins in Neisseria gonorrhoeae.
Research Article