Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
penicillin-binding protein 1
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| A516T | - | single resistance variant | Mycobacterium tuberculosis | rifabutin | Card Database | Established |
| Q365H | - | single resistance variant | Mycobacterium tuberculosis | rifabutin | Card Database | Established |
| T658A | - | single resistance variant | Mycobacterium tuberculosis | rifabutin | Card Database | Established |
| I41M | - | single resistance variant | Mycobacterium tuberculosis | rifabutin | Card Database | Established |
| G363D | - | single resistance variant | Mycobacterium tuberculosis | rifabutin | Card Database | Established |
| L421P | - | Neisseria gonorrhoeae | penicillincephalosporins | Reslit | Candidate | |
| - | - | - | teicoplanin | Reslit | Candidate | |
| - | - | - | teicoplanin | Reslit | Candidate |
Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
Research Article
Mycobacterium tuberculosis ponA1 mutations conferring resistance to rifabutin; CARD accession: CARD:3004960
Antimicrobial Resistance Profiling and Phylogenetic Analysis of Neisseria gonorrhoeae Clinical Isolates From Kenya in a Resource-Limited Setting.
Research Article
Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria.
Research Article
Mutations in PonA1 affect antibiotic susceptibility, particularly to teicoplanin and rifampicin.