Browse AMR Genes

Explore antimicrobial resistance genes from the literature

porA

pyruvate oxidoreductase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to porA

Browse AMR rules for porA

Validation StatusSupported

Overview

Validation Method: cloning in E. coli + enzyme assays
Drug Classes: Macrolide, Ertapenem, Meropenem, Ertapenem, Meropenem, Ciprofloxacin, CARBAPENEM
Organisms: Helicobacter pylori, Escherichia coli, Campylobacter jejuni, Campylobacter coli
Alleles: 2
Papers: 5
Databases: Reslit
Mutations: 6

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ins139D	-	Efflux	Campylobacter jejuni	Ertapenem, Meropenem	ResFinder Database	Established
D142H	-	loss of calcium-binding site in channel	Campylobacter jejuni	Ciprofloxacin	Reslit	Candidate
G56D	-	group 2 major outer membrane porin protein PorA, Efflux	Campylobacter jejuni	Ertapenem

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
por	Reslit	1	-	Helicobacter pylori +1	-	2002	-	-
porA	Reslit	2	Macrolide, Ertapenem +1	Campylobacter jejuni	-	2013, 2023	PRJEB42628\|PRJNA505131	-

Papers5

1

Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori.

PMID 12069963 · 2002

The study identifies three enzymes involved in the reductive activation of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori: RdxA, FrxA, and Por. These enzymes play a critical role in the antimicrobial activity of these drugs.

Gene Information

Gene Name: porA
Allele: por
Encodes: pyruvate oxidoreductase
Source Database: Reslit
Organisms Tested In: • Helicobacter pylori
• Escherichia coli
Validation Method: cloning in E. coli + enzyme assays

2

Resistance mechanisms in Campylobacter jejuni.

PMID 23406779 · 2013

The paper reviews the resistance mechanisms in Campylobacter jejuni, focusing on fluoroquinolone, macrolide, beta-lactam, tetracycline, and aminoglycoside resistance. Key mechanisms include mutations in gyrA, efflux pumps like CmeABC, modifications of 23S rRNA, and the presence of resistance genes such as aphA-3, TetO, and blaOXA-61.

Gene Information

Gene Name: porA
Allele: porA
Encodes: major outer membrane porin
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Campylobacter jejuni
Validation Method: experimental data generated in this study

3

Recurrent Campylobacter jejuni Infections with In Vivo Selection of Resistance to Macrolides and Carbapenems: Molecular Characterization of Resistance Determinants.

PMID 37358443 · 2023

The study identifies porA mutations and blaOXA-61 and cmeABC efflux pump modifications as key contributors to carbapenem resistance in Campylobacter jejuni, highlighting the role of structural changes in porin proteins and efflux systems in mediating resistance.

Gene Information

Gene Name: porA
Allele: porA
Encodes: major outer membrane protein (MOMP)
Source Database: Reslit
Confers Resistance To: ErtapenemMeropenem
Organisms Tested In: • Campylobacter jejuni
Validation Method: genetic analysis and structural modeling
Sequence Accession: PRJEB42628|PRJNA505131