Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G120K | decreased permeability of the cell membrane, decreased membrane permeability, reducing membrane permeability for hydrophilic antibiotics | Neisseria gonorrhoeae, Neisseria subflava | Penicillin, Tetracycline,CephalosporinsPenicillinTetracycline+6 more | ResFinder DatabaseReslit | Confirmed | |
| G103K | - | - | - | Ampicillin | Reslit |
| A121G | - | decreased permeability of the cell membrane | Neisseria gonorrhoeae | PenicillinCeftriaxone | Reslit | Supported |
| A121H | - | - | Neisseria gonorrhoeae | Penicillin, Tetracycline,Cephalosporins | ResFinder Database | Established |
| N122K | - | - | Neisseria gonorrhoeae | PenicillinCeftriaxone | Reslit | Candidate |
| A121N | decreased permeability of the cell membrane, reducing membrane permeability for hydrophilic antibiotics | Neisseria subflava, Neisseria gonorrhoeae | PenicillinTetracyclineCeftriaxone|Cefixime+1 more | Reslit | Supported |
| A121D | - | decreased permeability of the cell membrane | Neisseria gonorrhoeae, Neisseria subflava | PenicillinTetracyclineCeftriaxone+4 more | ResFinder DatabaseReslit | Confirmed |
| G120X | - | - | Neisseria gonorrhoeae | Ceftriaxone | Reslit | Candidate |
| A121X | - | - | Neisseria gonorrhoeae | Ceftriaxone | Reslit | Candidate |
| G120D | - | decreased permeability of the cell membrane, reducing membrane permeability for hydrophilic antibiotics | Neisseria gonorrhoeae | PenicillinPenicillin|TetracyclineTetracycline+3 more | ResFinder DatabaseReslit | Confirmed |
| V135L | - | - | - | Ceftriaxone | Reslit | Candidate |
| V151A | - | - | - | Ceftriaxone | Reslit | Candidate |
| A109V | - | - | - | Ceftriaxone | Reslit | Candidate |
| N134E | - | - | - | Ceftriaxone | Reslit | Candidate |
| Q143G | - | - | - | Ceftriaxone | Reslit | Candidate |
| A121S | - | - | - | Ceftriaxone | Reslit | Candidate |
| V135F | - | - | - | Ceftriaxone | Reslit | Candidate |
| Q143R | - | - | - | Ceftriaxone | Reslit | Candidate |
| F131Y | - | - | - | Ceftriaxone | Reslit | Candidate |
| Q143E | - | - | - | Ceftriaxone | Reslit | Candidate |
| Q143K | - | - | Neisseria gonorrhoeae | Ceftriaxone | Reslit | Candidate |
| G140K | - | - | - | Ceftriaxone | Reslit | Candidate |
| S295D | - | - | Neisseria gonorrhoeae | Ceftriaxone | Reslit | Candidate |
| L421P | - | - | Neisseria gonorrhoeae | Ceftriaxone | Reslit | Candidate |
| V123I | - | - | Neisseria gonorrhoeae | Tetracycline | Reslit | Candidate |
| V123A | - | - | Neisseria gonorrhoeae | Tetracycline | Reslit | Candidate |
| G120R | - | - | Neisseria gonorrhoeae | Penicillin, Tetracycline,Cephalosporins | ResFinder Database | Established |
| A121P | - | - | Neisseria gonorrhoeae | Penicillin, Tetracycline,Cephalosporins | ResFinder Database | Established |
| G120P | - | - | Neisseria gonorrhoeae | Penicillin, Tetracycline,Cephalosporins | ResFinder Database | Established |
Identification and analysis of amino acid mutations in porin IB that mediate intermediate-level resistance to penicillin and tetracycline in Neisseria gonorrhoeae.
Solo muttaion gives partial resistance
Solo mutation gives partial resistance
An antibiotic-resistance conferring mutation in a neisserial porin: Structure, ion flux, and ampicillin binding.
The G103K mutation in PorB contributes to ampicillin resistance by altering the pore's structure and electrostatic properties.
Molecular Epidemiology, Antimicrobial Surveillance, and PK/PD Analysis to Guide the Treatment of Neisseria gonorrhoeae Infections.
Mutations in the porB gene contribute to penicillin resistance.
Mutation pattern in the genome of Neisseria gonorrhoeae and its association with multidrug-resistant isolates from Delhi, India.
Exploration of the Neisseria Resistome Reveals Resistance Mechanisms in Commensals That May Be Acquired by N. gonorrhoeae through Horizontal Gene Transfer.
Genomic surveillance of Neisseria gonorrhoeae in the Philippines, 2013-2014.
Reliability of Genetic Alterations in Predicting Ceftriaxone Resistance in Neisseria gonorrhoeae Globally.
Molecular Typing of Neisseria gonorrhoeae Clinical Isolates in Russia, 2018-2019: A Link Between penA Alleles and NG-MAST Types.
Hydrogel Droplet Microarray for Genotyping Antimicrobial Resistance Determinants in Neisseria gonorrhoeae Isolates.
Genetic identification of mutations and MLST types associated with decreased susceptibility to ceftriaxone in Neisseria gonorrhoeae.
Mutations in PorB are associated with ceftriaxone resistance.
Mutations in porB are associated with ceftriaxone resistance.
Whole-genome phylogenomic heterogeneity of Neisseria gonorrhoeae isolates with decreased cephalosporin susceptibility collected in Canada between 1989 and 2013.
A Whole-genome Sequencing Analysis of Neisseria gonorrhoeae Isolates in China: An Observational Study.
Whole-Genome Sequencing of Russian Neisseria Gonorrhoeae Isolates Related to ST 1407 Genogroup.
Identification of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain FC428, China
PorB8 variant
A genomic perspective on the near-term impact of doxycycline post-exposure prophylaxis on Neisseria gonorrhoeae antimicrobial resistance.
Dissemination of Neisseria gonorrhoeae with decreased susceptibility to extended-spectrum cephalosporins in Southern China, 2021: a genome-wide surveillance from 20 cities.
Whole genome analysis and antimicrobial resistance of Neisseria gonorrhoeae isolates from Ghana.
Mutations in porB were associated with resistance to tetracycline and beta-lactams.
Phylogeny and antimicrobial resistance in Neisseria gonorrhoeae isolates from Rio de Janeiro, Brazil.
Cephalosporin-Resistant Neisseria gonorrhoeae Clone, China
Molecular Mechanisms of Drug Resistance and Epidemiology of Multidrug-Resistant Variants of Neisseria gonorrhoeae.
mutations in porB contribute to resistance by reducing antibiotic diffusion
Multidrug-resistant Neisseria gonorrhoeae infection in heterosexual men with reduced susceptibility to ceftriaxone, first report in Thailand.
Mutations in PorB porin associated with reduced ceftriaxone susceptibility
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