potA

polyamine transporter subunit

Validation StatusCandidate

Overview

Validation Method: direct interaction with SorX, decreased mRNA levels upon SorX overexpression, and increased sensitivity to organic hydroperoxides in potA deletion mutants
Drug Classes: Gentamicin
Organisms: Rhodobacter sphaeroides, Escherichia coli
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Q208L	-	increased gentamicin MIC	Escherichia coli	Gentamicin	Reslit	Candidate

Papers2

Regulation of a polyamine transporter by the conserved 3′ UTR-derived sRNA SorX confers resistance to singlet oxygen and organic hydroperoxides in Rhodobacter sphaeroides.

PMID 27420112 · 2016

The study identifies potA as a direct target of the sRNA SorX, which regulates resistance to organic hydroperoxides in Rhodobacter sphaeroides. SorX binds to the Shine-Dalgarno sequence of potA mRNA, leading to reduced translation and increased sensitivity to organic hydroperoxides when potA is deleted.

Gene Information

Gene Name: potA
Allele: potA
Encodes: polyamine transporter subunit
Source Database: Reslit
Organisms Tested In: • Rhodobacter sphaeroides
Validation Method: direct interaction with SorX, decreased mRNA levels upon SorX overexpression, and increased sensitivity to organic hydroperoxides in potA deletion mutants

Browse AMR Genes

potA

Mutations

Gene Information