poxB

carbapenem-hydrolyzing beta-lactamase

Validation StatusCandidate

Overview

Validation Method: expression in ampC-deficient background and measurement of MICs
Drug Classes: Meropenem, Doripenem, Ceftazidime/avibactam
Organisms: Pseudomonas aeruginosa PAO1, Pseudomonas aeruginosa
Papers: 2
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R49C	-	-	Pseudomonas aeruginosa	Ceftazidime/avibactam	Reslit	Candidate
L6F	-	-	Pseudomonas aeruginosa	Ceftazidime/avibactam	Reslit	Candidate

Papers2

Characterization of a Carbapenem-Hydrolyzing Enzyme, PoxB, in Pseudomonas aeruginosa PAO1.

PoxB is a carbapenem-hydrolyzing beta-lactamase that confers resistance to meropenem and doripenem in Pseudomonas aeruginosa PAO1.

Gene Name: poxB
Allele: poxB
Encodes: carbapenem-hydrolyzing beta-lactamase
Source Database: Reslit
Confers Resistance To: MeropenemDoripenem
Organisms Tested In: • Pseudomonas aeruginosa PAO1
Validation Method: expression in ampC-deficient background and measurement of MICs