Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ppsC

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to ppsC

Browse AMR rules for ppsC

Overview

Drug Classes: Pyrazinamide
Organisms: Mycobacterium tuberculosis
Papers: 1
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
N1899S	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	Card Database	Established
A957P	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	Card Database	Established

Papers1

1

Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.

PMID 30337678 · 2018

Mycobacterium tuberculosis ppsC mutations confer resistance to pyrazinamide; CARD accession: CARD:3004975

Mutation Information

ppsC: p.N1899S ppsC: p.A957P

Protein Change: N1899S, A957P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Pyrazinamide
Effect on Function: single resistance variant
Source Database: Card Database