Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ppsD

phosphopantothenoylcysteine synthetase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to ppsD

Browse AMR rules for ppsD

Validation StatusCandidate

Overview

Mechanism: mutation in the gene leads to resistance to para-aminosalicylic acid
Validation Method: machine learning and structural analysis
Drug Classes: Para-aminosalicylic acid, Clofazimine, Pyrazinamide
Organisms: Mycobacterium tuberculosis
Geographic Location: Belarus|South Africa|South Korea|India
Papers: 3
Databases: Reslit
Mutations: 9

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
L1173P	-	-	Mycobacterium tuberculosis	Clofazimine	Reslit	Candidate
I1508L	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	Card Database	Established
P563H	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide