ppsa-e

phenolpthiocerol synthesis type-I polyketide synthases

Validation StatusCandidate

Overview

Mechanism: frameshift mutations in ppsA-E lead to loss of function and resistance to POA
Validation Method: whole genome sequencing and functional validation
Organisms: Mycobacterium bovis BCG, Mycobacterium tuberculosis H37Rv
Papers: 1
Databases: Reslit

Papers1

Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis.

PMID 27759369 · 2016

The study identifies two distinct mechanisms of pyrazinamide resistance: (1) missense mutations in the aspartate decarboxylase panD, which prevent pyrazinoic acid (POA)-mediated coenzyme A (CoA) depletion, and (2) loss-of-function mutations in the polyketide synthases mas and ppsA-E, which affect the synthesis of the virulence factor phthiocerol dimycocerosate (PDIM).

Gene Information

Gene Name: ppsa-e
Allele: ppsA-E
Encodes: phenolpthiocerol synthesis type-I polyketide synthases
Source Database: Reslit
Mechanism: frameshift mutations in ppsA-E lead to loss of function and resistance to POA
Organisms Tested In: • Mycobacterium bovis BCG
• Mycobacterium tuberculosis H37Rv
Validation Method: whole genome sequencing and functional validation

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ppsa-e

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