proQ

RNA-binding protein

Validation StatusCandidate

Overview

Mechanism: mutation conferring isopropanol tolerance
Validation Method: adaptive laboratory evolution
Drug Classes: Aztreonam|Clavulanic acid
Organisms: Escherichia coli
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R741L	-	-	Escherichia coli	Aztreonam\|Clavulanic acid	Reslit	Candidate

Papers2

Biocide-tolerance and antibiotic-resistance in community environments and risk of direct transfers to humans: Unintended consequences of community-wide surface disinfecting during COVID-19?

PMID 33848900 · 2021

The paper discusses the mechanisms of biocide tolerance and antibiotic resistance in bacteria, highlighting the role of mutations, horizontal gene transfer, efflux pumps, membrane alterations, and biofilms in developing resistance to disinfectants and antibiotics. It emphasizes the risks posed by the extensive use of disinfectants during the COVID-19 pandemic and the potential for increased antimicrobial resistance.

Gene Information

Gene Name: proQ
Allele: proQ
Encodes: RNA-binding protein
Source Database: Reslit
Mechanism: mutation conferring isopropanol tolerance
Organisms Tested In: • Escherichia coli
Validation Method: adaptive laboratory evolution

Browse AMR Genes

proQ

Mutations

Gene Information