prpE

Propionate-CoA ligase

Validation StatusCandidate

Overview

Mechanism: Mutations in prpE are associated with bedaquiline resistance in NTM species.
Validation Method: Genotypic analysis and MIC testing
Drug Classes: Bedaquiline
Organisms: Mycobacterium smegmatis, M. smegmatis
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S465P	-	-	M. smegmatis	Bedaquiline	Reslit	Candidate

Papers1

Bedaquiline for treatment of non-tuberculous mycobacteria (NTM): a systematic review and meta-analysis.

PMID 38134888 · 2024

The study identifies several genes and mutations associated with bedaquiline resistance in non-tuberculous mycobacteria (NTM) species, including atpE, mmpT5, MAB_4384, MAB_2299c, MAV_2152, rpoB, and prpE. These findings highlight the genetic mechanisms underlying bedaquiline resistance in NTM.

Gene Information

Gene Name: prpE
Allele: prpE
Encodes: Propionate-CoA ligase
Source Database: Reslit
Mechanism: Mutations in prpE are associated with bedaquiline resistance in NTM species.
Confers Resistance To: Bedaquiline
Organisms Tested In: • Mycobacterium smegmatis
Validation Method: Genotypic analysis and MIC testing

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prpE

Mutations

Gene Information