pth

peptidyl-tRNA hydrolase

Validation StatusCandidate

Overview

Validation Method: CRISPRi-Seq and biochemical characterization
Drug Classes: Ampicillin
Organisms: Burkholderia cenocepacia K56-2, Escherichia coli
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
P101L	C304T	-	Escherichia coli	Ampicillin	Reslit	Candidate

Papers2

Rationally designed pooled CRISPRi-seq uncovers an inhibitor of bacterial peptidyl-tRNA hydrolase.

PMID 39541213 · 2024

The study identifies peptidyl-tRNA hydrolase (Pth) as a target of PHAR(A), a novel growth inhibitory compound. It also reveals that PHAR(A) affects translation-related genes such as rpsA, mnmA, pepP, and waaA.

Gene Information

Gene Name: pth
Allele: pth
Encodes: peptidyl-tRNA hydrolase
Source Database: Reslit
Organisms Tested In: • Burkholderia cenocepacia K56-2
Validation Method: CRISPRi-Seq and biochemical characterization

Browse AMR Genes

pth

Mutations

Gene Information