pykA

pyruvate kinase

Validation StatusCandidate

Overview

Mechanism: unknown
Validation Method: protein expression and purification
Drug Classes: Cycloserine
Organisms: Mycobacterium tuberculosis, Escherichia coli, Mycobacterium smegmatis
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	C-58T	-	Mycobacterium tuberculosis	Cycloserine	Reslit	Candidate

Papers2

Mycobacterium tuberculosis H37Ra: a surrogate for the expression of conserved, multimeric proteins of M.tb H37Rv.

PMID 27514669 · 2016

The study demonstrates that M. tuberculosis H37Ra is a suitable host for the expression of conserved, multimeric proteins of M. tuberculosis H37Rv, including GAPDH, Pyruvate kinase, and Enolase, offering advantages in solubility, functionality, and yield compared to E. coli and M. smegmatis.

Gene Information

Gene Name: pykA
Allele: pyka
Encodes: pyruvate kinase
Source Database: Reslit
Mechanism: unknown
Organisms Tested In: • Mycobacterium tuberculosis
• Escherichia coli
• Mycobacterium smegmatis
Validation Method: protein expression and purification

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pykA

Mutations

Gene Information