pykF

aerobic pyruvate kinase

Validation StatusCandidate

Overview

Validation Method: clean deletions of pykF in UTI89 resulted in increased fosfomycin MIC
Drug Classes: Fosfomycin, Carbapenem, Ampicillin|Ciprofloxacin|Polymyxin
Organisms: Escherichia coli, Klebsiella pneumoniae
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
M23K	-	-	Klebsiella pneumoniae	Carbapenem	Reslit	Candidate
K413Q	-	-	-	Ampicillin\|Ciprofloxacin\|Polymyxin	Reslit	Candidate

Papers3

Raising the alarm: fosfomycin resistance associated with non-susceptible inner colonies imparts no fitness cost to the primary bacterial uropathogen.

PMID 38078906 · 2024

The study identifies pykF as a novel gene associated with fosfomycin resistance in E. coli, showing that its deletion increases fosfomycin MIC without affecting bacterial fitness.

Gene Information

Gene Name: pykF
Allele: pykF
Encodes: aerobic pyruvate kinase
Source Database: Reslit
Confers Resistance To: Fosfomycin
Organisms Tested In: • Escherichia coli
Validation Method: clean deletions of pykF in UTI89 resulted in increased fosfomycin MIC
Sequence Accession: PRJNA819016|PRJNA975897

Browse AMR Genes

pykF

Mutations

Gene Information