Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
multidrug efflux
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| qacE | Card DatabaseReslit | 72 | Quaternary ammonium compounds, Chlorhexidine +11 |
| United Kingdom, Germany, Malaysia, Japan|Thailand|Canada|France|Spain|South Korea|United Kingdom|Croatia|Vietnam|global, China, China|Brazil|United Kingdom|Denmark, Egypt, Italy, South Korea, Ghana, Sweden, Vietnam, Iran, India, Milwaukee, Wisconsin, USA|USA, Québec, Canada|Quebec, Canada, Camden, NJ, USA, Abuja, Nigeria, Turkey, Oman, Switzerland, La Paz River basin, Bolivia|La Paz River basin, South Africa, Brazil, United Kingdom|soil|human oral microbiome|pig gut microbiome, swine manure, Moscow, Russia, Greece, Tamaulipas, Mexico, Central Greece, Uganda, North Carolina, Argentina, Brazil|Europe|United Kingdom|United States, Nigeria, Accra, Ghana|Ghana, Thailand, United States|Pakistan|Bangladesh|Nigeria|Iraq|India, United States, Europe, Tunisia, Bangladesh, Atlanta, Middle East|Europe|Asia|South America|Peru|Egypt|Saudi Arabia|Denmark|Pakistan|Jordan|Iraq|Lebanon|China|Ghana, United Arab Emirates |
| 2005, 2011, 2013, 2015, 2017, 2019, 2020, 2021, 2022, 2023, 2024, 2025 |
| KY662007|KY426918 |
| AEH26330.1 |
| qacΔE | Reslit | 1 | - | Klebsiella pneumoniae | China | 2015 | - | - |
| qacE delta 1 | Reslit | 1 | - | Enterobacter cloacae | Australia | 2015 | BX571857|HE798385|AM743169|NCBI acc. no. AF071413|NCBI acc. no. AB207867|NCBI acc. no. KM921776|NCBI acc. NZ_AFQQ01000000 | - |
| qacE/qacEΔ1 | Reslit | 2 | Quaternary ammonium compounds | Escherichia coli | Germany, Finland | 2018, 2025 | PRJEB78480 | - |
| qacE-H | Reslit | 1 | Fluoroquinolone, Aminoglycoside +3 | Pseudomonas aeruginosa | Italy | 2020 | JAABOY000000000 | - |
| qacE Δ | Reslit | 1 | - | Escherichia coli +2 | USA|Peru|Egypt|Cambodia|Kenya | 2020 | - | - |
| qacEΔ | Reslit | 1 | Quaternary ammonium compounds | Avian pathogenic Escherichia coli | China | 2021 | - | - |
| qacE Delta 1 | Reslit | 1 | Benzalkonium chloride | Staphylococcus aureus | - | 2021 | - | - |
| ΔqacE | Reslit | 1 | - | Escherichia coli | China | 2024 | CP095083|CP095084|CP095085 | - |
| qac-E | Reslit | 1 | - | Acinetobacter baumannii | Iran | 2024 | - | - |
| qacE-Δ1 | Reslit | 1 | - | Acinetobacter baumannii | Iran | 2024 | - | - |
| qac E | Reslit | 1 | Quaternary ammonium compounds | Salmonella enterica subsp. enterica serovar Enteritidis | Spain | 2025 | NC_010393|NC_031940|NC_019488 | - |
| qacE delta1 | Reslit | 1 | - | Acinetobacter baumannii | Europe | 2025 | PRJNA1173090 | - |
Incidence of class 1 integrons in a quaternary ammonium compound-polluted environment.
The study identifies the qacE gene as a multidrug efflux gene that confers resistance to quaternary ammonium compounds (QACs) and shows that class 1 integrons are prevalent in QAC-polluted environments, highlighting the potential for co-selection of antibiotic resistance.
Efflux-mediated antibiotic resistance in Acinetobacter spp.
The study characterizes several efflux pumps in Acinetobacter spp., including AdeABC, AdeIJK, AdeFGH, CraA, AmvA, AbeM, AbeS, AdeXYZ, AdeDE, TetA, TetB, CmlA, FloR, and QacE, which contribute to multidrug resistance by expelling antibiotics and other compounds.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
Extremely high prevalence of antiseptic resistant Quaternary Ammonium Compound E gene among clinical isolates of multiple drug resistant Acinetobacter baumannii in Malaysia.
The study identified a high prevalence of the qacE gene among multiple drug-resistant Acinetobacter baumannii isolates in Malaysia, indicating resistance to antiseptics such as chlorhexidine, benzalkonium, and benzethonium.
Insight into the mobilome of Aeromonas strains.
The study characterizes various antibiotic resistance genes (ARG) in Aeromonas strains, highlighting the presence of beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others. These genes are often located on plasmids and contribute to multidrug resistance.
Determining the resistance of carbapenem-resistant Klebsiella pneumoniae to common disinfectants and elucidating the underlying resistance mechanisms.
The study identified the presence of drug-resistance genes qacA, qacΔE, qacE, and acrA in carbapenem-resistant Klebsiella pneumoniae (CRKP) strains, which correlate with increased resistance to common disinfectants such as chlorhexidine acetate, benzalkonium bromide, and iodophor.
Determining the resistance of carbapenem-resistant Klebsiella pneumoniae to common disinfectants and elucidating the underlying resistance mechanisms.
The study identified the presence of drug-resistance genes qacA, qacΔE, qacE, and acrA in carbapenem-resistant Klebsiella pneumoniae (CRKP) strains, which correlate with increased resistance to common disinfectants such as chlorhexidine acetate, benzalkonium bromide, and iodophor.
Comparative genomics of non-pseudomonal bacterial species colonising paediatric cystic fibrosis patients.
The study analyzed non-pseudomonal bacterial species from pediatric cystic fibrosis patients, identifying several AMR genes and mutations. Key findings include the presence of beta-lactamase genes (blaZ, blaI, blaRI) in Staphylococcus aureus, fosfomycin resistance gene fosB, fusidic acid resistance gene fusC, and efflux pumps smeZ, smeJ, and smeK in Stenotrophomonas maltophilia. Additionally, Enterobacter cloacae isolates carried resistance genes qacE delta 1, sul1, and dfrA5.
Examination of Quaternary Ammonium Compound Resistance in Proteus mirabilis Isolated from Cooked Meat Products in China.
The study identified quaternary ammonium compound resistance genes, including mdfA, ydgE/ydgF, qacE, qacEΔ1, emrE, sugE(c), sugE(p), and qacH, in foodborne Proteus mirabilis isolates. It also discovered non-classic class 1 integrons carrying the gene structure qacH-IS440-sul3, which were located on conjugative plasmids, facilitating the co-dissemination of antimicrobial and disinfectant resistance genes.
Comparative genomics of clinical strains of Pseudomonas aeruginosa strains isolated from different geographic sites.
The study identified several AMR genes in Pseudomonas aeruginosa strains from different geographic locations, including beta-lactamases, aminoglycoside resistance genes, fosfomycin resistance, chloramphenicol resistance, sulfonamide resistance, quaternary ammonium compound resistance, tetracycline resistance, and others. Indian eye isolates exhibited a higher diversity of resistance genes compared to Australian isolates.
The Transferable Resistome of Produce.
The study identified multiple tetracycline resistance genes, beta-lactamases, and other resistance determinants in E. coli isolates from produce, highlighting the potential for horizontal gene transfer and the significance of the produce microbiome as a reservoir of antibiotic resistance genes.
Characterization of the emerging multidrug-resistant Salmonella enterica serovar Indiana strains in China.
The study identifies multiple AMR genes, including aac(6')-Ib, blaOXA-30, catB3, arr-3, qacE, sul1, intI1, armA, msrE, mphE, and blaCTX-M-3, in multidrug-resistant Salmonella enterica serovar Indiana strains in China, highlighting the role of class I integrons in the dissemination of resistance.
Loss and Gain in the Evolution of the Salmonella enterica Serovar Gallinarum Biovar Pullorum Genome.
The study identifies multiple multidrug resistance plasmids in Salmonella Pullorum, including pSPUR1, pSPUR2, pSPUR3, pSPUR4, and pSPUR5, which confer resistance to various antibiotics such as trimethoprim, streptomycin, sulfonamide, and tetracycline.
Genomic Features of High-Priority Salmonella enterica Serovars Circulating in the Food Production Chain, Brazil, 2000-2016.
The study identified several AMR genes in Salmonella enterica isolates from Brazil, including qnrE1, qnrB19, qnrS1, blaCTX-M-2, blaCTX-M-8, blaCMY-2, aadA1, aadA2, aac(3)-IVa, aac(3)-IIa, aac(6')-Ib, floR, sul1, sul2, tet(A), tet(B), strA, strB, drfA1, inu(F), qacEdelta1, and fosA7. These genes conferred resistance to various antibiotics such as fluoroquinolones, beta-lactams, aminoglycosides, sulfonamides, tetracyclines, chloramphenicol, trimethoprim, macrolides, quaternary ammonium compounds, and fosfomycin.
Evaluation of the efficacy of commonly used disinfectants against isolated chlorine-resistant strains from drinking water used in Egyptian cattle farms.
The study identified the qacE gene in 75% of the isolated chlorine-resistant E. coli strains, indicating resistance to quaternary ammonium compounds.
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.
The study identifies known and novel antimicrobial resistance genes using a machine learning approach on pan-genomes of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Key findings include the detection of resistance genes such as gyrA, parC, ermC, lmrS, aac(6')-aph(2"), dfrG, tetK, and various beta-lactamases.
First detection of autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 from a patient with bloodstream infection in Italy, October 2019.
The study reports the first autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 strain in Italy, highlighting the presence of multiple beta-lactamase genes, aminoglycoside modifying enzymes, and multidrug efflux pumps contributing to its extensive drug resistance.
Emergence of Multidrug-Resistant Salmonella enterica Subspecies enterica Serovar Infantis of Multilocus Sequence Type 2283 in German Broiler Farms.
Tracking Antimicrobial Resistance Determinants in Diarrheal Pathogens: A Cross-Institutional Pilot Study.
The study identified 55 different antimicrobial resistance determinants in diarrheal pathogens, highlighting the presence of genes conferring resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, macrolides, tetracyclines, phenicols, sulfonamides, and others. Notably, carbapenemase genes like bla OXA-48 and bla NDM were detected in certain isolates, indicating emerging resistance concerns.
Comparative Genomic Analysis of 450 Strains of Salmonella enterica Isolated from Diseased Animals.
The study identified 60 antimicrobial resistance genes (ARGs), 4 disinfectant resistance genes (DRGs), and 33 heavy metal resistance genes (HMRGs) in 450 Salmonella strains isolated from diseased animals. These genes contributed to resistance against multiple antimicrobial classes, including aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and phenicols.
Snapshot Study of Whole Genome Sequences of Escherichia coli from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.
The study identified multiple antimicrobial resistance genes (ARGs) and mutations in Escherichia coli isolates from various sources in Italy, highlighting the prevalence of resistance to tetracycline, sulfonamide, penicillin, fluoroquinolone, and colistin. Key genes included tetA, sul2, blaTEM-1b, mcr-1, qnrS1, and others, along with mutations in gyrA, parC, parE, and pmrB.
Genomic and phenotypic analyses of multidrug-resistant Acinetobacter baumannii NCCP 16007 isolated from a patient with a urinary tract infection.
The study identifies multiple AMR genes and mutations in the multidrug-resistant A. baumannii NCCP 16007 strain, including pmrC, pmrB, blaOXA-23, and various aminoglycoside, tetracycline, and beta-lactam resistance genes, contributing to its high resistance to polymyxin B and other antibiotics.
Effects of in ovo probiotic administration on the incidence of avian pathogenic Escherichia coli in broilers and an evaluation on its virulence and antimicrobial resistance properties.
The study identified various antimicrobial resistance genes in APEC isolates, including blaTEM, aac(3)-VIa, aac(3)-VIb, aadA, tetA, tetB, dfr7, qacEΔ, qnr, sul1, intl1, arsC, and merA. These genes conferred resistance to multiple antibiotics such as beta-lactams, aminoglycosides, tetracyclines, quinolones, sulfonamides, and heavy metals.
Endophytic Lifestyle of Global Clones of Extended-Spectrum β-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?
The study identifies multiple AMR genes in endophytic ESBL-producing Enterobacterales isolated from fresh vegetables, highlighting their potential role in the spread of antibiotic resistance.
Clonal Clusters, Molecular Resistance Mechanisms and Virulence Factors of Gram-Negative Bacteria Isolated from Chronic Wounds in Ghana.
The study identified various AMR genes and mutations in Gram-negative bacteria isolated from chronic wounds in Ghana, including beta-lactamases, fosfomycin resistance genes, chloramphenicol resistance genes, aminoglycoside resistance genes, fluoroquinolone resistance genes, tetracycline resistance genes, sulfonamide resistance genes, trimethoprim resistance genes, and efflux pumps. Mutations in gyrA, parE, and parC were also found to contribute to fluoroquinolone resistance.
Biocide-tolerance and antibiotic-resistance in community environments and risk of direct transfers to humans: Unintended consequences of community-wide surface disinfecting during COVID-19?
The paper discusses the mechanisms of biocide tolerance and antibiotic resistance in bacteria, highlighting the role of mutations, horizontal gene transfer, efflux pumps, membrane alterations, and biofilms in developing resistance to disinfectants and antibiotics. It emphasizes the risks posed by the extensive use of disinfectants during the COVID-19 pandemic and the potential for increased antimicrobial resistance.
The highly dynamic nature of bacterial heteroresistance impairs its clinical detection.
The study identifies gene amplifications, including ampC, qacE, and blaTEM, that contribute to heteroresistance in clinical isolates of Escherichia coli and Salmonella enterica. These amplifications increase resistance gene copy numbers, leading to enriched resistant subpopulations under sub-MIC antibiotic conditions.
Characterization of Proteobacterial Plasmid Integron-Encoded qac Efflux Pump Sequence Diversity and Quaternary Ammonium Compound Antiseptic Selection in Escherichia coli Grown Planktonically and as Biofilms.
The study characterizes diverse qac efflux pump sequences from proteobacterial plasmids, highlighting their roles in conferring resistance to quaternary ammonium compounds (QACs) and identifying distinct antimicrobial resistance profiles among different qac variants.
Genomic Characterization of Multidrug-Resistant Salmonella Serovars Derby and Rissen From the Pig Value Chain in Vietnam.
The study identified multiple antimicrobial resistance genes in Salmonella serovars Derby and Rissen from Vietnam, highlighting the presence of multidrug-resistant strains along the pig value chain.
Antibacterial effects of Octenicept, and benzalkonium chloride on Acinetobacter baumannii strains isolated from clinical samples and determination of genetic diversity of isolates by RAPD-PCR method.
The study identified the presence of antiseptic resistance genes qacE and qacDeltaE1 in Acinetobacter baumannii isolates, indicating resistance to benzalkonium chloride. It also determined the genetic diversity of the isolates using RAPD-PCR.
Mouse pneumonia model by Acinetobacter baumannii multidrug resistant strains: Comparison between intranasal inoculation, intratracheal instillation and oropharyngeal aspiration techniques.
The study identified various AMR genes in two multidrug-resistant Acinetobacter baumannii strains, ACC001 and ACC002, including aminoglycoside resistance genes, tetracycline resistance genes, beta-lactamases, and sulfonamide resistance genes. These genes contribute to resistance against multiple antibiotics such as gentamicin, tobramycin, tetracycline, penicillins, cephalosporins, and sulfonamides.
Genotypic and Phenotypic Characterization of Novel Sequence Types of Carbapenem-Resistant Acinetobacter baumannii, With Heterogeneous Resistance Determinants and Targeted Variations in Efflux Operons.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii strains, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, contributing to multidrug resistance.
Similarities in Virulence and Extended Spectrum Beta-Lactamase Gene Profiles among Cefotaxime-Resistant Escherichia coli Wastewater and Clinical Isolates.
The study identifies several beta-lactamase genes, including blaCTX-M-1, blaKPC-2, blaTEM-350, blaOXA-1, and blaCTX-M-15, as well as various aminoglycoside, macrolide, and tetracycline resistance genes in cefotaxime-resistant E. coli isolates from hospital and urban wastewater. Mutations in parC, parE, and gyrA contribute to fluoroquinolone resistance.
Impact of a Regulation Restricting Critical Antimicrobial Usage on Prevalence of Antimicrobial Resistance in Escherichia coli Isolates From Fecal and Manure Pit Samples on Dairy Farms in Québec, Canada.
The study found a significant decrease in multidrug-resistant (MDR) isolates in the generic E. coli collection, particularly for folate inhibitors and aminoglycosides, following the implementation of a regulation restricting antimicrobial use in dairy farms in Québec, Canada.
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
The study identified multiple AMR genes in multidrug-resistant E. coli and K. pneumoniae isolates from Kuwait, including beta-lactamases (blaKPC-2, blaCTX-M-15, blaOXA-1, blaCMY-4, blaTEM), aminoglycoside-modifying enzymes (aac(3)-IIa, aph(6)-Id, aadA5), sulfonamide resistance genes (sul1, sul2), quinolone resistance genes (gyrA_D87N, qnrB1), and others. Colistin resistance was linked to the pmrB_R256G mutation.
Evaluating the Effectiveness of Hospital Antiseptics on Multidrug-Resistant Acinetobacter baumannii: Understanding the Relationship between Microbicide and Antibiotic Resistance.
The study identified the presence of microbicide-resistance genes qacE, qacEΔ1, and cepA in Acinetobacter baumannii strains, which conferred higher tolerance to microbicides, particularly bleach. The presence of these genes was more prevalent in pan-susceptible strains.
mcr-1-Mediated Colistin Resistance and Genomic Characterization of Antimicrobial Resistance in ESBL-Producing Salmonella Infantis Strains from a Broiler Meat Production Chain in Italy.
The study identified mcr-1.1 and mcr-1.2 variants on IncX4 plasmids in colistin-resistant Salmonella Infantis strains, along with other resistance genes such as blaCTX-M-1, aac(6')-Iaa, tet(A), dfrA1, sul1, and qacE.
Genome analysis and virulence gene expression profile of a multi drug resistant Salmonella enterica serovar Typhimurium ms202.
The study identified multiple antimicrobial resistance genes in the multi-drug resistant Salmonella enterica serovar Typhimurium ms202 strain, including fosA7, sul1, aadA7, aac(6')-laa, tet(A), and qacE, which confer resistance to various antibiotics such as fosfomycin, sulfamethoxazole, spectinomycin, amikacin, tetracycline, and disinfectants.
Molecular epidemiological characteristics of carbapenem-resistant Klebsiella pneumoniae among children in China.
The study identified KPC-2, NDM-1, and IPM-4 carbapenemase genes as the primary contributors to carbapenem resistance in Klebsiella pneumoniae isolates from children in China. Additionally, qacE and cepA genes were found to confer resistance to disinfectants.
Emergence of a Novel NDM-5-Producing Sequence Type 4523 Klebsiella pneumoniae Strain Causing Bloodstream Infection in China.
The study identifies a novel sequence type 4523 Klebsiella pneumoniae strain, ST4523, which is resistant to multiple antibiotics, including carbapenems, and carries the bla NDM-5 gene on a plasmid. The strain also possesses various other resistance genes on plasmids pSHX180-1 and pSHX180-NDM5.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
Whole-genome sequencing-based characteristics of Escherichia coli Rize-53 isolate from Turkey.
The study identified ten antibiotic resistance genes in the E. coli Rize-53 isolate, including blaOXA-1, blaOXA-2, aac(6')-II, aac(6')-Ib-cr, tetB, catB3, qacE, sitABCD, mdfA, and sul2, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, chloramphenicol, sulfonamides, and quaternary ammonium compounds.
Antimicrobial Susceptibility of Fresh Produce-Associated Enterobacteriaceae and Enterococci in Oman.
The study identified the presence of qacEΔ1, qacE, qacG, and IntI 1 genes in Enterobacteriaceae, which are associated with chlorhexidine resistance. Enterococci showed resistance to several antibiotics, including erythromycin, ciprofloxacin, tetracycline, and vancomycin.
Three Distinct Annotation Platforms Differ in Detection of Antimicrobial Resistance Genes in Long-Read, Short-Read, and Hybrid Sequences Derived from Total Genomic DNA or from Purified Plasmid DNA.
The study compared different annotation platforms for detecting antimicrobial resistance (AMR) genes in various sequencing data types. It found that plasmid DNA purification was unnecessary for detecting plasmid-borne AMR genes and that hybrid sequencing improved AMR gene detection. The study also highlighted variations in AMR gene detection among different databases.
Genomic Characterization of an Extensively Drug-Resistant Extra-Intestinal Pathogenic (ExPEC) Escherichia coli Clinical Isolate Co-Producing Two Carbapenemases and a 16S rRNA Methylase.
The study describes an extensively drug-resistant (XDR) E. coli ST361 isolate co-carrying bla KPC-3, bla NDM-5, and various other resistance genes on multiple plasmids, showing resistance to nearly all antibiotics except tigecycline, colistin, and fosfomycin.
Conjugative transfer of multi-drug resistance IncN plasmids from environmental waterborne bacteria to Escherichia coli.
The study identified the transfer of multi-drug resistance IncN plasmids from environmental waterborne bacteria to E. coli, highlighting the presence of sulfonamide resistance genes sul1 and sul2 in transconjugants.
Susceptibility Tests and Predictions of Transporter Profile in Serratia Species.
The study identifies efflux pumps such as QacE, EmrE, and SmfY as responsible for disinfectant resistance in Serratia species, particularly showing that the resistant isolate Serratia sp. HRI has fewer resistance transporters compared to the susceptible strain ATCC 13880.
The pan-genome of the emerging multidrug-resistant pathogen Corynebacterium striatum.
The study identifies 15 antimicrobial resistance genes in Corynebacterium striatum, including genes conferring resistance to aminoglycosides, tetracyclines, chloramphenicol, macrolides, lincosamides, streptogramins, sulfonamides, and cationic antiseptics. These genes are often located in genomic islands and mobile genetic elements, highlighting the role of horizontal gene transfer in the spread of multidrug resistance.
Antimicrobial resistance profile of Escherichia coli isolated from poultry litter.
The study identified various antimicrobial resistance genes in E. coli isolates from poultry litter, including groEL, tetA, aadA, aph(3)IA, silP, pcoD, sull, qacEdelta1, iroN, ompTp, and hlyF, which were associated with resistance to multiple antibiotics such as cephalothin, tetracycline, ampicillin, streptomycin, and sulphonamides.
Salmonella Heidelberg and Salmonella Minnesota in Brazilian broilers: Genomic characterization of third-generation cephalosporin and fluoroquinolone-resistant strains.
The study identifies multiple AMR genes and mutations in Salmonella Heidelberg and Salmonella Minnesota isolates from Brazilian broilers, including bla CMY-2, qnrB19, aac(6')-Iaa, sul2, tet(A), fosA7, qacE, and formA, along with gyrA(S83F) and parC(T57S) mutations conferring resistance to various antibiotics.
Antimicrobial Resistance and Genetic Diversity of Pseudomonas aeruginosa Strains Isolated from Equine and Other Veterinary Samples.
The study identified several AMR genes in Pseudomonas aeruginosa strains isolated from equine and other veterinary samples, including beta-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes, sulfonamide resistance genes, phenicol resistance genes, tetracycline resistance genes, and efflux pumps. Additionally, genes conferring resistance to quaternary ammonium compounds were detected.
An ST131 clade and a phylogroup A clade bearing an O101-like O-antigen cluster predominate among bloodstream Escherichia coli isolates from South-West Nigeria hospitals.
The study identified several AMR genes and mutations in bloodstream E. coli isolates from South-West Nigeria, including bla CTX-M-15, dfrA, dfrB, and various quinolone resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Functional metagenomic libraries generated from anthropogenically impacted environments reveal importance of metabolic genes in biocide and antibiotic resistance.
GalE-like genes were identified in contaminated environments and shown to confer cross-resistance to biocides and antibiotics, highlighting the role of metabolic genes in antimicrobial resistance.
Antibiotic-Resistant Desulfovibrio Produces H(2)S from Supplements for Animal Farming.
The study identifies multiple antibiotic resistance genes in Desulfovibrio vulgaris L2, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and mercury resistance genes, highlighting its potential role in spreading antibiotic resistance in agricultural environments.
Genomic features, antimicrobial susceptibility, and epidemiological insights into Burkholderia cenocepacia clonal complex 31 isolates from bloodstream infections in India.
The study identifies several AMR genes and mutations in B. cenocepacia CC31 isolates, including beta-lactamases (OXA-192, PAU-1, TEM162, PME-1), chloramphenicol resistance gene (catB3), disinfectant resistance genes (qacEdelta1, qacL), aminoglycoside methyltransferases (rmtB, rmtD), and mutations in gyrA and 23S rRNA conferring fluoroquinolone and macrolide resistance, respectively.
Urinary Plasmids Reduce Permissivity to Coliphage Infection.
Urinary E. coli plasmids reduce permissivity to coliphage infection. Specific plasmid-encoded genes such as bla TEM-1B, aadA5, aac(6′)-Ib-cr, tet(B), sul2, dfrA17, mph(A), qacE, catB3, traT, and senB contribute to antibiotic resistance and phage resistance.
Multidrug-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Causing Nosocomial Meningitis in the Neurological Intensive Care Unit.
The study identified various AMR genes in 37 A. baumannii strains causing nosocomial meningitis, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, macrolide resistance genes, phenicol resistance genes, sulfonamide resistance genes, rifamycin resistance genes, and antiseptic resistance genes.
Virulence Factors and Antimicrobial Resistance of Uropathogenic Escherichia coli EQ101 UPEC Isolated from UTI Patient in Quetta, Balochistan, Pakistan.
The study identified multiple antimicrobial resistance genes in the E. coli EQ101 isolate, including genes involved in antibiotic efflux, inactivation, and drug replacement. Key resistance genes include TolC, emrR, evgA, qacEdelta1, H-NS, cpxA, mdtM, aadA5, mphA, CTX-M-15, sul1, and dfrA14.
First Detection and Molecular Characterization of Pseudomonas aeruginosa bla(NDM-1) ST308 in Greece.
The study reports the first detection of blaNDM-1-positive Pseudomonas aeruginosa ST308 in Greece, highlighting the presence of multiple resistance genes including blaNDM-1, blaPAO, blaOXA-10, blaOXA-488, and others, indicating multidrug resistance.
Genomic Analysis of Multidrug-Resistant Escherichia coli Strains Isolated in Tamaulipas, Mexico.
The study identified multiple antimicrobial resistance genes (ARGs) in multidrug-resistant E. coli strains isolated from human clinical, animal, and environmental sources in Tamaulipas, Mexico. These genes include beta-lactamases (bla CTX-M-15, bla OXA-1, bla TEM-1B, bla CMY-2), aminoglycoside resistance genes (aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aadA5, aac3-IIa), sulfonamide resistance genes (sul2, sul3), phenicol resistance gene (catB3), tetracycline resistance genes (tet(A), tet(B)), quaternary ammonium resistance genes (qacE, qacL), macrolide resistance genes (mdfA, mphA), and quinolone resistance gene (qnrB).
The Molecular Characterization of bla(NDM-1)-Positive Acinetobacter baumannii Isolated in Central Greece.
The study identifies multiple AMR genes in blaNDM-1-positive Acinetobacter baumannii isolates, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, macrolide resistance genes, tetracycline resistance genes, trimethoprim resistance genes, and quaternary ammonium resistance genes.
Phenotypic and genomic characterization of Pseudomonas aeruginosa isolates recovered from catheter-associated urinary tract infections in an Egyptian hospital.
The study identified multiple AMR genes and mutations in Pseudomonas aeruginosa isolates from catheter-associated urinary tract infections in Egypt, including beta-lactamases, aminoglycoside-modifying enzymes, quinolone resistance proteins, and efflux pump systems. Additionally, a pBT2436-like megaplasmid was detected, which contributes to multidrug resistance.
Decoding the genetic structure of conjugative plasmids in international clones of Klebsiella pneumoniae: A deep dive into blaKPC, blaNDM, blaOXA-48, and blaGES genes.
The study characterizes the genetic structure of plasmids harboring major carbapenemase genes (blaKPC, blaNDM, blaOXA-48, and blaGES) in Klebsiella pneumoniae, identifying the most prevalent allele types and their co-occurrence with other resistance genes.
Resistome and virulome of high-risk pandemic clones of multidrug-resistant extra-intestinal pathogenic Escherichia coli (ExPEC) isolated from tertiary healthcare settings in Uganda.
The study identified various AMR genes in multidrug-resistant E. coli isolates, including blaCTX-M-15, blaTEM-1B, blaOXA-1, and others, which confer resistance to beta-lactams, aminoglycosides, sulfonamides, tetracyclines, macrolides, and quinolones. Additionally, chromosomal mutations in gyrA and parC were found to contribute to fluoroquinolone resistance.
CRISPR-Cas9-mediated IncF plasmid curing in extraintestinal pathogenic Escherichia coli.
The study identified several AMR genes carried on IncF plasmids in MDR ExPEC strains, including bla TEM-1, aac(3)-IId, tet(A), aph(6)-Id, aph(3')-Ib, mphA, sul1, sul2, aadA5, dfrA17, strAB, qacEdelta1, bla CTX-M-14, bla CTX-M-15, catB3, bla OXA-1, bla CTX-M-27, and aac(6')-Ib-cr5. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, sulfonamides, and chloramphenicol.
Genomic characterization of tigecycline-resistant Escherichia coli and Klebsiella pneumoniae isolates from hospital sewage.
The study identifies tet(X4) and tmexCD1-toprJ1 as key genes contributing to tigecycline resistance in E. coli and K. pneumoniae isolates from hospital sewage, highlighting the role of plasmid-mediated resistance and efflux pump overexpression.
Serovars, Virulence and Antimicrobial Resistance Genes of Non-Typhoidal Salmonella Strains from Dairy Systems in Mexico.
Characteristics of antimicrobial resistance in Escherichia coli isolated from retail meat products in North Carolina.
The study identified several AMR genes in E. coli isolates from retail meat products in North Carolina, including aac(3)-IV, aadA1, aph(3'')-lb, blaTEM-1, tetB, and others, highlighting the prevalence of multidrug-resistant E. coli in ground turkey.
Genomic Characterization of Two NDM-5-Producing Isolates of Klebsiella pneumoniae ST11 from a Single Patient.
The study identified two NDM-5-producing K. pneumoniae ST11 isolates from a single patient, highlighting the presence of multiple acquired antimicrobial resistance genes, including blaNDM-5, blaCTX-M-15, and rmtB, along with other resistance determinants.
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.
Genomic Characterization of a Plasmid-Free and Highly Drug-Resistant Salmonella enterica Serovar Indiana Isolate in China.
The study identifies 54 AMR genes and three AMR gene cassettes in the plasmid-free, highly drug-resistant Salmonella enterica serovar Indiana isolate S1467, contributing to resistance against multiple antimicrobial classes.
Whole-Genome Sequencing of an Escherichia coli ST69 Strain Harboring bla(CTX-M-27) on a Hybrid Plasmid.
The study identifies a multidrug-resistant E. coli ST69 strain carrying the bla(CTX-M-27) gene on a hybrid plasmid, along with various other antibiotic resistance genes such as aminoglycoside, macrolide, sulfonamide, tetracycline, and trimethoprim resistance genes.
Genomic Features and Phylogenetic Analysis of Antimicrobial-Resistant Salmonella Mbandaka ST413 Strains.
The study identified nine resistance genes, including aac(6')-Iaa, sul1, qacE, blaOXA-129, tet(B), and aadA1, as well as a point mutation in ParC (T57S) associated with quinolone resistance in Salmonella Mbandaka ST413 strains.
Impact of template denaturation prior to whole genome amplification on gene detection in high GC-content species, Burkholderia mallei and B. pseudomallei.
The study identified the presence of several antimicrobial resistance genes, including bla BP/MBL-3, bla OXA-42/43, qacE, penA-BP, and bla TEM, in Burkholderia mallei and B. pseudomallei strains using ARDM and PCR. The detection of bla TEM in these species is reported for the first time.
Molecular characterization of non-aureus staphylococci and Mammaliicoccus from Hipposideros bats in Southwest Nigeria.
The study identified mecA, SalA, and qacE as antibiotic resistance genes in Mammaliicoccus sciuri and Staphylococcus gallinarum isolates from Hipposideros bats in Nigeria, highlighting the potential for these bacteria to act as reservoirs of resistance genes.
Horizontal transfer characterization of ColV plasmids in bla(CTX-M)-bearing avian Escherichia coli.
The study characterizes the horizontal transfer of ColV plasmids in bla(CTX-M)-bearing avian E. coli, identifying multiple resistance genes and virulence factors associated with these plasmids.
Genomic analysis of multidrug-resistant Escherichia coli from Urban Environmental water sources in Accra, Ghana, Provides Insights into public health implications.
The study identified several AMR genes in multidrug-resistant E. coli isolates from urban environmental water sources in Accra, Ghana, highlighting the presence of beta-lactamases (blaTEM-1B, blaCTX-M-15, blaTEM-1C, blaDHA-1, blaOXA-1, blaOXA-181), sulfonamide resistance genes (sul2, sul1), aminoglycoside resistance genes (aph(6)-Id, aadA2, mph(A)), quinolone resistance gene (qnrS1), tetracycline resistance gene (tet(B)), chloramphenicol resistance gene (catA1), dihydrofolate reductase (dfrA14), and others.
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
The study identified several carbapenem-resistant genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla OXA-50, bla OXA-395, bla NDM-7, and bla NDM-5, in various bacterial species in Fiji.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
Genomic analysis of carbapenem- and colistin-resistant Klebsiella pneumoniae complex harbouring mcr-8 and mcr-9 from individuals in Thailand.
The study identifies mcr-8 and mcr-9 genes in carbapenem-resistant Klebsiella pneumoniae complex isolates from Thailand, highlighting their role in colistin resistance. It also characterizes additional AMR genes such as bla NDM-1, bla IMP-14, and various other resistance determinants.
Mobile genetic elements define the non-random structure of the Salmonella enterica serovar Typhi pangenome.
The study identifies multiple AMR genes, including blaTEM-1B, qnrS1, sul2, tet(A), aph(3'')-Ib, aph(6)-Id, dfrA14, blaCTX-M-15, blaCTX-M-88, catA1, qacE, sul1, and tet(B), which are associated with multidrug-resistant and extensively drug-resistant Salmonella enterica serovar Typhi strains.
Metagenome-wide characterization of shared antimicrobial resistance genes in sympatric people and lemurs in rural Madagascar.
The study identified five tetracycline resistance genes (tet(32), tet(40), tet(W), tet(Q)) and one trimethoprim resistance gene (dfrF) that were significantly more abundant in human microbiomes compared to lemur microbiomes. These genes were found to be highly conserved between human and lemur microbiomes.
Tracing the origin of NDM-1-producing and extensively drug-resistant Pseudomonas aeruginosa ST357 in the Netherlands.
The study identifies the NDM-1-producing Pseudomonas aeruginosa ST357 as an extensively drug-resistant strain with a unique resistome, highlighting the importance of tracking the origin of such isolates through genomic epidemiology.
An in-depth study on survival mechanism of bacterial isolates in disinfectants within the hospital environment.
The study identified multiple AMR genes, including blaDIM-1, qacE, and various efflux pump genes, in bacterial isolates from hospital disinfectants, indicating their adaptation to survive in disinfectant environments.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
Phenotypic and genotypic determination of resistance to common disinfectants among strains of Acinetobacter baumannii producing and non-producing biofilm isolated from Iran.
The study identified the presence of efflux pump genes qac-E, qacE-Δ1, and sug-E in Acinetobacter baumannii isolates, which contribute to resistance against common disinfectants.
Phenotypic and genotypic determination of resistance to common disinfectants among strains of Acinetobacter baumannii producing and non-producing biofilm isolated from Iran.
The study identified the presence of efflux pump genes qac-E, qacE-Δ1, and sug-E in Acinetobacter baumannii isolates, which contribute to resistance against common disinfectants.
Antibiotic Resistance Genes and Plasmid Characteristics in Enterobacteriaceae Isolated from Fresh Produce
The study identified several antibiotic resistance genes on plasmids and chromosomes of Enterobacteriaceae strains isolated from fresh produce, highlighting the diversity of resistance mechanisms and the potential for horizontal gene transfer.
Genome-Based Analysis of Genetic Diversity, Antimicrobial Susceptibility, and Virulence Gene Distribution in Salmonella Pullorum Isolates from Poultry in China.
The study identified several AMR genes and mutations in Salmonella Pullorum isolates from China, including aac(6')-Iaa, aadA5, blaTEM1β, sul2, tet(A), and qacE, as well as gyrA mutations (S83F, S84F, D87N), which are associated with resistance to streptomycin, ampicillin, ciprofloxacin, sulfamethoxazole, tetracycline, and disinfectants.
Investigation on the mechanisms of carbapenem resistance among the non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae.
The study identified non-carbapenemase β-lactamase genes and chromosomal mutations, including missense mutation or loss of ompK36 porin and frameshift missense mutation in efflux pump systems, as potential mechanisms of carbapenem resistance in NC-CRKP.
Environmental contamination with carbapenem resistant Acinetobacter baumannii in healthcare settings in Fiji: a potential source of infection.
The study identified several carbapenem-resistant Acinetobacter baumannii (CR Ab) isolates from high-touch surfaces in Fijian hospitals, revealing the presence of resistance genes such as bla OXA-23, bla NDM-1, and others, along with mutations in genes like parC and gyrA, contributing to resistance against multiple antibiotics.
Genomic and metabolic characterization of Trueperella pyogenes isolated from domestic and wild animals.
The study identified multiple antimicrobial resistance (AMR) genes in Trueperella pyogenes, including tet(W/32/O), erm(X), vanG, sul1, and qacEdelta1, which confer resistance to tetracyclines, MLS B, glycopeptides, sulfonamides, and biocides, respectively. These genes were detected in various T. pyogenes isolates from different animal hosts and body sites, highlighting the genetic diversity and potential for AMR dissemination among different hosts.
Comprehensive genomic insights into a highly pathogenic clone ST656 of mcr8.1 containing multidrug-resistant Klebsiella pneumoniae from Bangladesh.
The study identifies multiple beta-lactamase genes (blaLAP-2, blaTEM-1, blaSHV-11, blaOXA-1) and the mcr8.1 gene, which confers resistance to colistin, in a multidrug-resistant K. pneumoniae ST656 isolate from Bangladesh. Additionally, the qacEdelta1 gene, which contributes to resistance against disinfectants and antibiotics, was detected.
Genetic characterization and in silico serotyping of 62 Salmonella enterica isolated from Korean poultry operations.
Eradication of Helicobacter pylori reshapes gut microbiota and facilitates the evolution of antimicrobial resistance through gene transfer and genomic mutations in the gut.
H. pylori eradication led to the enrichment of various AMR genes, including beta-lactamases, macrolide phosphotransferases, erythromycin ribosome methyltransferases, sulfonamide resistance proteins, tetracycline efflux pumps, dihydrofolate reductase, quaternary ammonium compound efflux pumps, and aminoglycoside phosphotransferases. Additionally, genomic mutations in parC, parE, and gyrA were associated with fluoroquinolone resistance in E. coli.
Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
The study identified various AMR genes and mutations in Salmonella Enteritidis isolates from Spain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and aminoglycoside resistance genes. Chromosomal mutations in the gyrA gene were also found to contribute to quinolone resistance.
Wastewater based genomic surveillance key to population level monitoring of AmpC/ESBL producing Escherichia coli.
The study identified various AMR genes and mutations in AmpC/ESBL-producing E. coli from wastewater samples in Finland, highlighting the prevalence of blaCTX-M-15, blaCTX-M-27, and other resistance determinants.
Broiler litter moisture and trace metals contribute to the persistence of Salmonella strains that harbor large plasmids carrying siderophores.
The study identified several antimicrobial resistance genes in Salmonella strains isolated from broiler litter, including aadA1, aac(3)-IV, aph(3′)-Ia, aph(4)-Ia, dfrA14, floR, sul1, tetA, sul2, merRTPCA, qacE, aph(3″)-Ib, aph(6)-Id, pcoABCDRE, silP, and silE. These genes were found on various plasmids and contributed to resistance against multiple antibiotics such as streptomycin, chloramphenicol, sulfamethoxazole, tetracycline, mercury, quaternary ammonium compounds, copper, and silver.
Isolation, Identification, and Characteristics of Aeromonas salmonicida subsp. masoucida from Diseased Starry Flounder (Platichthys stellatus).
The study identified 11 antimicrobial resistance genes in Aeromonas salmonicida subsp. masoucida strains isolated from diseased starry flounders, including genes conferring resistance to beta-lactams, tetracyclines, sulfonamides, chloramphenicol, and biocides.
Providencia pseudovermicola sp. nov.: redefining Providencia vermicola and unveiling multidrug-resistant strains from diabetic foot ulcers in Egypt.
The study identifies multiple multidrug-resistant genes in Providencia pseudovermicola sp. nov., including bla CTX-M-14, bla CMY-6, bla NDM-1, qnrD1, aadA, armA, msrE, mphE, lnuF, rmtC, aac(6')-Ib10, sul1, aph(3')-Ia, qacEΔ1, and dfrA1, highlighting the significance of these genes in conferring resistance to various antibiotics.
Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?
The study identified multiple antibiotic resistance genes in clinical Klebsiella pneumoniae isolates, including bla TEM, bla SHV, bla CTX-M, and bla OXA families, as well as aminoglycoside, fluoroquinolone, and sulfonamide resistance genes. Effluent isolates showed fewer resistance genes and lower resistance levels compared to clinical isolates.
A decade of genomic and phenotypic adaptation of carbapenem-resistant Acinetobacter baumannii.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii isolates, including blaOXA-23, blaOXA-51-like, and several aminoglycoside resistance genes, contributing to extensive drug resistance.
A decade of genomic and phenotypic adaptation of carbapenem-resistant Acinetobacter baumannii.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii isolates, including blaOXA-23, blaOXA-51-like, and several aminoglycoside resistance genes, contributing to extensive drug resistance.
OXA-204 Carbapenemase in Clinical Isolate of Pseudomonas guariconensis, Tunisia.
The study reports the isolation of a Pseudomonas guariconensis clinical isolate producing OXA-204 carbapenemase, highlighting the spread of OXA-48-like genes beyond Enterobacterales. The isolate exhibited resistance to multiple antibiotics due to the presence of various resistance genes, including blaOXA-204, blaCMY-16, blaDHA-1, and others.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Cefiderocol-resistant pathogens in German hospital wastewater: a reservoir for multidrug resistance.
The study identifies multiple AMR genes, including bla NDM−1, bla VIM−1, bla OXA−48, and bla KPC−2, in cefiderocol-resistant isolates from German hospital wastewater, highlighting the presence of multidrug-resistant pathogens with diverse resistance mechanisms.
Cefiderocol-resistant pathogens in German hospital wastewater: a reservoir for multidrug resistance.
The study identifies multiple AMR genes, including bla NDM−1, bla VIM−1, bla OXA−48, and bla KPC−2, in cefiderocol-resistant isolates from German hospital wastewater, highlighting the presence of multidrug-resistant pathogens with diverse resistance mechanisms.
Multidrug-Resistant pESI-Harboring Salmonella enterica Serovar Muenchen Sequence Type 82 in Poultry and Humans, Israel, 2020-2023.
Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.
The study identifies 42 antimicrobial resistance (AMR) genes in the pan-drug resistant Klebsiella pneumoniae isolate KPNW, including beta-lactamases (bla CTX-M-15, bla NDM-1, bla OXA-1, bla TEM-63, bla TEM-104, bla SHV-28), tetracycline resistance genes (tet(A)), and efflux pump genes (oqxA, oqxB, marA, marR, ompK37, pbp3, crp, h-ns, kpnG, kpnH, parC, rsmA). Additionally, the isolate shows resistance to polymyxin B and colistin through modifications in lipid A (eptB, arnT, lptD, msbA, vanG) and other mechanisms.
No evidence of multidrug-resistant Enterobacterales transmission between healthy companion animals and pet owners in the greater Atlanta area: a pilot study.
The study identified several AMR genes and mutations in E. coli isolates from both humans and pets, including blaCMY-2, blaCTX-M-15, blaTEM-1B, and mutations in gyrA and parC. These findings highlight the presence of multidrug-resistant Enterobacterales in healthy individuals and their companion animals.
Diversity and antimicrobial resistance among bacterial isolates from finfish aquaculture in Thailand.
The study identified high levels of antimicrobial resistance in bacterial isolates from finfish aquaculture in Thailand, with particular emphasis on beta-lactam, tetracycline, and fluoroquinolone resistance in Gram-negative bacteria, and beta-lactam, macrolide, fluoroquinolone, and peptide resistance in Gram-positive bacteria. Unique resistance gene families, such as the SMR efflux pump and OXA beta-lactamase, were found in Aeromonas spp. and V. vulnificus.
Global emergence of Acinetobacter baumannii International Clone 12 predominantly found in the Middle East.
The study identifies multiple acquired antimicrobial resistance genes in Acinetobacter baumannii International Clone 12, including bla OXA-23, bla GES-11, bla GES-12, bla GES-22, bla GES-35, bla CARB-16, bla CARB-49, aphA6a, aadB, strA, strB, cmlA1, aadA2b, sul1, drfA7, dfrA1, qacE, tet(B), tet(X3), msr(E), mph(E), bla TEM-1B, and aacC3. These genes contribute to resistance against various antibiotics, highlighting the complexity of resistance mechanisms in this clone.
A quantitative characterization of antibiotic resistance and its influencing factors in hospital wastewaters across Lebanon.
The study identifies multiple antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in hospital wastewaters across Lebanon, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, tetracyclines, sulfonamides, and glycopeptides.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
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