qace∆1

efflux pump

Validation StatusSupported

Overview

Mechanism: disinfectant resistance
Validation Method: genomic analysis
Drug Classes: Quaternary ammonium compounds
Organisms: Escherichia coli B2C, Stenotrophomonas maltophilia, Acinetobacter baumannii
Geographic Location: Brazil, Egypt|Tunisia|Middle East|North Africa, Italy
Papers: 3
Databases: Reslit

Papers3

Genomic features of a multidrug-resistant and mercury-tolerant environmental Escherichia coli recovered after a mining dam disaster in South America.

PMID 35122850 · 2022

The study identifies a multidrug-resistant Escherichia coli strain (B2C) carrying the bla CTX-M-2 ESBL gene, qacE∆1 efflux pump, and the mer operon, indicating resistance to antibiotics, heavy metals, and disinfectants.

Gene Information

Gene Name: qace∆1
Allele: qacE∆1
Encodes: efflux pump
Source Database: Reslit
Mechanism: disinfectant resistance
Confers Resistance To: Quaternary ammonium compounds
Organisms Tested In: • Escherichia coli B2C
Geographic Location: Brazil
Validation Method: genomic analysis
Sequence Accession: JACSWD000000000.1

Evidence of dissemination of a clc-type integrative and conjugative element to Stenotrophomonas maltophilia, mediating acquisition of sul1 and other resistance determinants.

PMID 39817763 · 2025

The study reports the isolation of a Stenotrophomonas maltophilia strain carrying a clc-type integrative and conjugative element (ICE) that mediates the acquisition of multiple resistance determinants, including sul1, blaVIM-1, aac(6')-Ib, aac(6')-31, qacE∆1, cld, and merEDAPTR.

Gene Information

Gene Name: qace∆1
Allele: qacE∆1
Encodes: multidrug efflux pump
Source Database: Reslit
Mechanism: efflux pump
Confers Resistance To: Quaternary ammonium compounds
Organisms Tested In: • Stenotrophomonas maltophilia
Geographic Location: Italy
Validation Method: whole-genome sequencing and experimental confirmation
Sequence Accession: CP148075

Genomic insights into ST85 and ST158 belonging to recently emerged global clones of multidrug-resistant Acinetobacter baumannii isolates from Egypt: in vitro assessment of repurposed drug-antibiotic combinations.

PMID 41241719 · 2025

The study identified multiple antibiotic resistance genes, including blaOXA-23, aadA1, armA, aph(3')-VIa, aph(3')-Ia, and ant(3'')-IIa, in multidrug-resistant Acinetobacter baumannii isolates from Egypt.

Gene Information

Gene Name: qace∆1
Allele: qacE∆1
Encodes: efflux pump
Source Database: Reslit
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Egypt|Tunisia|Middle East|North Africa
Validation Method: genomic analysis
Sequence Accession: LT984690.1|CP121592|KY022424.1|CP121591.1|CP082952.1|CP121563.1|CP121595.1

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qace∆1

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