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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
quinolone resistance pentapeptide repeat protein QnrB52
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| QnrB52 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | QUINOLONE, CIPROFLOXACIN +2 | Proteus mirabilis +2 | China, Ecuador |
| 2006, 2021, 2023 |
| EF488762.1 |
| ABO93588.1 |
| qnrB2 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter koseri | - | 2006 | DQ351242 | - |
| QnrB1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 94 | QUINOLONE, CIPROFLOXACIN +6 | Klebsiella pneumoniae +24 | Accra, Ghana, Belgium, Anhui province, PR China, Chennai, Global, Egypt, France, Netherlands, Nepal, Tunisia, Middle East, Iran, Qazvin|Alborz|Tehran, Guadeloupe, Ghana, La Paz, Bolivia|La Paz River basin, Hungary, Tanzania|Thailand|human|swine, Brazil, China, Philippines, China|USA|Italy|Israel, Italy|Colombia|United States|South Africa|India|Greece|North Africa, Russia, Guadeloupe|French West Indies, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, Germany, Guadeloupe (French West Indies)|Guadeloupe, Europe, Caribbean, Portugal, Kuwait, Australia|Melbourne, Australia, Chile, Switzerland, United States, Dar es Salaam, Tanzania, Europe|Portugal, Wales|Nigeria, Mozambique, Brazilian Amazon Region, South Africa, India, Slovak Republic, Shanghai, China, Pakistan, Norway, Malaysia, Europe|Czech Republic, Armenia, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, Argentina, southwestern Nigeria, East Africa|Tanzania|Uganda | 2006, 2011, 2012, 2013, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | DQ351241.1 | ABC86904.2 |
| QnrB2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 42 | QUINOLONE, CIPROFLOXACIN +5 | Citrobacter koseri +29 | United States, United Kingdom, Spain, Accra, Ghana, Belgium, Anhui province, PR China, Global, China, Australia, Uruguay, Pakistan, Mexico, Germany, Asia|Europe|North America|South America|Africa|Taiwan|India|South Africa|China|Brazil, Ethiopia|USA|Israel|Turkey|United Kingdom|France|Belgium|Denmark|Czechia, USA|China|Japan|Spain|United Kingdom|Germany|France|South Korea|Netherlands|Viet Nam|Laos|Canada|Czech Republic|Argentina|Brazil|Belgium|Denmark|Iran|Australia|Croatia|Ghana|Mexico|Missing, Kentucky|USA, Northern Italy, Europe, Ghana, USA|China|Spain|Australia|Japan|Switzerland|Netherlands|Brazil|Taiwan|New Hampshire, USA|global, Normandy|France | 2006, 2007, 2008, 2009, 2011, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | DQ351242.1 | ABC86905.1 |
| QnrB5 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | QUINOLONE, CIPROFLOXACIN +4 | Salmonella enterica subsp. enterica serovar Berta +7 | United Kingdom, Spain, Global, Brazil, Peru, Norway, Portugal|various regions | 2006, 2008, 2009, 2019, 2022, 2023, 2024 | DQ303919.1 | ABC17628.2 |
| QnrB3 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | QUINOLONE, CIPROFLOXACIN +1 | Escherichia coli +1 | Global | 2006, 2023 | DQ303920.1 | ABC17629.2 |
| QnrB4 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 71 | QUINOLONE, CIPROFLOXACIN +6 | Escherichia coli +26 | China, Korea, Anhui province, PR China, Global, Spain, France, Algeria, Nepal, USA, Iran, Qazvin|Alborz|Tehran, South Korea, West Africa|Conakry, Guinea, Shanghai, China, Hungary, Tanzania|Thailand|human|swine, Australia|United States, China|Shenzhen, China, Vietnam, Kenya, Europe, Europe|Belgium, Philippines, Henan province, China|Henan, China, Al-Kharj, KSA, Yangzhou, China, Czech Republic|location A|location B|location C, Kuwait, Germany, Beijing, Australia, Ghana, Tunisia, India, Malaysia, Bangladesh, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, Taiwan, Oman, Western Balkans|Hungary, China|Europe|Americas|Asia|North Africa|Middle East, Normandy|France, Europe|China | 2006, 2009, 2010, 2011, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | DQ303921.2 | ABC17630.3 |
| qnrB4 | ResFinder Database | 1 | CIPROFLOXACIN | Escherichia coli | - | 2006 | DQ303921 | - |
| qnrB3 | ResFinder Database | 1 | CIPROFLOXACIN | Escherichia coli | - | 2006 | DQ303920 | - |
| qnrB | Reslit | 223 | Ciprofloxacin, Quinolone +5 | Enterobacter cloacae +76 | Taiwan, Japan, China, Europe, United States|China|Japan|France|Germany|South Korea|Brazil|Colombia|Canada|Israel|Taiwan|Singapore|Australia|Egypt|Lebanon|Vietnam|Hong Kong, Australia, China|Japan|Europe|Denmark|Italy|Spain, Ho Chi Minh City, Vietnam, Dhaka, Bangladesh, Madagascar, Taiwan|India|Morocco|Hong Kong, Germany, Canada, Peru, South India, Southeast Asia|Indian subcontinent|northern Africa|southern Africa|southern Europe|Central America|South America, Malaysia, Western Pennsylvania, Belgium, Côte d'Ivoire|Ta¯ National Park, Ivory Coast, Central African Republic, Romania, Ecuador, Iran, Heilongjiang province, China, Israel, India, Greece, Brazil, Maanshan Anhui Province, China, Al-Najaf Province, Iraq, United States|coastal wetlands, Dublin, Egypt, Africa, Xinjiang, China, Hamadan, West of Iran, Tehran, Iran, South Western Nigeria, Saudi Arabia, Chicago|Southwest Chicago|Downtown Chicago, United States, Malawi, Senegal, Togo, Odisha, India, Chicago|Illinois, Southern China, Madagascar|Cambodia|Senegal, Tunisia, Bangladesh, Yunnan Province, Shanxi Province, China, Burkina Faso|Gabon|Ghana|Tanzania, Sikkim|India, South Africa, Global|global|Turkey, Vietnam, Baghdad, Delta State, Nigeria, South Korea, Tanzania, California|Europe|North America|Republic of Congo, Gyeonggi-do, South Korea, Southeastern Asia|South Asia|North Africa|Eastern Africa|Southern Asia|Northern Africa|Southeast Asia|global, Korea, Slovakia, Nigeria, Thailand, Europe|China|Egypt|Vietnam|Colombia, Colombia, Mexico|Mexico City, Portugal, Philippines, Kanto Region, Japan, Europe|dairy calves in the US, Blantyre, Malawi, Japan|France|United Kingdom|North America|South America|Europe|Asia/Oceania|Africa, Brazilian Amazon, Germany|UK, global, Northern China, Central Panama, Pakistan, Anhui, China, Kenya, Czech Republic, Finland, Lagos, Nigeria|Nigeria, Wenzhou, China, Poland, New Orleans metropolitan area, Azerbaijan, Nepal, Tamaulipas, Mexico, Iraq, Jordan, Punjab, Pakistan, Turkey, Côte d'Ivoire, Shenzhen, China, Bulgaria|Europe, Europe|Tunisia, Zimbabwe, Northwestern Transylvania, Romania, Croatia, Shandong Province, Bushehr, south of Iran, Central Inner Mongolia, China, Khartoum, Sudan|Sudan, Türkiye, India|Delhi NCR, northwest China|China | 2007, 2008, 2009, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | DQ989302 | - |
| QnrB8 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | QUINOLONE, CIPROFLOXACIN +2 | Citrobacter freundii +3 | Global, Asia|Europe|North America|South America|Africa|Taiwan|India|South Africa|China|Brazil | 2007, 2021, 2023 | EU043312.2 | ABW03157.2 |
| QnrB7 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | QUINOLONE, CIPROFLOXACIN +2 | Enterobacter cloacae +6 | Global, Japan, India|Pakistan|Bangladesh|Philippines|Democratic Republic of the Congo, Senegal, Europe, Nigeria | 2007, 2017, 2021, 2022, 2023, 2025 | EU043311.3 | ABW03156.3 |
| qnrB8 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2007 | EU043312 | - |
| qnrB7 | ResFinder Database | 1 | CIPROFLOXACIN | Enterobacter cloacae | - | 2007 | EU043311 | - |
| QnrB10 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 12 | QUINOLONE, CIPROFLOXACIN +3 | Citrobacter freundii +15 | Argentina, Portugal, Anhui province, PR China, Global, India|Europe|North America, Armenia|Georgia, Brazil | 2007, 2011, 2013, 2017, 2020, 2022, 2023 | FJ769283.1 | ACP31588.1 |
| qnrB10 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii, Citrobacter braakii | - | 2007 | DQ631414, HM439644 | - |
| qnrB12 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter werkmanii | - | 2008 | AM774474 | - |
| QnrB12 | Card DatabaseReference Gene CatalogReslit | 5 | Ciprofloxacin, QUINOLONE +1 | Citrobacter werkmanii +2 | Germany, Global, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China | 2008, 2023, 2024 | AM774474 | CAO82104.1 |
| qnrB1 | ResFinder Database | 1 | CIPROFLOXACIN | Klebsiella pneumoniae | - | 2008 | DQ351241 | - |
| QnrB19 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 118 | QUINOLONE, CIPROFLOXACIN +7 | Escherichia coli +54 | Colombia, Peru|Bolivia, Global, Argentina, Mexico, Venezuela, Brazil, Europe, United States|New York|Florida|Illinois|Gaza|Colombia|South America|Mediterranean region, Guadeloupe, Europe|United States|China|Brazil|Australia|Spain|Germany|Iran|Switzerland|France|Portugal|Japan|Belgium|South Korea|Vietnam|Taiwan|India|Egypt|South Africa|Algeria, United States, Ecuador, UK, Netherlands|Brazil|Argentina, Chile|United States|Argentina|Peru|Colombia|Germany, Europe|USA|Italy|Switzerland|Egypt|Iran|Ecuador, Spain, Europe|Italy, Portugal, Italy, Tennessee|United States, Uruguay, Nigeria, Dominican Republic, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, Germany, Europe|Poland, Europe|Belgium, Africa|Asia|Europe|North America|South America|global, Europe|Denmark|France|Germany|United Kingdom, Guadeloupe (French West Indies)|Guadeloupe, Europe|broiler production pyramid, Uruguay|Brazil, North Carolina|USA, Hungary, Senegal, southern Ontario, Canada, Basque Country, northern Spain|Basque Country, Abuja, Nigeria, Peru, Japan, United States|USA, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Chile, United Kingdom|Australia|France|Belgium|United States of America, Saudi Arabia, Belgium, Lagos, Nigeria|Nigeria, Northern Italy, Poland, Salish Sea, Uganda, Ghana, Tennessee, USA|East Tennessee, USA|Honduras|UK|Kenya, North Carolina, Peruvian Amazon, Bangkok, Thailand, Norway, Portugal|various regions, Europe|Tunisia, Latin America, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, Europe|Africa|North America|South America|Asia|Oceania, Santa Catarina, Brazil|Brazil, China, Western Balkans|Hungary, Panama, China|Europe|Americas|Asia|North Africa|Middle East, Paraíba, northeastern Brazil, Harare, Zimbabwe, Algeria | 2008, 2010, 2013, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | EU432277.1 | ACA28712.1 |
| qnrB19 | ResFinder Database | 1 | CIPROFLOXACIN | Escherichia coli | - | 2008 | EU432277 | - |
| qnrB14 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2008 | EU273757 | - |
| QnrB13 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | QUINOLONE, CIPROFLOXACIN +3 | Citrobacter freundii +2 | Global, Anhui Province, China, China, South Africa | 2008, 2018, 2021, 2023 | JN173050.1 | AEL00446.1 |
| QnrB14 | Card DatabaseReference Gene CatalogReslit | 3 | QUINOLONE, Fluoroquinolone | Citrobacter freundii +1 | Global | 2008, 2023 | EU273757.1 | ABX72044.1 |
| qnrB15 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2008 | EU302865 | - |
| QnrB15 | Card DatabaseReference Gene CatalogReslit | 6 | QUINOLONE, Fluoroquinolone +2 | Citrobacter freundii +4 | Global, India|Europe|North America, Mexico|United States|China|Europe|Asia, United States | 2008, 2017, 2018, 2019, 2023 | EU302865.1 | ABX72227.1 |
| qnrB13 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2008 | EU273755 | - |
| QnrB6 | Card DatabaseReference Gene CatalogReslit | 29 | Quinolone, Fluoroquinolone +4 | Klebsiella pneumoniae +22 | China, Spain, Global, St. Louis, MO, USA, China|Shenzhen, China, South Africa, Vietnam, Thailand, central Adriatic Sea|Croatia|Croatian marine environment, South America, Shenzhen, China|China, Mozambique, Malaysia, Europe, China|United Kingdom|Argentina|Europe|Americas|Asia|Africa|Australasia|Vietnam|Switzerland|Thailand|Mexico, East Africa|Tanzania|Uganda | 2009, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | EU543271|EU543272 | ABP87778.1 |
| QnrB20 | Card DatabaseReference Gene CatalogReslit | 6 | QUINOLONE, Fluoroquinolone +2 | Escherichia coli +3 | Global, United Kingdom, Northern Italy, Europe|China | 2009, 2019, 2023, 2025 | AB379831.1 | BAG55487.1 |
| qnrB5 | ResFinder Database | 1 | CIPROFLOXACIN | Salmonella enterica subsp. enterica serovar Berta | - | 2009 | DQ303919 | - |
| QnrB16 | Card DatabaseReference Gene CatalogReslit | 5 | QUINOLONE, Fluoroquinolone +2 | Citrobacter freundii +1 | Spain, Global, Anhui Province, China | 2009, 2018, 2023 | EU136183.1 | ABV66096.1 |
| qnrB16 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2009 | EU136183 | - |
| qnrB23 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2010 | FJ981622 | - |
| QnrB22 | Card DatabaseReference Gene CatalogReslit | 4 | QUINOLONE, Fluoroquinolone | Citrobacter werkmanii +2 | South Korea, Global | 2010, 2023 | FJ981621.1 | ACS71746.1 |
| QnrB23 | Card DatabaseReference Gene CatalogReslit | 5 | QUINOLONE, Fluoroquinolone +1 | Citrobacter freundii +4 | South Korea, Global, Mexico|United States|China|Europe|Asia | 2010, 2018, 2023 | FJ981622.1 | ACS71747.1 |
| qnrB22 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter werkmanii | - | 2010 | FJ981621 | - |
| qnrB53 | ResFinder Database | 1 | CIPROFLOXACIN | Klebsiella pneumoniae | - | 2011 | HQ704413 | - |
| QnrB31 | Card DatabaseReference Gene CatalogReslit | 4 | QUINOLONE, Fluoroquinolone +1 | Klebsiella pneumoniae +2 | Global, Mexico|United States|China|Europe|Asia | 2011, 2018, 2023 | HQ418999.2 | ADQ43424.1 |
| qnrB31 | ResFinder Database | 1 | CIPROFLOXACIN | Klebsiella pneumoniae | - | 2011 | HQ418999 | - |
| QnrB53 | Reference Gene Catalog | 1 | QUINOLONE | Klebsiella pneumoniae | - | 2011 | HQ704413.2 | - |
| qnrB24 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2011 | HM192542 | - |
| QnrB24 | Card DatabaseReference Gene CatalogReslit | 4 | Fluoroquinolone, QUINOLONE | Citrobacter freundii +1 | Anhui province, PR China, Global | 2011, 2023 | HM192542.1 | ADI46626.1 |
| QnrB40 | Card DatabaseReference Gene CatalogResFinder Database | 3 | CIPROFLOXACIN, QUINOLONE | Citrobacter braakii | - | 2011 | NG_050503.1 | WP_063866081.1 |
| qnrB40 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter braakii | - | 2011 | JN166689 | - |
| QnrB28 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | QUINOLONE, CIPROFLOXACIN +1 | Citrobacter freundii +1 | Global | 2011, 2023 | HM439643.1 | ADM52188.1 |
| qnrB28 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2011 | HM439643 | - |
| qnrB30 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter braakii | - | 2011 | HM439650 | - |
| qnrB41 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2011 | JN166690 | - |
| QnrB27 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | QUINOLONE, CIPROFLOXACIN +2 | Citrobacter braakii +2 | Global, India|Europe|North America | 2011, 2017, 2023 | HM439641.1 | ADM52186.1 |
| QnrB29 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | QUINOLONE, CIPROFLOXACIN +1 | Citrobacter freundii +1 | Global | 2011, 2023 | JN173053.1 | AEL00449.1 |
| qnrB29 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2011 | HM439649 | - |
| QnrB30 | Card DatabaseReference Gene CatalogReslit | 3 | QUINOLONE, Fluoroquinolone | Citrobacter braakii +1 | Global | 2011, 2023 | HM439650.1 | ADM52194.1 |
| qnrB27 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter braakii | - | 2011 | HM439641 | - |
| QnrB36 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | QUINOLONE, CIPROFLOXACIN +1 | Citrobacter freundii +1 | United States | 2011 | JN173058.1 | AEL00458.1 |
| QnrB17 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | QUINOLONE, CIPROFLOXACIN +3 | Citrobacter freundii +3 | Global, Anhui Province, China, China, Sri Lanka, Europe|China | 2011, 2018, 2023, 2025 | JN173051.1 | AEL00447.1 |
| QnrB34 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | Fluoroquinolone, QUINOLONE +1 | Citrobacter freundii complex +1 | United States | 2011 | JN173050|JN173051|JN173052|JN173053|JN173054|JN173055|JN173056|JN173057|JN173058|JN173059 | AEL00452.2 |
| QnrB35 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | QUINOLONE, CIPROFLOXACIN +1 | Citrobacter freundii +2 | United States, France | 2011, 2024 | JN173057.1 | AEL00456.1 |
| QnrB32 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | Fluoroquinolone, QUINOLONE +4 | Citrobacter freundii complex +4 | United States, Mexico|United States|China|Europe|Asia, India | 2011, 2018, 2025 | JN173050|JN173051|JN173052|JN173053|JN173054|JN173055|JN173056|JN173057|JN173058|JN173059 | AEL00450.1 |
| qnrB32 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2011 | JN173054 | - |
| qnrB36 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2011 | JN173058 | - |
| qnrB35 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2011 | JN173057 | - |
| qnrB33 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter braakii | - | 2011 | JN173055 | - |
| QnrB33 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | Fluoroquinolone, QUINOLONE +1 | Citrobacter freundii complex +1 | United States | 2011 | JN173050|JN173051|JN173052|JN173053|JN173054|JN173055|JN173056|JN173057|JN173058|JN173059 | AEL00451.1 |
| qnrB34 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter werkmanii | - | 2011 | JN173056 | - |
| qnrB37 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2011 | JN173059 | - |
| QnrB38 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | Fluoroquinolone, QUINOLONE +2 | Citrobacter freundii complex +5 | United States, China, Germany, Kuwait, Bulgaria|Europe | 2011, 2021, 2023, 2024 | JN173050|JN173051|JN173052|JN173053|JN173054|JN173055|JN173056|JN173057|JN173058|JN173059 | AEL00461.1 |
| qnrB38 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2011 | JN173060 | - |
| qnrB39 | ResFinder Database | 1 | CIPROFLOXACIN | - | - | 2011 | ABWL02000005 | - |
| QnrB37 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | QUINOLONE, CIPROFLOXACIN +2 | Citrobacter freundii +3 | United States, Mexico|United States|China|Europe|Asia | 2011, 2018 | JN173059.1 | AEL00459.1 |
| qnrB17 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2011 | JN173051, AM919398 | - |
| QnrB9 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 10 | Fluoroquinolone, QUINOLONE +4 | Citrobacter +5 | Global, United States, Anhui Province, China, China, Finland, Bulgaria|Europe, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China | 2014, 2018, 2022, 2023, 2024 | V00622|X53796|X07848|M11587|P20074|K00544|X02529|AY355285|NC_002013|U15027|M35190|S48276|M93113|M55620|M58472|AF047479|AJ009818|AF036933|AF462019|AF878850|M64556|M22614|AF071555|AJ549214|X59968|U09991|Z12001|U85507|AJ579365|HM537013 | ABP88094.1 |
| QnrB11 | Card DatabaseReference Gene CatalogReslit | 3 | Fluoroquinolone, QUINOLONE | Citrobacter +1 | Global | 2023 | V00622|X53796|X07848|M11587|P20074|K00544|X02529|AY355285|NC_002013|U15027|M35190|S48276|M93113|M55620|M58472|AF047479|AJ009818|AF036933|AF462019|AF878850|M64556|M22614|AF071555|AJ549214|X59968|U09991|Z12001|U85507|AJ579365|HM537013 | ABS30107.1 |
| QnrB18 | Card DatabaseReference Gene CatalogReslit | 3 | Fluoroquinolone, QUINOLONE | Citrobacter +1 | Global | 2012, 2023 | V00622|X53796|X07848|M11587|P20074|K00544|X02529|AY355285|NC_002013|U15027|M35190|S48276|M93113|M55620|M58472|AF047479|AJ009818|AF036933|AF462019|AF878850|M64556|M22614|AF071555|AJ549214|X59968|U09991|Z12001|U85507|AJ579365|HM537013 | CAP45903.1 |
| QnrB21 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | Fluoroquinolone, QUINOLONE +1 | Escherichia +1 | Global | 2023 | V00622|X53796|X07848|M11587|P20074|K00544|X02529|AY355285|NC_002013|U15027|M35190|S48276|M93113|M55620|M58472|AF047479|AJ009818|AF036933|AF462019|AF878850|M64556|M22614|AF071555|AJ549214|X59968|U09991|Z12001|U85507|AJ579365|HM537013 | ACM50952.1 |
| QnrB25 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | Fluoroquinolone, QUINOLONE +1 | Citrobacter +1 | Global | 2012, 2023 | V00622|X53796|X07848|M11587|P20074|K00544|X02529|AY355285|NC_002013|U15027|M35190|S48276|M93113|M55620|M58472|AF047479|AJ009818|AF036933|AF462019|AF878850|M64556|M22614|AF071555|AJ549214|X59968|U09991|Z12001|U85507|AJ579365|HM537013 | ADN94685.1 |
| QnrB26 | Card DatabaseReference Gene CatalogReslit | 3 | Fluoroquinolone, QUINOLONE | Citrobacter +1 | Global | 2013, 2023 | V00622|X53796|X07848|M11587|P20074|K00544|X02529|AY355285|NC_002013|U15027|M35190|S48276|M93113|M55620|M58472|AF047479|AJ009818|AF036933|AF462019|AF878850|M64556|M22614|AF071555|AJ549214|X59968|U09991|Z12001|U85507|AJ579365|HM537013 | AEH59666.1 |
| QnrB49 | Card DatabaseReference Gene Catalog | 2 | QUINOLONE | Citrobacter freundii | - | 2012 | JQ582718.1 | AFD54601.1 |
| qnrB49 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2012 | JQ582718 | - |
| QnrB42 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Klebsiella pneumoniae | - | 2012 | JN680743.1 | AEQ94272.1 |
| qnrB42 | ResFinder Database | 1 | CIPROFLOXACIN | Klebsiella pneumoniae | - | 2012 | JN680743 | - |
| qnrB25 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2012 | HQ172108 | - |
| QnrB60 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | QUINOLONE, CIPROFLOXACIN +1 | Citrobacter freundii +1 | - | 2013 | AB734055.1 | BAN04743.1 |
| QnrB61 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | QUINOLONE, CIPROFLOXACIN +1 | Citrobacter braakii +1 | - | 2013 | AB734053.1 | BAN04737.1 |
| qnrB61 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter braakii | - | 2013 | AB734053 | - |
| qnrB60 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2013 | AB734055 | - |
| qnrB65 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2014 | KC580654 | - |
| QnrB65 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter freundii | - | 2014 | KC580654.1 | AGL43626.1 |
| QnrB64 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter freundii | - | 2014 | KC580653.1 | AGL43625.1 |
| QnrB66 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | QUINOLONE, CIPROFLOXACIN +2 | Citrobacter freundii +1 | South Korea, Italy, Madagascar | 2014, 2017, 2021, 2022 | KC580655.1 | AGL43627.1 |
| QnrB67 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter braakii | - | 2014 | KC580656.1 | AGL43628.1 |
| QnrB47 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter freundii | - | 2014 | JX440358.1 | AFU25658.1 |
| QnrB68 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter braakii | - | 2014 | KC580657.1 | AGL43629.1 |
| QnrB69 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter freundii | - | 2014 | KC580658.1 | AGL43630.1 |
| qnrB71 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter braakii | - | 2014 | KC580660 | - |
| qnrB70 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter braakii | - | 2014 | KC580659 | - |
| qnrB69 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2014 | KC580658 | - |
| qnrB68 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter braakii | - | 2014 | KC580657 | - |
| qnrB67 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter braakii | - | 2014 | KC580656 | - |
| qnrB66 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2014 | KC580655 | - |
| qnrB64 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2014 | KC580653 | - |
| QnrB70 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter braakii | - | 2014 | KC580659.1 | AGL43631.1 |
| QnrB71 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | QUINOLONE, CIPROFLOXACIN +1 | Citrobacter braakii +1 | - | 2014, 2024 | KC580660.1 | AGL43632.1 |
| qnr B1 | Reslit | 4 | Fluoroquinolone, Ciprofloxacin +1 | Escherichia coli +1 | Middle East, Southeast Nigeria, Portugal | 2014, 2022, 2025 | PRJEB43719 | - |
| qnrB50 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2015 | JX440357 | - |
| QnrB50 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter freundii | - | 2015 | JX440357.1 | AFU25656.1 |
| QnrB54 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | Ciprofloxacin, QUINOLONE +1 | Citrobacter freundii +1 | Spain | 2015 | HG974539|LN624598|HE820727 | CCI51002.2 |
| qnrB54 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | 2015 | HE820727 | - |
| QnrB | Reslit | 4 | Fluoroquinolone, Quinolone +1 | Stenotrophomonas maltophilia WJ66 +4 | China, Greece, Netherlands|Greece|Romania, Netherlands | 2015, 2016, 2021, 2022 | AZRF00000000 | - |
| QnrB55 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | Ciprofloxacin, Quinolone +2 | Klebsiella pneumoniae +2 | Austria|Germany, Al-Kharj, KSA | 2016, 2022 | KU245543 | AHE41343.1 |
| qnr B | Reslit | 10 | Ciprofloxacin, Quinolone +2 | Salmonella enterica +3 | Egypt, Saudi Arabia, Edo State, Nigeria, North America, Bangladesh, Iran, Spain, Iraq, Guadeloupe, India|Delhi NCR | 2017, 2022, 2023, 2024, 2025 | ERP146025 | - |
| Qnr B1 | Reslit | 1 | Ciprofloxacin | Klebsiella pneumoniae | Cameroon | 2018 | PDVM00000000|PDVF00000000|PDVG00000000|PDVC00000000|PDVE00000000|PDVU00000000|PDVD00000000 | - |
| qnr B2 | Reslit | 1 | Ciprofloxacin | Salmonella enterica | United States | 2018 | PRJNA433689 | - |
| QnrB77 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | Ciprofloxacin, Levofloxacin +3 | Citrobacter freundii +1 | Anhui Province, China, United States | 2018, 2020 | KM985469.1|MG744557 | AKO62869.1 |
| qnrB-1 | Reslit | 1 | Fluoroquinolone | Enterobacter cloacae +1 | Brazil | 2018 | NCBI:MH051105 | - |
| QnrB-4 | Reslit | 1 | Fluoroquinolone | Escherichia coli +2 | Maputo, Mozambique | 2019 | - | - |
| QnrB-8 | Reslit | 1 | Fluoroquinolone | Escherichia coli +2 | Maputo, Mozambique | 2019 | - | - |
| QnrB-1 | Reslit | 1 | Fluoroquinolone | Escherichia coli +2 | Maputo, Mozambique | 2019 | - | - |
| QnrB96 | Reference Gene CatalogReslit | 3 | Ciprofloxacin, QUINOLONE +2 | Escherichia coli +2 | Sweden, Austria | 2019, 2025 | CP041225|SNVX00000000|QKME00000000|QZWH00000000|MK558235|MK561856 | QCX19849.1 |
| QnrB89 | Reference Gene CatalogResFinder DatabaseReslit | 4 | Fluoroquinolone, QUINOLONE +1 | Citrobacter gillenii +2 | Chile | 2019, 2021 | MK261222 | QPA35678.1 |
| QnrB81 | Reference Gene CatalogResFinder DatabaseReslit | 6 | Fluoroquinolone, Ciprofloxacin +3 | Salmonella enterica subsp. enterica serovar Infantis +4 | Europe|USA|Italy|Switzerland|Egypt|Iran|Ecuador, Saudi Arabia, Colombia, Europe|Tunisia | 2020, 2023, 2024 | PRJEB23728|PRJEB34620 | AOE23833.1 |
| qnrB91 | ResFinder Database | 1 | CIPROFLOXACIN | Klebsiella pneumoniae | - | 2020 | AP023150 | - |
| QnrB91 | Reference Gene CatalogResFinder DatabaseReslit | 5 | Fluoroquinolone, QUINOLONE +1 | Klebsiella pneumoniae +1 | Europe, China | 2020, 2021, 2023 | JAHRXK000000000|JAHRXL000000000 | OCV95526.1 |
| qnrB89 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter gillenii | - | 2021 | MT544491 | - |
| qnr B19 | Reslit | 4 | Fluoroquinolone, Quinolone +1 | Escherichia coli +1 | Europe, Italy, Portugal|various regions, Spain | 2021, 2024, 2025 | PRJEB41365 | - |
| QnrB58 | Card DatabaseReference Gene CatalogReslit | 3 | Fluoroquinolone, QUINOLONE | Enterobacterales +1 | Vietnam | 2021 | AP018565|AP018566|AP018567|AP018568|AP018571|AP018572|AP018577|AP018578|AP018579|AP018580|AP018581|AP018582|AP018583|AP018584|CP021952|CP040884|CP041930|CP043383|CP034846|CP026053|CP041177|PRJDB6655 | AFR46589.1 |
| qnr-B | Reslit | 1 | Quinolone | Escherichia coli | Anhui Province | 2022 | - | - |
| qnrB-type | Reslit | 1 | Ciprofloxacin | Citrobacter braakii | Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea | 2022 | - | - |
| QnrB44 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | Ciprofloxacin, CIPROFLOXACIN +1 | C. freundii +1 | Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea | 2022 | NG_050507.1 | WP_063866105.1 |
| QnrB82 | Reference Gene CatalogResFinder DatabaseReslit | 3 | Quinolone, QUINOLONE +1 | Salmonella enterica serovar Enteritidis +1 | Colombia | 2023 | PRJEB35182|PRJEB47910 | AOE23835.1 |
| qnr B5 | Reslit | 1 | Fluoroquinolone | Escherichia coli | Portugal|various regions | 2024 | SAMN37007325|SAMN37007368|SAMN42001311|PRJNA1006036 | - |
| QnrB39 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | Fluoroquinolone, Quinolone +2 | Buttiauxella massiliensis +1 | Austria | 2025 | PRJNA1224714 | EFE09657.1 |
| qnrB 1 | Reslit | 1 | Fluoroquinolone | Klebsiella pneumoniae | Iran | 2025 | JARGDG000000000|JARGDG010000000 | - |
| qnrb | Reslit | 1 | Fluoroquinolone | Stenotrophomonas tuberculopleuritidis | Europe | 2025 | CP130831.1|OR964852 | - |
| qnrB20 | ResFinder Database | 1 | CIPROFLOXACIN | Escherichia coli | - | - | AB379831 | - |
| qnrB26 | ResFinder Database | 1 | CIPROFLOXACIN | Proteus vulgaris | - | - | HQ386846 | - |
| qnrB62 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | JX987101 | - |
| qnrB72 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter sp. TR21_24 | - | - | KC741443 | - |
| qnrB73 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter europaeus | - | - | KF443075 | - |
| qnrB74 | ResFinder Database | 1 | CIPROFLOXACIN | Escherichia coli | - | - | KJ415247 | - |
| qnrB75 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | KP207591 | - |
| qnrB77 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | KM985470 | - |
| qnrB78 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | KM985471 | - |
| qnrB80 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | KM985473 | - |
| qnrB81 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | KX372671 | - |
| qnrB82 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | KX372672 | - |
| qnrB9 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | EF526508 | - |
| qnrB6 | ResFinder Database | 1 | CIPROFLOXACIN | Pantoea agglomerans, Klebsiella pneumoniae | - | - | EF520349, EF523819 | - |
| qnrB43 | ResFinder Database | 1 | CIPROFLOXACIN | Escherichia coli | - | - | JQ349151 | - |
| qnrB44 | ResFinder Database | 1 | CIPROFLOXACIN | Escherichia coli | - | - | JQ349153 | - |
| qnrB45 | ResFinder Database | 1 | CIPROFLOXACIN | Escherichia coli | - | - | JQ349152 | - |
| qnrB46 | ResFinder Database | 1 | CIPROFLOXACIN | Escherichia coli | - | - | JQ349154 | - |
| qnrB47 | ResFinder Database | 1 | CIPROFLOXACIN | Escherichia coli | - | - | JQ349155 | - |
| qnrB48 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | JQ762640 | - |
| qnrB52 | ResFinder Database | 1 | CIPROFLOXACIN | Proteus mirabilis | - | - | EF488762 | - |
| qnrB55 | ResFinder Database | 1 | CIPROFLOXACIN | Klebsiella terrigena | - | - | KF730650 | - |
| qnrB56 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | JX259317 | - |
| qnrB57 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | JX259318 | - |
| qnrB58 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | JX259319 | - |
| qnrB59 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | JX259320 | - |
| QnrB43 | Card DatabaseReference Gene CatalogResFinder Database | 3 | CIPROFLOXACIN, QUINOLONE | Escherichia coli | - | - | NG_050506.1 | WP_063866099.1 |
| QnrB45 | Card DatabaseReference Gene CatalogResFinder Database | 3 | CIPROFLOXACIN, QUINOLONE | Escherichia coli | - | - | NG_050508.1 | WP_063866109.1 |
| qnrB11 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | EF653270 | - |
| qnrB18 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter freundii | - | - | AM919399 | - |
| qnrB21 | ResFinder Database | 1 | CIPROFLOXACIN | Escherichia coli | - | - | FJ611948 | - |
| qnrB90 | ResFinder Database | 1 | CIPROFLOXACIN | Citrobacter braakii | - | - | MG182074 | - |
| QnrB46 | Card DatabaseReference Gene Catalog | 2 | QUINOLONE | Klebsiella pneumoniae +1 | - | - | HQ704413.2 | ADW54092.1 |
| QnrB56 | Card DatabaseReference Gene Catalog | 2 | QUINOLONE | Citrobacter freundii | - | - | JX259317.1 | AFR46587.1 |
| QnrB59 | Card DatabaseReference Gene Catalog | 2 | QUINOLONE | Citrobacter freundii | - | - | JX259320.1 | AFR46590.1 |
| QnrB62 | Card DatabaseReference Gene Catalog | 2 | QUINOLONE | Citrobacter freundii | - | - | JX987101.1 | AFY16910.1 |
| QnrB76 | Card Database | 1 | - | Citrobacter portucalensis | - | - | AP022513.1 | BBW41109.1 |
| QnrB48 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter freundii | - | - | JQ762640.1 | AFH88686.1 |
| QnrB73 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter europaeus | - | - | KF443075.1 | AGT59159.1 |
| QnrB72 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter sp. TR21_24 | - | - | KC741443.1 | AGN92479.1 |
| QnrB74 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Escherichia coli | - | - | KJ415247.1 | AHX97725.1 |
| QnrB75 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter freundii | - | - | KP207591.1 | AKI82195.1 |
| QnrB78 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter freundii | - | - | KM985471.1 | AKO62870.1 |
| QnrB80 | Card DatabaseReference Gene CatalogResFinder Database | 3 | QUINOLONE, CIPROFLOXACIN | Citrobacter freundii | - | - | KM985473.1 | AKO62872.1 |
| QnrB84 | Reference Gene Catalog | 1 | QUINOLONE | - | - | - | JANGZI010000011.1 | - |
| QnrB85 | Reference Gene Catalog | 1 | QUINOLONE | Citrobacter sp. MGH110 | - | - | KQ089830.1 | - |
| QnrB90 | Reference Gene CatalogResFinder Database | 2 | QUINOLONE, CIPROFLOXACIN | Citrobacter braakii | - | - | MG182074.1 | AXH80082.1 |
| QnrB93 | Reference Gene Catalog | 1 | QUINOLONE | Citrobacter portucalensis | - | - | JABVAY010000005.1 | NUH56804.1 |
| QnrB94 | Reference Gene Catalog | 1 | QUINOLONE | Citrobacter freundii | - | - | MK047607.1 | AYJ77151.1 |
| QnrB95 | Reference Gene Catalog | 1 | QUINOLONE | Klebsiella pneumoniae subsp. pneumoniae | - | - | FXSR01000057.1 | - |
| QnrB97 | Reference Gene Catalog | 1 | QUINOLONE | Citrobacter meridianamericanus | - | - | OL606719.1 | UGN21643.1 |
| QnrB98 | Reference Gene Catalog | 1 | QUINOLONE | Citrobacter youngae | - | - | OR896918.1 | WPR17912.1 |
| QnrB99 | Reference Gene Catalog | 1 | QUINOLONE | Enterobacter bugandensis | - | - | PP740512.1 | XAJ73578.1 |
| QnrB41 | Card DatabaseReference Gene Catalog | 2 | QUINOLONE | Citrobacter freundii | - | - | JN166690.1 | AEL31272.1 |
qnrB, another plasmid-mediated gene for quinolone resistance.
qnrB, another plasmid-mediated gene for quinolone resistance.
qnrB, another plasmid-mediated gene for quinolone resistance.
qnrB, another plasmid-mediated gene for quinolone resistance.
qnrB, another plasmid-mediated gene for quinolone resistance.
qnrB, another plasmid-mediated gene for quinolone resistance.
qnrB, another plasmid-mediated gene for quinolone resistance.
qnrB, another plasmid-mediated gene for quinolone resistance.
qnrB, another plasmid-mediated gene for quinolone resistance.
Plasmid-mediated quinolone resistance in non-Typhi serotypes of Salmonella enterica.
Plasmid-mediated quinolone resistance in non-Typhi serotypes of Salmonella enterica.
qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States.
qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States.
qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States.
qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States.
qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States.
qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States.
qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States.
Prevalence of plasmid-mediated quinolone resistance determinants QnrA, QnrB, and QnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital.
The study identified the prevalence of plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital, highlighting the significant role of these genes in quinolone resistance.
Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates.
Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates.
Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates.
Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates.
Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates.
Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates.
Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates.
Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates.
Zoo animals as reservoirs of gram-negative bacteria harboring integrons and antimicrobial resistance genes.
The study identified various antimicrobial resistance genes in gram-negative bacteria isolated from zoo animals, including bla TEM-1, bla OXY-2, bla SHV-36, bla CTX-M-2, bla CMY-26, qnrB, qnrS, and aac(6')-Ib-cr.
Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina.
Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina.
Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina.
The study identifies a novel quinolone resistance determinant, qnrB10, and a variant of aac(6')-Ib, termed aac(6')-Ib-cr, associated with ISCR1 in clinical enterobacterial isolates from Argentina.
Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina.
Novel variant of the qnrB gene, qnrB12, in Citrobacter werkmanii.
Novel variant of the qnrB gene, qnrB12, in Citrobacter werkmanii.
The study identifies a novel variant of the qnrB gene, qnrB12, in Citrobacter werkmanii, which confers resistance to nalidixic acid and ciprofloxacin.
Novel variant of the qnrB gene, qnrB12, in Citrobacter werkmanii.
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
The study identifies various beta-lactamase genes (bla CMY-2, bla CMY-23, bla SHV-12, bla SHV-30, bla OXA-1, bla OXA-9) and a qnrB2 gene associated with reduced susceptibility to quinolones and extended-spectrum cephalosporins in Salmonella isolates. Additionally, mutations in gyrA and parC genes contribute to quinolone resistance.
Plasmid-mediated quinolone resistance in Salmonella enterica, United Kingdom.
The study identifies qnrS1, qnrB5, and qnrB2 as plasmid-mediated quinolone resistance genes in Salmonella enterica isolates in the United Kingdom, contributing to reduced susceptibility to ciprofloxacin and nalidixic acid.
Plasmid-mediated quinolone resistance in Salmonella enterica, United Kingdom.
The study identifies qnrS1, qnrB5, and qnrB2 as plasmid-mediated quinolone resistance genes in Salmonella enterica isolates in the United Kingdom, contributing to reduced susceptibility to ciprofloxacin and nalidixic acid.
qnr Gene nomenclature.
Presence of qnr gene in Escherichia coli and Klebsiella pneumoniae resistant to ciprofloxacin isolated from pediatric patients in China.
The study identified the presence of qnrA, qnrB, and qnrS genes in ciprofloxacin-resistant E. coli and K. pneumoniae isolates from pediatric patients in China, demonstrating plasmid-mediated quinolone resistance.
ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli.
ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli.
The study identifies a novel plasmid-mediated quinolone resistance determinant, qnrB19, in an E. coli clinical isolate from Colombia, which is associated with an IS Ecp1-like element and shows increased MICs of quinolones and fluoroquinolones.
ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli.
ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli.
ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli.
European emergence of ciprofloxacin-resistant Escherichia coli clonal groups O25:H4-ST 131 and O15:K52:H1 causing community-acquired uncomplicated cystitis.
The study identified qnrB-like genes in ciprofloxacin-resistant E. coli strains and mutations in gyrA and parC genes contributing to fluoroquinolone resistance.
Plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacteriaceae in a Korean hospital.
Plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacteriaceae in a Korean hospital.
Plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacteriaceae in a Korean hospital.
Plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacteriaceae in a Korean hospital.
Plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacteriaceae in a Korean hospital.
Plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacteriaceae in a Korean hospital.
Plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacteriaceae in a Korean hospital.
High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6′)-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals.
The study identified the high prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6′)-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals in China.
High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6′)-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals.
The study identified the high prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6′)-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals in China.
Detection and genetic characterisation of qnrB in hospital isolates of Klebsiella pneumoniae in Singapore.
SOS regulation of qnrB expression.
SOS Regulation of qnrB Expression
The study demonstrates that qnrB is regulated by the SOS system, leading to increased expression in response to quinolone exposure, thereby contributing to quinolone resistance.
The pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex.
QnrB4 exhibits protective effects against fluoroquinolone inhibition of E. coli DNA gyrase, whereas MfpA Mt does not provide protection against fluoroquinolone inhibition of M. tuberculosis gyrase.
Mobilization of qnrB2 and ISCR1 in plasmids.
The study identifies the qnrB2 gene, which confers quinolone resistance, and its mobilization via ISCR1 in plasmids from Enterobacter cloacae clinical isolates.
Detection of plasmid-mediated quinolone resistance genes in clinical isolates of Enterobacter spp. in Spain.
The study identified plasmid-mediated quinolone resistance genes qnrS1, qnrB5, qnrB2, aac(6')-Ib-cr, and a qnrB7-like gene in clinical isolates of Enterobacter spp. in Spain.
Detection of plasmid-mediated quinolone resistance genes in clinical isolates of Enterobacter spp. in Spain.
The study identified plasmid-mediated quinolone resistance genes qnrS1, qnrB5, qnrB2, aac(6')-Ib-cr, and a qnrB7-like gene in clinical isolates of Enterobacter spp. in Spain.
Two chromosomally located qnrB variants, qnrB6 and the new qnrB16, in Citrobacter spp. isolates causing bacteraemia.
Two chromosomally located qnrB variants, qnrB6 and the new qnrB16, in Citrobacter spp. isolates causing bacteraemia.
Two chromosomally located qnrB variants, qnrB6 and the new qnrB16, in Citrobacter spp. isolates causing bacteraemia.
The study identified two chromosomally located qnrB variants, qnrB6 and qnrB16, in Citrobacter spp. isolates causing bacteraemia. These variants contribute to quinolone resistance.
Two chromosomally located qnrB variants, qnrB6 and the new qnrB16, in Citrobacter spp. isolates causing bacteraemia.
The study identified two chromosomally located qnrB variants, qnrB6 and qnrB16, in Citrobacter spp. isolates causing bacteraemia. These variants contribute to quinolone resistance.
Two chromosomally located qnrB variants, qnrB6 and the new qnrB16, in Citrobacter spp. isolates causing bacteraemia.
The SOS response promotes qnrB quinolone-resistance determinant expression.
The study identifies the qnrB2 promoter and demonstrates that qnrB2 expression is regulated by the SOS response through LexA, leading to increased quinolone resistance.
Salmonella enterica serovar Typhi with CTX-M beta-lactamase, Germany.
Plasmid-mediated quinolone resistance: a multifaceted threat.
The paper discusses plasmid-mediated quinolone resistance (PMQR) mechanisms, focusing on qnr genes and other resistance determinants like aac(6')-Ib-cr, oqxAB, and qepA. These genes confer low-level resistance to quinolones, facilitating the selection of higher-level resistant mutants.
Characterization of small ColE-like plasmids mediating widespread dissemination of the qnrB19 gene in commensal enterobacteria.
The study characterizes two small ColE-like plasmids, pECY6-7 and pECC14-9, which encode the qnrB19 gene, a quinolone resistance determinant. These plasmids are widely disseminated among commensal enterobacteria, contributing significantly to the spread of qnrB19 in healthy children in Peru and Bolivia.
Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii.
Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii.
Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii.
Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii.
Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii.
The study identifies two novel qnrB variants, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii, which confer resistance to fluoroquinolones.
Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii.
The study identifies two novel qnrB variants, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii, which confer resistance to fluoroquinolones.
Molecular characteristics of extended spectrum beta-lactamases in Escherichia coli and Klebsiella pneumoniae and the prevalence of qnr in Extended spectrum beta-lactamase isolates in a tertiary care hospital in Korea.
The study identified CTX-M15 as the most prevalent ESBL in E. coli and K. pneumoniae, along with CTX-M14 in E. coli and CTX-M15 and SHV-12 in K. pneumoniae. High prevalence of qnrB4 and qnrS1 was found in ESBL-producing K. pneumoniae.
Quinolone resistance in Escherichia coli from Accra, Ghana.
The study identifies quinolone resistance in Escherichia coli from Accra, Ghana, through mutations in gyrA and parC, as well as horizontally acquired genes qnrS1, qnrB1, qnrB2, and qepA.
Quinolone resistance in Escherichia coli from Accra, Ghana.
The study identifies quinolone resistance in Escherichia coli from Accra, Ghana, through mutations in gyrA and parC, as well as horizontally acquired genes qnrS1, qnrB1, qnrB2, and qepA.
Emergence of NDM-1-producing Enterobacteriaceae in Belgium.
The study reports the emergence of NDM-1-producing Enterobacteriaceae in Belgium, highlighting the presence of multiple resistance mechanisms including blaNDM-1, qnrA6, qnrB1, qnrB2, and various beta-lactamases, rRNA methylases, and quinolone resistance genes.
Emergence of NDM-1-producing Enterobacteriaceae in Belgium.
The study reports the emergence of NDM-1-producing Enterobacteriaceae in Belgium, highlighting the presence of multiple resistance mechanisms including blaNDM-1, qnrA6, qnrB1, qnrB2, and various beta-lactamases, rRNA methylases, and quinolone resistance genes.
Structure of QnrB1, a plasmid-mediated fluoroquinolone resistance factor.
QnrB1 is a plasmid-encoded pentapeptide repeat protein that confers moderate resistance to fluoroquinolones by protecting DNA gyrase from inhibition.
Commonality among fluoroquinolone-resistant sequence type ST131 extraintestinal Escherichia coli isolates from humans and companion animals in Australia.
The study identifies the plasmid-mediated quinolone resistance gene qnrB as being significantly more prevalent in companion animal isolates compared to human isolates among fluoroquinolone-resistant ST131 E. coli strains in Australia.
A novel complex class 1 integron found in a Klebsiella pneumoniae isolate from Portugal
A novel complex class 1 integron was identified in a Klebsiella pneumoniae isolate from Portugal, containing genes arr-3, dfrA27, aadA16, and qnrB10, which confer resistance to various antibiotics including rifampin, trimethoprim, aminoglycosides, and quinolones.
Novel variants of the qnrB gene, qnrB31 and qnrB32, in Klebsiella pneumoniae.
Novel variants of the qnrB gene, qnrB31 and qnrB32, in Klebsiella pneumoniae.
Novel variants of the qnrB gene, qnrB31 and qnrB32, in Klebsiella pneumoniae.
Novel variants of the qnrB gene, qnrB31 and qnrB32, in Klebsiella pneumoniae.
Prevalence of plasmid-mediated quinolone resistance determinants in Citrobacter freundii isolates from Anhui province, PR China.
The study identified several plasmid-mediated quinolone resistance determinants, including qnrA1, qnrB1, qnrB2, qnrB4, qnrB10, and a newly discovered qnrB24, in Citrobacter freundii isolates from Anhui province, PR China.
Prevalence of plasmid-mediated quinolone resistance determinants in Citrobacter freundii isolates from Anhui province, PR China.
Prevalence of plasmid-mediated quinolone resistance determinants in Citrobacter freundii isolates from Anhui province, PR China.
The study identified several plasmid-mediated quinolone resistance determinants, including qnrA1, qnrB1, qnrB2, qnrB4, qnrB10, and a newly discovered qnrB24, in Citrobacter freundii isolates from Anhui province, PR China.
Prevalence of plasmid-mediated quinolone resistance determinants in Citrobacter freundii isolates from Anhui province, PR China.
The study identified several plasmid-mediated quinolone resistance determinants, including qnrA1, qnrB1, qnrB2, qnrB4, qnrB10, and a newly discovered qnrB24, in Citrobacter freundii isolates from Anhui province, PR China.
Prevalence of plasmid-mediated quinolone resistance determinants in Citrobacter freundii isolates from Anhui province, PR China.
The study identified several plasmid-mediated quinolone resistance determinants, including qnrA1, qnrB1, qnrB2, qnrB4, qnrB10, and a newly discovered qnrB24, in Citrobacter freundii isolates from Anhui province, PR China.
Prevalence of plasmid-mediated quinolone resistance determinants in Citrobacter freundii isolates from Anhui province, PR China.
The study identified several plasmid-mediated quinolone resistance determinants, including qnrA1, qnrB1, qnrB2, qnrB4, qnrB10, and a newly discovered qnrB24, in Citrobacter freundii isolates from Anhui province, PR China.
Prevalence of plasmid-mediated quinolone resistance determinants in Citrobacter freundii isolates from Anhui province, PR China.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
The study identifies seven novel qnrB alleles (qnrB32 to qnrB38) in Citrobacter spp., demonstrating their role in fluoroquinolone resistance.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
The study identifies seven novel qnrB alleles (qnrB32 to qnrB38) in Citrobacter spp., demonstrating their role in fluoroquinolone resistance.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
The study identifies seven novel qnrB alleles (qnrB32 to qnrB38) in Citrobacter spp., demonstrating their role in fluoroquinolone resistance.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
The study identifies seven novel qnrB alleles (qnrB32 to qnrB38) in Citrobacter spp., demonstrating their role in fluoroquinolone resistance.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
The study identifies seven novel qnrB alleles (qnrB32 to qnrB38) in Citrobacter spp., demonstrating their role in fluoroquinolone resistance.
Citrobacter spp. as a source of qnrB Alleles.
The study identifies seven novel qnrB alleles (qnrB32 to qnrB38) in Citrobacter spp., demonstrating their role in fluoroquinolone resistance.
Citrobacter spp. as a source of qnrB Alleles.
The study identifies seven novel qnrB alleles (qnrB32 to qnrB38) in Citrobacter spp., demonstrating their role in fluoroquinolone resistance.
Citrobacter spp. as a source of qnrB Alleles.
Citrobacter spp. as a source of qnrB Alleles.
Identification of plasmid-mediated quinolone resistance genes qnrA1, qnrB1 and aac(6')-1b-cr in a multiple drug-resistant isolate of Klebsiella pneumoniae from Chennai.
The study identified plasmid-mediated quinolone resistance genes qnrA1, qnrB1, and aac(6')-1b-cr in a multidrug-resistant isolate of Klebsiella pneumoniae from Chennai, highlighting their role in resistance to ciprofloxacin and levofloxacin.
Prevalence of plasmid-mediated quinolone resistance and its association with extended-spectrum beta-lactamase and AmpC beta-lactamase in Enterobacteriaceae.
The study identified qnrA1, qnrB4, and qnrS1 as plasmid-mediated quinolone resistance genes in Enterobacteriaceae, with qnrB4 being the most prevalent subtype. These genes were associated with increased resistance to quinolones and often co-existed with extended-spectrum beta-lactamases and AmpC beta-lactamases.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Plasmid-Mediated Quinolone Resistance; Interactions between Human, Animal, and Environmental Ecologies.
The paper discusses plasmid-mediated quinolone resistance (PMQR) mechanisms, including Qnr proteins, the aminoglycoside acetyltransferase AAC(6′)-Ib-cr, and the efflux pumps QepA and OqxAB. These genes contribute to low-level resistance to quinolones and fluoroquinolones, and their presence in various bacterial species highlights the role of environmental and animal reservoirs in the dissemination of PMQR.
Plasmid-mediated quinolone resistance genes in fecal bacteria from rooks commonly wintering throughout Europe.
Plasmid-mediated quinolone resistance genes in fecal bacteria from rooks commonly wintering throughout Europe.
Plasmid-mediated quinolone resistance genes in fecal bacteria from rooks commonly wintering throughout Europe.
High prevalence of qnr and aac(6')-Ib-cr genes in both water-borne environmental bacteria and clinical isolates of Citrobacter freundii in China.
The study identified the high prevalence of qnrB, qnrS1, qnrS2, and aac(6')-Ib-cr genes in both water-borne environmental bacteria and clinical isolates of Citrobacter freundii in China. These genes confer resistance to quinolones and aminoglycosides.
High-resolution melting analysis for rapid characterization of qnr alleles in clinical isolates and detection of two novel alleles, qnrB25 and qnrB42.
High-resolution melting analysis for rapid characterization of qnr alleles in clinical isolates and detection of two novel alleles, qnrB25 and qnrB42.
High-resolution melting analysis for rapid characterization of qnr alleles in clinical isolates and detection of two novel alleles, qnrB25 and qnrB42.
High-resolution melting analysis for rapid characterization of qnr alleles in clinical isolates and detection of two novel alleles, qnrB25 and qnrB42.
High-resolution melting analysis for rapid characterization of qnr alleles in clinical isolates and detection of two novel alleles, qnrB25 and qnrB42.
High-resolution melting analysis for rapid characterization of qnr alleles in clinical isolates and detection of two novel alleles, qnrB25 and qnrB42.
High-resolution melting analysis for rapid characterization of qnr alleles in clinical isolates and detection of two novel alleles, qnrB25 and qnrB42.
High-resolution melting analysis for rapid characterization of qnr alleles in clinical isolates and detection of two novel alleles, qnrB25 and qnrB42.
The co-selection of fluoroquinolone resistance genes in the gut flora of Vietnamese children.
The study identifies the co-selection of qnrA, qnrB, and qnrS genes in the gut flora of Vietnamese children following antimicrobial therapy, highlighting the role of non-fluoroquinolone antimicrobials in increasing the prevalence and copy number of these plasmid-mediated quinolone resistance genes.
Plasmid mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qep in ESBL-producing Escherichia coli clinical isolates from Egypt.
The study identifies the presence of plasmid-mediated quinolone resistance determinants qnrA1, qnrB1, qnrS1, aac(6')-Ib-cr, and qepA4 in ESBL-producing E. coli isolates from Egypt, highlighting their association with CTX-M genes.
Genome Sequence of Klebsiella pneumoniae KpQ3, a DHA-1 β-Lactamase-Producing Nosocomial Isolate.
The genome of Klebsiella pneumoniae KpQ3 was sequenced, revealing the presence of the plasmid-mediated DHA-1 β-lactamase gene and the QnrB4 quinolone resistance determinant.
Differential distribution of plasmid-mediated quinolone resistance genes in clinical enterobacteria with unusual phenotypes of quinolone susceptibility from Argentina.
The study identified and characterized plasmid-mediated quinolone resistance (PMQR) genes, including qnrB19, qnrB10, qnrS1, and aac(6')-Ib-cr, in clinical enterobacteria from Argentina. These genes were found to be differentially distributed among various enterobacterial species, with distinct epidemiological settings for community-acquired and hospital-acquired infections.
Differential distribution of plasmid-mediated quinolone resistance genes in clinical enterobacteria with unusual phenotypes of quinolone susceptibility from Argentina.
The study identified and characterized plasmid-mediated quinolone resistance (PMQR) genes, including qnrB19, qnrB10, qnrS1, and aac(6')-Ib-cr, in clinical enterobacteria from Argentina. These genes were found to be differentially distributed among various enterobacterial species, with distinct epidemiological settings for community-acquired and hospital-acquired infections.
Characterization of qnrB-like genes in Citrobacter species of the American Type Culture Collection.
Characterization of qnrB-like genes in Citrobacter species of the American Type Culture Collection.
Characterization of qnrB-like genes in Citrobacter species of the American Type Culture Collection.
Characterization of qnrB-like genes in Citrobacter species of the American Type Culture Collection.
Characterization of qnrB-like genes in Citrobacter species of the American Type Culture Collection.
Characterization of qnrB-like genes in Citrobacter species of the American Type Culture Collection.
Characterization of qnrB-like genes in Citrobacter species of the American Type Culture Collection.
Characterization of qnrB-like genes in Citrobacter species of the American Type Culture Collection.
Characterization of qnrB-like genes in Citrobacter species of the American Type Culture Collection.
The study identifies and characterizes two novel qnrB-like genes, qnrB60 and qnrB61, in Citrobacter species, demonstrating their ability to confer reduced susceptibility to fluoroquinolones and nalidixic acid when expressed in E. coli.
Characterization of qnrB-like genes in Citrobacter species of the American Type Culture Collection.
The study identifies and characterizes two novel qnrB-like genes, qnrB60 and qnrB61, in Citrobacter species, demonstrating their ability to confer reduced susceptibility to fluoroquinolones and nalidixic acid when expressed in E. coli.
Antimicrobial resistance, virulence factors and genetic diversity of Escherichia coli isolates from household water supply in Dhaka, Bangladesh.
The study identified several AMR genes in E. coli isolates from household water in Dhaka, including bla CTX-M-15, bla CTX-M-1-group, bla TEM, bla OXA-1-group, bla OXA-47, qnrS, qnrB, and bla CMY-2. These genes conferred resistance to multiple antibiotics, highlighting the presence of multidrug-resistant E. coli in the water supply.
Molecular characterization of multidrug-resistant extended-spectrum β-lactamase-producing Enterobacteriaceae isolated in Antananarivo, Madagascar.
The study identified bla CTX-M-15 and bla SHV-12 as the predominant ESBL genes in multidrug-resistant Enterobacteriaceae isolates in Antananarivo, along with other resistance genes such as aac(6')-Ib, tetA, sul1, sul2, qnrA, qnrB, and catB-3.
Copy Number Change of the NDM-1 sequence in a multidrug-resistant Klebsiella pneumoniae clinical isolate.
The study identifies the blaNDM-1 gene on plasmid pKPX-1 as a key factor in carbapenem resistance in a multidrug-resistant Klebsiella pneumoniae isolate. It also characterizes additional resistance genes such as aac(6')-Ib, aac(6')-Ib-cr, aph(3')-I, strB, qnrB, tetA, catA1, and catB4, which contribute to resistance against aminoglycosides, fluoroquinolones, tetracycline, and chloramphenicol.
Outbreak of a cluster with epidemic behavior due to Serratia marcescens after colistin administration in a hospital setting.
The study identifies the bla CTX-M-2, qnrB10, and bla PER-2 genes as responsible for multidrug resistance in Serratia marcescens isolates during an outbreak following colistin administration in a hospital setting.
Outbreak of multidrug-resistant Klebsiella pneumoniae carrying qnrB1 and blaCTX-M15 in a French intensive care unit.
The study reports an outbreak of multidrug-resistant Klebsiella pneumoniae in a French ICU, carrying the genes blaCTX-M15, qnrB1, and aac(6')-Ib-cr, which confer resistance to ceftazidime, ciprofloxacin, and tobramycin respectively.
Identification of plasmid-mediated quinolone resistance qnr genes in multidrug-resistant Gram-negative bacteria from hospital wastewaters and receiving waters in the Jinan area, China.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
Risk factors and clinical characteristics of patients with qnr-positive Klebsiella pneumoniae bacteraemia.
The study identified qnrB and qnrS genes as contributors to quinolone resistance in Klebsiella pneumoniae isolates, highlighting their association with prior antimicrobial exposure, particularly cephalosporins.
Mechanisms of reduced susceptibility to ciprofloxacin in Escherichia coli isolates from Canadian hospitals.
The study identified aac(6')-Ib-cr and qnrB as plasmid-mediated quinolone resistance (PMQR) determinants contributing to reduced susceptibility to ciprofloxacin in E. coli isolates. Additionally, mutations in the quinolone resistance-determining regions (QRDR) of gyrA and parC genes were found to be responsible for the reduced susceptibility.
Prevalence of plasmid-mediated quinolone resistance determinants among oxyiminocephalosporin-resistant Enterobacteriaceae in Argentina
Characteristics of cefotaxime-resistant Escherichia coli from wild birds in the Netherlands.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-3, bla CTX-M-14, bla CTX-M-32, and bla CMY-2, as well as plasmid-mediated quinolone resistance (PMQR) genes such as aac(6')-lb-cr, qnrB1, and qnrS1, in cefotaxime-resistant Escherichia coli isolates from wild birds in the Netherlands.
ESBL, plasmidic AmpC, and associated quinolone resistance determinants in coliforms isolated from hospital effluent: first report of qnrB2, qnrB9, qnrB19, and blaCMY-4 in Algeria.
ESBL, plasmidic AmpC, and associated quinolone resistance determinants in coliforms isolated from hospital effluent: first report of qnrB2, qnrB9, qnrB19, and blaCMY-4 in Algeria.
Incidence, clinical presentation, and antimicrobial resistance trends in Salmonella and Shigella infections from children in Yucatan, Mexico.
The study identified bla CMY-2 as a common gene conferring ceftriaxone resistance in Salmonella isolates and qnrA1 and qnrB19 as genes contributing to ciprofloxacin resistance.
Association of Transferable Quinolone Resistance Determinant qnrB19 with Extended-Spectrum β-Lactamases in Salmonella Give and Salmonella Heidelberg in Venezuela.
The study identifies the qnrB19 gene as a transferable quinolone resistance determinant associated with extended-spectrum β-lactamases in Salmonella Give and Salmonella Heidelberg in Venezuela.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance genes in Enterobacteriaceae from American crows: high prevalence of bacteria with variable qnrB genes.
Plasmid-mediated quinolone resistance (PMQR) and mutations in the topoisomerase genes of Salmonella enterica strains from Brazil.
The study identified qnrA1 and qnrB19 genes as plasmid-mediated quinolone resistance determinants in Salmonella enterica strains from Brazil, along with various mutations in the gyrA gene that contribute to ciprofloxacin resistance.
Analysis of quinolone-resistance in commensal and diarrheagenic Escherichia coli isolates from infants in Lima, Peru.
The study identifies the aac(6')-Ib-cr and qnrB genes as important contributors to quinolone resistance in commensal and diarrheagenic E. coli isolates from infants in Lima, Peru.
Plasmid-mediated quinolone resistance in typhoidal Salmonellae: a preliminary report from South India.
The study identified the plasmid gene qnrB and the aac(6')-Ib-cr gene as contributors to ciprofloxacin resistance in Salmonella Typhi isolates.
High rates of antimicrobial drug resistance gene acquisition after international travel, The Netherlands.
The study found high rates of acquisition of the extended-spectrum beta-lactamase encoding gene bla CTX-M and quinolone resistance encoding genes qnrB and qnrS after international travel, particularly to the Indian subcontinent and Southeast Asia.
IncH-type plasmid harboring bla CTX-M-15, bla DHA-1, and qnrB4 genes recovered from animal isolates.
The study identified an IncH-type plasmid carrying the blaCTX-M-15, blaDHA-1, and qnrB4 genes in animal-derived Klebsiella pneumoniae isolates, highlighting the potential for horizontal gene transfer of these resistance mechanisms.
Molecular analysis of ciprofloxacin resistance mechanisms in Malaysian ESBL-producing Klebsiella pneumoniae isolates and development of mismatch amplification mutation assays (MAMA) for rapid detection of gyrA and parC mutations.
The study identified aac(6')-Ib-cr and qnrB as major plasmid-mediated quinolone resistance (PMQR) genes contributing to ciprofloxacin resistance in Malaysian ESBL-producing Klebsiella pneumoniae isolates. Multiple mutations in gyrA and parC were also found to be associated with increased ciprofloxacin resistance.
Resistance determinants and mobile genetic elements of an NDM-1-encoding Klebsiella pneumoniae strain.
The study identifies multiple antibiotic resistance genes in the NDM-1-encoding Klebsiella pneumoniae strain, including eight beta-lactamase genes and various other resistance determinants, highlighting the complexity of its resistance profile.
Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system.
The study identifies blaKPC-2 and blaKPC-3 as the primary carbapenem resistance genes in KPC-producing Enterobacter isolates, along with various ESBL genes such as blaSHV-5, blaSHV-12, blaSHV-154, blaCTX-M-15, and blaTEM-1. Additionally, plasmid-mediated fluoroquinolone resistance genes qnrA and qnrB were detected.
The characterization and antibiotic resistance profiles of clinical Escherichia coli O25b-B2-ST131 isolates in Kuwait.
The study identified bla CTX-M-15, bla CTX-M-2, bla CTX-M-56, qnr B1, qnr S1, bla CMY-2, and aac(6')-Ib-cr as significant AMR genes in E. coli O25b-B2-ST131 isolates in Kuwait. These genes contribute to resistance against various antibiotics including cephalosporins, penicillins, beta-lactamase inhibitors, fluoroquinolones, and aminoglycosides.
Plasmid-mediated resistance to cephalosporins and fluoroquinolones in various Escherichia coli sequence types isolated from rooks wintering in Europe.
The study identified several plasmid-mediated resistance genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-24, bla TEM-52, bla CTX-M-14, bla CTX-M-55, bla SHV-12, bla CTX-M-8, bla CTX-M-25, bla CTX-M-28, bla CMY-2, qnrS1, qnrB19, and aac(6′)-Ib-cr, in Escherichia coli isolates from rooks in Europe.
Trends in serotype distribution and antimicrobial susceptibility in Salmonella enterica isolates from humans in Belgium, 2009 to 2013.
The study identifies plasmid-mediated quinolone resistance (PMQR) alleles qnrS1, qnrD1, and qnrB, as well as beta-lactamase genes blaSHV-12, blaTEM-52, blaCTX-M-14, and blaCTX-M-15 in Salmonella enterica isolates from Belgium. It also reports chromosomal mutations in gyrA and parC contributing to fluoroquinolone resistance.
Low rates of antimicrobial-resistant Enterobacteriaceae in wildlife in Taï National Park, Côte d'Ivoire, surrounded by villages with high prevalence of multiresistant ESBL-producing Escherichia coli in people and domestic animals.
The study identified ESBL-producing E. coli isolates carrying bla CTX-M-15 and PMQR genes such as qnrS1, aac(6')-Ib-cr, and qnrB in human and domestic animal samples from villages, but no ESBL or PMQR genes were found in wildlife from Taï National Park.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Detection of QnrB54 and Its Novel Genetic Context in Citrobacter freundii Isolated from a Clinical Case
The study identifies a new allele of the quinolone resistance protein QnrB, designated QnrB54, in a clinical isolate of Citrobacter freundii. The gene was shown to confer resistance to ciprofloxacin and nalidixic acid when cloned and expressed in E. coli.
Detection of QnrB54 and its novel genetic context in Citrobacter freundii isolated from a clinical case.
Detection of QnrB54 and its novel genetic context in Citrobacter freundii isolated from a clinical case.
Detection of QnrB54 and its novel genetic context in Citrobacter freundii isolated from a clinical case.
Detection of QnrB54 and its novel genetic context in Citrobacter freundii isolated from a clinical case.
Molecular characterization and epidemiology of cefoxitin resistance among Enterobacteriaceae lacking inducible chromosomal ampC genes from hospitalized and non-hospitalized patients in Algeria: description of new sequence type in Klebsiella pneumoniae isolates.
The study identified blaCMY-4 and blaDHA-1 as the primary plasmid-mediated AmpC beta-lactamase genes responsible for cefoxitin resistance in Enterobacteriaceae isolates in Algeria. Additionally, blaTEM-1, qnrB4, and aac(6')-Ib were found to coexist with these genes, contributing to multidrug resistance.
Dissemination of IncF-type plasmids in multiresistant CTX-M-15-producing Enterobacteriaceae isolates from surgical-site infections in Bangui, Central African Republic.
The study identifies the dissemination of IncF-type plasmids carrying the blaCTX-M-15, aac(6')-Ib-cr, qnrB, and qnrS genes among multiresistant CTX-M-15-producing Enterobacteriaceae isolates from surgical-site infections in Bangui, Central African Republic.
Identification and characterization of a serious multidrug resistant Stenotrophomonas maltophilia strain in China.
The study identifies a multidrug-resistant Stenotrophomonas maltophilia strain WJ66 with resistance genes aadA2, qepA, and QnrB, along with mutations in gyrA, parC, and parE contributing to fluoroquinolone resistance.
A high-resolution genomic analysis of multidrug-resistant hospital outbreaks of Klebsiella pneumoniae.
The study identified two multidrug-resistant Klebsiella pneumoniae lineages responsible for hospital outbreaks, characterized by the presence of bla NDM-1, qnrB1, and other resistance genes, along with fluoroquinolone resistance mutations in gyrA and parC.
Clinical epidemiology and molecular analysis of extended-spectrum-β-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types 131 and 648.
The study identified bla CTX-M-15, aac (3)-IIa, aadA1, aadA2, aadA5, qnrB4, qnrS1, aac (6')-Ib-cr, bla OXA-1, bla TEM-1B, bla SHV-12, bla CMY-42, bla DHA-1, mphA, ermB, catA1, catB3, sul1, sul2, dfrA12, dfrA17, dfrA1, dfrA5, tetA, tetB, and tetD as key AMR genes in ESBL-producing E. coli isolates in Nepal, highlighting the prevalence of multidrug resistance.
Occurrence of bla CTX-M-1, qnrB1 and virulence genes in avian ESBL-producing Escherichia coli isolates from Tunisia.
The study identified blaCTX-M-1, qnrB1, tetA, tetB, sul1, sul2, and sul3 genes in avian ESBL-producing E. coli isolates from Tunisia, highlighting their role in resistance to beta-lactams, quinolones, and sulfonamides.
Interactions between QnrB, QnrB mutants, and DNA gyrase.
The study characterizes the interactions between QnrB, a plasmid-encoded quinolone resistance protein, and DNA gyrase subunits, revealing that QnrB protects gyrase from quinolone inhibition and that specific structural features of QnrB are crucial for this resistance mechanism.
First description of plasmid-mediated quinolone resistance determinants and β-lactamase encoding genes in non-typhoidal Salmonella isolated from humans, one companion animal and food in Romania.
The study identified plasmid-mediated quinolone resistance (PMQR) genes such as qnrA, qnrB, qnrS, aac(6')-Ib-cr, and qepA, along with beta-lactamase-encoding genes like blaTEM, blaPSE-1, blaSHV, and blaCTX-M in non-typhoidal Salmonella isolates from humans, a companion animal, and food in Romania.
The emergence of plasmid mediated quinolone resistance qnrA2 in extended spectrum β-lactamase producing Klebsiella pneumoniae in the Middle East.
The study identifies the emergence of plasmid-mediated quinolone resistance gene qnrA2 in ESBL-producing K. pneumoniae in Kuwait, along with the dissemination of qnrB1 and qnrS genes, contributing to increased fluoroquinolone resistance.
Effects of selection pressure and genetic association on the relationship between antibiotic resistance and virulence in Escherichia coli.
The study identifies tetA, tetB, intl1, and qnrB as genes associated with antibiotic resistance in Escherichia coli, highlighting their roles in tetracycline, sulfamethoxazole-trimethoprim, and quinolone resistance.
Housefly Larva Vermicomposting Efficiently Attenuates Antibiotic Resistance Genes in Swine Manure, with Concomitant Bacterial Population Changes.
The study found that housefly larva vermicomposting significantly reduces the abundance of tetracycline resistance genes (tet(M), tet(O), tet(Q), tet(W)) and increases the abundance of sulfonamide resistance genes (sul1, sul2) in swine manure. It also observed changes in the bacterial community structure, with a significant decrease in the diversity and richness of bacteria.
Molecular characterization of multidrug-resistant Klebsiella pneumoniae isolates.
The study identified several AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (bla SHV, bla TEM, bla CTX-M), aminoglycoside resistance genes (aacC1, aacC4, aadA1, strB), carbapenemase (bla KPC-2), and quinolone resistance gene (qnrB). Additionally, a gyrA mutation (S83L) was found to confer quinolone resistance.
Dissemination of Extended-Spectrum β-Lactamases and Quinolone Resistance Genes Among Clinical Isolates of Uropathogenic Escherichia coli in Children.
The study identified the prevalence of extended-spectrum β-lactamase (ESBL) genes (bla-CTX-M, bla-SHV, bla-TEM) and quinolone resistance genes (qnrB, qnrS) in uropathogenic E. coli isolates from children with urinary tract infections. bla-CTX-M was the most prevalent ESBL gene, while qnrB and qnrS were the most commonly detected quinolone resistance genes.
Prevalence and characteristics of extended-spectrum β-lactamase genes in Escherichia coli isolated from piglets with post-weaning diarrhea in Heilongjiang province, China.
The study identified various extended-spectrum β-lactamase (ESBL) genes, including bla CTX-M-14, bla CTX-M-55, bla CTX-M-65, and bla TEM-52, along with plasmid-mediated quinolone resistance (PMQR) genes such as oqxAB, qnrS, qnrB, qepA, and aac(6')-Ib-cr in Escherichia coli isolates from piglets with post-weaning diarrhea in Heilongjiang province, China.
Prevalence of qnr and aac(6')-Ib-cr Genes in Clinical Isolates of Klebsiella Pneumoniae from Imam Hussein Hospital in Tehran.
The study found a high prevalence of aac(6')-Ib-cr and qnrB genes among quinolone and cephalosporin-resistant Klebsiella pneumoniae isolates, with a significant association between their co-carriage and resistance to quinolones, cephalosporins, and aminoglycosides.
Genomic and Functional Characterization of qnr-Encoding Plasmids from Municipal Wastewater Biosolid Klebsiella pneumoniae Isolates.
The study identified two types of plasmids harboring qnr genes in Klebsiella pneumoniae isolates from municipal wastewater biosolids. One plasmid, pKPSH-11XL, was a large multidrug-resistant IncF plasmid containing qnrB, beta-lactamase genes, tetracycline resistance genes, aminoglycoside resistance genes, and chloramphenicol resistance genes. Another group of smaller plasmids contained qnrS and other resistance genes.
Comparative analysis of an IncR plasmid carrying armA, blaDHA-1 and qnrB4 from Klebsiella pneumoniae ST37 isolates.
The study identifies an MDR IncR plasmid carrying armA, blaDHA-1, and qnrB4 in K. pneumoniae ST37 isolates, highlighting the dissemination of these resistance genes.
Emergence of plasmid-mediated quinolone-resistant determinants in Klebsiella pneumoniae isolates from Tehran and Qazvin provinces, Iran.
The study identified qnrB1, qnrB4, and qnrS1 genes as plasmid-mediated quinolone resistance determinants in K. pneumoniae isolates from Iran.
Emergence of plasmid-mediated quinolone-resistant determinants in Klebsiella pneumoniae isolates from Tehran and Qazvin provinces, Iran.
The study identified qnrB1, qnrB4, and qnrS1 genes as plasmid-mediated quinolone resistance determinants in K. pneumoniae isolates from Iran.
Outbreak of plasmid-mediated NDM-1-producing Klebsiella pneumoniae ST105 among neonatal patients in Yunnan, China.
The study identifies blaNDM-1, blaIMP-4, blaCTX-M-15, blaSHV-1, qnrS1, qnrB4, and aacA4 as the primary resistance genes in NDM-1-producing K. pneumoniae ST105 isolates during an outbreak in a neonatal ICU in China.
Frequency, Antimicrobial Resistance and Genetic Diversity of Klebsiella pneumoniae in Food Samples.
The study identified various AMR genes and mutations in K. pneumoniae isolates from food samples, including beta-lactamases (blaSHV, blaCTX-M-1, blaCTX-M-10), folate pathway inhibitor gene (dhfr), quinolone resistance genes (qnrB, qnrA, qnrS, aac(6')-Ib-cr), aminoglycoside resistance genes (aacA4, aacC2, aadA1), and mutations in gyrA and parC genes associated with fluoroquinolone resistance.
Characterization of Antibiotic Resistance Profiles of Ocular Enterobacteriaceae Isolates.
The study identified ESBL genes (blaCTX-M, blaOXA, blaSHV, blaTEM), QNR genes (qnrA, qnrB, qnrS), and gyra mutations (Ser83Leu) in ocular Enterobacteriaceae isolates, highlighting the prevalence of multidrug resistance.
High incidence of plasmid-mediated quinolone resistance genes among ciprofloxacin-resistant clinical isolates of Enterobacteriaceae at a tertiary care hospital in Puducherry, India.
The study found a high prevalence of plasmid-mediated quinolone resistance (PMQR) genes, including aac(6')-Ib-cr, qnrB, and qnrS, among ciprofloxacin-resistant Enterobacteriaceae isolates in a tertiary care hospital in India.
Characterization of ESBL- and AmpC-Producing and Fluoroquinolone-Resistant Enterobacteriaceae Isolated from Mouflons (Ovis orientalis musimon) in Austria and Germany.
The study identified ESBL- and AmpC-producing Enterobacteriaceae in a mouflon, including E. coli ST744 carrying bla CTX-M-15 and bla OXA-1, and K. pneumoniae ST11 carrying bla SHV-11, bla OXA-1, bla DHA-1, and the PMQR gene qnrB55.
High prevalence of plasmid-mediated quinolone resistance determinants in Enterobacter cloacae isolated from hospitals of the Qazvin, Alborz, and Tehran provinces, Iran.
The study identified the high prevalence of plasmid-mediated quinolone resistance determinants, specifically qnrB1, qnrS1, and qnrB4, in Enterobacter cloacae isolates from hospitals in Iran.
High prevalence of plasmid-mediated quinolone resistance determinants in Enterobacter cloacae isolated from hospitals of the Qazvin, Alborz, and Tehran provinces, Iran.
The study identified the high prevalence of plasmid-mediated quinolone resistance determinants, specifically qnrB1, qnrS1, and qnrB4, in Enterobacter cloacae isolates from hospitals in Iran.
High Prevalence of Plasmid-Mediated Quinolone Resistance and IncQ Plasmids Carrying qnrS2 Gene in Bacteria from Rivers near Hospitals and Aquaculture in China.
The study identified qnrS2, aac(6')-Ib-cr, and qnrB2 as the predominant plasmid-mediated quinolone resistance genes in bacteria from rivers near hospitals and aquaculture in China. These genes were found to be associated with multidrug resistance and were prevalent in Enterobacteriaceae and Aeromonadaceae.
Phenotypic and Molecular Characterization of Antimicrobial Resistance in Klebsiella spp. Isolates from Companion Animals in Japan: Clonal Dissemination of Multidrug-Resistant Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae.
The study identified multiple extended-spectrum β-lactamase (ESBL) genes, including blaCTX-M-15, blaCTX-M-14, blaCTX-M-55, and blaSHV-2, as well as the AmpC β-lactamase gene blaDHA-1, in multidrug-resistant Klebsiella pneumoniae isolates from companion animals in Japan. Additionally, plasmid-mediated quinolone resistance (PMQR) genes such as qnrS, qnrB, aac(6')-Ib-cr, and oqxAB were detected, contributing to resistance against fluoroquinolones and aminoglycosides.
Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION(TM) sequencing.
The study presents a real-time analysis framework for MinION sequencing data, demonstrating the ability to identify pathogens and antibiotic resistance genes within a few hours of sequencing. Key resistance genes identified include blaSHV, mphA, strA, strB, blaTEM, sul2, blaOXA, aac3, aac6, blaCMY, blaCFE, blaLAT, blaBIL, QnrB, aadA, oqxA, tetA, oqxB, rmtC, sul1, sul3, fosA, blaNDM, oqxA, blaSHV, oqxB, aadB, sul1, sul3, blaOXA, blaOKP, fosA, blaSHV, blaOKP, blaLEN, oqxA, and oqxB.
Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION(TM) sequencing.
The study presents a real-time analysis framework for MinION sequencing data, demonstrating the ability to identify pathogens and antibiotic resistance genes within a few hours of sequencing. Key resistance genes identified include blaSHV, mphA, strA, strB, blaTEM, sul2, blaOXA, aac3, aac6, blaCMY, blaCFE, blaLAT, blaBIL, QnrB, aadA, oqxA, tetA, oqxB, rmtC, sul1, sul3, fosA, blaNDM, oqxA, blaSHV, oqxB, aadB, sul1, sul3, blaOXA, blaOKP, fosA, blaSHV, blaOKP, blaLEN, oqxA, and oqxB.
The Emergence of Quinolone Resistant Shigella sonnei, Pondicherry, India.
The study identified qnrB as the most prevalent plasmid-mediated quinolone resistance gene in ciprofloxacin-resistant Shigella sonnei isolates, along with aac(6')-lb. Chromosomal mutations in gyrA and parC were also found to contribute to quinolone resistance.
Isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from cats.
The study identifies the blaIMP-4 gene in Salmonella enterica Typhimurium from cats, which confers resistance to carbapenems. The gene is part of a multidrug-resistant IncHI2 plasmid carrying various resistance genes.
High Prevalence of β-lactamase and Plasmid-Mediated Quinolone Resistance Genes in Extended-Spectrum Cephalosporin-Resistant Escherichia coli from Dogs in Shaanxi, China.
The study identified a high prevalence of β-lactamase and plasmid-mediated quinolone resistance genes in extended-spectrum cephalosporin-resistant Escherichia coli from dogs in Shaanxi, China. Key genes included bla CTX-M-15, bla TEM-1, bla SHV-12, and aac(6')-Ib-cr, along with other β-lactamase and PMQR genes.
Comprehensive Genome Analysis of Carbapenemase-Producing Enterobacter spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms.
The study identifies multiple carbapenemase genes (bla KPC-2, bla KPC-3, bla KPC-4, and bla NDM-1) and other resistance genes (such as qnrB19, qnrB2, qnrS1, bla TEM-1A, bla TEM-1B, bla OXA-9, bla SHV-12, aadA2, aac(6')-Ib, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ic, strA, strB, sul1, sul2, dfrA14, dfrA18, mph(A), catB3, arr-3, and tet(D)) in carbapenem-resistant Enterobacter spp. These genes are primarily located on plasmids and contribute to multidrug resistance.
High Prevalence of Gut Microbiota Colonization with Broad-Spectrum Cephalosporin Resistant Enterobacteriaceae in a Tunisian Intensive Care Unit.
The study identified various AMR genes including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CMY-2, bla OXA-48, bla NDM-1, qnrB1, qnrS1, and qnrA6 in CTX-R Enterobacteriaceae isolates from ICU patients in Tunisia.
Whole-Genome Analysis of Antimicrobial-Resistant and Extraintestinal Pathogenic Escherichia coli in River Water.
The study identified numerous antimicrobial resistance genes in Escherichia coli isolates from river water, highlighting the presence of multidrug-resistant and extraintestinal pathogenic strains. Key resistance genes included blaTEM-1, aac(3)-IId, qnrB7, and others.
Panel strain of Klebsiella pneumoniae for beta-lactam antibiotic evaluation: their phenotypic and genotypic characterization.
The study characterizes various AMR genes and mutations in K. pneumoniae panel strains, including beta-lactamases (bla SHV-11, bla TEM-1, bla CTX-M15, bla OXA-1, bla SHV-12, bla SHV-187, bla SHV-158, bla DHA-1, bla CMY-2), aminoglycoside modifying enzymes (aac(6')-Ib, strA, strB, aadA1, aadA2), quinolone resistance genes (qnrB66, qnrB4, oqxA, oqxB), tetracycline resistance (tet(A)), trimethoprim resistance (dfrA14), sulfonamide resistance (sul1, sul2), and porin genes (OmpK35, OmpK36).
Panel strain of Klebsiella pneumoniae for beta-lactam antibiotic evaluation: their phenotypic and genotypic characterization.
The study characterizes various AMR genes and mutations in K. pneumoniae panel strains, including beta-lactamases (bla SHV-11, bla TEM-1, bla CTX-M15, bla OXA-1, bla SHV-12, bla SHV-187, bla SHV-158, bla DHA-1, bla CMY-2), aminoglycoside modifying enzymes (aac(6')-Ib, strA, strB, aadA1, aadA2), quinolone resistance genes (qnrB66, qnrB4, oqxA, oqxB), tetracycline resistance (tet(A)), trimethoprim resistance (dfrA14), sulfonamide resistance (sul1, sul2), and porin genes (OmpK35, OmpK36).
Resistance to antimicrobial drugs in different surface waters and wastewaters of Guadeloupe.
The study identified several AMR genes including blaCTX-M, blaSHV, blaTEM, qnrB19, qnrB1, aac(6')-Ib-cr, VEB-1, CMY-2, and CMY-8 in Enterobacteriaceae isolates from surface waters and wastewaters in Guadeloupe. These genes conferred resistance to various antibiotics such as ceftazidime, cefotaxime, ampicillin, ciprofloxacin, gentamicin, and cefoxitin.
Resistance to antimicrobial drugs in different surface waters and wastewaters of Guadeloupe.
The study identified several AMR genes including blaCTX-M, blaSHV, blaTEM, qnrB19, qnrB1, aac(6')-Ib-cr, VEB-1, CMY-2, and CMY-8 in Enterobacteriaceae isolates from surface waters and wastewaters in Guadeloupe. These genes conferred resistance to various antibiotics such as ceftazidime, cefotaxime, ampicillin, ciprofloxacin, gentamicin, and cefoxitin.
Characteristics of Quinolone Resistance in Salmonella spp. Isolates from the Food Chain in Brazil.
The study identified qnrB, qnrS, qnrD, and aac(6')-Ib genes as contributors to quinolone resistance in Salmonella spp. isolates from Brazil, highlighting the role of plasmid-mediated resistance mechanisms.
Multidrug Resistance Mechanisms of Carbapenem Resistant Klebsiella pneumoniae Strains Isolated in Chongqing, China.
The study identified the high prevalence of blaNDM-1 and blaKPC-2 genes in carbapenem-resistant Klebsiella pneumoniae isolates, along with various quinolone and aminoglycoside resistance genes such as qnrB, aac(6')-Ib, rmtB, qnrS, and acc(6')-Ib-cr.
Extensively Drug-Resistant Klebsiella pneumoniae Causing Nosocomial Bloodstream Infections in China: Molecular Investigation of Antibiotic Resistance Determinants, Informing Therapy, and Clinical Outcomes.
The study identified multiple AMR genes and mutations in XDR K. pneumoniae isolates, including bla KPC−2, rmtB, aac(6′)-Ib, APH(3′)-Ia, AAC(3)-IV, qnrS, qnrB, aac(6′)-Ib-cr, bla CTX−M−14, bla CTX−M−65, bla SHV−11, bla TEM, bla CMY, bla DHA−1, gyrA, and parC, which contribute to resistance against various antibiotics.
Antimicrobial Resistance and Cytotoxicity of Citrobacter spp. in Maanshan Anhui Province, China.
The study identified the blaTEM-1 gene in two C. freundii isolates, qnrS1 in three Citrobacter isolates, and aac(6')-Ib-cr in three Citrobacter isolates. Additionally, a variant of qnrB77 was found in two C. freundii isolates.
Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets.
The study identifies 20 putatively novel qnr genes from metagenomic data, with six of them experimentally validated to confer resistance to ciprofloxacin when expressed in E. coli.
Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets.
The study identifies 20 putatively novel qnr genes from metagenomic data, with six of them experimentally validated to confer resistance to ciprofloxacin when expressed in E. coli.
Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets.
The study identifies 20 putatively novel qnr genes from metagenomic data, with six of them experimentally validated to confer resistance to ciprofloxacin when expressed in E. coli.
Zoonotic Potential and Antibiotic Resistance of Escherichia coli in Neonatal Calves in Uruguay.
The study identified qnrB2, qnrS1, and bla CTX-M-14 genes in E. coli isolates from neonatal calves in Uruguay, indicating the presence of plasmid-mediated quinolone resistance and extended-spectrum beta-lactamase resistance.
Molecular characterization of antimicrobial multi-drug resistance in non-typhoidal Salmonellae from chicken and clam in Mangalore, India.
Phenotypic and Molecular Characterization of Multidrug Resistant Klebsiella pneumoniae Isolated from Different Clinical Sources in Al-Najaf Province-Iraq.
The study identified blaSHV, blaTEM, blaCTX-M, qnrB, and aac(6')-Ib-cr genes as the main contributors to multidrug resistance in Klebsiella pneumoniae isolates from burns and urinary tract infections in Iraq.
Characterization of Four Multidrug Resistance Plasmids Captured from the Sediments of an Urban Coastal Wetland.
Four multidrug resistance plasmids were captured from the sediments of an urban coastal wetland. These plasmids carried various resistance genes, including beta-lactamases, tetracycline resistance genes, sulfonamide resistance genes, and others, conferring resistance to multiple antibiotics.
Occurrence of Salmonella enterica and Escherichia coli in raw chicken and beef meat in northern Egypt and dissemination of their antibiotic resistance markers.
The study identified several AMR genes in Salmonella enterica and Escherichia coli isolates from raw chicken and beef meat in northern Egypt, including bla CTX-M, bla TEM, qnr A, and qnr B, which confer resistance to various antibiotics.
Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli.
The study demonstrates that increased expression of qnrB and qnrS genes in Escherichia coli can confer clinical resistance to ciprofloxacin, with qnrS achieving MICs above the EUCAST clinical breakpoint without significant fitness costs.
Exploring the Genome and Phenotype of Multi-Drug Resistant Klebsiella pneumoniae of Clinical Origin.
The study identified multiple antimicrobial resistance genes in 11 multidrug-resistant Klebsiella pneumoniae isolates, including ESBL genes (blaCTX-M-15, blaSHV-12, blaTEM-1B), fluoroquinolone resistance genes (oqxAB, qnrB), and others such as catA, catB, tet, sul, dfr, and fosA. These genes contribute to resistance against various antibiotics, highlighting the complex resistance profile of these isolates.
Different phenotypic and molecular mechanisms associated with multidrug resistance in Gram-negative clinical isolates from Egypt.
The study identified various AMR genes and mutations contributing to multidrug resistance in Gram-negative clinical isolates from Egypt, highlighting the role of efflux pumps and plasmid-mediated quinolone resistance.
Molecular epidemiology of fluoroquinolone resistant Salmonella in Africa: A systematic review and meta-analysis.
Mutations in gyrA, gyrB, and parC genes were identified as the main mechanisms of fluoroquinolone resistance in Salmonella isolates from Africa.
Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population.
The study identifies clinically relevant ESBL-producing K. pneumoniae ST307 and E. coli ST38 in an urban West African rat population, highlighting the presence of multidrug-resistant strains carrying various resistance genes such as blaCTX-M-15, blaCTX-M-14, blaCTX-M-9, and others.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
Overview of the development of quinolone resistance in Salmonella species in China, 2005-2016.
The study identifies qnrB as the most common indicator of ciprofloxacin (CIP) resistance in Salmonella, alongside aac(6')-Ib-cr. Gyrase A (gyrA) mutations are frequently found in isolates with reduced CIP susceptibility but not always in CIP-resistant isolates.
Molecular epidemiology and drug resistant mechanism in carbapenem-resistant Klebsiella pneumoniae isolated from pediatric patients in Shanghai, China.
The study identified various AMR genes in CR-KP isolates, including blaNDM-1, blaIMP, blaKPC-2, SHV, TEM, CTX-M, aac(6')-Ib-cr, qnrS1, qnrB4, oqxAB, and rmtB, which contribute to resistance against carbapenems, beta-lactams, aminoglycosides, and fluoroquinolones.
Detection of CTX-M-15 harboring Escherichia coli isolated from wild birds in Tunisia.
The study identifies CTX-M-15-harboring Escherichia coli in wild birds in Tunisia, highlighting the presence of multidrug resistance genes such as bla CTX-M-15, bla TEM-1b, tetA, qnrA1, qnrB1, aac(6')-Ib-cr, aac(3)-II, and sul3.
Dominant serotype distribution and antimicrobial resistance profile of Shigella spp. in Xinjiang, China.
The study identified multiple AMR genes and mutations in Shigella isolates from Xinjiang, China, including bla OXA-1, bla TEM-1, bla CTX-M, qnrB, qnrS, and QRDR mutations in gyrA and parC. These genes and mutations contribute to resistance against cephalosporins, quinolones, and other antibiotics.
Serotype Diversity and Antimicrobial Resistance among Salmonella enterica Isolates from Patients at an Equine Referral Hospital.
The study identified various AMR genes in Salmonella enterica isolates from equine patients, including beta-lactamases, aminoglycoside modifying enzymes, and genes conferring resistance to tetracyclines, macrolides, and other antibiotics.
Detection of plasmid-mediated quinolone resistance in clinical isolates of Enterobacteriaceae strains in Hamadan, West of Iran.
The study detected the presence of qnrB, qnrS, and aac(6′)-Ib-cr genes in fluoroquinolone-resistant Enterobacteriaceae isolates, highlighting their role in plasmid-mediated quinolone resistance.
The prevalence of quinolone resistance genes of A, B, S in Escherichia coli strains isolated from three major hospitals in Tehran, Iran.
The study identified the prevalence of quinolone resistance genes qnrB and qnrS in Escherichia coli strains isolated from patients with urinary tract infections in Tehran, Iran. The frequency of qnrB was 25% and qnrS was 36%.
The Genomic Basis of Intrinsic and Acquired Antibiotic Resistance in the Genus Serratia.
The study identified 123 distinct antibiotic resistance genes (ARGs) in the genus Serratia, including intrinsic and acquired resistance genes, as well as efflux pump-related genes. Key findings include the detection of various beta-lactamases, aminoglycoside resistance genes, quinolone resistance genes, and efflux pumps. Notably, the study highlights the presence of plasmid-borne ARGs in nosocomial strains and the role of efflux pumps in multidrug resistance.
The Genomic Basis of Intrinsic and Acquired Antibiotic Resistance in the Genus Serratia.
The study identified 123 distinct antibiotic resistance genes (ARGs) in the genus Serratia, including intrinsic and acquired resistance genes, as well as efflux pump-related genes. Key findings include the detection of various beta-lactamases, aminoglycoside resistance genes, quinolone resistance genes, and efflux pumps. Notably, the study highlights the presence of plasmid-borne ARGs in nosocomial strains and the role of efflux pumps in multidrug resistance.
The Genomic Basis of Intrinsic and Acquired Antibiotic Resistance in the Genus Serratia.
The study identified 123 distinct antibiotic resistance genes (ARGs) in the genus Serratia, including intrinsic and acquired resistance genes, as well as efflux pump-related genes. Key findings include the detection of various beta-lactamases, aminoglycoside resistance genes, quinolone resistance genes, and efflux pumps. Notably, the study highlights the presence of plasmid-borne ARGs in nosocomial strains and the role of efflux pumps in multidrug resistance.
The Genomic Basis of Intrinsic and Acquired Antibiotic Resistance in the Genus Serratia.
The study identified 123 distinct antibiotic resistance genes (ARGs) in the genus Serratia, including intrinsic and acquired resistance genes, as well as efflux pump-related genes. Key findings include the detection of various beta-lactamases, aminoglycoside resistance genes, quinolone resistance genes, and efflux pumps. Notably, the study highlights the presence of plasmid-borne ARGs in nosocomial strains and the role of efflux pumps in multidrug resistance.
The Genomic Basis of Intrinsic and Acquired Antibiotic Resistance in the Genus Serratia.
The study identified 123 distinct antibiotic resistance genes (ARGs) in the genus Serratia, including intrinsic and acquired resistance genes, as well as efflux pump-related genes. Key findings include the detection of various beta-lactamases, aminoglycoside resistance genes, quinolone resistance genes, and efflux pumps. Notably, the study highlights the presence of plasmid-borne ARGs in nosocomial strains and the role of efflux pumps in multidrug resistance.
The Genomic Basis of Intrinsic and Acquired Antibiotic Resistance in the Genus Serratia.
The study identified 123 distinct antibiotic resistance genes (ARGs) in the genus Serratia, including intrinsic and acquired resistance genes, as well as efflux pump-related genes. Key findings include the detection of various beta-lactamases, aminoglycoside resistance genes, quinolone resistance genes, and efflux pumps. Notably, the study highlights the presence of plasmid-borne ARGs in nosocomial strains and the role of efflux pumps in multidrug resistance.
The Use of a Combined Bioinformatics Approach to Locate Antibiotic Resistance Genes on Plasmids From Whole Genome Sequences of Salmonella enterica Serovars From Humans in Ghana.
The study identified several AMR genes in Salmonella isolates from Ghana, including blaTEM-1B, blaTEM-52B, blaCTX-M-15, tet(A), dfrA15, sul1, sul2, catA1, strA, strB, aadA1, catB3, qnrB1, aac(6')Ib-cr, and blaOXA-1. These genes were found on various plasmids, highlighting the diversity of resistance mechanisms in the studied isolates.
Molecular characterization of fluoroquinolone and/or cephalosporin resistance in Shigella sonnei isolates from yaks.
The study identified fluoroquinolone and cephalosporin resistance mechanisms in Shigella sonnei isolates from yaks, including mutations in gyrA and parC, and the presence of aac(6')-Ib-cr, qnrS, qnrB, blaTEM-1, blaOXA-1, blaCTX-M-14, and blaCTX-M-79 genes.
Prevalence of extended spectrum beta lactamase and plasmid mediated quinolone resistant genes in strains of Klebsiella pneumonia, Morganella morganii, Leclercia adecarboxylata and Citrobacter freundii isolated from poultry in South Western Nigeria.
The study identified the presence of ESBL genes (SHV, TEM, CTX-M) and PMQR genes (qnrA, qnrB, qepA, oqxB) in Klebsiella pneumonia, Morganella morganii, Leclercia adecarboxylata, and Citrobacter freundii isolated from poultry in South Western Nigeria.
A pan-genome-based machine learning approach for predicting antimicrobial resistance activities of the Escherichia coli strains.
The study identifies and characterizes several AMR genes in E. coli, including beta-lactamases (blaTEM-1, blaOXA-1, blaCMY-2, ampC), aminoglycoside modifying enzymes (aac(3')-Ia, aac(3')-VI), dihydrofolate reductases (dfrA1, dfrA5, dfrA12, dfrA15), quinolone resistance proteins (qnrB2, qnrB6, qnrS2), and others. These genes were validated through computational and wet lab methods, showing their roles in conferring resistance to various antibiotics.
A pan-genome-based machine learning approach for predicting antimicrobial resistance activities of the Escherichia coli strains.
The study identifies and characterizes several AMR genes in E. coli, including beta-lactamases (blaTEM-1, blaOXA-1, blaCMY-2, ampC), aminoglycoside modifying enzymes (aac(3')-Ia, aac(3')-VI), dihydrofolate reductases (dfrA1, dfrA5, dfrA12, dfrA15), quinolone resistance proteins (qnrB2, qnrB6, qnrS2), and others. These genes were validated through computational and wet lab methods, showing their roles in conferring resistance to various antibiotics.
First description of plasmid mediated quinolone resistance genes in salmonella isolates from Saudi hospitals.
The study reports the first detection of plasmid-mediated quinolone resistance genes qnrB and qnrS in Salmonella isolates from Saudi hospitals, highlighting the emergence of fluoroquinolone-resistant Salmonella in the region.
Antimicrobial Resistance in Escherichia coli.
The paper discusses the characterization of various antimicrobial resistance genes in Escherichia coli, including extended-spectrum beta-lactamases (ESBLs), AmpC cephalosporinases, carbapenemases, plasmid-mediated quinolone resistance (PMQR) genes, aminoglycoside-modifying enzymes, fosfomycin resistance genes, and tetracycline resistance genes. These genes confer resistance to multiple classes of antibiotics, highlighting the complex nature of antimicrobial resistance in E. coli.
Genetic Diversity, Multidrug Resistance, and Virulence of Citrobacter freundii From Diarrheal Patients and Healthy Individuals.
The study identified several AMR genes in Citrobacter freundii isolates, including bla TEM−1, bla CTX−M−9, aac(6')-Ib-cr, qnrS1, and various qnrB alleles such as qnrB9, qnrB13, qnrB16, qnrB17, qnrB76, qnrB77, and a newly discovered qnrB92. These genes were associated with resistance to multiple antibiotics, including beta-lactams, aminoglycosides, and quinolones.
Genetic Diversity, Multidrug Resistance, and Virulence of Citrobacter freundii From Diarrheal Patients and Healthy Individuals.
The study identified several AMR genes in Citrobacter freundii isolates, including bla TEM−1, bla CTX−M−9, aac(6')-Ib-cr, qnrS1, and various qnrB alleles such as qnrB9, qnrB13, qnrB16, qnrB17, qnrB76, qnrB77, and a newly discovered qnrB92. These genes were associated with resistance to multiple antibiotics, including beta-lactams, aminoglycosides, and quinolones.
Genetic Diversity, Multidrug Resistance, and Virulence of Citrobacter freundii From Diarrheal Patients and Healthy Individuals.
The study identified several AMR genes in Citrobacter freundii isolates, including bla TEM−1, bla CTX−M−9, aac(6')-Ib-cr, qnrS1, and various qnrB alleles such as qnrB9, qnrB13, qnrB16, qnrB17, qnrB76, qnrB77, and a newly discovered qnrB92. These genes were associated with resistance to multiple antibiotics, including beta-lactams, aminoglycosides, and quinolones.
Genetic Diversity, Multidrug Resistance, and Virulence of Citrobacter freundii From Diarrheal Patients and Healthy Individuals.
The study identified several AMR genes in Citrobacter freundii isolates, including bla TEM−1, bla CTX−M−9, aac(6')-Ib-cr, qnrS1, and various qnrB alleles such as qnrB9, qnrB13, qnrB16, qnrB17, qnrB76, qnrB77, and a newly discovered qnrB92. These genes were associated with resistance to multiple antibiotics, including beta-lactams, aminoglycosides, and quinolones.
Genetic Diversity, Multidrug Resistance, and Virulence of Citrobacter freundii From Diarrheal Patients and Healthy Individuals.
The study identified several AMR genes in Citrobacter freundii isolates, including bla TEM−1, bla CTX−M−9, aac(6')-Ib-cr, qnrS1, and various qnrB alleles such as qnrB9, qnrB13, qnrB16, qnrB17, qnrB76, qnrB77, and a newly discovered qnrB92. These genes were associated with resistance to multiple antibiotics, including beta-lactams, aminoglycosides, and quinolones.
Superficieibacter electus gen. nov., sp. nov., an Extended-Spectrum β-Lactamase Possessing Member of the Enterobacteriaceae Family, Isolated From Intensive Care Unit Surfaces.
The study identifies multiple antibiotic resistance genes in the newly described species Superficieibacter electus, including beta-lactamases, aminoglycoside modifying enzymes, and others, indicating its ability to resist various antibiotics.
Enterobacter cloacae harbouring bla(KPC-2) and qnrB-1 isolated from a cystic fibrosis patient: a case report.
The study identified the presence of bla(KPC-2) and qnrB-1 genes in an Enterobacter cloacae isolate from a cystic fibrosis patient, highlighting the potential for dissemination of carbapenem and quinolone resistance.
Multiple mechanisms contributing to ciprofloxacin resistance among Gram negative bacteria causing infections to cancer patients.
The study identifies multiple mechanisms contributing to ciprofloxacin resistance in Gram-negative bacteria causing infections in cancer patients, including target site mutations in gyrA and parC genes, plasmid-mediated quinolone resistance (PMQR) genes such as aac(6')-Ib-cr, qnrS, and qnrB, and efflux pump activity.
Community Origins and Regional Differences Highlight Risk of Plasmid-mediated Fluoroquinolone Resistant Enterobacteriaceae Infections in Children.
The study identifies plasmid-mediated fluoroquinolone resistance (PMFQR) genes such as aac(6')-Ib-cr, oqxA, oqxB, qepA, and various qnr alleles in pediatric Enterobacteriaceae isolates, highlighting the role of community environments in the spread of these resistant strains.
Using Machine Learning To Predict Antimicrobial MICs and Associated Genomic Features for Nontyphoidal Salmonella.
The study presents a machine learning model capable of predicting antimicrobial MICs for nontyphoidal Salmonella using whole-genome sequence data, identifying key genomic features associated with resistance.
Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.
The study identified various AMR genes and mutations in carbapenem-resistant Klebsiella pneumoniae isolates, including bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-48, ampC, qnrB, qnrS, aac(6')-Ib-cr, armA, rmtB, tet(A), tet(B), tet(D), tet(G), sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, dfrA25, dfrA26, dfrA30, oqxA, oqxB, and mgrB, as well as mutations in ompK35, ompK36, gyrA, parC, phoP, phoQ, pmrA, and pmrB, which contribute to resistance against multiple antibiotics.
Endogenous endophthalmitis caused by a multidrug-resistant hypervirulent Klebsiella pneumoniae strain belonging to a novel single locus variant of ST23: first case report in China.
The study identifies a multidrug-resistant hypervirulent Klebsiella pneumoniae strain, KP587, which exhibits resistance to multiple antibiotics including ceftazidime, ceftriaxone, piperacillin-tazobactam, amikacin, and gentamicin. The strain harbors the ESBL gene blaCTX-M-14, the AmpC beta-lactamase gene blaDHA, the 16S rRNA methylase gene armA, and the quinolone resistance gene qnrB.
Population Structure, Antibiotic Resistance, and Uropathogenicity of Klebsiella variicola.
The study identifies several antibiotic resistance genes in Klebsiella variicola, including blaLEN, oqxAB, blaKPC-2, blaNDM-1, blaNDM-9, blaOXA-48, aac(6')-Ib, aadA16, sul1, sul2, qnrB6, arr-3, and floR. These genes confer resistance to various antibiotics such as ampicillin, ciprofloxacin, meropenem, gentamicin, kanamycin, sulfamethoxazole, rifampin, and chloramphenicol.
Diarrheal bacterial pathogens and multi-resistant enterobacteria in the Choqueyapu River in La Paz, Bolivia.
The study identified multidrug-resistant Enterobacteriaceae in the Choqueyapu River, including E. coli and Enterobacter cloacae carrying bla CTX-M, bla KPC, bla NDM, bla VIM, and bla OXA-48 genes, highlighting the environmental spread of antibiotic resistance.
Circulation of Plasmids Harboring Resistance Genes to Quinolones and/or Extended-Spectrum Cephalosporins in Multiple Salmonella enterica Serotypes from Swine in the United States.
The study identifies multiple plasmid-mediated resistance genes in Salmonella enterica serotypes from swine in the United States, including qnrB19, qnrB2, qnrB15, qnrD, qnrS1, qnrS2, aac(6')-Ib-cr, bla CMY-2, bla CTX-M-1, bla CTX-M-27, and bla SHV-12, which confer resistance to quinolones and extended-spectrum cephalosporins.
Circulation of Plasmids Harboring Resistance Genes to Quinolones and/or Extended-Spectrum Cephalosporins in Multiple Salmonella enterica Serotypes from Swine in the United States.
The study identifies multiple plasmid-mediated resistance genes in Salmonella enterica serotypes from swine in the United States, including qnrB19, qnrB2, qnrB15, qnrD, qnrS1, qnrS2, aac(6')-Ib-cr, bla CMY-2, bla CTX-M-1, bla CTX-M-27, and bla SHV-12, which confer resistance to quinolones and extended-spectrum cephalosporins.
Circulation of Plasmids Harboring Resistance Genes to Quinolones and/or Extended-Spectrum Cephalosporins in Multiple Salmonella enterica Serotypes from Swine in the United States.
The study identifies multiple plasmid-mediated resistance genes in Salmonella enterica serotypes from swine in the United States, including qnrB19, qnrB2, qnrB15, qnrD, qnrS1, qnrS2, aac(6')-Ib-cr, bla CMY-2, bla CTX-M-1, bla CTX-M-27, and bla SHV-12, which confer resistance to quinolones and extended-spectrum cephalosporins.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Multiple Benefits of Plasmid-Mediated Quinolone Resistance Determinants in Klebsiella pneumoniae ST11 High-Risk Clone and Recently Emerging ST307 Clone.
The study identifies plasmid-mediated quinolone resistance genes (qnrB4, qnrA1, qnrB1, and oqxAB) in Klebsiella pneumoniae ST11 and ST307 clones, along with chromosomal mutations in gyrA and parC contributing to fluoroquinolone resistance.
Multiple Benefits of Plasmid-Mediated Quinolone Resistance Determinants in Klebsiella pneumoniae ST11 High-Risk Clone and Recently Emerging ST307 Clone.
The study identifies plasmid-mediated quinolone resistance genes (qnrB4, qnrA1, qnrB1, and oqxAB) in Klebsiella pneumoniae ST11 and ST307 clones, along with chromosomal mutations in gyrA and parC contributing to fluoroquinolone resistance.
The plasmid-borne quinolone resistance protein QnrB, a novel DnaA-binding protein, increases the bacterial mutation rate by triggering DNA replication stress.
QnrB, a plasmid-borne quinolone resistance protein, increases the bacterial mutation rate by inducing DNA replication stress.
Evaluation of co-transfer of plasmid-mediated fluoroquinolone resistance genes and bla(NDM) gene in Enterobacteriaceae causing neonatal septicaemia.
The study identifies the co-transfer of plasmid-mediated fluoroquinolone resistance genes (aac(6')-Ib-cr, qnrB, qnrS) with bla(NDM) in Enterobacteriaceae causing neonatal sepsis. Mutations in gyrA and parC contribute to fluoroquinolone resistance.
Evolution and transmission of a conjugative plasmid encoding both ciprofloxacin and ceftriaxone resistance in Salmonella.
The study identified a novel conjugative plasmid, pSa44-CIP-CRO, which encodes resistance to both ciprofloxacin and ceftriaxone. This plasmid contains the bla CTX-M130 gene for ceftriaxone resistance and qnrB6-aac(6')-Ib-cr genes for ciprofloxacin resistance.
Prevalence of antimicrobial resistance and potential pathogenicity, and possible spread of third generation cephalosporin resistance, in Escherichia coli isolated from healthy chicken farms in the region of Dakar, Senegal.
The study identified various AMR genes and mutations in E. coli isolates from healthy chicken farms in Senegal, including bla CTX-M, bla CMY-2, tetA, dfrA1, dfrA7, aadA1, qnrB, and bla TEM, as well as mutations in gyrA and parC genes contributing to ciprofloxacin resistance.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Diverse Commensal Escherichia coli Clones and Plasmids Disseminate Antimicrobial Resistance Genes in Domestic Animals and Children in a Semirural Community in Ecuador.
The study identified various antimicrobial resistance (AMR) genes in commensal Escherichia coli isolates from children and domestic animals in a semirural community in Ecuador. These genes included blaTEM-1B, dfrA8, qnrB19, strA, strB, tetA, tetB, sul1, sul2, and others, contributing to resistance against multiple antibiotics such as ampicillin, trimethoprim, tetracycline, and sulfamethoxazole. The research highlights the role of plasmids in disseminating these AMR genes and emphasizes the complexity of AMR transmission in such environments.
Heavy metal resistance genes and plasmid-mediated quinolone resistance genes in Arthrobacter sp. isolated from Brazilian soils.
The study identified plasmid-mediated quinolone resistance (PMQR) genes such as qepA, qnrS, qnrB, oqx B, and oqx A, as well as heavy metal resistance (HMR) genes like copA and czcA in Arthrobacter sp. isolated from Brazilian soils.
Identification of Quinolone and Colistin Resistance Genes in Escherichia Coli Strains Isolated from Mucosal Samples of Patients with Colorectal Cancer and Healthy Subjects.
The study identified qnrA and qnrB genes as contributors to ciprofloxacin resistance in E. coli strains from colorectal cancer patients and healthy subjects, while no colistin-resistant strains were found.
Phenotypic screening for quinolone resistance in Escherichia coli.
Distribution of quinolone resistance gene (qnr) in ESBL-producing Escherichia coli and Klebsiella spp. in Lomé, Togo.
The study identified qnrB, qnrS, and qnrA genes in ESBL-producing E. coli and Klebsiella spp. in Togo, highlighting their role in quinolone resistance.
Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods.
The study identified various AMR genes and mutations in Salmonella enterica serovar Typhimurium, including aadA, strAB, blaTEM, blaCARB, floR, cmlA1, catA1, qnrB19, sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, tetA, tetB, tetC, tetG, and mutations in gyrA. These genes and mutations were validated through whole genome sequencing and phenotypic ASTs.
Characterization and whole genome sequencing of closely related multidrug-resistant Salmonella enterica serovar Heidelberg isolates from imported poultry meat in the Netherlands.
The study identified blaCMY-2, qnrB19, blaCTX-M-2, blaCTX-M-8, and blaTEM-1B as key resistance genes in multidrug-resistant Salmonella enterica serovar Heidelberg isolates from imported poultry meat in the Netherlands. Mutations in gyrA (S83F) and parC (T57S) were also linked to ciprofloxacin and nalidixic acid resistance.
Prevalence of quinolone-resistant uropathogenic Escherichia coli in a tertiary care hospital in south Iran.
The study found a high prevalence of quinolone resistance among E. coli isolates from UTI patients in southern Iran, with 33.1% positive for qnrS and 12.4% positive for qnrB genes. However, no significant association was found between qnr genes and increased quinolone resistance.
Genomic Features of High-Priority Salmonella enterica Serovars Circulating in the Food Production Chain, Brazil, 2000-2016.
The study identified several AMR genes in Salmonella enterica isolates from Brazil, including qnrE1, qnrB19, qnrS1, blaCTX-M-2, blaCTX-M-8, blaCMY-2, aadA1, aadA2, aac(3)-IVa, aac(3)-IIa, aac(6')-Ib, floR, sul1, sul2, tet(A), tet(B), strA, strB, drfA1, inu(F), qacEdelta1, and fosA7. These genes conferred resistance to various antibiotics such as fluoroquinolones, beta-lactams, aminoglycosides, sulfonamides, tetracyclines, chloramphenicol, trimethoprim, macrolides, quaternary ammonium compounds, and fosfomycin.
Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal.
Molecular Epidemiology of Multidrug-Resistant Klebsiella pneumoniae Isolates in a Brazilian Tertiary Hospital.
The study identified various AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates, including bla KPC, bla CTX-M, bla TEM, and mutations in ompk35, ompk36, gyrA, and parC. These findings highlight the complex resistance mechanisms contributing to the persistence of MDR-Kp in the hospital setting.
Tracking Carbapenem-Producing Klebsiella pneumoniae Outbreak in an Intensive Care Unit by Whole Genome Sequencing.
The study identified multiple carbapenem-resistant Klebsiella pneumoniae (CP-Kp) strains carrying various resistance genes, including blaKPC-2, blaNDM-1, and others, contributing to multidrug resistance. Plasmid analysis revealed the presence of resistance genes on different plasmids, highlighting the complexity of resistance mechanisms.
Clinical Resistome Screening of 1,110 Escherichia coli Isolates Efficiently Recovers Diagnostically Relevant Antibiotic Resistance Biomarkers and Potential Novel Resistance Mechanisms.
The study identifies several AMR genes including aac(3)-IIa, aac(6')-lb-cr, ant (2")-Ia, aph3'-1, dfrA14, dfrA17, sul1, and qnrB19, which confer resistance to Tobramycin, Ciprofloxacin, and Trimethoprim-Sulfamethoxazole. These genes were validated through cloning and MIC testing.
Cooccurrence of NDM-1, ESBL, RmtC, AAC(6')-Ib, and QnrB in Clonally Related Klebsiella pneumoniae Isolates Together with Coexistence of CMY-4 and AAC(6')-Ib in Enterobacter cloacae Isolates from Saudi Arabia.
The study identifies the coexistence of multiple AMR genes, including blaNDM-1, blaVIM-1, qnrB, rmtC, aac(6')-Ib, and blaCMY-4, in carbapenem-resistant K. pneumoniae and E. cloacae isolates from Saudi Arabia.
An Outbreak of Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae in an Intensive Care Unit of a Major Teaching Hospital in Wenzhou, China.
The study identified carbapenem-resistant and hypervirulent Klebsiella pneumoniae isolates carrying bla KPC−2, aac(3')-Ia, aac(6')-Ib, ANT(3')-Ia, rmtB, rmtC, qnrB, qnrS, oqxA, bla SHV−11, bla CTX−M−2 group, bla CTX−M−9 group, bla TEM−1, bla CMY−2, and bla DHA genes, contributing to multidrug resistance.
Genetic characterization of a novel sequence type of multidrug-resistant Citrobacter freundii strain recovered from wastewater treatment plant.
The study reports the identification of a multidrug-resistant Citrobacter freundii strain R17 carrying 13 antibiotic-resistance genes, including blaCMY-85, aadA2, aac(3)-lld, blaDHA-1, blaTEM-1B, qnrB4, mph(A), catA2, sul1, sul2, tet(D), and dfrA12, which confer resistance to various antibiotic classes.
Florfenicol Resistance in Enterobacteriaceae and Whole-Genome Sequence Analysis of Florfenicol-Resistant Leclercia adecarboxylata Strain R25.
The study identifies the floR gene as a major contributor to florfenicol resistance in Enterobacteriaceae, particularly in Leclercia adecarboxylata strain R25. Other resistance genes such as mdfA, aac(6')-Ib-cr, aadA16, qnrB6, sul1, dfrA27, arr-3, and qacEΔ1 were also characterized.
Comparison of the inoculum size effects of antibiotics on IMP-6 β-lactamase-producing Enterobacteriaceae co-harboring plasmid-mediated quinolone resistance genes.
The study identified several plasmid-mediated quinolone resistance genes (aac(6')-Ib-cr, oqxA, qnrS, qnrB) and their association with reduced susceptibility to fluoroquinolones and carbapenems in IMP-6 β-lactamase-producing Enterobacteriaceae.
Impact of co-existence of PMQR genes and QRDR mutations on fluoroquinolones resistance in Enterobacteriaceae strains isolated from community and hospital acquired UTIs.
Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors.
The study identified several antimicrobial resistance genes (ARGs) in the gut of young children in urban Maputo, Mozambique, including aadA1, SHV, ermA, ermB, mefA, tetA, tetB, and others, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, macrolides, tetracyclines, and fluoroquinolones.
Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors.
The study identified several antimicrobial resistance genes (ARGs) in the gut of young children in urban Maputo, Mozambique, including aadA1, SHV, ermA, ermB, mefA, tetA, tetB, and others, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, macrolides, tetracyclines, and fluoroquinolones.
Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors.
The study identified several antimicrobial resistance genes (ARGs) in the gut of young children in urban Maputo, Mozambique, including aadA1, SHV, ermA, ermB, mefA, tetA, tetB, and others, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, macrolides, tetracyclines, and fluoroquinolones.
Scandinavium goeteborgense gen. nov., sp. nov., a New Member of the Family Enterobacteriaceae Isolated From a Wound Infection, Carries a Novel Quinolone Resistance Gene Variant.
The study identifies a novel quinolone resistance gene variant, qnrB96, in the bacterium Scandinavium goeteborgense, which confers increased resistance to ciprofloxacin when expressed in E. coli.
Scandinavium goeteborgense gen. nov., sp. nov., a New Member of the Family Enterobacteriaceae Isolated From a Wound Infection, Carries a Novel Quinolone Resistance Gene Variant.
Diversity of Serotype, Genotype, and Antibiotic Susceptibility of Salmonella Prevalent in Pickled Ready-to-Eat Meat.
The study identified several AMR genes and mutations in Salmonella isolates from pickled ready-to-eat meat, including qnrB, oqxAB, aac(6')-Ib, and qnrA, as well as mutations in gyrA and parC contributing to quinolone resistance.
Transduction as a Potential Dissemination Mechanism of a Clonal qnrB19-Carrying Plasmid Isolated From Salmonella of Multiple Serotypes and Isolation Sources.
The study identifies the qnrB19 gene as a major contributor to quinolone resistance in Salmonella isolates, demonstrating its presence in various serotypes and sources, and highlights transduction as a potential dissemination mechanism.
Etiology of childhood diarrhoea among under five children and molecular analysis of antibiotic resistance in isolated enteric bacterial pathogens from a tertiary care hospital, Eastern Odisha, India.
The study identified NDM-1, qnrB, and aac(6')-Ib-cr genes associated with carbapenem and fluoroquinolone resistance in enteric bacterial pathogens. Mutations in gyrA (S83L) and parC (S80I) were linked to quinolone resistance.
Characterization of Mechanisms Lowering Susceptibility to Flumequine among Bacteria Isolated from Chilean Salmonid Farms.
The study identified a new variant of the qnrB gene (qnrB89) in Citrobacter gillenii FP75, which confers low-level resistance to fluoroquinolones. No other quinolone resistance genes were found in the 65 isolates examined.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Increasing Prevalence of ESBL-Producing Multidrug Resistance Escherichia coli From Diseased Pets in Beijing, China From 2012 to 2017.
The study identified a high prevalence of multidrug-resistant (MDR) Escherichia coli isolates from diseased pets in Beijing, China, with a significant increase in resistance rates from 2012 to 2017. Key AMR genes characterized include bla CTX-M, bla CTX-M-65, bla CTX-M-15, bla NDM-5, mcr-1, and qnrB, which confer resistance to beta-lactams, carbapenems, colistin, and quinolones.
Characterization and Bio-Typing of Multidrug Resistance Plasmids From Uropathogenic Escherichia coli Isolated From Clinical Setting.
The study characterized multidrug-resistant plasmids in uropathogenic E. coli, identifying genes such as blaTEM, blaCTX-M, blaOXA, aac(6')-Ib-cr, oqxAB, and qnrB, which confer resistance to various antibiotics. These plasmids were found to be transmissible via conjugation, highlighting the role of IncF and IncI conjugation systems in the spread of resistance.
A Pilot Study of Chicago Waterways as Reservoirs of Multidrug-Resistant Enterobacteriaceae (MDR-Ent) in a High-Risk Region for Community-Acquired MDR-Ent Infection in Children.
The study identified various multidrug-resistant Enterobacteriaceae (MDR-Ent) in Chicago waterways, including genes encoding beta-lactamases (CTX-M-1, CTX-M-9, SHV-ESBL, CMY-II-AmpC), aminoglycoside modifying enzymes (aac-6'-Ib), quinolone resistance proteins (qnrB), efflux pump components (oqxA/B), and colistin resistance (mcr-1). These genes were found in E. coli, K. pneumoniae, and E. cloacae isolates and conferred resistance to multiple antibiotics.
Carbapenem-Resistant Enterobacter hormaechei ST1103 with IMP-26 Carbapenemase and ESBL Gene bla (SHV-178).
The study identifies a multidrug-resistant Enterobacter hormaechei strain L51 carrying the bla IMP-26 carbapenemase gene and bla SHV-178 ESBL gene, along with other resistance genes on a conjugative IncHI2/2A plasmid.
Investigation of plasmid-mediated resistance in E. coli isolated from healthy and diarrheic sheep and goats.
The study identified several plasmid-mediated resistance genes in E. coli isolates from healthy and diarrheic sheep and goats, including rmtB, qnrA, qnrB, qnrS, CTX-M2, CTX-M8/25, CTX-M9, CTX-M1, and armA. These genes conferred resistance to aminoglycosides, fluoroquinolones, and cephalosporins.
International clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil.
The study identified various AMR genes in CTX-M-producing E. coli isolates from peri-urban wild animals in Brazil, including bla CTX-M-55, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, and others, indicating the presence of multidrug-resistant bacteria in wildlife.
International clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil.
The study identified various AMR genes in CTX-M-producing E. coli isolates from peri-urban wild animals in Brazil, including bla CTX-M-55, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, and others, indicating the presence of multidrug-resistant bacteria in wildlife.
Prevalence, Antimicrobial Resistance, Virulence Genes and Genetic Diversity of Salmonella Isolated from Retail Duck Meat in Southern China.
The study identified multiple antimicrobial resistance genes in Salmonella isolates from retail duck meat in Southern China, including blaTEM, blaCTX-M, strA, aadA1, qnrS, aac(6')-Ib, qnrB, and floR, which confer resistance to various antibiotics such as ampicillin, cefotaxime, streptomycin, ciprofloxacin, ofloxacin, and florfenicol.
Molecular epidemiology of Salmonella Infantis in Europe: insights into the success of the bacterial host and its parasitic pESI-like megaplasmid.
The study characterizes the molecular epidemiology of Salmonella Infantis in Europe, highlighting the presence of a pESI-like megaplasmid carrying multidrug-resistant genes, including bla CTX-M-1, bla CTX-M-65, tet(A), sul1, dfrA14, erm(B), mph, mef, qnrB, fosA3, merA, and qacEΔ. Chromosomal mutations in gyrA were also associated with fluoroquinolone resistance.
Molecular epidemiology of Salmonella Infantis in Europe: insights into the success of the bacterial host and its parasitic pESI-like megaplasmid.
The study characterizes the molecular epidemiology of Salmonella Infantis in Europe, highlighting the presence of a pESI-like megaplasmid carrying multidrug-resistant genes, including bla CTX-M-1, bla CTX-M-65, tet(A), sul1, dfrA14, erm(B), mph, mef, qnrB, fosA3, merA, and qacEΔ. Chromosomal mutations in gyrA were also associated with fluoroquinolone resistance.
Co-occurrence of mcr-1, mcr-3, mcr-7 and clinically relevant antimicrobial resistance genes in environmental and fecal samples.
The study identified the co-occurrence of mcr-1, mcr-3, mcr-7.1, and various clinically relevant antimicrobial resistance genes in environmental and fecal samples from a Brazilian zoo, highlighting the potential reservoir of these genes in zoological environments.
Klebsiella pneumoniae carriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors.
The study identified various AMR genes and mutations in Klebsiella pneumoniae isolates from pregnant women in low-income countries, highlighting the prevalence of multidrug-resistant strains and the role of environmental factors in their carriage.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines.
The study identifies various carbapenemase genes such as blaNDM-1, blaNDM-7, blaCTX-M-15, and blaOXA-181, along with other AMR genes like rmtC, sul1, aac(6')-Ib-cr, mph(A), qnrB1, and others, which contribute to resistance against multiple antibiotics in Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa in the Philippines.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Detection of Extended-Spectrum β-Lactamases (ESBL) Producing Enterobacteriaceae from Fish Trapped in the Lagoon Area of Bizerte, Tunisia.
The study identified several β-lactamase genes (bla CTX-M-1, bla CTX-M-15, bla CTX-M-9, bla OXA-1, and bla TEM-1-a) and other resistance genes (sul1, sul2, tetA, aac(6')-Ib-cr, qnrA, and qnrB) in ESBL-producing Enterobacteriaceae isolated from fish in the Bizerte lagoon, highlighting the presence of multidrug-resistant bacteria in aquatic environments.
Structural Genomics of repA, repB 1-Carrying IncFIB Family pA1705-qnrS, P911021-tetA, and P1642-tetA, Multidrug-Resistant Plasmids from Klebsiella pneumoniae.
The study characterizes multidrug-resistant plasmids pA1705-qnrS, p911021-tetA, and p1642-tetA from Klebsiella pneumoniae, identifying several AMR genes including beta-lactamases (bla CTX-M-14, bla TEM-1, bla OXA-1, bla SHV-12, bla CTX-M-15, bla CTX-M-65), quinolone resistance gene qnrS1, tetracycline resistance genes tetA (A) and tetA (D), aminoglycoside resistance genes aacA4cr and aacC2, streptomycin resistance genes strA and strB, dihydrofolate reductase genes dfrA1 and dfrA14, sulfonamide resistance gene sul2, macrolide resistance gene mph (A), efflux pump gene oqxAB, chloramphenicol acetyltransferase gene catB3, and tunicamycin resistance gene tmrB.
Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Drinking Water Samples From a Forcibly Displaced, Densely Populated Community Setting in Bangladesh.
The study identified ESBL-producing E. coli in drinking water samples from Rohingya camps in Bangladesh, highlighting the presence of multidrug-resistant strains with genes such as bla CTX-M-1, bla CTX-M-15, bla TEM, qnrS, and qnrB.
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
The study identified multiple AMR genes, including bla CTX-M-55, bla CMY-2, bla CTX-M-1, bla SHV-12, sul2, aac(3)-Ia, aadA, strA, strB, tet(A), tet(B), dfrA14, floR, cmlA1, catA1, catB3, qnrS1, qnrS2, qnrB19, mph(A), mph(B), arr-3, and aac(6')Ib-cr, in ESBL/pAmpC-producing E. coli isolates from broiler production.
Antibiotic Resistance Patterns of Pseudomonas spp. Isolated From Raw Milk Revealed by Whole Genome Sequencing.
The study identified various AMR genes and mutations in Pseudomonas spp. isolated from raw milk, highlighting the prevalence of multidrug-resistant strains and the presence of resistance determinants such as beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps.
Tracking Recombination Events That Occur in Conjugative Virulence Plasmid p15WZ-82_Vir during the Transmission Process.
The study characterizes the recombination events in the conjugative virulence plasmid p15WZ-82_Vir during transmission, identifying multiple antibiotic resistance genes and their roles in the formation of mosaic plasmids that carry both virulence and resistance traits.
Escherichia coli ST8196 is a novel, locally evolved, and extensively drug resistant pathogenic lineage within the ST131 clonal complex.
The study identified a novel sequence type, ST8196, within the ST131 clonal complex, which exhibits extensive drug resistance. Key resistance mechanisms include the presence of blaCTX-M-15, qnrB4, and blaDHA-1 genes, along with chromosomal mutations in parC and gyrA contributing to fluoroquinolone resistance.
Emerging Antimicrobial-Resistant High-Risk Klebsiella pneumoniae Clones ST307 and ST147.
The study identifies and characterizes the antimicrobial resistance genes and mutations associated with the high-risk Klebsiella pneumoniae clones ST307 and ST147, highlighting their global spread and the diversity of resistance mechanisms they employ.
Molecular Relatedness of Salmonella enterica Typhimurium Isolates from Feces and an Infected Surgical Wound.
The study identified the presence of blaCTX-M-15, blaTEM-1, qnrS-1, qnrB, aac-3, and blaCMY-2 in Salmonella enterica serovar Typhimurium isolates SM043 and SM080, which conferred resistance to third- and fourth-generation cephalosporins and other antibiotics.
Characterization and Source Investigation of Multidrug-Resistant Salmonella Anatum from a Sustained Outbreak, Taiwan.
The study identifies blaDHA-1, qnrB, and blaCMY-2 as key AMR genes in multidrug-resistant Salmonella Anatum isolates from a sustained outbreak in Taiwan.
Bacterial Diversity and Antibiotic Susceptibility of Sparus aurata from Aquaculture.
The study identified the qnrB19 gene in a Leclercia adecarboxylata strain with reduced susceptibility to ciprofloxacin and non-synonymous mutations in the parC gene of a Klebsiella pneumoniae strain, contributing to ciprofloxacin resistance.
Outbreak of multi-drug-resistant (MDR) Shigella flexneri in northern Australia due to an endemic regional clone acquiring an IncFII plasmid.
The study identifies several AMR genes in a multi-drug-resistant Shigella flexneri strain, including bla DHA, bla OXA-1, tet(B), catA1, dfrA1, mph(A), ermB, qnrB, aadA, and qacEΔ1, which confer resistance to various antibiotics such as beta-lactams, tetracyclines, chloramphenicol, trimethoprim, macrolides, quinolones, aminoglycosides, and quaternary ammonium compounds.
Emergence of NDM-5-Producing Carbapenem-Resistant Klebsiella pneumoniae and SIM-Producing Hypervirulent Klebsiella pneumoniae Isolated from Aseptic Body Fluid in a Large Tertiary Hospital, 2017-2018: Genetic Traits of blaNDM-Like and blaSIM-Like Genes as Determined by NGS.
The study identified NDM-5-producing CRKP and SIM-producing hvKP strains, highlighting the emergence of novel resistance mechanisms and the effectiveness of tigecycline-carbapenem combinations in treating these infections.
Characterization of Hypervirulent Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Among Urinary Tract Infections: The First Report from Iran.
The study identified ESBL genes (bla SHV, bla TEM, bla CTX-M) and PMQR genes (qnrA, qnrB, qnrS) in hypervirulent Klebsiella pneumoniae isolates from urinary tract infections in Iran. These genes contribute to resistance against beta-lactam antibiotics and quinolones.
Colonization of a hand washing sink in a veterinary hospital by an Enterobacter hormaechei strain carrying multiple resistances to high importance antimicrobials.
The study identified multiple antimicrobial resistance genes in an Enterobacter hormaechei strain isolated from a veterinary hospital sink, including blaSHV-12, qnrB2, and mcr-9.1, which confer resistance to cephalosporins, quinolones, and colistin, respectively.
Regional Variation of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacterales, Fluoroquinolone-Resistant Salmonella enterica and Methicillin-Resistant Staphylococcus aureus Among Febrile Patients in Sub-Saharan Africa.
The study identified bla CTX-M15 as the dominant ESBL gene in Enterobacterales and qnrB as a fluoroquinolone resistance gene in Salmonella enterica. Mutations in gyrA and gyrB were associated with ciprofloxacin resistance in Salmonella isolates.
Genetic Determinants of Resistance to Extended-Spectrum Cephalosporin and Fluoroquinolone in Escherichia coli Isolated from Diseased Pigs in the United States.
The study identified bla CMY-2, bla CTX-M, and bla SHV-12 genes as major contributors to extended-spectrum cephalosporin resistance, along with qnrB77, qnrB2, qnrS1, qnrS2, and aac(6')-Ib-cr for fluoroquinolone resistance. The colistin resistance gene mcr-9 was also detected in several isolates.
Genetic Determinants of Resistance to Extended-Spectrum Cephalosporin and Fluoroquinolone in Escherichia coli Isolated from Diseased Pigs in the United States.
The study identified bla CMY-2, bla CTX-M, and bla SHV-12 genes as major contributors to extended-spectrum cephalosporin resistance, along with qnrB77, qnrB2, qnrS1, qnrS2, and aac(6')-Ib-cr for fluoroquinolone resistance. The colistin resistance gene mcr-9 was also detected in several isolates.
Characteristics and Epidemiology of Extended-Spectrum β-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae From Red Kangaroo, China.
The study identified multiple AMR genes in a multidrug-resistant Klebsiella pneumoniae isolate from a Red Kangaroo, including beta-lactamases (bla DHA–3, bla SHV–1, bla CTX–M–14, bla TEM–191, bla TEM–1, bla CTX–M–3), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aac(3)-IIa, aac(6′)-Ib-cr, aadA16, arr-3), quinolone resistance genes (qnrS1, qnrB2), macrolide resistance gene (mphA), sulfonamide resistance genes (sul3, sul1), dihydrofolate reductase (dfrA3, dfrA27), chloramphenicol resistance gene (floR), tetracycline resistance genes (tetG, tetR), and multidrug efflux pump (qacEΔ1).
Genomic Characterization of Salmonella Minnesota Clonal Lineages Associated with Poultry Production in Brazil.
The study identified multiple antimicrobial resistance genes, including aac(6')-Iaa, mdf(A), sul2, tet(A), blaCMY-2, aph(3')-Ia_1, qnrB19, and ant(3'')-Ia, in Salmonella Minnesota isolates from Brazilian poultry farms, indicating widespread resistance to various antibiotics.
Snapshot Study of Whole Genome Sequences of Escherichia coli from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.
The study identified multiple antimicrobial resistance genes (ARGs) and mutations in Escherichia coli isolates from various sources in Italy, highlighting the prevalence of resistance to tetracycline, sulfonamide, penicillin, fluoroquinolone, and colistin. Key genes included tetA, sul2, blaTEM-1b, mcr-1, qnrS1, and others, along with mutations in gyrA, parC, parE, and pmrB.
Characterization of Plasmid-Mediated Quinolone Resistance and Serogroup Distributions of Uropathogenic Escherichia coli among Iranian Kidney Transplant Patients.
The study identified qnrS and qnrB genes as the most prevalent plasmid-mediated quinolone resistance genes in Uropathogenic Escherichia coli isolates from Iranian kidney transplant patients, with qnrS being more common than qnrB.
Distribution of Antibiotic-Resistant Enterobacteriaceae Pathogens in Potable Spring Water of Eastern Indian Himalayas: Emphasis on Virulence Gene and Antibiotic Resistance Genes in Escherichia coli.
The study identified antibiotic resistance genes CITM, aadA1, tetO, and qnrB in Escherichia coli isolates from spring water in Sikkim, indicating the presence of multidrug-resistant Enterobacteriaceae.
Genomic characterization and phylogenetic analysis of Salmonella enterica serovar Javiana.
The study identified several AMR genes in Salmonella enterica serovar Javiana isolates, including aac(6')-Iaa, aph(3')-Ia, sul3, and qnrB19, which confer resistance to aminoglycosides, sulfonamides, and fluoroquinolones.
Antibiotic Susceptibility and Molecular Characterization of Uropathogenic Escherichia coli Associated with Community-Acquired Urinary Tract Infections in Urban and Rural Settings in South Africa.
The study identified several AMR genes in UPEC isolates, including bla CTX-M, bla TEM, qnrA, qnrB, qnrS, gyrA, parC, aac(6')-Ib-cr, and qepA, which confer resistance to beta-lactams and fluoroquinolones. Multidrug-resistant isolates were also found.
Molecular Epidemiology of Antibiotic-Resistant Escherichia coli from Farm-To-Fork in Intensive Poultry Production in KwaZulu-Natal, South Africa.
The study identified the presence of bla CTX-M, sul1, tetA, and tetB genes in Escherichia coli isolates from various stages of the farm-to-fork continuum in intensive poultry production in South Africa.
Antimicrobial Resistance and Genomic Characterization of OXA-48- and CTX-M-15-Co-Producing Hypervirulent Klebsiella pneumoniae ST23 Recovered from Nosocomial Outbreak.
The study characterizes the AMR genes in a multidrug-resistant hypervirulent Klebsiella pneumoniae ST23 isolate, MAR14-456, which co-produces OXA-48 and CTX-M-15. The isolate shows resistance to multiple antibiotics, including carbapenems, cephalosporins, and aminoglycosides.
Transferable Resistance to Highest Priority Critically Important Antibiotics for Human Health in Escherichia coli Strains Obtained From Livestock Feces in Uruguay.
The study identified multiple AMR genes in E. coli isolates from livestock in Uruguay, including qnrB19, qnrS1, qnrE1, bla CTX-M-8, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, bla CTX-M-55, bla CMY-2, bla SHV-12, and mcr-1, highlighting the presence of transferable resistance to critically important antibiotics.
Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid.
The study identifies the blaCTX-M-1 gene carried on an IncI1/ST3 plasmid in Enterobacter cloacae and Escherichia coli isolates from humans and wild animals in Guadeloupe, highlighting the dissemination of this resistance determinant in the environment.
Evolution of Ciprofloxacin Resistance-Encoding Genetic Elements in Salmonella.
The study identifies multiple PMQR genes, including qnrS1, qnrS2, aac(6')-Ib-cr, oqxAB, qnrB6, and qnrB4, as key contributors to ciprofloxacin resistance in Salmonella. These genes are predominantly located on plasmids and transposable units, facilitating their spread among different Salmonella serotypes.
Evolution of Ciprofloxacin Resistance-Encoding Genetic Elements in Salmonella.
The study identifies multiple PMQR genes, including qnrS1, qnrS2, aac(6')-Ib-cr, oqxAB, qnrB6, and qnrB4, as key contributors to ciprofloxacin resistance in Salmonella. These genes are predominantly located on plasmids and transposable units, facilitating their spread among different Salmonella serotypes.
Colistin-resistant Enterobacter kobei carrying mcr-9.1 and bla(CTX-M-15) infecting a critically endangered franciscana dolphin (Pontoporia blainvillei), Brazil.
The study reports the emergence of the mcr-9.1 gene in a colistin-resistant Enterobacter kobei strain isolated from a critically endangered franciscana dolphin in Brazil, along with various other AMR genes.
Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica.
The study identified several β-lactamase genes, including bla CTX-M-5, bla OXA-1, bla CTX-M-15, bla CTX-M-3, and bla TEM-1, which contribute to extended-spectrum β-lactamase (ESBL) production in multidrug-resistant non-typhoidal Salmonella enterica isolates. Additionally, a mutation in the gyrA gene (D87N) was linked to quinolone resistance.
Pentapeptide repeat protein QnrB1 requires ATP hydrolysis to rejuvenate poisoned gyrase complexes.
QnrB1, a pentapeptide repeat protein, provides specific protection against fluoroquinolones by requiring ATP hydrolysis by gyrase.
Emergence of the Novel Aminoglycoside Acetyltransferase Variant aac(6')-Ib-D179Y and Acquisition of Colistin Heteroresistance in Carbapenem-Resistant Klebsiella pneumoniae Due to a Disrupting Mutation in the DNA Repair Enzyme MutS.
Emergence of the Novel Aminoglycoside Acetyltransferase Variant aac(6')-Ib-D179Y and Acquisition of Colistin Heteroresistance in Carbapenem-Resistant Klebsiella pneumoniae Due to a Disrupting Mutation in the DNA Repair Enzyme MutS.
Genomic Analysis of Antimicrobial Resistance and Resistance Plasmids in Salmonella Serovars from Poultry in Nigeria.
The study identified various antimicrobial resistance genes in Salmonella isolates from Nigerian poultry, including aac(6')-Ia, aac(6')-Ib, aadA7, aph(3")-Ia, aph(3")-Ib, aph(6')-Id, aph(6')-Ic, aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-IIa, aac(3)-Id, sul1, sul2, sul3, tet(A), tet(M), qnrS1, qnrB19, blaTEM, dfrA14, dfrA15, dfrA17, catA1, cmlA1, and floR. Mutations in gyrA (Ser83Phe, Asp87Tyr) and parC (Thr57Ser, Ser80Ile) were also associated with resistance to nalidixic acid and ciprofloxacin.
Colonization with Staphylococcus aureus and Klebsiella pneumoniae causes infections in a Vietnamese intensive care unit.
The study identifies multidrug-resistant Staphylococcus aureus ST188 and various Klebsiella pneumoniae strains with distinct resistance mechanisms, highlighting the role of colonization in causing infections in ICU patients.
Resistome of a carbapenemase-producing novel ST232 Klebsiella michiganensis isolate from urban hospital effluent in South Africa.
The study reports the first carbapenemase-producing Klebsiella michiganensis isolate from South African hospital effluent, harboring multiple resistance genes including blaOXA-181, blaOXY-5-1, qnrB6, qnrS1, aadA16, aac(6')-Ib-cr, aph(6)-Id, arr-3, sul1, sul2, dfrA14, and dfrA27.
Distribution of Beta-Lactamase Producing Gram-Negative Bacterial Isolates in Isabela River of Santo Domingo, Dominican Republic.
The study identified several beta-lactamase genes, including bla TEM, bla OXA, bla SHV, and bla KPC, as well as other resistance genes such as CTX-M-15, CTX-M-55, OXA-1, OXA-72, OXA-132, KPC-3, QnrS1, QnrB19, sul2, sul1, dfrA12, dfrA14, dfrA17, mphA, aadA, aadA2, aadA5, ampC, ampC1, ampH, PmrF, bacA, and eptA, in various Gram-negative bacterial isolates from the Isabela River in the Dominican Republic.
Interplay between ESKAPE Pathogens and Immunity in Skin Infections: An Overview of the Major Determinants of Virulence and Antibiotic Resistance.
The paper discusses the major determinants of virulence and antibiotic resistance in ESKAPE pathogens, focusing on genes such as vanA, poxtA, blaZ, mecA, blaKPC-2, blaKPC-3, armA, aacA4, aadA1, acrAB, blaCTX-M, blaGES, blaPER, blaSHV, blaTEM, blaVEB, aac(3')-Ia, ant(2’)-Ia, tetA, tetB, gyrA, parC, pmrC, pmrA, and pmrB, which are associated with resistance to various antibiotics.
Endophytic Lifestyle of Global Clones of Extended-Spectrum β-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?
The study identifies multiple AMR genes in endophytic ESBL-producing Enterobacterales isolated from fresh vegetables, highlighting their potential role in the spread of antibiotic resistance.
Emerging carbapenem-resistant Klebsiella pneumoniae sequence type 16 causing multiple outbreaks in a tertiary hospital in southern Vietnam.
The study identifies carbapenem-resistant Klebsiella pneumoniae sequence type 16 causing multiple outbreaks in a hospital in Vietnam. Key AMR genes include blaOXA-181, blaOXA-48, and mutations in gyrA and parC contributing to fluoroquinolone resistance. Colistin resistance was due to disruption of the mgrB gene by an IS L3-like element.
Detection of gyrA and parC Mutations and Prevalence of Plasmid-Mediated Quinolone Resistance Genes in Klebsiella pneumoniae.
The study identified high levels of quinolone resistance in K. pneumoniae isolates from Baghdad, primarily due to mutations in gyrA and parC, along with the presence of plasmid-mediated quinolone resistance (PMQR) genes such as aac(6')-Ib, qnrB, qnrS, and qepA.
Emergence of fosA3 and bla (CTX-M-) (14) in Multidrug-Resistant Citrobacter freundii Isolates From Flowers and the Retail Environment in China.
The study identifies fosA3 and bla CTX-M-14 in multidrug-resistant Citrobacter freundii isolates from flowers and retail environments in China, highlighting the role of untypable plasmids in the spread of these resistance genes.
Emergence of fosA3 and bla (CTX-M-) (14) in Multidrug-Resistant Citrobacter freundii Isolates From Flowers and the Retail Environment in China.
The study identifies fosA3 and bla CTX-M-14 in multidrug-resistant Citrobacter freundii isolates from flowers and retail environments in China, highlighting the role of untypable plasmids in the spread of these resistance genes.
Emergence of fosA3 and bla (CTX-M-) (14) in Multidrug-Resistant Citrobacter freundii Isolates From Flowers and the Retail Environment in China.
The study identifies fosA3 and bla CTX-M-14 in multidrug-resistant Citrobacter freundii isolates from flowers and retail environments in China, highlighting the role of untypable plasmids in the spread of these resistance genes.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya.
The study identified various carbapenemase genes (blaNDM-1, blaNDM-5, blaVIM-1, blaVIM-6, blaOXA-23, blaOXA-58, blaOXA-66, blaOXA-69, blaOXA-91, blaOXA-181, blaOXA-50) and other resistance genes (such as armA, rmtC, rmtF, aac(3)-I, aadA1, aph(3')-Ia, aph(3')-VI, aph(3')-Via, aph(6')-Id, mphE, msrE, mphA, ereA, dfrA1, dfrA12, dfrA14, dfrA17, dfrA20, sul1, sul2, tetB, tetD, tetG, tet39, qnrVC1, qnrS1, qnrB4, floR, catA1, catA2, catB3, catB7, cmlA1, cmlA5, arr-3, arr-2, sat2, acrF, mdtM, emrD, mexA, mexE, mexX, kdeA, oxa-10, oxa-395, oxa-396, oxa-846, adc-25, dha-1, act-16, cmY, ctx-m-15, shv-67, tem-1b) in carbapenem non-susceptible clinical isolates of gram-negative bacteria in Kenya, highlighting the diversity and prevalence of multidrug resistance.
Molecular investigation of an outbreak associated with total parenteral nutrition contaminated with NDM-producing Leclercia adecarboxylata.
The study identified NDM-1, TEM-1B, and SHV-12 carbapenemase genes along with various other AMR genes in Leclercia adecarboxylata isolates causing an outbreak linked to contaminated TPN.
Characterization of a Novel Variant of the Quinolone-Resistance Gene qnrB (qnrB89) Carried by a Multi-Drug Resistant Citrobacter gillenii Strain Isolated from Farmed Salmon in Chile.
Characterization of a Novel Variant of the Quinolone-Resistance Gene qnrB (qnrB89) Carried by a Multi-Drug Resistant Citrobacter gillenii Strain Isolated from Farmed Salmon in Chile.
The study characterizes a novel variant of the quinolone-resistance gene qnrB (qnrB89) carried by a multidrug-resistant Citrobacter gillenii strain isolated from farmed salmon in Chile. The qnrB89 gene was found to be unable to confer resistance to quinolones in C. gillenii FP75 strain.
Occurrence of plasmid mediated fluoroquinolone resistance genes amongst enteric bacteria isolated from human and animal sources in Delta State, Nigeria.
The study identified the presence of plasmid-mediated fluoroquinolone resistance (PMQR) genes, including qnrA, qnrB, qnrS, and qepA, in enteric bacteria from human and animal sources in Delta State, Nigeria. PMQR was more prevalent in animal-derived isolates compared to human-derived ones.
Open Waste Canals as Potential Sources of Antimicrobial Resistance Genes in Aerosols in Urban Kanpur, India.
The study identified the presence of antimicrobial resistance genes (ARGs) including intI1, tetA, blaTEM, and qnrB in aerosols near open wastewater canals (OWCs) in Kanpur, India, highlighting the potential role of these environments in the spread of ARGs.
High fecal carriage of bla(CTX-M), bla(CMY-2), and plasmid-mediated quinolone resistance genes among healthy Korean people in a metagenomic analysis.
The study found high fecal carriage of bla(CTX-M), bla(CMY-2), and plasmid-mediated quinolone resistance genes among healthy Korean individuals, highlighting the widespread presence of these resistance genes in the gut microbiome.
Deceiving Phenotypic Susceptibility Results on a Klebsiella pneumoniae Blood Isolate Carrying Plasmid-Mediated AmpC Gene bla(DHA-1).
The study identifies a carbapenem-resistant Klebsiella pneumoniae isolate carrying the plasmid-mediated AmpC gene blaDHA-1, along with other resistance genes such as blaOXA-1, aac(6')-Ib-cr, aph(3')-Ia, sul1, oqxA, oqxB, qnrB4, arr-3, tet(A), catB3, mph(A), fosA, IncFIB(K), and IncR.
Genetic but No Phenotypic Associations between Biocide Tolerance and Antibiotic Resistance in Escherichia coli from German Broiler Fattening Farms.
The study identified various AMR genes in E. coli isolates from German broiler farms, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-1C, blaCTX-M-1, blaCMY-2), quinolone resistance genes (qnrB19, qnrS1), chloramphenicol resistance gene (cat1), tetracycline resistance genes (tetA, tetB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase genes (drfA1, drfA5, drfA14, drfA17), aminoglycoside resistance gene (aadA1), and efflux pump genes (sugEp, qacEΔ1, mdfA).
Genetic mechanisms and correlated risk factors of antimicrobial-resistant ESKAPEE pathogens isolated in a tertiary hospital in Malaysia.
The study identified several AMR genes and mutations in ESKAPEE pathogens, including vanA, vanB, blaTEM, blaSHV, blaCTX-M, blaOXA, blaVEB, blaVIM, blaNDM, aac(6')-Ib, aadB, ermC, qnrS1, and gyrA mutations, highlighting the prevalence of multidrug resistance in these isolates.
Antimicrobial Resistance Glides in the Sky-Free-Living Birds as a Reservoir of Resistant Escherichia coli With Zoonotic Potential.
The study identified multiple AMR genes and mutations in E. coli from free-living birds, highlighting the zoonotic potential of these resistant strains. Key findings include bla CTX-M-15, bla CMY-2, bla SHV-12, bla TEM-1B, qnrS1, qnrB19, mcr-1, fosA7, aac(3)-IIa, ant(3")-Ia, aph(3")-Ib, and aph(6)-Id, as well as mutations in gyrA, parC, and parE.
Colistin-Resistant mcr-1-Positive Escherichia coli ST131-H22 Carrying bla (CTX-M-15) and qnrB19 in Agricultural Soil.
The study identifies a multidrug-resistant E. coli strain ST131-H22 carrying mcr-1.1, bla CTX-M-15, and qnrB19 in agricultural soil, highlighting the risk of antimicrobial resistance spread through the environment.
Antimicrobial Resistance Genes in ESBL-Producing Escherichia coli Isolates from Animals in Greece.
The study identified several AMR genes in ESBL-producing E. coli isolates from animals in Greece, including bla CTX-M-1/15, bla TEM, aadA1, aadA2, aphA, strA, strB, sul1, sul2, sul3, dfrA1, dfrA5, dfrA7, dfrA12, dfrA14, dfrA15, dfrA17, dfrA19, mph, mrx, intI1, tnpISE cp1, qnrS, and qnrB.
Phylogenomic Investigation of Increasing Fluoroquinolone Resistance among Belgian Cases of Shigellosis between 2013 and 2018 Indicates Both Travel-Related Imports and Domestic Circulation.
The study identifies qnrS1, qnrB4, and qnrB19 genes as well as mutations in gyrA (S83L, D87N, D87G) and parC (S80I) and parE (S458A) associated with ciprofloxacin resistance in Shigella isolates from Belgium.
Phylogenomic Investigation of Increasing Fluoroquinolone Resistance among Belgian Cases of Shigellosis between 2013 and 2018 Indicates Both Travel-Related Imports and Domestic Circulation.
The study identifies qnrS1, qnrB4, and qnrB19 genes as well as mutations in gyrA (S83L, D87N, D87G) and parC (S80I) and parE (S458A) associated with ciprofloxacin resistance in Shigella isolates from Belgium.
Multidrug-Resistant, Including Extended-Spectrum Beta Lactamase-Producing and Quinolone-Resistant, Escherichia coli Isolated from Poultry and Domestic Pigs in Dar es Salaam, Tanzania.
The study identified bla CTX-M, aac(6')-Ib-cr, qnrB, and qepA as the primary AMR genes in MDR E. coli isolates from poultry and domestic pigs in Tanzania.
Prevalence and Characterization of Quinolone-Resistance Determinants in Escherichia coli Isolated from Food-Producing Animals and Animal-Derived Food in the Philippines.
The study identified qnrS1, qnrB4, and qnrA1 as plasmid-mediated quinolone resistance genes in E. coli isolates from food-producing animals and animal-derived food in the Philippines. Additionally, several mutations in the QRDR regions of gyrA, parC, gyrB, and parE were found to confer resistance to quinolones.
Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.
The study identifies plasmid-mediated cephalosporin resistance in Salmonella Typhi isolates from India, including bla SHV-12, bla TEM-1B, bla DHA-1, qnrB7, qnrB4, aac(6')Iaa, dfrA14, sul1, and sul2 genes. Chromosomal mutations in gyrA (S83F, D87N, S80I) and parC (S80I, E84K) contribute to fluoroquinolone resistance.
A Peek into the Plasmidome of Global Sewage
The study identifies several antimicrobial resistance (AMR) genes in plasmidomes from global sewage samples, highlighting the prevalence of macrolide, lincosamide, streptogramin B, and quinolone resistance genes on plasmids.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
Presence of plasmid-mediated quinolone resistance (PMQR) genes in non-typhoidal Salmonella strains with reduced susceptibility to fluoroquinolones isolated from human salmonellosis in Gyeonggi-do, South Korea from 2016 to 2019.
The study identified PMQR genes such as qnrA, qnrB, qnrS, and aac(6')-Ib-cr in non-typhoidal Salmonella strains with reduced susceptibility to fluoroquinolones.
Distribution of fluoroquinolone resistance determinants in Carbapenem-resistant Klebsiella pneumoniae clinical isolates associated with bloodstream infections in China.
The study identified PMQR genes (aac(6')-Ib-cr, qnrS1, qnrB4, qnrB2, qnrB1) and mutations in the QRDRs of gyrA and parC as key contributors to fluoroquinolone resistance in CRKP isolates.
Distribution of fluoroquinolone resistance determinants in Carbapenem-resistant Klebsiella pneumoniae clinical isolates associated with bloodstream infections in China.
The study identified PMQR genes (aac(6')-Ib-cr, qnrS1, qnrB4, qnrB2, qnrB1) and mutations in the QRDRs of gyrA and parC as key contributors to fluoroquinolone resistance in CRKP isolates.
Distribution of fluoroquinolone resistance determinants in Carbapenem-resistant Klebsiella pneumoniae clinical isolates associated with bloodstream infections in China.
The study identified PMQR genes (aac(6')-Ib-cr, qnrS1, qnrB4, qnrB2, qnrB1) and mutations in the QRDRs of gyrA and parC as key contributors to fluoroquinolone resistance in CRKP isolates.
Destination shapes antibiotic resistance gene acquisitions, abundance increases, and diversity changes in Dutch travelers.
The study identifies the acquisition of various antibiotic resistance genes, including blaCTX-M, qnr, and mcr-1, in Dutch travelers after international travel, highlighting the impact of travel on the gut resistome.
The Spatiotemporal Dynamics and Microevolution Events That Favored the Success of the Highly Clonal Multidrug-Resistant Monophasic Salmonella Typhimurium Circulating in Europe.
The study identifies various AMR genes in the highly clonal multidrug-resistant monophasic Salmonella Typhimurium ST34, including beta-lactamases, sulfonamide resistance genes, tetracycline resistance genes, phenicol resistance genes, and polymyxin resistance genes.
Exploring antimicrobial resistance to beta-lactams, aminoglycosides and fluoroquinolones in E. coli and K. pneumoniae using proteogenomics.
The study identifies several beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps involved in resistance to beta-lactams, aminoglycosides, and fluoroquinolones in E. coli and K. pneumoniae using proteogenomics.
Characterization of β-lactamase and quinolone resistant Clostridium perfringens recovered from broiler chickens with necrotic enteritis in Bangladesh.
The study identified β-lactamase genes (bla TEM, bla SHV, bla OXA) and quinolone resistance genes (qnrB, qnrS) in Clostridium perfringens isolates from broiler chickens with necrotic enteritis, indicating multidrug resistance.
Molecular characterization of fluoroquinolone-resistant Escherichia coli from broiler breeder farms.
The study identified mutations in gyrA, parC, and parE genes, as well as PMQR genes qnrS, qnrA, qnrB, and aac(6')-Ib-cr in fluoroquinolone-resistant E. coli isolates from broiler breeder farms in Korea.
First Detection of Human ST131-CTX-M-15-O25-B2 Clone and High-Risk Clonal Lineages of ESBL/pAmpC-Producing E. coli Isolates from Diarrheic Poultry in Tunisia.
The study identified the presence of the human pandemic ST131-CTX-M-15-O25-B2 clone and high-risk clonal lineages of ESBL/pAmpC-producing E. coli isolates from diarrheic poultry in Tunisia, highlighting the emergence of multidrug-resistant clones with various virulence determinants.
Antibiotic Resistant and Biofilm-Associated Escherichia coli Isolates from Diarrheic and Healthy Dogs.
The study identified several AMR genes in E. coli isolates from healthy and diarrheic dogs, including blaTEM-1, qnrB, qnrS, aac(6')-Ib-cr, tetA, tetB, dfrA, sul1, sul2, int1, and tn3. These genes confer resistance to various antibiotics such as ampicillin, ciprofloxacin, tetracycline, trimethoprim, and sulfonamide.
Phenotypic and Genotypic Properties of Fluoroquinolone-Resistant, qnr-Carrying Escherichia coli Isolated from the German Food Chain in 2017.
The study identifies qnrS1 as the most prevalent qnr gene in fluoroquinolone-resistant E. coli isolates from the German food chain in 2017. It also detects point mutations in gyrA, parC, and parE genes that contribute to increased fluoroquinolone resistance.
Phenotypic and Genotypic Properties of Fluoroquinolone-Resistant, qnr-Carrying Escherichia coli Isolated from the German Food Chain in 2017.
The study identifies qnrS1 as the most prevalent qnr gene in fluoroquinolone-resistant E. coli isolates from the German food chain in 2017. It also detects point mutations in gyrA, parC, and parE genes that contribute to increased fluoroquinolone resistance.
Phenotypic and Genotypic Properties of Fluoroquinolone-Resistant, qnr-Carrying Escherichia coli Isolated from the German Food Chain in 2017.
The study identifies qnrS1 as the most prevalent qnr gene in fluoroquinolone-resistant E. coli isolates from the German food chain in 2017. It also detects point mutations in gyrA, parC, and parE genes that contribute to increased fluoroquinolone resistance.
Wide Distribution and Specific Resistance Pattern to Third-Generation Cephalosporins of Enterobacter cloacae Complex Members in Humans and in the Environment in Guadeloupe (French West Indies).
The study identifies several AMR genes and mutations associated with third-generation cephalosporin resistance in Enterobacter cloacae complex, including blaACT-16, blaACT-15, blaACT-7, qnrB1, qnrB19, qnrS2, fosA, oqxA, oqxB, mdfA, and mutations in ampD.
Wide Distribution and Specific Resistance Pattern to Third-Generation Cephalosporins of Enterobacter cloacae Complex Members in Humans and in the Environment in Guadeloupe (French West Indies).
The study identifies several AMR genes and mutations associated with third-generation cephalosporin resistance in Enterobacter cloacae complex, including blaACT-16, blaACT-15, blaACT-7, qnrB1, qnrB19, qnrS2, fosA, oqxA, oqxB, mdfA, and mutations in ampD.
Plasmid-mediated quinolone resistance genes transfer among enteric bacteria isolated from human and animal sources.
The study identifies and characterizes plasmid-mediated quinolone resistance (PMQR) genes including qnrA, qnrB, qnrS, aac(6')-Ib-cr, and qepA, demonstrating their transferability among enteric bacteria through conjugation and transformation.
Genomic evolution of antimicrobial resistance in Escherichia coli.
The study identified several AMR genes in Escherichia coli isolates from different animal sources in Europe, including blaTEM-1B, qnrB19, qnrS1, sul1, sul2, sul3, tet(A), aadA1, and aph(6)-Id. These genes were associated with resistance to beta-lactams, fluoroquinolones, sulfonamides, tetracyclines, and aminoglycosides.
Detection of bla(TEM), bla(CTX-M), bla(CMY), and bla(SHV) Genes Among Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolated from Migratory Birds Travelling to Bangladesh.
The study identified bla(TEM), bla(CTX-M), bla(CMY), and bla(SHV) genes in extended-spectrum beta-lactamase-producing Escherichia coli isolated from migratory birds in Bangladesh, highlighting the role of migratory birds as potential carriers of antibiotic resistance genes.
Plasmid analysis of NDM metallo-β-lactamase-producing Enterobacterales isolated in Vietnam.
The study characterizes bla NDM-1 and bla NDM-4 carrying plasmids in Enterobacterales isolates from Vietnam, highlighting their role in carbapenem resistance and horizontal gene transfer.
Plasmid analysis of NDM metallo-β-lactamase-producing Enterobacterales isolated in Vietnam.
The study characterizes bla NDM-1 and bla NDM-4 carrying plasmids in Enterobacterales isolates from Vietnam, highlighting their role in carbapenem resistance and horizontal gene transfer.
Emerging Threat of Multidrug Resistant Pathogens From Neonatal Sepsis.
The study identified several AMR genes, including bla CTX-M-15, bla SHV-2, bla NDM-1, and qnrB, which confer resistance to various antibiotics in E. coli and K. pneumoniae isolated from neonatal sepsis cases.
Molecular Characterization of Cephalosporin and Fluoroquinolone Resistant Salmonella Choleraesuis Isolated from Patients with Systemic Salmonellosis in Thailand.
The study identified multiple ESBL genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CMY-2, bla ACC-1, and bla TEM-1, along with PMQR genes such as qnrA, qnrB, qnrS, and aac(6′)-Ib-cr, contributing to resistance against cephalosporins and fluoroquinolones in Salmonella Choleraesuis isolates from Thailand.
High Prevalence of ESBL and Plasmid-Mediated Quinolone Resistance Genes in Salmonella enterica Isolated from Retail Meats and Slaughterhouses in Egypt.
The study identified various ESBL and PMQR genes in Salmonella enterica isolates from retail meats and slaughterhouses in Egypt, highlighting their high prevalence and potential public health implications.
Bacterial colonization dynamics and antibiotic resistance gene dissemination in the hospital environment after first patient occupancy: a longitudinal metagenetic study.
The study identified the presence of various antibiotic resistance genes (ARGs) in the hospital environment, including blaSHV, blaCMY, blaNDM, blaVIM, qnrB1, and mecA, which conferred resistance to beta-lactams, quinolones, and methicillin. These genes were detected in environmental samples and patient samples, indicating the dissemination of ARGs in the hospital setting.
Antimicrobial Resistance of Non-Typhoid Salmonella in Meat and Meat Products.
The study highlights the prevalence of antimicrobial resistance in non-typhoid Salmonella isolates from meat and meat products, emphasizing the resistance patterns to antibiotics such as tetracycline, sulfonamides, ampicillin, and streptomycin. It identifies Enteritidis and Typhimurium as the most common serovars with significant resistance levels.
Molecular identification of fluoroquinolone resistance in Salmonella spp. isolated from broiler farms and human samples obtained from two regions in Colombia.
The study identifies the qnrB gene and the aac(6')-Ib gene as contributors to fluoroquinolone resistance in Salmonella isolates from broiler farms and human samples in Colombia.
Whole Genome Sequencing of Pediatric Klebsiella pneumoniae Strains Reveals Important Insights Into Their Virulence-Associated Traits.
The study identified various AMR genes in K. pneumoniae strains, including beta-lactamases (blaSHV, blaOXA, blaTEM, blaCTX-M), fosfomycin resistance (fosA), quinolone resistance (oqxA, qnrB), chloramphenicol resistance (catB3), aminoglycoside resistance (aac(3), aadA1, strB), sulfonamide resistance (sul1), trimethoprim resistance (dfrA), and tetracycline resistance (tet(A)).
Genomic Investigation of Antimicrobial-Resistant Salmonella enterica Isolates From Dead Chick Embryos in China.
The study identified several AMR genes in Salmonella enterica isolates from dead chick embryos in China, including aac(6')-Iaa, qnrB4, bla, and sul1, which confer resistance to various antibiotics.
Occurrence of Colibacillosis in Broilers and Its Relationship With Avian Pathogenic Escherichia coli (APEC) Population Structure and Molecular Characteristics.
The study identified multiple antimicrobial resistance genes in Avian Pathogenic Escherichia coli (APEC) isolates, including beta-lactamases (blaCMY-2, blaSHV-12, blaTEM-52, blaCTX-M-1), aminoglycoside resistance genes (aac(3)-IV, aadA, strA, strB, aph(3')-Ib), sulfonamide resistance gene (sul1), tetracycline resistance genes (tet(A), tet(B)), trimethoprim resistance gene (dfrA), quinolone resistance genes (qnrS1, qnrS2, qnrB19), macrolide resistance genes (mph(A), mph(B)), and chloramphenicol resistance gene (catA1).
Assessing the Bacterial Community Composition of Bivalve Mollusks Collected in Aquaculture Farms and Respective Susceptibility to Antibiotics.
The study identified qnrA, qnrB, oqxAB, and blaTEM-1 genes in various bacterial isolates from bivalve mollusks, indicating the presence of plasmid-mediated quinolone resistance and beta-lactam resistance mechanisms.
Whole-Genome Sequencing (WGS) of Carbapenem-Resistant K. pneumoniae Isolated in Long-Term Care Facilities in the Northern Italian Region.
The study identified various carbapenem-resistance genes including blaKPC-2, blaKPC-3, blaKPC-9, blaSHV-11, blaSHV-28, blaCTX-M-15, blaOXA-1, blaOXA-9, blaOXA-23, qnrS1, qnrB19, qnrB66, aac(6')-Ib-cr, and fosA in carbapenem-resistant K. pneumoniae isolates from long-term care facilities in northern Italy.
Whole-Genome Sequencing (WGS) of Carbapenem-Resistant K. pneumoniae Isolated in Long-Term Care Facilities in the Northern Italian Region.
The study identified various carbapenem-resistance genes including blaKPC-2, blaKPC-3, blaKPC-9, blaSHV-11, blaSHV-28, blaCTX-M-15, blaOXA-1, blaOXA-9, blaOXA-23, qnrS1, qnrB19, qnrB66, aac(6')-Ib-cr, and fosA in carbapenem-resistant K. pneumoniae isolates from long-term care facilities in northern Italy.
Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms.
The study identified several ESBL genes, colistin resistance genes, and other AMR genes in ESBL-producing E. coli from pigs and pig farm workers in Vietnam. Key findings include the prevalence of bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27, along with mcr-1 and mcr-3 for colistin resistance, and various other resistance genes for aminoglycosides, quinolones, tetracyclines, chloramphenicol, macrolides, and sulfonamides.
Multidrug Resistance Dynamics in Salmonella in Food Animals in the United States: An Analysis of Genomes from Public Databases.
The study analyzed 22,102 Salmonella genomes from public databases to track antimicrobial resistance (AMR) trends in food animals in the United States. It found that the prevalence of multidrug resistance (MDR) decreased in bovines and swine but increased in poultry. Key AMR genes identified include bla CMY-2, bla CTX-M-65, floR, tetA, sul2, aadA2, aac(3)-VIa, qnrB19, qnrB2, bla SHV-12, bla TEM-1, bla CARB-2, aph(3")-Ib, aph(6)-Id, aph(3')-Ia, ant(3")-Ia, aph(4)-Ia, and aac(3)-IVa. A significant mutation, gyrA D87Y, was associated with quinolone resistance in poultry.
Multidrug Resistance Dynamics in Salmonella in Food Animals in the United States: An Analysis of Genomes from Public Databases.
The study analyzed 22,102 Salmonella genomes from public databases to track antimicrobial resistance (AMR) trends in food animals in the United States. It found that the prevalence of multidrug resistance (MDR) decreased in bovines and swine but increased in poultry. Key AMR genes identified include bla CMY-2, bla CTX-M-65, floR, tetA, sul2, aadA2, aac(3)-VIa, qnrB19, qnrB2, bla SHV-12, bla TEM-1, bla CARB-2, aph(3")-Ib, aph(6)-Id, aph(3')-Ia, ant(3")-Ia, aph(4)-Ia, and aac(3)-IVa. A significant mutation, gyrA D87Y, was associated with quinolone resistance in poultry.
Imported One-Day-Old Chicks as Trojan Horses for Multidrug-Resistant Priority Pathogens Harboring mcr-9, rmtG, and Extended-Spectrum β-Lactamase Genes.
The study identified multidrug-resistant pathogens in imported 1-day-old chicks harboring mcr-9, rmtG, and extended-spectrum β-lactamase genes, highlighting the role of these chicks as vectors for the spread of antimicrobial resistance.
Whole-Genomic Analysis of NDM-5-Producing Enterobacteriaceae Recovered from an Urban River in China.
The study identified multiple antimicrobial resistance genes, including bla NDM-5, bla OXA-10, and bla TEM-1B, in NDM-5-producing Enterobacteriaceae isolates from an urban river in China. These genes conferred resistance to various antibiotics such as carbapenems, cephalosporins, quinolones, and aminoglycosides.
Whole-Genomic Analysis of NDM-5-Producing Enterobacteriaceae Recovered from an Urban River in China.
The study identified multiple antimicrobial resistance genes, including bla NDM-5, bla OXA-10, and bla TEM-1B, in NDM-5-producing Enterobacteriaceae isolates from an urban river in China. These genes conferred resistance to various antibiotics such as carbapenems, cephalosporins, quinolones, and aminoglycosides.
Co-occurrence of Klebsiella variicola and Klebsiella pneumoniae Both Carrying bla (KPC) from a Respiratory Intensive Care Unit Patient.
The study identified Klebsiella variicola and Klebsiella pneumoniae strains carrying multiple resistance genes, including bla KPC-2, bla TEM-1A, bla LEN17, aadA16, arr-3, qnrB4, oqxA/B, dfrA27, sul1, tetD, fosA, qacEΔ1, bla CTX-M-3, bla TEM-1B, bla CTX-M-65, bla SHV-27, aac(6')-IIa, rmtB, aph(3')-Ia, aadA16, qnrS1, aac(6')-Ib-cr, qnrB91, oqxA/B, mph(A), tet(A), fosA, dfrA27, and two copies of qacEΔ1-sul1.
Co-occurrence of Klebsiella variicola and Klebsiella pneumoniae Both Carrying bla (KPC) from a Respiratory Intensive Care Unit Patient.
The study identified Klebsiella variicola and Klebsiella pneumoniae strains carrying multiple resistance genes, including bla KPC-2, bla TEM-1A, bla LEN17, aadA16, arr-3, qnrB4, oqxA/B, dfrA27, sul1, tetD, fosA, qacEΔ1, bla CTX-M-3, bla TEM-1B, bla CTX-M-65, bla SHV-27, aac(6')-IIa, rmtB, aph(3')-Ia, aadA16, qnrS1, aac(6')-Ib-cr, qnrB91, oqxA/B, mph(A), tet(A), fosA, dfrA27, and two copies of qacEΔ1-sul1.
Co-conjugation of Virulence Plasmid and KPC Plasmid in a Clinical Klebsiella pneumoniae Strain.
The study characterizes a carbapenem-resistant hypervirulent Klebsiella pneumoniae strain that harbors a conjugative virulence plasmid and a bla KPC–2-bearing plasmid. The virulence plasmid contains multiple resistance genes, including bla KPC–2, qnrB4, bla DHA–1, sul1, msr(E), mph(E), bla TEM–1B, aac(3)-IId, bla SHV–12, mph(A), bla CTX–M–65, bla TEM–1B, fosA3, and rmtB. The study also shows that these plasmids can be transferred to other bacterial strains, contributing to the spread of multidrug-resistant and hypervirulent K. pneumoniae.
Antimicrobial Susceptibility and Detection of Virulence-Associated Genes in Escherichia coli Strains Isolated from Commercial Broilers.
The study identified several AMR genes in E. coli strains from commercial broilers, including bla CTX-M-1 and bla CTX-M-2 for cephalosporin resistance, qnrA, qnrB, qnrS for fluoroquinolone resistance, aac(6')-Ib-cr for fluoroquinolone and aminoglycoside resistance, tetA and tetB for tetracycline resistance, sul1 and sul2 for sulfonamide resistance, aadA for aminoglycoside resistance, dfrA and dfrB for trimethoprim resistance, and mcr1 and mcr2 for polymyxin resistance.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
The study identified various CTX-M-type beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, bla CTX-M-55, and bla CTX-M-65, as well as other beta-lactamase genes such as bla TEM-1, bla CARB-2, and bla CMY-2 in ESBL E. coli isolates from sheep and their abattoir environment. Additional AMR genes related to aminoglycosides, macrolides, phenicols, quinolones, sulfonamides, tetracyclines, and trimethoprim were also detected.
Comparison of antimicrobial resistance and molecular characterization of Escherichia coli isolates from layer breeder farms in Korea.
The study identified several AMR genes in E. coli isolates from layer breeder farms in Korea, including bla TEM-1, tetA, tetB, qnrB, qnrS, sul1, sul2, aac(3)-II, and aac(6')-Ib. These genes conferred resistance to various antibiotics such as beta-lactams, tetracyclines, quinolones, sulfonamides, and aminoglycosides.
Genome Sequencing Identifies Previously Unrecognized Klebsiella pneumoniae Outbreaks in Neonatal Intensive Care Units in the Philippines.
The study identified several AMR genes, including bla CTX-M-15, bla NDM-1, rmtC, aac(6')-Ib, aac(3)-II, aph(3′′)-Ib, oqxA, oqxB, qnrB1, qnrS1, sul1, sul2, and dfrA, which were associated with resistance to various antibiotics in Klebsiella pneumoniae isolates from the Philippines.
Carbapenem-Resistant Citrobacter spp. as an Emerging Concern in the Hospital-Setting: Results From a Genome-Based Regional Surveillance Study.
The study identifies various carbapenemase genes, including bla KPC-2, bla OXA-48, bla VIM-1, bla NDM-5, bla OXA-162, and bla KPC-3, in Citrobacter spp. isolates, highlighting their role in carbapenem resistance.
Carbapenem-Resistant Citrobacter spp. as an Emerging Concern in the Hospital-Setting: Results From a Genome-Based Regional Surveillance Study.
The study identifies various carbapenemase genes, including bla KPC-2, bla OXA-48, bla VIM-1, bla NDM-5, bla OXA-162, and bla KPC-3, in Citrobacter spp. isolates, highlighting their role in carbapenem resistance.
Mechanisms of Resistance to Quinolones and Their Impact on Human and Animal Health
The paper discusses various mechanisms of quinolone resistance, including the role of qnr genes, aac(6')-Ib-cr, and efflux pumps like oqxAB and qepA. It highlights the importance of these resistance mechanisms in clinical settings and their implications for public health.
Antimicrobial Susceptibility and Frequency of bla and qnr Genes in Salmonella enterica Isolated from Slaughtered Pigs.
The study identified the presence of bla TEM and bla CTX-M genes in 61.2% of Salmonella enterica isolates, along with qnrA, qnrB, and qnrS genes, contributing to antimicrobial resistance against β-lactams and fluoroquinolones.
Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars.
The study characterizes mutations in the quinolone resistance-determining regions (QRDRs) of type-II topoisomerases in various Salmonella serovars, highlighting the role of GyrA, GyrB, ParC, and ParE mutations in conferring ciprofloxacin resistance.
Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars.
The study characterizes mutations in the quinolone resistance-determining regions (QRDRs) of type-II topoisomerases in various Salmonella serovars, highlighting the role of GyrA, GyrB, ParC, and ParE mutations in conferring ciprofloxacin resistance.
High prevalence of plasmid-mediated quinolone resistance (PMQR) among E. coli from aquatic environments in Bangladesh.
The study found a high prevalence of plasmid-mediated quinolone resistance (PMQR) genes in E. coli from aquatic environments in Bangladesh, with qnrS being the most common. Other PMQR genes included aac(6')-lb-cr, oqxAB, qnrB, and qepA.
Outbreak of Multidrug-Resistant Salmonella Heidelberg Infections Linked to Dairy Calf Exposure, United States, 2015-2018.
The study identifies a multidrug-resistant (MDR) Salmonella Heidelberg outbreak linked to dairy calf exposure, highlighting the presence of plasmid-borne resistance genes such as aadA1, aph(3')-Ia, bla CMY-2, floR, fosA7, qnrB19, strA, strB, sull, sul2, tet(A), tet(B), tet(O), and a novel gene dfrA34.
Impact of Carbapenem Heteroresistance Among Multidrug-Resistant ESBL/AmpC-Producing Klebsiella pneumoniae Clinical Isolates on Antibiotic Treatment in Experimentally Infected Mice.
Three IPM-heteroresistant strains of MDR ESBL/AmpC-producing K. pneumoniae were identified, which exhibited reduced expression of ompK36 and failed IPM therapy in a mouse model of peritonitis.
Surveillance of antimicrobial-resistant Escherichia coli in Sheltered dogs in the Kanto Region of Japan.
The study identified beta-lactamase genes (blaTEM, blaDHA-1, blaCTX-M-9 group CTX-M-14), quinolone-resistance protein genes (qnrB, qnrS), and mutations in quinolone-resistance-determining regions (gyrA and parC) in multidrug-resistant E. coli isolates from shelter dogs in the Kanto Region of Japan.
The Genomic Characterization of KPC-Producing Klebsiella pneumoniae from the ICU of a Teaching Hospital in Shanghai, China.
The study identified the carbapenemase gene blaKPC-2 and blaKPC-24, along with fosfomycin resistance gene fosA6, and various extended-spectrum beta-lactamase genes such as blaCTX-M-15, blaCTX-M-65, and blaCTX-M-27 in KPC-producing Klebsiella pneumoniae strains. Additionally, genes associated with fluoroquinolone, macrolide, aminoglycoside, and sulfonamide resistance were also characterized.
One Health Genomic Study of Human and Animal Klebsiella pneumoniae Isolated at Diagnostic Laboratories on a Small Caribbean Island.
The study identified various AMR genes in Klebsiella pneumoniae isolates from humans and animals on St. Kitts, including bla CTX-M-15, bla TEM-1b, bla TEM-206, bla OXA-1, and others, highlighting host-specific differences in resistance profiles.
NDM-1 Introduction in Portugal through a ST11 KL105 Klebsiella pneumoniae Widespread in Europe.
The study characterizes the first recognized outbreak of NDM-1-producing K. pneumoniae in Portugal, highlighting the introduction of a new ST11 KL105 strain carrying blaNDM-1 in a unique genetic context. Several antibiotic resistance genes, including blaNDM-1, blaCTX-M-15, and others, were identified, along with chromosomal mutations conferring reduced susceptibility to fluoroquinolones and fosfomycin.
Developing Qualitative Plasmid DNA Reference Materials to Detect Mechanisms of Quinolone and Fluoroquinolone Resistance in Foodborne Pathogens.
The study developed 11 qualitative plasmid DNA reference materials for detecting quinolone and fluoroquinolone resistance mechanisms in foodborne pathogens. These materials were validated for genetic stability, homogeneity, and storage stability.
Population snapshot of the extended-spectrum β-lactamase-producing Escherichia coli invasive strains isolated from a Hungarian hospital.
The study identified bla CTX-M-15, bla CTX-M-27, and bla TEM-1B as the primary beta-lactamase genes responsible for extended-spectrum beta-lactamase (ESBL) production in E. coli isolates. Additionally, qnrB19 and aac(3)-IIa were found to contribute to fluoroquinolone and aminoglycoside resistance, respectively.
Occurrence of plasmid-mediated quinolone resistance genes in Pseudomonas aeruginosa strains isolated from clinical specimens in southwest Iran: a multicentral study.
The study identified the presence of qnrB, qnrA, and qnrS genes in Pseudomonas aeruginosa isolates from southwest Iran, indicating plasmid-mediated quinolone resistance. These genes were found in 38.3% of the quinolone-resistant isolates.
Prevalence and Profiles of Antibiotic Resistance Genes mph(A) and qnrB in Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Isolated from Dairy Calf Feces.
The study identified the presence of mph(A) and qnrB resistance genes in ESBL-producing E. coli isolates from dairy calves, highlighting their association with specific bla CTX-M groups and age-related prevalence.
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China.
The study identifies multiple antimicrobial resistance genes in multidrug-resistant E. coli isolates from pig farms in China, including ESBL genes, fluoroquinolone resistance genes, carbapenem resistance genes, and colistin resistance genes. It highlights the widespread presence of these resistance mechanisms and their potential to spread to human pathogens.
Genomic and antigenic diversity of colonizing Klebsiella pneumoniae isolates mirrors that of invasive isolates in Blantyre, Malawi.
The study identified a high prevalence of ESBL-encoding genes, including blaCTX-M-15, sulII, aadA1-pm, qnrB, and qnrS, in colonizing Klebsiella pneumoniae isolates in Blantyre, Malawi. These genes confer resistance to various antibiotics, including beta-lactams, sulfonamides, aminoglycosides, and quinolones.
Global population structure of the Serratia marcescens complex and identification of hospital-adapted lineages in the complex.
The study identified multiple antimicrobial resistance (AMR) genes and mutations in the Serratia marcescens complex, highlighting the presence of hospital-adapted lineages with a high prevalence of multidrug-resistant (MDR) strains. Key AMR genes include blaCTX-M, blaNDM, blaOXA, qnrS1, tet(A), aac(6')-Ib, mph(A), erm(B), aadA, floR, sul1, and dfrA12, which confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, tetracyclines, aminoglycosides, macrolides, florfenicol, sulfonamides, and trimethoprim.
Gut Commensal Escherichia coli, a High-Risk Reservoir of Transferable Plasmid-Mediated Antimicrobial Resistance Traits.
The study identified multiple plasmid-mediated antimicrobial resistance genes in gut commensal Escherichia coli isolates from healthy individuals, highlighting the potential risk of these bacteria as reservoirs of resistance traits.
Genomics of human and chicken Salmonella isolates in Senegal: Broilers as a source of antimicrobial resistance and potentially invasive nontyphoidal salmonellosis infections.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella isolates from Senegal, highlighting the prevalence of resistance to fluoroquinolones, sulfamethoxazole-trimethoprim, tetracycline, and erythromycin. Key genes included aac(3)-Id, aadA7, blaTEM-1b, blaDHA-1, blaOXA-10, blaCMY-2, dfrA1, dfrA14, floR, fosA, qnrB19, qnrB7, sul2, tetA, tetB, aph(3')-Ib, aph(3")-Ib, and aph(6)-Id. Mutations in parC and gyrA were also associated with fluoroquinolone resistance.
Genomics of human and chicken Salmonella isolates in Senegal: Broilers as a source of antimicrobial resistance and potentially invasive nontyphoidal salmonellosis infections.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella isolates from Senegal, highlighting the prevalence of resistance to fluoroquinolones, sulfamethoxazole-trimethoprim, tetracycline, and erythromycin. Key genes included aac(3)-Id, aadA7, blaTEM-1b, blaDHA-1, blaOXA-10, blaCMY-2, dfrA1, dfrA14, floR, fosA, qnrB19, qnrB7, sul2, tetA, tetB, aph(3')-Ib, aph(3")-Ib, and aph(6)-Id. Mutations in parC and gyrA were also associated with fluoroquinolone resistance.
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
The study identified multiple AMR genes in multidrug-resistant E. coli and K. pneumoniae isolates from Kuwait, including beta-lactamases (blaKPC-2, blaCTX-M-15, blaOXA-1, blaCMY-4, blaTEM), aminoglycoside-modifying enzymes (aac(3)-IIa, aph(6)-Id, aadA5), sulfonamide resistance genes (sul1, sul2), quinolone resistance genes (gyrA_D87N, qnrB1), and others. Colistin resistance was linked to the pmrB_R256G mutation.
Multidrug-Resistant Klebsiella pneumoniae Complex From Clinical Dogs and Cats in China: Molecular Characteristics, Phylogroups, and Hypervirulence-Associated Determinants.
The study identified multidrug-resistant Klebsiella pneumoniae complex isolates from clinical dogs and cats in China, highlighting the presence of various AMR genes such as bla SHV, bla CTX-M, bla NDM-5, aac(6')Ib-cr, qnrB, qnrS, oqxAB, aph(3')-Ia, aph(3')-Ib, bla OXA, bla DHA, bla LEN, and bla OKP.
Using whole-genome sequence data to examine the epidemiology of antimicrobial resistance in Escherichia coli from wild meso-mammals and environmental sources on swine farms, conservation areas, and the Grand River watershed in southern Ontario, Canada.
The study identified several AMR genes in E. coli isolates from wild meso-mammals and environmental sources, including blaTEM-1, tet(A), tet(B), sul1, sul2, aph(3”)-Ib, aph(6)-Id, blaCMY-2, qnrS1, and floR. These genes conferred resistance to various antibiotics such as beta-lactams, tetracyclines, sulfonamides, aminoglycosides, and quinolones.
In vitro Synergistic Activities of Fosfomycin in Combination with Other Antimicrobial Agents Against Carbapenem-Resistant Escherichia coli Harboring bla (NDM-1) on the IncN2 Plasmid and a Study of the Genomic Characteristics of These Pathogens.
The study identified several AMR genes in bla NDM-1 -harboring CREC isolates, including bla NDM-1, aac(3)-IId, aph(3")-Ib, aph(6)-Id, aadA5, aadA16, aac(6')-Ib-cr, qnrB6, ARR-3, dfrA17, dfrA27, sul1, sul2, tet(A), mph(A), bla TEM-1C, bla TEM-57, bla CTX-M-14, bla CTX-M-15, and bla CMY-2. These genes conferred resistance to various antibiotics, including carbapenems, aminoglycosides, fluoroquinolones, rifampicin, trimethoprim, sulfonamides, tetracycline, and macrolides.
High Genetic Diversity and Antimicrobial Resistance in Escherichia coli Highlight Arapaima gigas (Pisces: Arapaimidae) as a Reservoir of Quinolone-Resistant Strains in Brazilian Amazon Rivers.
The study identifies bla CTX-M, qnrA, and qnrB as the primary AMR genes in quinolone-resistant E. coli isolates from Arapaima gigas in the Brazilian Amazon, indicating the fish as a reservoir of AMR strains.
Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017.
The study identified several AMR genes in K. pneumoniae isolates, including bla CTX-M-15, bla SHV-27, bla SHV-1, bla SHV-101, bla SHV-108, bla TEM-1B, qnrB66, aac(3)-IIa, dfrA14, strA, strB, sul2, and tet(A). These genes conferred resistance to various antibiotics such as beta-lactams, quinolones, aminoglycosides, sulfonamides, and tetracyclines.
Bacterial diversity and the antimicrobial resistome in the southwestern highlands of Saudi Arabia.
The study identified 102 antimicrobial resistance genes (ARGs) in the soil microbiota of the southwestern highlands of Saudi Arabia, primarily associated with multidrug resistance, macrolide, tetracycline, glycopeptide, bacitracin, and beta-lactam antibiotic resistance. qPCR confirmed the detection of 18 clinically important ARGs.
Characterization of qnrB-carrying plasmids from ESBL- and non-ESBL-producing Escherichia coli.
The study characterized qnrB-carrying plasmids from ESBL- and non-ESBL-producing E. coli, identifying qnrB1, qnrB2, and qnrB19 as major quinolone resistance determinants. These plasmids were found to be self-transmissible and associated with various resistance genes.
Characterization of qnrB-carrying plasmids from ESBL- and non-ESBL-producing Escherichia coli.
The study characterized qnrB-carrying plasmids from ESBL- and non-ESBL-producing E. coli, identifying qnrB1, qnrB2, and qnrB19 as major quinolone resistance determinants. These plasmids were found to be self-transmissible and associated with various resistance genes.
Characterization of qnrB-carrying plasmids from ESBL- and non-ESBL-producing Escherichia coli.
The study characterized qnrB-carrying plasmids from ESBL- and non-ESBL-producing E. coli, identifying qnrB1, qnrB2, and qnrB19 as major quinolone resistance determinants. These plasmids were found to be self-transmissible and associated with various resistance genes.
Submarine Outfalls of Treated Wastewater Effluents are Sources of Extensively- and Multidrug-Resistant KPC- and OXA-48-Producing Enterobacteriaceae in Coastal Marine Environment.
The study identified extensively drug-resistant (XDR) and multidrug-resistant (MDR) KPC- and OXA-48-producing Enterobacteriaceae in coastal marine environments, highlighting the presence of various AMR genes including bla KPC-2, bla OXA-48, and others.
Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen.
The study identifies multiple AMR genes and mutations in Klebsiella pneumoniae isolates, including bla CTX-M-15, bla IMP-4, bla OXA-48, qnrB1, qnrS1, aac(6')-Ib-cr, rmtB, aac(6')-Ib4, aadA2, ant(2")-Ia, ermB, arr-2, dfrA14, sul2, and sul1, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, aminoglycosides, and sulfonamides.
Characterization of metal(loid)s and antibiotic resistance in bacteria of human gut microbiota from chronic kidney disease subjects.
The study identified several antibiotic and metal(loid) resistance genes in gut microbiota from chronic kidney disease (CKD) subjects, including genes encoding beta-lactamases, quinolone resistance proteins, macrolide phosphotransferases, and efflux pumps. Additionally, genes conferring resistance to arsenicals and heavy metals were detected.
Epidemiological Characteristics of OXA-232-Producing Carbapenem-Resistant Klebsiella pneumoniae Strains Isolated during Nosocomial Clonal Spread Associated with Environmental Colonization.
The study identified OXA-232-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) strains that exhibited multidrug resistance, including resistance to carbapenems, cephalosporins, aminoglycosides, and quinolones. The strains were part of a clonal spread within the ICU, showing genetic similarities and carrying resistance genes such as blaOXA-232, blaCTX-M-15, blaSHV-106, and others.
KPC-3-Producing Klebsiella pneumoniae Sequence Type 392 from a Dog's Clinical Isolate in Portugal.
The study characterizes a KPC-3-producing Klebsiella pneumoniae ST392 isolate from a dog in Portugal, highlighting the presence of multiple AMR genes including blaKPC-3, aac(6')-lb-cr, tet(A), sul2, qnrB1, and OqxB/A, indicating multidrug resistance.
Cross-Sectional Survey of Antibiotic Resistance in Extended Spectrum β-Lactamase-Producing Enterobacteriaceae Isolated from Pigs in Greece.
The study identified a high prevalence of ESBL-producing Enterobacteriaceae in Greek pigs, with a focus on resistance mechanisms involving bla CTX-M1/15, bla TEM, and bla SHV genes, as well as resistance to fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and colistin.
Characterization of β-Lactamases and Multidrug Resistance Mechanisms in Enterobacterales from Hospital Effluents and Wastewater Treatment Plant.
The study identified several β-lactamase genes, including bla CTX-M-27, bla TEM-1, bla CTX-M-15, bla CTX-M-30, and bla SHV-12, along with a variety of other AMR genes such as aadA5, aph(3''-Ib), aph(6)-Id, aac(3)-IIa, sul1, sul2, dfrA17, dfrA14, qnrB1, tet(A), mph(A), qacE∆, and catB3, which confer resistance to various antibiotics in Enterobacterales isolated from hospital effluents and wastewater treatment plants.
Genomic Analysis of a Highly Virulent NDM-1-Producing Escherichia coli ST162 Infecting a Pygmy Sperm Whale (Kogia breviceps) in South America.
The study identifies a multidrug-resistant NDM-1-producing E. coli ST162 strain isolated from a pygmy sperm whale, highlighting the presence of various AMR genes including blaNDM-1, blaTEM-1C, blaOXA-1, and others, as well as mutations in gyrA and parC contributing to fluoroquinolone resistance.
Detection of Antimicrobial Resistance Mechanisms in Third-Generation Cephalosporin and Ciprofloxacin Resistant Salmonella Isolates from Livestock Meat and Human Diarrhea Patients
The study identified several AMR genes and mutations associated with third-generation cephalosporin and ciprofloxacin resistance in Salmonella isolates from livestock meat and human diarrhea patients.
Molecular Characterization of Antibiotic Resistance and Genetic Diversity of Klebsiella pneumoniae Strains.
The study identified qnrA, qnrB, qnrS, and gyrA mutations as key contributors to quinolone resistance in Klebsiella pneumoniae isolates.
Effects of Dietary Antimicrobial Growth Promoters on Performance Parameters and Abundance and Diversity of Broiler Chicken Gut Microbiome and Selection of Antibiotic Resistance Genes.
The study identified several antibiotic resistance genes (ARGs) in the chicken gut microbiome, including blaCTX-M, mcr-1, and qnrS1, which were detected using conventional PCR. These genes were associated with resistance to beta-lactams, colistin, and fluoroquinolones, respectively.
Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates.
The study identified various antimicrobial resistance genes and mutations in Klebsiella pneumoniae bloodstream isolates, highlighting the presence of multidrug-resistant and hypervirulent strains in the United States.
Using Targeted Liquid Chromatography-Tandem Mass Spectrometry to Rapidly Detect β-Lactam, Aminoglycoside, and Fluoroquinolone Resistance Mechanisms in Blood Cultures Growing E. coli or K. pneumoniae.
The study developed and validated a targeted LC-MS/MS assay for the rapid detection of β-lactam, aminoglycoside, and fluoroquinolone resistance mechanisms in blood cultures growing E. coli or K. pneumoniae. The assay successfully detected various resistance genes including β-lactamases (SHV, TEM, CTX-M-1-like, OXA-1, CMY-2-like, cAmpC, KPC, OXA-48, NDM, VIM), aminoglycoside-modifying enzymes (AAC(3)-Ia, AAC(3)-II, AAC(3)-IV, AAC(3)-VI, AAC(6′)-Ib, ANT(2′′)-I, APH(3′)-VI), 16S-RMTases (ArmA, RmtB, RmtC, RmtF), and quinolone resistance mechanisms (QnrA, QnrB, AAC(6′)-Ib-cr, and wildtype QRDR of GyrA).
Characterization of NDM-5 Carbapenemase-Encoding Gene (bla (NDM-5)) - Positive Multidrug Resistant Commensal Escherichia coli from Diarrheal Patients.
The study characterizes the bla NDM-5 gene in multidrug-resistant commensal E. coli from diarrheal patients, highlighting its resistance to various antibiotics and its potential for horizontal transfer.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Genomic epidemiological analysis of Klebsiella pneumoniae from Portuguese hospitals reveals insights into circulating antimicrobial resistance.
The study identifies bla KPC-3 and bla CTX-M-15 as the primary carbapenem and extended-spectrum beta-lactamase resistance genes, respectively, in Klebsiella pneumoniae isolates from Portugal. Other notable AMR genes include aac(6')-Ib-cr, qnrB, aac(3)-II, APH(3')-I, ANT(3'')-I, and APH(6)-I, which contribute to resistance against fluoroquinolones and aminoglycosides.
Within-farm dynamics of ESBL-producing Escherichia coli in dairy cattle: Resistance profiles and molecular characterization by long-read whole-genome sequencing.
The study identified multiple ESBL-encoding genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, and bla SHV-12, as well as carbapenemase gene bla NDM-1, in ESBL-producing E. coli isolates from dairy cattle farms. These genes were associated with resistance to various beta-lactam antibiotics. Additionally, several other AMR genes such as aadA2, ant(3")-Ia, aph(3')-Ia, dfrA12, sul3, cmlA1, and others were identified, contributing to resistance against aminoglycosides, trimethoprim, sulfamethoxazole, and chloramphenicol. Mutations in gyrA, parC, and parE were linked to fluoroquinolone resistance.
Emergence of a Novel NDM-5-Producing Sequence Type 4523 Klebsiella pneumoniae Strain Causing Bloodstream Infection in China.
The study identifies a novel sequence type 4523 Klebsiella pneumoniae strain, ST4523, which is resistant to multiple antibiotics, including carbapenems, and carries the bla NDM-5 gene on a plasmid. The strain also possesses various other resistance genes on plasmids pSHX180-1 and pSHX180-NDM5.
Exploring the Bacteriome and Resistome of Humans and Food-Producing Animals in Brazil.
The study identified various antimicrobial resistance genes (ARGs) in humans and food-producing animals in Brazil, including novel carbapenemase-encoding genes such as blaAIM-1, blaCAM-1, blaGIM-2, and blaHMB-1, which were not previously reported in Latin America. Other significant ARGs included aac(6')-Ib-cr, ermF, ermB, ermG, tetO, tetQ, tetW, qnrB10, qnrB19, qnrD1, and crpP.
Exploring the Bacteriome and Resistome of Humans and Food-Producing Animals in Brazil.
The study identified various antimicrobial resistance genes (ARGs) in humans and food-producing animals in Brazil, including novel carbapenemase-encoding genes such as blaAIM-1, blaCAM-1, blaGIM-2, and blaHMB-1, which were not previously reported in Latin America. Other significant ARGs included aac(6')-Ib-cr, ermF, ermB, ermG, tetO, tetQ, tetW, qnrB10, qnrB19, qnrD1, and crpP.
Genomic surveillance of Salmonella spp. in the Philippines during 2013-2014.
The study characterized various AMR genes and mutations in Salmonella isolates from the Philippines, highlighting the presence of ESBL genes, plasmid-mediated quinolone resistance genes, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
Genomic characterization of invasive typhoidal and non-typhoidal Salmonella in southwestern Nigeria.
The study identified multiple antibiotic resistance genes and mutations in invasive Salmonella isolates from Nigeria, highlighting the prevalence of multidrug-resistant S. Typhi 3.1.1 and other serovars carrying resistance determinants such as blaTEM-1, aph(3')-Ib, catA1, dfrA14, sul2, tetA, and qnrB19.
World Health Organization critical priority Escherichia coli clone ST648 in magnificent frigatebird (Fregata magnificens) of an uninhabited insular environment.
The study identified a multidrug-resistant ST648 E. coli isolate carrying various AMR genes, including blaCTX-M-2, blaCMY-2, qnrB, tetB, sul1, sul2, aadA1, aac(3)-VIa, and mdfA, highlighting the presence of critical priority pathogens in wild birds.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
Resistance Phenotype and Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Nanjing Children's Hospital in Jiangsu Province, China.
The study identified several carbapenemase genes, including blaKPC-2, blaNDM-1, blaNDM-5, blaIMP-8, and blaOXA-181, as well as other resistance genes such as blaCTX-M, blaSHV-2, APH(3)-IB, APH(6)-ID, FosA5, tetC, qnrB1, and tetA, contributing to multidrug resistance in CRKP strains isolated from children in Nanjing, China.
WGS-Based Lineage and Antimicrobial Resistance Pattern of Salmonella Typhimurium Isolated during 2000-2017 in Peru.
The study identifies 63 different AMR genes in 90 S. Typhimurium isolates from Peru, including beta-lactamases (blaTEM-181, blaSHV-12, blaSHV-134, blaCTX-M-15), quinolone resistance genes (qnrB5, qnrB19, qnrE2), tetracycline resistance genes (tetA, tetD, tetR), sulfonamide resistance genes (sul3), dihydrofolate reductase (dfrA1, dfrA12), florfenicol resistance gene (floR), lincomycin resistance gene (linG), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aadA2), colistin resistance gene (mcr-1), and fosfomycin resistance gene (fosA3).
WGS-Based Lineage and Antimicrobial Resistance Pattern of Salmonella Typhimurium Isolated during 2000-2017 in Peru.
The study identifies 63 different AMR genes in 90 S. Typhimurium isolates from Peru, including beta-lactamases (blaTEM-181, blaSHV-12, blaSHV-134, blaCTX-M-15), quinolone resistance genes (qnrB5, qnrB19, qnrE2), tetracycline resistance genes (tetA, tetD, tetR), sulfonamide resistance genes (sul3), dihydrofolate reductase (dfrA1, dfrA12), florfenicol resistance gene (floR), lincomycin resistance gene (linG), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aadA2), colistin resistance gene (mcr-1), and fosfomycin resistance gene (fosA3).
Investigation of In Vitro Susceptibility and Resistance Mechanisms in Skin Pathogens: Perspectives for Fluoroquinolone Therapy in Canine Pyoderma.
The study identified chromosomal mutations in gyrA, grlA, and parC, as well as PMQR genes aac(6')-Ib-cr, qnrS, and qnrB, which contribute to fluoroquinolone resistance in canine skin pathogens.
Identification of a Novel IncHI1B Plasmid in MDR Klebsiella pneumoniae 200 from Swine in China.
The study identifies a novel IncHI1B plasmid, pYhe2001, in MDR Klebsiella pneumoniae 200 from swine, along with several resistance genes including blaCTX-M-27, aadA16, dfrA27, arr-6, aac(6')-Ib-cr, sul1, qnrB2, tetA, and floR. These genes contribute to resistance against multiple antibiotics.
Exposure to Veterinary Antibiotics via Food Chain Disrupts Gut Microbiota and Drives Increased Escherichia coli Virulence and Drug Resistance in Young Adults.
The study found that exposure to veterinary antibiotics via the food chain leads to increased drug resistance and virulence in Escherichia coli, with the identification of multiple resistance genes such as cmlA, tetA, ctx-M1, and various multidrug efflux pump genes.
Emergence of Extensively Drug-Resistant ST170 Citrobacter portucalensis with Plasmids pK218-KPC, pK218-NDM, and pK218-SHV from a Tertiary Hospital, China.
The study identifies the emergence of an extensively drug-resistant Citrobacter portucalensis strain, K218, which carries multiple resistance genes including bla KPC-2 and bla NDM-1, contributing to its multidrug-resistant phenotype.
Whole genome sequencing of OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae in human bloodstream infection co-harboring chromosomal ISEcp1-based bla (CTX-M-15) and one rmpA2-associated virulence plasmid.
The study characterizes an OXA-232-producing ST15 CRKP strain with a multidrug-resistant profile, harboring chromosomal bla CTX-M-15 and plasmid-mediated bla OXA-232, along with other resistance genes such as strAB, rmtF, sul2, dfrA14, qnrB1, arr-2, and catB. Mutations in gyrA (S83F) and parC (S80I) contribute to fluoroquinolone resistance.
Emergence of a Novel Lineage and Wide Spread of a bla(CTX-M-15)/IncHI2/ST1 Plasmid among Nosocomial Enterobacter in Guadeloupe.
The study identifies the bla CTX-M-15 gene as the most prevalent ESBL determinant in ESBL-producing Enterobacter cloacae complex isolates, along with the IncHI2/ST1 plasmid. It also reports the presence of other resistance genes such as mcr-9, aac(3)-IIa, aac(6′)-Ib-cr, aph(3″)-Ib, aph(6)-Id, bla OXA-1, bla TEM-1B, qnrB1, fosA, sul2, tet(A), dfrA14, ars, mer, tni, and the ter operon.
Epidemiological links and antimicrobial resistance of clinical Salmonella enterica ST198 isolates: a nationwide microbial population genomic study in Switzerland.
The study identifies several AMR genes and mutations associated with ciprofloxacin resistance in Salmonella enterica ST198 isolates, including aac(3)-Id, aadA7, bla TEM-1b, sul1, tetA, qnrB1, qnrS1, bla CTX-M-14b, bla VEB-8, and bla OXA-48. Additionally, inactivating mutations in ramR and acrB were found to contribute to high-level ciprofloxacin resistance.
A survey of antimicrobial-resistant Escherichia coli prevalence in wild mammals in Japan using antimicrobial-containing media.
The study identified several beta-lactamase genes (bla CTX-M-1, bla CTX-M-27, bla CTX-M-55, and bla CMY-2) and the quinolone resistance gene qnrB19 in cefotaxime- and ciprofloxacin-resistant Escherichia coli isolates from wild mammals in Japan.
Multistate reptile- and amphibian-associated salmonellosis outbreaks in humans, United States, 2009-2018.
The study identified various AMR genes and mutations in Salmonella isolates from multistate reptile- and amphibian-associated salmonellosis outbreaks in the United States, including bla CMY-2, qnrB19, qnrS1, bla TEM-116, bla TEM-1C, bla TEM-1B, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, dfrA12, sul1, sul3, floR, tet(A), and sul2, which conferred resistance to multiple antibiotics such as ciprofloxacin, ceftriaxone, ampicillin, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, chloramphenicol, and tetracycline.
Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance.
The paper discusses the role of qnr genes in mediating low-level quinolone resistance in aquatic environments and their potential contribution to high-level resistance when combined with chromosomal mutations or efflux pumps.
Genomic Study of Chromosomally and Plasmid-Mediated Multidrug Resistance and Virulence Determinants in Klebsiella Pneumoniae Isolates Obtained from a Tertiary Hospital in Al-Kharj, KSA.
The study identified several AMR genes in K. pneumoniae isolates, including blaOXA-1, blaCTX-M-3, blaOXA-232, catB3, aac(6')-Ib-cr, dfrA14, IntI1, IS1, RepE, qnrB4, qnrB55, qnrS1, aph(3")-Ib, sul2, aadA2, SHV-190, SHV-26, SHV-11, tet(A), fosA, OqxA, and OqxB, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, trimethoprim, quinolones, sulfonamides, and fosfomycin.
Genomic Study of Chromosomally and Plasmid-Mediated Multidrug Resistance and Virulence Determinants in Klebsiella Pneumoniae Isolates Obtained from a Tertiary Hospital in Al-Kharj, KSA.
The study identified several AMR genes in K. pneumoniae isolates, including blaOXA-1, blaCTX-M-3, blaOXA-232, catB3, aac(6')-Ib-cr, dfrA14, IntI1, IS1, RepE, qnrB4, qnrB55, qnrS1, aph(3")-Ib, sul2, aadA2, SHV-190, SHV-26, SHV-11, tet(A), fosA, OqxA, and OqxB, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, trimethoprim, quinolones, sulfonamides, and fosfomycin.
Antimicrobial resistance and genomic characterization of Salmonella enterica serovar Senftenberg isolates in production animals from the United States.
The study characterized antimicrobial resistance genes and mutations in Salmonella enterica serovar Senftenberg isolates from production animals in the United States, identifying genes such as aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, blaTEM-1B, blaCMY-2, blaSHV-12, floR, catA2, qnrB2, aac(6')-Ib-cr, aadA1, aadA2, sul1, sul2, tetA, and mcr-9.1, along with mutations in gyrA and parC genes contributing to resistance against various antibiotics.
Klebsiella Species and Enterobacter cloacae Isolates Harboring bla(OXA-181) and bla(OXA-48): Resistome, Fitness Cost, and Plasmid Stability.
The study identified blaOXA-181 and blaOXA-48 genes in Klebsiella species and Enterobacter cloacae isolates, along with blaDHA-1 and qnrB1, highlighting their roles in carbapenem and fluoroquinolone resistance.
The hazard of carbapenemase (OXA-181)-producing Escherichia coli spreading in pig and veal calf holdings in Italy in the genomics era: Risk of spill over and spill back between humans and animals.
The study identifies multiple AMR genes, including bla OXA-181, bla TEM-1B, aac (3)-IId, aad A2, cml A1, dfr A12, mef (B), sul 3, tet (A), tet (M), incX3, incX1, incFII, qnr S1, aph (3″)-Ib, aph (6)-Id, flo R, lnu (F), sul 2, sul 3, tet (B), mph (A), mph (G), qnr B4, rmt B, and fos A3, in OXA-181-producing E. coli isolates from pigs and bovines in Italy. These genes confer resistance to various antibiotics, including carbapenems, cephalosporins, penicillins, aminoglycosides, trimethoprim, macrolides, sulfonamides, tetracyclines, fluoroquinolones, and fosfomycin.
Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae in a Tertiary Hospital in Northern China.
The study identified bla KPC-2, bla GES, bla NDM-1, and bla IMP as the main carbapenemase genes in CRKP isolates. Additionally, various ESBL genes, aminoglycoside resistance genes, and PMQR genes were detected.
Paratype: a genotyping tool for Salmonella Paratyphi A reveals its global genomic diversity.
Genomic Characterization of ESBL/AmpC-Producing Escherichia coli in Stray Dogs Sheltered in Yangzhou, China.
The study identified several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-55, and others, along with additional resistance genes such as tet(A), qnrS1, and oqxAB, contributing to multidrug resistance in ESBL/AmpC-producing E. coli isolated from stray dogs in Yangzhou, China.
Salmonella Heidelberg and Salmonella Minnesota in Brazilian broilers: Genomic characterization of third-generation cephalosporin and fluoroquinolone-resistant strains.
The study identifies multiple AMR genes and mutations in Salmonella Heidelberg and Salmonella Minnesota isolates from Brazilian broilers, including bla CMY-2, qnrB19, aac(6')-Iaa, sul2, tet(A), fosA7, qacE, and formA, along with gyrA(S83F) and parC(T57S) mutations conferring resistance to various antibiotics.
Chicken Production and Human Clinical Escherichia coli Isolates Differ in Their Carriage of Antimicrobial Resistance and Virulence Factors.
The study identified differences in the carriage of antimicrobial resistance (AMR) genes and virulence factors between chicken production and human clinical Escherichia coli isolates, highlighting the presence of specific AMR genes like aac(6')-Ib-cr, qnrB19, fosA7, and mcr-9 in human clinical isolates, and mutations in parC and gyrA contributing to fluoroquinolone resistance.
Genetic Diversity and New Sequence Types of Escherichia coli Coharboring β-Lactamases and PMQR Genes Isolated from Domestic Dogs in Central Panama.
The study identified blaTEM-1, qnrS, and qnrB genes in E. coli isolates from domestic dogs in Panama, along with mutations in the AmpC gene promoter regions contributing to resistance.
Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009-2018.
The study identifies multiple AMR genes associated with multidrug-resistant Salmonella enterica serotype 4,[5],12:i:-, including genes conferring resistance to ampicillin, streptomycin, sulfamethoxazole, tetracycline, ciprofloxacin, ceftriaxone, azithromycin, and colistin. These genes are prevalent in a multidrug-resistant clade linked to pork consumption.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Prevalence and abundance of antibiotic-resistant genes in culturable bacteria inhabiting a non-polar passu glacier, karakorum mountains range, Pakistan.
The study identified multiple antibiotic-resistant genes (ARGs) in culturable bacteria from a non-polar glacier in Pakistan, highlighting the presence of resistance mechanisms against various antibiotics.
Antibacterial efficacy of indigenous Pakistani honey against extensively drug-resistant clinical isolates of Salmonella enterica serovar Typhi: an alternative option to combat antimicrobial resistance.
The study identifies multiple AMR genes, including blaCTX-M-15, blaTEM-1, qnrS, qnrA, qnrB, Sul1, and pltB, in XDR S. Typhi isolates. Indigenous Pakistani honeys, particularly beri and neem honey, show potent antibacterial activity against these isolates.
Characterization of a Tigecycline-Resistant and blaCTX-M-Bearing Klebsiella pneumoniae Strain from a Peacock in a Chinese Zoo.
The study identified a multidrug-resistant Klebsiella pneumoniae strain, LYS105A, from a peacock in a Chinese zoo, carrying blaCTX-M-3, aac(6')-Ib-cr5, and qnrB91 genes, which confer resistance to beta-lactams, aminoglycosides, and fluoroquinolones, respectively. Additionally, mutations in phoP were linked to colistin resistance.
Quinolone-resistant Escherichia coli at the interface between humans, poultry and their shared environment- a potential public health risk.
The study identified qnrS1, qnrB19, aac(6')-Ib-cr, and mcr-1.1 as significant quinolone and colistin resistance genes in E. coli isolates from humans, poultry, and the environment in Abuja, Nigeria. Additionally, specific mutations in gyrA, parC, parE, and pmrB were linked to quinolone and colistin resistance.
Fluoroquinolone-resistance mechanisms and molecular epidemiology of ciprofloxacin-resistant Klebsiella pneumoniae isolates in Iran.
The study identified plasmid-mediated quinolone resistance genes (qnrS, qnrD, qnrB, qnrA, qepA, aac(6')-Ib-cr, and qnrC) and target site mutations in gyrA (S83I) and parC (S129A, A141V) as key mechanisms of ciprofloxacin resistance in Klebsiella pneumoniae isolates in Iran.
Antimicrobial resistance profiles of Campylobacter jejuni and Salmonella spp. isolated from enteritis patients in Japan.
The study identified several AMR genes including blaCMY-2, aac(6')-Iaa, ant(3")-Ib, aph(6)-Id, floR, qnrB19, sul2, and tet(A) in cefotaxime-resistant Salmonella isolates. Additionally, mutations in the gyrA gene, specifically Thr86Ile, were found in ciprofloxacin-resistant C. jejuni isolates.
Fluoroquinolone resistance among fecal extended spectrum βeta lactamases positive Enterobacterales isolates from children in Dar es Salaam, Tanzania.
The study identified high levels of fluoroquinolone resistance among ESBL-producing Enterobacterales isolates from children in Dar es Salaam, Tanzania, primarily due to plasmid-mediated quinolone resistance (PMQR) genes and chromosomal mutations.
Multidrug-resistant extended spectrum β-lactamase (ESBL)-producing Escherichia coli from farm produce and agricultural environments in Edo State, Nigeria.
The study identified various AMR genes in ESBL-producing E. coli isolates from agricultural farms and open markets in Edo State, Nigeria, including blaTEM, blaCTX-M-1, blaCTX-M-15, tetM, tetA, tetB, sul1, sul2, sul3, ant(4')-Ia, aacC(3)-1, qnrA, qnrB, qnrC, qnrS, cat::pC194, cat::pC221, intI1, and intI2. These genes conferred resistance to multiple antibiotics, indicating the presence of multidrug-resistant E. coli in the studied environments.
Phenotypic and genotypic survey of antibiotic resistance in Salmonella enterica isolates from dairy farms in Uruguay.
The study identified 21 AMR genes in Salmonella enterica isolates from dairy farms in Uruguay, including genes conferring resistance to aminoglycosides, tetracyclines, sulfonamides, beta-lactams, and quinolones. Two chromosomal mutations, parC_T57S and acrB_R717Q, were also detected, contributing to resistance against quinolones and azithromycin, respectively.
Serotype Occurrence, Virulence Profiles, Antimicrobial Resistance and Molecular Characterization of Salmonella Isolated from Hospitalized Patients with Gastroenteritis in Great Tunisia between 2010 and 2020.
The study identified qnrB and dfrA1 genes as contributors to fluoroquinolone and trimethoprim-sulfamethoxazole resistance in Salmonella isolates from Tunisia.
Prevalence and Characterization of Salmonella Isolated from Chickens in Anhui, China.
The study identified several AMR genes in Salmonella isolates from chickens in Anhui, China, including blaTEM, blaCMY-2, aadA, strA, aph(3')-IIa, aac(6')-Ib-cr, qnrB, qnrS, sul1, sul2, tetA, tetB, cat1, and floR. These genes were associated with resistance to various antibiotics such as ampicillin, cephalosporins, streptomycin, gentamicin, amikacin, fluoroquinolones, sulfamethoxazole, tetracycline, chloramphenicol, and florfenicol.
Mobile genetic elements drive the multidrug resistance and spread of Salmonella serotypes along a poultry meat production line.
The study identifies multiple antimicrobial resistance genes in Salmonella isolates from a poultry production line, highlighting the role of mobile genetic elements in the spread of multidrug resistance.
The evolution and international spread of extensively drug resistant Shigella sonnei.
The study identifies bla CTX-M-27 and qnrB19 as key genes contributing to the extensive drug resistance in Shigella sonnei, highlighting the role of plasmids in the spread of resistance.
High frequency of NDM-1 and OXA-48 carbapenemase genes among Klebsiella pneumoniae isolates in central Iran.
The study identified high frequencies of bla TEM, bla CTX-M1, bla SHV, bla CTX-M15, bla CIT, bla CMY-2, bla NDM, bla OXA-48, qnrB, qnrS, qnrA, tetA, tetB, sul1, sul2, int1, and int2 genes in Klebsiella pneumoniae isolates from central Iran, highlighting the prevalence of multidrug-resistant and carbapenem-resistant strains.
Antimicrobial resistance and genomic characterization of Salmonella enterica isolates from chicken meat.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from chicken meat, including aminoglycoside, beta-lactam, quinolone, tetracycline, sulfonamide, and phenicol resistance genes. These genes were detected using whole genome sequencing and correlated with phenotypic resistance profiles.
Antimicrobial resistance and genomic characterization of Salmonella enterica isolates from chicken meat.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from chicken meat, including aminoglycoside, beta-lactam, quinolone, tetracycline, sulfonamide, and phenicol resistance genes. These genes were detected using whole genome sequencing and correlated with phenotypic resistance profiles.
Genetic characterization of ESBL-producing and ciprofloxacin-resistant Escherichia coli from Belgian broilers and pigs.
The study identified various ESBL genes such as bla CTX-M-1, bla CTX-M-32, bla CTX-M-15, bla SHV-12, bla TEM-52C, and bla TEM-52B, as well as PMQR genes like qnrS1 and qnrB19, in ESBL-producing and ciprofloxacin-resistant E. coli from Belgian broilers and pigs. Additionally, colistin resistance genes mcr-1.1, mcr-2.1, and mcr-9 were detected. Mutations in gyrA (S83L, D87N) and parC (S80I) were strongly associated with fluoroquinolone resistance.
A Nationwide Genomic Study of Clinical Klebsiella pneumoniae Carrying bla(OXA-232) and rmtF in China.
The study characterizes the AMR genes blaOXA-232 and rmtF in OXA-232-producing Klebsiella pneumoniae isolates in China, along with other resistance genes such as blaCTX-M-15, blaTEM-1B, aacA4'-17, aadA2, arr-2, qnrB1, and qnrS1. Mutations in gyrA and parC contribute to fluoroquinolone resistance.
Phenotypic and Genotypic Characteristics of Antimicrobial Resistance in Citrobacter freundii Isolated from Domestic Ducks (Anas platyrhynchos domesticus) in Bangladesh.
The study identified multiple AMR genes in Citrobacter freundii isolates from domestic ducks in Bangladesh, including beta-lactamases (bla TEM-1, bla CMY-2, bla CMY-9, bla CTX-M-14), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tetA, tetB), fluoroquinolone resistance genes (qnrA, qnrB, qnrS), and an aminoglycoside resistance gene (aacC4).
Occurrence of High-Risk Clonal Lineages ST58, ST69, ST224, and ST410 among Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated from Healthy Free-Range Chickens (Gallus gallus domesticus) in a Rural Region in Tunisia.
The study identified high-risk clonal lineages ST58, ST69, ST224, and ST410 among ESBL-producing E. coli isolates from free-range chickens in Tunisia. Key AMR genes included bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, aac(6')-Ib-cr, qnrS, qnrB, tetB, tetA, sul1, sul2, and mcr-2.
Plasmid-mediated quinolone resistance genes detected in Ciprofloxacin non-susceptible Escherichia coli and Klebsiella isolated from children under five years at hospital discharge, Kenya.
The study identified plasmid-mediated quinolone resistance (PMQR) genes, including aac(6')-Ib-cr, qnrB, qnrS, and qepA, in Ciprofloxacin non-susceptible Escherichia coli and Klebsiella isolates from children in Kenya. The qepA gene was reported for the first time in clinical isolates in Kenya.
Plasmid-mediated colistin resistance among human clinical Enterobacterales isolates: national surveillance in the Czech Republic.
The study identified mcr-1, mcr-4, and mcr-9 genes in colistin-resistant Enterobacterales isolates from the Czech Republic, highlighting their association with plasmid-mediated resistance and multidrug resistance features.
Impact of immigration on antibiotic resistance genes in activated sludge: A study using digital droplet PCR and amplicon sequencing
The study reveals that immigration of influent wastewater into activated sludge leads to an increase in the abundance of over 70% of the quantified antibiotic resistance genes (ARGs). Specific ARGs such as blaTEM, blaMOX, qnrS, qnrB, mphE, dfrA, tetO, tetQ, tetE, marR, msrD, robA, qacL, blaOXA, and ereA were found to increase in abundance with immigration, indicating the impact of influent immigration on the persistence of AMR in wastewater treatment plants.
Characterization of multidrug and heavy metal resistance of carbapenemases producing Klebsiella pneumoniae from poultry samples in Bangladesh.
The study identified multiple AMR genes, including bla TEM, bla SIM-1, bla IMP-4, bla OXA-48, and qnr B, in carbapenemase-producing Klebsiella pneumoniae isolates from poultry in Bangladesh, highlighting the prevalence of multidrug resistance.
Hospital and community wastewater as a source of multidrug-resistant ESBL-producing Escherichia coli.
The study identifies several AMR genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-1, bla GES-5, bla OXA-244, qnrS1, qnrB4, aac(3)-IId, aph(3'')-Ib, aph(6)-Id, catA1, cmlA1, and bla TEM-1, which confer resistance to various antibiotics in multidrug-resistant ESBL-producing E. coli isolates from hospital and environmental sources.
Genomic epidemiology of nosocomial carbapenemase-producing Citrobacter freundii in sewerage systems in the Helsinki metropolitan area, Finland.
The study identified bla KPC-2 and bla VIM-1 carbapenemase genes, along with various other AMR genes such as aac(6′)-If, aph(6)-Id, aac(3)-IIa, aadA1, dfrA1, sul2, sat2, qnrB, cmlA5, bla OXA-9, bla CMY-79, bla CMY-116, bla TEM-1A, bla CMY-117, bla OXA-10, bla CFE, bla CMY-100, aac(6′)-Ib, aadA2, sul1, qnrS1, qnrB9, mph(E), msr(E), aac(6′)-Iic, and dfrA16 in carbapenemase-producing Citrobacter freundii isolates from hospital environments and municipal wastewater in Finland.
Genomic epidemiology of nosocomial carbapenemase-producing Citrobacter freundii in sewerage systems in the Helsinki metropolitan area, Finland.
The study identified bla KPC-2 and bla VIM-1 carbapenemase genes, along with various other AMR genes such as aac(6′)-If, aph(6)-Id, aac(3)-IIa, aadA1, dfrA1, sul2, sat2, qnrB, cmlA5, bla OXA-9, bla CMY-79, bla CMY-116, bla TEM-1A, bla CMY-117, bla OXA-10, bla CFE, bla CMY-100, aac(6′)-Ib, aadA2, sul1, qnrS1, qnrB9, mph(E), msr(E), aac(6′)-Iic, and dfrA16 in carbapenemase-producing Citrobacter freundii isolates from hospital environments and municipal wastewater in Finland.
Blab(TEM)-positive Salmonella enterica serovars Agona and Derby are prevalent among food-producing animals in Chongqing, China.
Whole genome sequencing of Salmonella enterica serovars isolated from humans, animals, and the environment in Lagos, Nigeria.
The study identified several AMR genes in Salmonella enterica isolates, including aac(6')-Iaa, mdf(A), qnrB, qnrB19, sinH, mdsB, mdsA, golT, and golS, which contribute to resistance against various antibiotics.
Whole genome sequencing of Salmonella enterica serovars isolated from humans, animals, and the environment in Lagos, Nigeria.
The study identified several AMR genes in Salmonella enterica isolates, including aac(6')-Iaa, mdf(A), qnrB, qnrB19, sinH, mdsB, mdsA, golT, and golS, which contribute to resistance against various antibiotics.
A global genomic analysis of Salmonella Concord reveals lineages with high antimicrobial resistance in Ethiopia.
The study identifies multiple antimicrobial resistance (AMR) genes in Salmonella enterica serovar Concord, including sul1, sul2, blaCTX-M-15, qnrA1, qnrB2, and mph(A), which contribute to multidrug resistance (MDR), extensive drug resistance (XDR), and pandrug resistance (PDR).
Characterization of microbial community and antibiotic resistome in intra urban water, Wenzhou China.
The study identified several antimicrobial resistance genes (ARGs) in urban water samples from Wenzhou, China, including intI1, tetA, ermA, ermB, qnrB, sul1, sul2, blaSHV, and blaCTX-M. These genes were found to be associated with different bacterial species and were linked to resistance against various antibiotics such as tetracyclines, erythromycin, fluoroquinolones, sulfonamides, and beta-lactams.
The evolutionary mechanism of non-carbapenemase carbapenem-resistant phenotypes in Klebsiella spp.
The study identified bla DHA-1 as a critical gene for carbapenem resistance in K. quasipneumoniae FK688, and showed that its loss leads to decreased resistance. Other resistance genes such as qnrB4, tetA[B], arr-3, dfrA27, aadA16, qacΔE1, and sul1 were also found on the pNAR1 plasmid.
From Farm to Fork: Persistence of Clinically Relevant Multidrug-Resistant and Copper-Tolerant Klebsiella pneumoniae Long after Colistin Withdrawal in Poultry Production.
The study identified silA and pcoD genes associated with copper tolerance in Klebsiella pneumoniae isolates from poultry, and numerous chromosomal mutations linked to colistin resistance.
Role of a typical swine liquid manure treatment plant in reducing elements of antibiotic resistance.
The study identified and characterized several antibiotic resistance genes (ARGs) in swine wastewater treatment plants, including blaTEM, ermB, qnrB, sul1, and tetA, which were found to be present in the raw wastewater and showed significant reductions after anaerobic digestion.
Genome-Based Epidemiologic Analysis of VIM/IMP Carbapenemase-Producing Enterobacter spp., Poland.
The study identified multiple bla VIM and bla IMP genes, along with various other AMR genes, in VIM/IMP carbapenemase-producing Enterobacter spp. in Poland. These genes were associated with different integrons and plasmid types, contributing to the spread of multidrug-resistant strains.
Case of Extensively Drug-Resistant Shigella sonnei Infection, United States
The study reports a case of extensively drug-resistant Shigella sonnei infection in an immunocompromised patient, highlighting the challenge of identifying XDR strains using traditional microbiological methods and emphasizing the need for whole-genome sequencing for accurate diagnosis. The isolate exhibited resistance to all first-line antimicrobials, including ciprofloxacin, azithromycin, and ceftriaxone, and carried several AMR genes such as blaCTX-M-27, qnrB19, mph(A), sul1, sul2, dfrA1, dfrA17, and tet(A).
Quinolone resistance and biofilm formation capability of uropathogenic Escherichia coli isolates from an Iranian inpatients' population.
The study identified qnrS and qnrB genes as contributors to quinolone resistance in uropathogenic Escherichia coli isolates from Iranian inpatients, with notable resistance rates to fluoroquinolones and quinolones.
Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
The study identified various AMR genes in multidrug-resistant Gram-negative pathogens, highlighting the prevalence of bla CTX-M-15, bla CMY-42, bla NDM-5, aadA, bla TEM-1B, bla OXA-232, bla NDM-1, rmtB, rmtC, bla VEB, bla VIM-2, aph(3'), strA/B, bla OXA-23, aph (3′), catB, dfrB, bla VIM-2, fosA, oqxA, oqxB, bla OXA-23, bla CARB, bla OXA-91, bla OXA-51, bla PAO, bla SHV, aph (3′)-Ib, aph (6)-Id, mphE, msrE, ermB, mphA, aadA, rmtB, qnrB, dfrA, sul1, sul2, and fosA7.
Comparing antimicrobial resistant genes and phenotypes across multiple sequencing platforms and assays for Enterobacterales clinical isolates.
The study compared antimicrobial resistance genes and phenotypes across different sequencing platforms and assays for Enterobacterales clinical isolates, highlighting the detection of various AMR genes such as blaKPC-2, qnrB, oqxA, oqxB, sul1, sul2, drfA*, aac(3)-IIe, and blaCTX-M-1, which conferred resistance to multiple antibiotics.
Molecular characterization of PMQR carrying bacteriophages in effluent discharge samples of Azerbaijan hospitals.
The study identified PMQR genes (qnrB, qnrD, qnrA, and qnrC) in bacteriophages and bacterial isolates from hospital effluent samples in Azerbaijan, highlighting the role of generalized transduction in the spread of quinolone resistance.
Prevalence and molecular characterization of cefotaxime-resistant Salmonella strains recovered from retail meat samples in Shenzhen, China, during 2014-2017.
The study identified several beta-lactamase genes, including bla CTX-M-14, bla CTX-M-55, bla CTX-M-65, bla CTX-M-130, bla CTX-M-27, and bla CMY-2, as well as other resistance genes such as qnrS1, qnrB6, mph(A), oqxAB, mcr-1.1, tet(A), tet(B), sul1, sul2, sul3, aac(6')-Ib, aph(3")-Ib, floR, drfA14, drfA1, and Inu(F), which contribute to cefotaxime resistance in Salmonella strains isolated from retail meat samples in Shenzhen, China.
Various arrangements of mobile genetic elements among CC147 subpopulations of Klebsiella pneumoniae harboring bla(NDM-1): a comparative genomic analysis of carbapenem resistant strains.
The study identified bla(NDM-1), bla(OXA-48), qnrS1, aac(6')-Ib-cr, armA, bla(CTX-M-15), sul1, dfrA, aadA5, and qnrB1 as key resistance genes in CC147 subpopulations of Klebsiella pneumoniae. Additionally, a mutation in ompK36 was found to contribute to decreased susceptibility to antibiotics.
Genetic Diversity and Antimicrobial Resistance of Extraintestinal E. coli Populations Pre- and Post-Antimicrobial Therapy on Broilers Affected by Colisepticemia.
The study identified several AMR genes and mutations in extraintestinal E. coli populations from broilers treated with enrofloxacin. Key findings include the presence of qnrB19 and qnrS1 genes, which confer fluoroquinolone resistance, and mutations in gyrA, parC, and parE genes associated with fluoroquinolone resistance. Additionally, multiple other AMR genes were detected, indicating multidrug resistance.
High Prevalence of Plasmid-Mediated Quinolone Resistance among ESBL/AmpC-Producing Enterobacterales from Free-Living Birds in Poland.
The study identifies the qnrB19 gene as a prevalent plasmid-mediated quinolone resistance gene among ESBL/AmpC-producing Enterobacterales isolated from free-living birds in Poland.
High Levels of Antibiotic Resistance in MDR-Strong Biofilm-Forming Salmonella Typhimurium ST34 in Southern China.
The study identifies multiple AMR genes and mutations in Salmonella Typhimurium ST34, including gyrA, parC, oqxAB, aac(6')-Ib-cr, qnrB, bla TEM, bla CTX-M, bla OXA, mcr-1, and bla NDM-5, highlighting the high levels of antibiotic resistance and biofilm formation in this strain.
Multidrug resistance pattern and molecular epidemiology of pathogens among children with diarrhea in Bangladesh, 2019-2021.
The study identified various AMR genes including blaTEM, qnrB, mcr-1, sxt, and tetA in E. coli, V. cholerae, Salmonella spp., and Shigella spp. These genes conferred resistance to cephalosporins, quinolones, colistin, cotrimoxazole, and tetracycline, highlighting the emergence of multidrug-resistant pathogens among children with diarrhea in Bangladesh.
Clonal expansion and rapid characterization of Klebsiella pneumoniae ST1788, an otherwise uncommon strain spreading in Wales, UK.
The study identified several AMR genes in Klebsiella pneumoniae ST1788, including blaSHV-232, blaCTX-M-15, blaCTX-M-266, blaOXA-1, blaTEM-1, aac(3')-lla, aac(6')-lb-cr, strA, strB, qnrB1, dfrA14, sul2, and blaOXA-48. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, trimethoprim, sulfamethoxazole, and carbapenems.
Outbreak of OXA-232-producing carbapenem-resistant Klebsiella pneumoniae ST15 in a Chinese teaching hospital: a molecular epidemiological study.
The study identified the presence of multiple AMR genes, including blaOXA-232, blaCTX-M-15, blaSHV-28, fosA, oqxA, oqxB, tet(E), AAC(6')-Ib, APH(3'')-Ib, APH(6)-Id, TEM-1, sul2, QnrB17, QnrB1, dfrA14, arr-2, AAC(6')-Ib9, and rmtF, in OXA-232-producing CRKP isolates from a hospital outbreak in China.
Outbreak of OXA-232-producing carbapenem-resistant Klebsiella pneumoniae ST15 in a Chinese teaching hospital: a molecular epidemiological study.
The study identified the presence of multiple AMR genes, including blaOXA-232, blaCTX-M-15, blaSHV-28, fosA, oqxA, oqxB, tet(E), AAC(6')-Ib, APH(3'')-Ib, APH(6)-Id, TEM-1, sul2, QnrB17, QnrB1, dfrA14, arr-2, AAC(6')-Ib9, and rmtF, in OXA-232-producing CRKP isolates from a hospital outbreak in China.
Genomic characterization of colistin-resistant Klebsiella pneumoniae isolated from intensive care unit patients in Egypt.
The study identifies mcr-1.1 as a plasmid-mediated colistin resistance gene and characterizes several chromosomal mutations in mgrB, arnT, pmrA, pmrB, pmrC, phoQ, and arnB that contribute to colistin resistance in K. pneumoniae isolates from Egypt.
Characterization of Transferrable Mechanisms of Quinolone Resistance (TMQR) among Quinolone-resistant Escherichia coli and Klebsiella pneumoniae causing Urinary Tract Infection in Nepalese Children.
The study identified aac(6')-Ib-cr, qnrB, and qnrS as the most prevalent TMQR genes among quinolone-resistant E. coli and K. pneumoniae isolates in Nepalese children, contributing to increased ciprofloxacin resistance.
Antibiotic Resistance Mediated by Escherichia coli in Kuwait Marine Environment as Revealed through Genomic Analysis.
The study identified various antibiotic resistance genes in Escherichia coli isolates from Kuwait's marine environment, including beta-lactamases, aminoglycoside-modifying enzymes, fluoroquinolone resistance genes, sulfonamide resistance genes, tetracycline resistance genes, and macrolide resistance genes. Additionally, the MFS-type drug efflux gene mdfA was commonly found in E. coli isolates.
Antibiotic Resistance Mediated by Escherichia coli in Kuwait Marine Environment as Revealed through Genomic Analysis.
The study identified various antibiotic resistance genes in Escherichia coli isolates from Kuwait's marine environment, including beta-lactamases, aminoglycoside-modifying enzymes, fluoroquinolone resistance genes, sulfonamide resistance genes, tetracycline resistance genes, and macrolide resistance genes. Additionally, the MFS-type drug efflux gene mdfA was commonly found in E. coli isolates.
Polyclonal Multidrug ESBL-Producing Klebsiella pneumoniae and Emergence of Susceptible Hypervirulent Klebsiella pneumoniae ST23 Isolates in Mozambique.
The study identified multiple AMR genes in Klebsiella isolates, including bla CTX-M-15, bla TEM-1, bla SHV, and bla OXA-1, which confer resistance to beta-lactams. Other genes like aac(3)-IIa, aac(6')-Ib-cr, qnrB1, qnrB6, catA1, catA2, catB3, dfrA5, dfrA7, dfrA12, dfrA14, dfrA27, sul1, sul2, mph(A), tet(A), tet(D), fosA, ARR-3, and oqxAB were also found, contributing to resistance against aminoglycosides, quinolones, chloramphenicol, trimethoprim, sulfamethoxazole, macrolides, tetracycline, fosfomycin, rifampicin, and quinolones respectively. Mutations in ompK36, ompK37, and acrR were associated with resistance to cephalosporins and fluoroquinolones, while mutations in RamR were linked to tigecycline resistance.
Polyclonal Multidrug ESBL-Producing Klebsiella pneumoniae and Emergence of Susceptible Hypervirulent Klebsiella pneumoniae ST23 Isolates in Mozambique.
The study identified multiple AMR genes in Klebsiella isolates, including bla CTX-M-15, bla TEM-1, bla SHV, and bla OXA-1, which confer resistance to beta-lactams. Other genes like aac(3)-IIa, aac(6')-Ib-cr, qnrB1, qnrB6, catA1, catA2, catB3, dfrA5, dfrA7, dfrA12, dfrA14, dfrA27, sul1, sul2, mph(A), tet(A), tet(D), fosA, ARR-3, and oqxAB were also found, contributing to resistance against aminoglycosides, quinolones, chloramphenicol, trimethoprim, sulfamethoxazole, macrolides, tetracycline, fosfomycin, rifampicin, and quinolones respectively. Mutations in ompK36, ompK37, and acrR were associated with resistance to cephalosporins and fluoroquinolones, while mutations in RamR were linked to tigecycline resistance.
Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract Infections: The Molecular Basis for Challenges to Effective Treatment.
This review discusses the molecular basis of challenges to effective treatment of UPEC-associated urinary tract infections, focusing on virulence factors and antibiotic resistance mechanisms.
Genomic Analysis of Multidrug-Resistant Escherichia coli Strains Isolated in Tamaulipas, Mexico.
The study identified multiple antimicrobial resistance genes (ARGs) in multidrug-resistant E. coli strains isolated from human clinical, animal, and environmental sources in Tamaulipas, Mexico. These genes include beta-lactamases (bla CTX-M-15, bla OXA-1, bla TEM-1B, bla CMY-2), aminoglycoside resistance genes (aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aadA5, aac3-IIa), sulfonamide resistance genes (sul2, sul3), phenicol resistance gene (catB3), tetracycline resistance genes (tet(A), tet(B)), quaternary ammonium resistance genes (qacE, qacL), macrolide resistance genes (mdfA, mphA), and quinolone resistance gene (qnrB).
Unveiling the genome of a high-risk pandrug-resistant Klebsiella pneumoniae emerging in the Brazilian Amazon Region, 2022.
The study identified a pandrug-resistant Klebsiella pneumoniae strain (Kp196) with a complex resistome comprising numerous acquired and intrinsic resistance mechanisms, including multiple beta-lactamases, aminoglycoside-modifying enzymes, quinolone resistance proteins, and mutations in genes involved in colistin, tigecycline, and fluoroquinolone resistance.
Evaluation of antibiotic resistance, toxin-antitoxin systems, virulence factors, biofilm-forming strength and genetic linkage of Escherichia coli strains isolated from bloodstream infections of leukemia patients.
The study identified bla CTX-M, bla TEM, bla SHV, bla OXA-48, qnr B, and qnr S genes as the main contributors to antibiotic resistance in E. coli strains isolated from bloodstream infections of leukemia patients.
High prevalence of antibiotic resistance and biofilm formation in Salmonella Gallinarum.
The study identified multiple antibiotic resistance genes in Salmonella Gallinarum isolates, including GES, IMP, VIM, NDM, SHV, KPC, FOX, qnrB, qnrS, and sdiA, which are associated with resistance to various antibiotics. Additionally, all isolates were found to form biofilms, indicating a potential link between biofilm formation and antibiotic resistance.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Study of heavy metal resistance genes in Escherichia coli isolates from a marine ecosystem with a history of environmental pollution (arsenic, cadmium, copper, and mercury).
The study identified several heavy metal resistance genes (HMRGs) in Escherichia coli isolates from a marine ecosystem with a history of environmental pollution, highlighting the prevalence of these genes and their potential interactions with antibiotic resistance genes.
Resistome and virulome of high-risk pandemic clones of multidrug-resistant extra-intestinal pathogenic Escherichia coli (ExPEC) isolated from tertiary healthcare settings in Uganda.
The study identified various AMR genes in multidrug-resistant E. coli isolates, including blaCTX-M-15, blaTEM-1B, blaOXA-1, and others, which confer resistance to beta-lactams, aminoglycosides, sulfonamides, tetracyclines, macrolides, and quinolones. Additionally, chromosomal mutations in gyrA and parC were found to contribute to fluoroquinolone resistance.
Polyinfection in Fish Aeromoniasis: A Study of Co-Isolated Aeromonas Species in Aeromonas veronii Outbreaks.
The study identified the tetracycline resistance gene tetE and the quinolone resistance gene qnrB in Aeromonas salmonicida AG2.13.2 and Aeromonas rivipollensis AG2.13.5, indicating their resistance to tetracycline, oxytetracycline, and quinolones.
A One Health approach based on genomics for enhancing the Salmonella enterica surveillance in Colombia.
The study identified various AMR genes in Salmonella enterica serovars, including qnrB81, aph_6, sul2, tetA, blaCMY_2, qnrB19, aac_3_IV, blaLEN_15, aph4_la, aadA1, blaTEM_95, qnrB82, and mcr-5.1, which confer resistance to quinolones, aminoglycosides, sulfonamides, tetracyclines, beta-lactams, and colistin.
A One Health approach based on genomics for enhancing the Salmonella enterica surveillance in Colombia.
The study identified various AMR genes in Salmonella enterica serovars, including qnrB81, aph_6, sul2, tetA, blaCMY_2, qnrB19, aac_3_IV, blaLEN_15, aph4_la, aadA1, blaTEM_95, qnrB82, and mcr-5.1, which confer resistance to quinolones, aminoglycosides, sulfonamides, tetracyclines, beta-lactams, and colistin.
A One Health approach based on genomics for enhancing the Salmonella enterica surveillance in Colombia.
The study identified various AMR genes in Salmonella enterica serovars, including qnrB81, aph_6, sul2, tetA, blaCMY_2, qnrB19, aac_3_IV, blaLEN_15, aph4_la, aadA1, blaTEM_95, qnrB82, and mcr-5.1, which confer resistance to quinolones, aminoglycosides, sulfonamides, tetracyclines, beta-lactams, and colistin.
Genomic characterization of tigecycline-resistant Escherichia coli and Klebsiella pneumoniae isolates from hospital sewage.
The study identifies tet(X4) and tmexCD1-toprJ1 as key genes contributing to tigecycline resistance in E. coli and K. pneumoniae isolates from hospital sewage, highlighting the role of plasmid-mediated resistance and efflux pump overexpression.
Prevalence and genomic characterization of Salmonella isolates from commercial chicken eggs retailed in traditional markets in Ghana.
The study identified several AMR genes and mutations in Salmonella isolates from chicken eggs in Ghana, including aadA1, aph(3")-Ib, aph(6)-Id, catA1, dfrA1, dfrA14, fosA7.2, qnrB19, sul1, sul2, and tet(A), as well as mutations in gyrA (D87N) and gyrA (S83Y).
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
The study identified multiple AMR genes and mutations in ESBL-producing E. coli and K. pneumoniae isolates from bulk tank milk, highlighting the presence of multidrug-resistant strains with resistance to beta-lactams, fluoroquinolones, aminoglycosides, and tetracyclines.
The phylogenomic landscape of extended-spectrum β-lactamase producing Citrobacter species isolated from surface water.
The study identified several β-lactamase genes, including bla-CMY-101, bla-CMY-59, and bla-CMY-77, as well as the quinolone resistance gene qnrB13, in Citrobacter species isolated from surface water. These genes were found to confer resistance to various antibiotics, highlighting the potential public health risks posed by these multidrug-resistant strains.
Gut microbiome and antibiotic resistance effects during travelers' diarrhea treatment and prevention.
The study found that twice-daily rifaximin prophylaxis significantly increased antibiotic resistance gene (ARG) abundance in the gut microbiome, while other treatment groups showed no significant changes. Several ARGs, including blaTEM-1, mdtM, sul2, aph(6)-Id, aph(3")-Ib, erm(B), mph(A), qepA4, qnrB19, qnrS1, and arr, were identified in E. coli isolates from the TrEAT TD cohort.
The secrets of environmental Pseudomonas aeruginosa in slaughterhouses: Antibiogram profile, virulence, and antibiotic resistance genes.
The study identified multiple antibiotic resistance genes in Pseudomonas aeruginosa isolates from slaughterhouses, including blaCTX-M, blaAmpC, blaSHV, blaNDM, IMP-1, aac(6')-Ib, ant(4')IIb, qnrB, tetA, mexY, TEM, and rmtC. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, and tetracyclines.
Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients.
The study characterizes various AMR genes, including bla CTX-M-15, bla TEM-1B, bla OXA-1, qnrB1, qnrS1, aph(6)-Id, aph(3”)-Ib, aac(3)-IIa, ant(3”)-Ia, dfrA14, dfrA1, aac(6’)-Ib-cr, tet(A), tet(D), sul2, sul1, fosA6, fosA_5, fosA_3, bla CTX-M-1, bla CTX-M-14, bla CTX-M-14b, bla CTX-M-8, bla CMY-2, bla TEM-190, aac(3)-IVa, aph(4)-Ia, and catB3_2, in ESBL-producing Enterobacterales isolates from long-term colonized patients.
Serovars, Virulence and Antimicrobial Resistance Genes of Non-Typhoidal Salmonella Strains from Dairy Systems in Mexico.
Resistance to aminoglycoside and quinolone drugs among Klebsiella pneumoniae clinical isolates from northern Jordan.
The study identified several aminoglycoside-modifying enzymes and plasmid-mediated quinolone resistance genes in K. pneumoniae isolates from northern Jordan, including aac(6')-Ib, aac(3')-II, ant(3")-I, aph(3')-VI, armA, rmtB, qnrS, qnrB, oqxAB, and aac(6')-Ib-cr. These genes were significantly associated with non-susceptibility to aminoglycosides, quinolones, and beta-lactams.
Characteristics of antimicrobial resistance in Escherichia coli isolated from retail meat products in North Carolina.
The study identified several AMR genes in E. coli isolates from retail meat products in North Carolina, including aac(3)-IV, aadA1, aph(3'')-lb, blaTEM-1, tetB, and others, highlighting the prevalence of multidrug-resistant E. coli in ground turkey.
Mechanism for transmission and pathogenesis of carbapenem-resistant Enterobacterales harboring the carbapenemase IMP and clinical countermeasures.
The study identifies blaIMP-4 and blaIMP-26 as carbapenemase genes responsible for carbapenem resistance in Enterobacterales. Additionally, various other AMR genes such as aac(6')-lb3, armAC, aph(3'')-lb, aph(6)-ld, aadA5, aac(6')-llc, aac(3)-IId, dfrA19, dfrA1, sul1, tet(D), tet(A), qnrS1, qnrB4, msr(E), mph(E), ere(A), mph(A), mcr-9, and ARR-3 were characterized for their roles in resistance to different antibiotics.
Genotypic Characterization of Uropathogenic Escherichia coli from Companion Animals: Predominance of ST372 in Dogs and Human-Related ST73 in Cats.
The study identified several AMR genes and mutations in uropathogenic E. coli isolates from companion animals, including blaTEM-1B, sul2, tet(A), qnrS1, aac(6')-Ib-c, qnrS2, qnrB19, qnrB4, CTX-M-15, CTX-M-27, CMY-2, DHA-1, blaEC, blaEC-6, and mcr-4.6. Mutations in gyrA (S83L, D87N) and parC (S80I) were also found to confer fluoroquinolone resistance.
Genotypic Characterization of Uropathogenic Escherichia coli from Companion Animals: Predominance of ST372 in Dogs and Human-Related ST73 in Cats.
The study identified several AMR genes and mutations in uropathogenic E. coli isolates from companion animals, including blaTEM-1B, sul2, tet(A), qnrS1, aac(6')-Ib-c, qnrS2, qnrB19, qnrB4, CTX-M-15, CTX-M-27, CMY-2, DHA-1, blaEC, blaEC-6, and mcr-4.6. Mutations in gyrA (S83L, D87N) and parC (S80I) were also found to confer fluoroquinolone resistance.
Rare serovars of non-typhoidal Salmonella enterica isolated from humans, beef cattle and abattoir environments in Nigeria.
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.
Genomic insights into ESBL-producing Escherichia coli isolated from non-human primates in the Peruvian Amazon.
The study identified three bla CTX-M variants (bla CTX-M-15, bla CTX-M-55, and bla CTX-M-65) and a broad resistome in ESBL-producing E. coli strains isolated from non-human primates in the Peruvian Amazon.
Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
The study identified various antimicrobial resistance genes and mutations in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain, highlighting the presence of multidrug-resistant strains and the role of plasmids in the dissemination of resistance mechanisms.
Fate of fluoroquinolones in field soil environment after incorporation of poultry litter from a farm with enrofloxacin administration via drinking water.
The study identified the presence of fluoroquinolone resistance genes in poultry litter and soil samples after the incorporation of poultry litter from a farm where enrofloxacin was administered via drinking water.
Whole genome sequence-based molecular characterization of blood isolates of carbapenem-resistant Enterobacter cloacae complex from ICU patients in Kolkata, India, during 2017-2022: emergence of phylogenetically heterogeneous Enterobacter hormaechei subsp. xiangfangensis.
The study identified several carbapenemase and extended-spectrum beta-lactamase genes, including bla NDM-1, bla NDM-4, bla NDM-5, bla NDM-7, bla OXA-181, bla OXA-232, bla KPC-3, bla CTX-M-15, bla SFO-1, bla ACT, and bla CMH-3, in carbapenem-resistant Enterobacter cloacae complex isolates from Kolkata, India. Novel integrons (In180, In4874, In4887, and In4888) were also discovered.
Polymyxin Resistance in Salmonella: Exploring Mutations and Genetic Determinants of Non-Human Isolates.
The study identified mutations in pmrA, pmrB, phoP, and phoQ associated with polymyxin resistance in Salmonella isolates, as well as other resistance genes such as aac(6')-Iaa, blaTEM-1, blaCTX-M-2, blaCMY-2, qnrB19, qnrS1, oqxA, and oqxB.
Distribution and genetic characterization of fluoroquinolone resistance gene qnr among Salmonella strains from chicken in China.
The study identified the qnrS and qnrB genes as the primary fluoroquinolone resistance genes in Salmonella strains from chicken in China, with qnrS being more prevalent. The genetic environments of these genes were characterized, highlighting their potential for horizontal gene transfer.
Genomic insights and antimicrobial resistance profiles of CRKP and non-CRKP isolates in a Beijing geriatric medical center: emphasizing the bla(KPC-2) carrying high-risk clones and their spread.
The study identifies blaKPC-2 as a key gene in carbapenem resistance among CRKP isolates, along with other resistance genes such as rmtB, APH(3')-Ia, and QnrB4. It also highlights the prevalence of ST11-KL47-OL101 clones and the role of plasmid pKpnR03_2 in the spread of resistance.
Isolation, Identification, Antimicrobial Resistance, Genotyping, and Whole-Genome Sequencing Analysis of Salmonella Enteritidis Isolated from a Food-Poisoning Incident.
The study identified multiple antimicrobial resistance genes in Salmonella Enteritidis strain 21A, including aac(6')-Iaa, blaTEM-1, qnrB, floR, tetA, sul1, and sul2, which conferred resistance to various antibiotics such as aminoglycosides, beta-lactams, quinolones, tetracyclines, and sulfonamides.
Gut diversity and the resistome as biomarkers of febrile neutropenia outcome in paediatric oncology patients undergoing hematopoietic stem cell transplantation.
The study identifies several antibiotic-resistance genes associated with febrile neutropenia in pediatric oncology patients undergoing hematopoietic stem cell transplantation, including msr(C), dfrG, erm(T), VanHAX, aac(6')-Ib, aph(3')-III, ant(6)-Ia, and aac(6')-Ii.
Emergence of carbapenem resistant gram-negative pathogens with high rate of colistin resistance in Egypt: A cross sectional study to assess resistance trends during the COVID-19 pandemic.
The study identified high prevalence of carbapenem resistance in Gram-negative pathogens in Egypt, with bla NDM and bla OXA-48-like being the most prevalent carbapenemase genes. Plasmid-mediated quinolone resistance genes qnrS and qnrB were also detected. Additionally, several aminoglycoside resistance genes and integron-associated gene cassettes were characterized.
Outbreak of NDM-5-producing Klebsiella pneumoniae ST307: an emerging high-risk antimicrobial resistance clone in Shanghai, China.
The study reports an outbreak of NDM-5-producing Klebsiella pneumoniae ST307 in Shanghai, China, highlighting the presence of multiple resistance genes including bla NDM-5, bla CTX-M-15, and bla DHA-1, which confer resistance to carbapenems, cephalosporins, and other antibiotics.
Outbreak of NDM-5-producing Klebsiella pneumoniae ST307: an emerging high-risk antimicrobial resistance clone in Shanghai, China.
The study reports an outbreak of NDM-5-producing Klebsiella pneumoniae ST307 in Shanghai, China, highlighting the presence of multiple resistance genes including bla NDM-5, bla CTX-M-15, and bla DHA-1, which confer resistance to carbapenems, cephalosporins, and other antibiotics.
Molecular characterization of Aeromonas hydrophila detected in Channa marulius and Sperata sarwari sampled from rivers of Punjab in Pakistan.
The study identified several AMR genes in Aeromonas hydrophila isolates from fish samples, including tetA, blaTEM, qnrA, qnrB, sul1, and sul3, indicating multidrug resistance.
Genomic analysis of Salmonella isolated from canal water in Bangkok, Thailand.
The study identified 35 AMR genes and 30 chromosomal-mediated gene mutations in Salmonella strains from Bangkok canal water, highlighting the presence of multidrug-resistant strains with resistance to various antimicrobial classes.
Comparison of genotypic and phenotypic antimicrobial resistance profiles of Salmonella enterica isolates from poultry diagnostic specimens.
The study identified 31 AMR genes in 97 Salmonella enterica isolates from poultry, including aac(3)-IId, aac(3)-IVa, aac(3)-VIa, aac(6′)-Ib4, ant(2′′)-Ia, grdA, aph(3′)-Ia, aph(3′)-IIa, aadA1, aadA2, aadA7, aadA13, aph(3′)-Ib, aph(6)-Ic, aph(6)-Id, aph(4)-Ia, blaCMY-2, blaCTX-M-1, blaHER-3, blaTEM-1, floR, tetA, tetB, tetC, dfrA12, sul1, sul2, fosA7, qnrB19, ble, and mcr-9.
Development of an in vitro biofilm model for the study of the impact of fluoroquinolones on sewer biofilm microbiota.
The study identified the presence of qnrA, qnrB, qnrD, and qnrS genes in in vitro biofilms, which contribute to fluoroquinolone resistance. Additionally, mutations in gyrA (S83L) and parC (S80I) were observed in response to high concentrations of fluoroquinolones.
Exploring the resistome, virulome, and mobilome of multidrug-resistant Klebsiella pneumoniae isolates: deciphering the molecular basis of carbapenem resistance.
The study identifies multiple antibiotic resistance genes, including bla CTX-M-15, bla TEM, bla SHV, bla NDM, bla OXA, and others, contributing to carbapenem resistance in Klebsiella pneumoniae isolates. Mutations in porin genes ompK35 and ompK36, as well as in gyrA and parC, are associated with reduced susceptibility to carbapenems and fluoroquinolones.
Heterogeneous Antibiotic Resistance Gene Removal Impedes Evaluation of Constructed Wetlands for Effective Greywater Treatment.
The study identifies several antibiotic resistance genes (ARGs) in greywater and filter bed samples, including blaTEM, sul1, intI1, tetG, tetW, and others, indicating the presence of resistance to beta-lactams, sulfonamides, tetracyclines, and other antibiotics. The research highlights the variability in ARG removal efficiency by constructed wetlands and the potential for ARG proliferation in treated greywater.
Resistome Analysis of Klebsiella pneumoniae Complex from Residential Aged Care Facilities Demonstrates Intra-facility Clonal Spread of Multidrug-Resistant Isolates.
The study identified several AMR genes and mutations in K. pneumoniae isolates from RACFs, including beta-lactamases (bla DHA-1, bla SHV-1, bla SHV-27, bla CTX-M-14), fluoroquinolone resistance determinant qnrB4, and trimethoprim-sulfamethoxazole resistance determinants dfrA17 and sul1. Mutations in ompK35, ompK37, prmA, pmrB, eptA, and parC were also found to contribute to resistance.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are genetically related but distinct from those causing prostatic abscesses.
The study identifies multiple AMR genes and mutations in multidrug-resistant E. coli strains causing infections in dogs and cats, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla CMY-2, bla CMY-148, aac(6')-Ib-cr, qnrS1, qnrB6, aadA2, aadA5, aadA16, ant(3′′)-Ia, aph(3′)-Ia, aph(3′′)-Ib, aph(6)-Id, rmtB, floR, cmlA, catA, sul1, sul2, sul3, dfrA12, dfrA14, dfr17, dfrA27, tet(A), tet(B), tet(M), mph(A), erm(B), lnu(F), and arr-3, as well as the gyrA:p.S83L mutation.
Study of plasmid mediated quinolone resistance genes among Escherichia coli and Klebsiella pneumoniae isolated from pediatric patients with sepsis.
The study identified high prevalence of plasmid-mediated quinolone resistance (PMQR) genes qnrA, qnrB, and qnrS among E. coli and K. pneumoniae isolates from pediatric patients with sepsis, with qnrA being the most prevalent.
Bacterial dynamics of the plastisphere microbiome exposed to sub-lethal antibiotic pollution.
The study identifies the ciprofloxacin resistance gene aac(6')-Ib-cr and the gentamicin resistance gene aac(6')-IIc, along with the plasmid-borne ciprofloxacin resistance gene qnrB, in the plastisphere microbiome under sub-lethal antibiotic exposure.
Bacterial dynamics of the plastisphere microbiome exposed to sub-lethal antibiotic pollution.
The study identifies the ciprofloxacin resistance gene aac(6')-Ib-cr and the gentamicin resistance gene aac(6')-IIc, along with the plasmid-borne ciprofloxacin resistance gene qnrB, in the plastisphere microbiome under sub-lethal antibiotic exposure.
Phagosomal granulocytic ROS in septic patients induce the bacterial SOS response.
The study identifies qnrB2 as a quinolone resistance gene induced by the bacterial SOS response in septic patients, highlighting the link between immune responses and antibiotic resistance development.
Occurrence and genomic characterization of antimicrobial-resistant and potential pathogenic Escherichia coli from Italian artisanal food productions of animal origin.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia coli isolates from Italian artisanal food products, including beta-lactamases, aminoglycoside-modifying enzymes, trimethoprim resistance genes, macrolide resistance genes, quinolone resistance proteins, sulfonamide resistance proteins, and tetracycline resistance genes. These genes were primarily carried on plasmids and contributed to multidrug resistance.
Plasmid-mediated quinolone resistance in Escherichia coli isolates from commercial broiler chickens in Semnan, Iran.
The study identified the presence of plasmid-mediated quinolone resistance (PMQR) genes, namely aac(6')-Ib-cr, qnrB, and qnrS, in E. coli isolates from broiler chickens in Iran. These genes were associated with resistance to quinolone antibiotics.
Four novel Acinetobacter lwoffii strains isolated from the milk of cows in China with subclinical mastitis.
Four Acinetobacter lwoffii strains were isolated from the milk of cows with subclinical mastitis in China. These strains exhibited multidrug resistance and carried 17 resistance genes, including beta-lactamase, aminoglycoside-modifying, fluoroquinolone, tetracycline, sulfonamide, and chloramphenicol resistance genes.
Emergence of Plasmid-Mediated Quinolone Resistance (PMQR) Genes in Campylobacter coli in Tunisia and Detection of New Sequence Type ST13450.
This study reports the first occurrence of plasmid-mediated quinolone resistance (PMQR) genes in Campylobacter coli isolates in Tunisia and globally. The PMQR genes qnrB, qnrS, qepA, and aac(6')-Ib-cr were detected in a significant proportion of isolates, highlighting the emergence of these resistance mechanisms in C. coli.
Whole-Genome Analysis of Extensively Drug-Resistant Enterobacter hormaechei Isolated from a Patient with Non-Hodgkin's Lymphoma.
The study identifies an extensively drug-resistant Enterobacter hormaechei ST90 clone carrying multiple resistance genes, including bla CTX-M-15, bla GES-2, bla TEM-1A, bla OXA-1, bla NDM-1, and bla ACT-15, along with genes encoding resistance to aminoglycosides, quinolones, sulfonamides, chloramphenicol, fosfomycin, and other antibiotics.
Whole-Genome Analysis of Extensively Drug-Resistant Enterobacter hormaechei Isolated from a Patient with Non-Hodgkin's Lymphoma.
The study identifies an extensively drug-resistant Enterobacter hormaechei ST90 clone carrying multiple resistance genes, including bla CTX-M-15, bla GES-2, bla TEM-1A, bla OXA-1, bla NDM-1, and bla ACT-15, along with genes encoding resistance to aminoglycosides, quinolones, sulfonamides, chloramphenicol, fosfomycin, and other antibiotics.
Comparative genomics of quinolone-resistant Escherichia coli from broilers and humans in Norway.
The study identified mutations in the gyrA and parC genes as the primary mechanism of quinolone resistance in Escherichia coli isolates from both broilers and humans in Norway. Additionally, plasmid-mediated quinolone resistance genes such as qnrS1, qnrB19, aac(6')-Ib-cr, qnrB1, and qnrB5 were detected in human isolates.
Comparative genomics of quinolone-resistant Escherichia coli from broilers and humans in Norway.
The study identified mutations in the gyrA and parC genes as the primary mechanism of quinolone resistance in Escherichia coli isolates from both broilers and humans in Norway. Additionally, plasmid-mediated quinolone resistance genes such as qnrS1, qnrB19, aac(6')-Ib-cr, qnrB1, and qnrB5 were detected in human isolates.
Comparative genomics of quinolone-resistant Escherichia coli from broilers and humans in Norway.
The study identified mutations in the gyrA and parC genes as the primary mechanism of quinolone resistance in Escherichia coli isolates from both broilers and humans in Norway. Additionally, plasmid-mediated quinolone resistance genes such as qnrS1, qnrB19, aac(6')-Ib-cr, qnrB1, and qnrB5 were detected in human isolates.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
Molecular Characterization and Antibacterial Resistance Determination of Escherichia coli Isolated from Fresh Raw Mussels and Ready-to-Eat Stuffed Mussels: A Major Public Health Concern.
The study identified several AMR genes in E. coli isolates from mussels, including tetB, sul1, sul2, floR, qnrA, and qnrB, which confer resistance to tetracycline, sulfonamides, chloramphenicol, and fluoroquinolones.
Investigation of plasmid-mediated quinolone resistance among extended-spectrum β-lactamase isolates of E. coli and K. pneumoniae.
The study identified several plasmid-mediated quinolone resistance genes, including qnrS, qnrC, qnrD, qnrB, and qnrVC, in extended-spectrum β-lactamase-producing E. coli and K. pneumoniae isolates.
Assessing the Public Health Implications of Virulent and Antibiotic-Resistant Bacteria in Côte d'Ivoire's Ready-to-Eat Salads.
The study identified antibiotic resistance genes such as blaTEM, qnrA, qnrB, qnrS, and mecA in E. coli and S. aureus isolates from ready-to-eat salads in Côte d'Ivoire, highlighting the challenge of multidrug resistance.
Antimicrobial resistance profiles and genome characteristics of Klebsiella isolated from the faeces of neonates in the neonatal intensive care unit.
The study identified multiple antimicrobial resistance genes in Klebsiella isolates from neonates in the NICU, including bla NDM-1, bla CTX-M-15, bla SHV-67, aac(6')-Ib-cr, aadA16, aph(3'')-Ib, and others. These genes confer resistance to various antibiotics such as carbapenems, cephalosporins, aminoglycosides, and fluoroquinolones. Additionally, the study found a multidrug-resistant Klebsiella pneumoniae strain carrying several resistance genes and plasmids.
Evolution of the Antibiotic Resistance Levels, Multi-Resistance Patterns, and Presence of Antibiotic Resistance Genes in E. coli Isolates from the Feces of Breeding Hens during the Rearing Period.
The study identified several antibiotic resistance genes in E. coli isolates from breeding hens, including bla TEM, bla SHV, qnr B, and bla CMY-2. These genes were associated with resistance to various antibiotics, and their prevalence varied across different stages of hen rearing.
Carriage Rate of Enterobacterales Resistant to Extended-Spectrum Cephalosporins in the Tunisian Population.
The study identified bla CTX-M-15 and bla DHA-1 as the primary genes conferring resistance to extended-spectrum cephalosporins in Enterobacterales isolated from healthy Tunisian individuals. Additional resistance mechanisms included aminoglycoside, sulfonamide, tetracycline, and quinolone resistance genes.
Phylogenetics and Mobilization of Genomic Traits of Cephalosporin-Resistant Escherichia coli Originated from Retail Meat.
The study identified multiple AMR genes in cephalosporin-resistant E. coli from retail meat, including bla CTX-M-1, bla SHV-12, bla CMY-2, and others, highlighting the role of mobile genetic elements in the spread of resistance.
An in-depth study on survival mechanism of bacterial isolates in disinfectants within the hospital environment.
The study identified multiple AMR genes, including blaDIM-1, qacE, and various efflux pump genes, in bacterial isolates from hospital disinfectants, indicating their adaptation to survive in disinfectant environments.
An in-depth study on survival mechanism of bacterial isolates in disinfectants within the hospital environment.
The study identified multiple AMR genes, including blaDIM-1, qacE, and various efflux pump genes, in bacterial isolates from hospital disinfectants, indicating their adaptation to survive in disinfectant environments.
Genomic Characteristics of a Carbapenem-Resistant Klebsiella pneumoniae Co-Carrying bla (NDM-5) and bla (KPC-2) Capsular Type KL25 Recovered from a County Level Hospital in China.
The study reports the genomic characteristics of a multidrug-resistant ST11 Klebsiella pneumoniae isolate SM117 with capsular serotype KL25, co-carrying bla NDM-5, two copies of bla KPC-2, and multiple plasmid-borne virulence genes. The isolate shows resistance to all antibiotics except polymyxin.
Genetic landscape of ESBL producing international clone ST410 of Escherichia coli from pediatric infections in Shenzhen, China.
The study identifies multiple ESBL genes, including bla CTX-M, bla TEM, and bla SHV, along with other resistance genes such as bla OXA-1, bla KPC-2, bla NDM-1, and others, contributing to multidrug resistance in E. coli ST410 isolates from pediatric infections in Shenzhen, China.
Detection of Salmonella Mbandaka Carrying the bla(CTX-M-8) Gene Located on IncI1 Plasmid Isolated from a Broiler Flock Environment.
Comprehensive Genomic Analysis of Uropathogenic E. coli: Virulence Factors, Antimicrobial Resistance, and Mobile Genetic Elements.
The study identified numerous antimicrobial resistance genes and mutations in uropathogenic E. coli isolates, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and quinolone resistance genes. Mutations in gyrA, parC, parE, and marR were associated with fluoroquinolone resistance, while mutations in PmrB, CyaA, GlpT, PtsI, and UhpT were linked to fosfomycin resistance.
Investigation on the mechanisms of carbapenem resistance among the non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae.
The study identified non-carbapenemase β-lactamase genes and chromosomal mutations, including missense mutation or loss of ompK36 porin and frameshift missense mutation in efflux pump systems, as potential mechanisms of carbapenem resistance in NC-CRKP.
Investigation on the mechanisms of carbapenem resistance among the non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae.
The study identified non-carbapenemase β-lactamase genes and chromosomal mutations, including missense mutation or loss of ompK36 porin and frameshift missense mutation in efflux pump systems, as potential mechanisms of carbapenem resistance in NC-CRKP.
Investigation on the mechanisms of carbapenem resistance among the non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae.
The study identified non-carbapenemase β-lactamase genes and chromosomal mutations, including missense mutation or loss of ompK36 porin and frameshift missense mutation in efflux pump systems, as potential mechanisms of carbapenem resistance in NC-CRKP.
Genomic Characterization of 16S rRNA Methyltransferase-Producing Enterobacterales Reveals the Emergence of Klebsiella pneumoniae ST6260 Harboring rmtF, rmtB, bla(NDM-5), bla(OXA-232) and bla(SFO-1) Genes in a Cancer Hospital in Bulgaria.
The study identifies the emergence of Klebsiella pneumoniae ST6260 harboring multiple AMR genes, including rmtF, rmtB, bla(NDM-5), bla(OXA-232), and bla(SFO-1), highlighting the complexity of resistance mechanisms in Enterobacterales.
Genomic Characterization of 16S rRNA Methyltransferase-Producing Enterobacterales Reveals the Emergence of Klebsiella pneumoniae ST6260 Harboring rmtF, rmtB, bla(NDM-5), bla(OXA-232) and bla(SFO-1) Genes in a Cancer Hospital in Bulgaria.
The study identifies the emergence of Klebsiella pneumoniae ST6260 harboring multiple AMR genes, including rmtF, rmtB, bla(NDM-5), bla(OXA-232), and bla(SFO-1), highlighting the complexity of resistance mechanisms in Enterobacterales.
Genomic Characterization of 16S rRNA Methyltransferase-Producing Enterobacterales Reveals the Emergence of Klebsiella pneumoniae ST6260 Harboring rmtF, rmtB, bla(NDM-5), bla(OXA-232) and bla(SFO-1) Genes in a Cancer Hospital in Bulgaria.
The study identifies the emergence of Klebsiella pneumoniae ST6260 harboring multiple AMR genes, including rmtF, rmtB, bla(NDM-5), bla(OXA-232), and bla(SFO-1), highlighting the complexity of resistance mechanisms in Enterobacterales.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Distribution and Molecular Characterization of Antibiotic-Resistant Pseudomonas aeruginosa in Hospital Settings of Sulaymaniyah, Iraq.
The study identified the presence of bla CTX-M, bla SHV, qnr B, and bla ACC-1 genes among P. aeruginosa isolates, indicating the presence of multiple antibiotic resistance mechanisms.
Genomic characterization of a clonal emergent Salmonella Minnesota lineage in Brazil reveals the presence of a novel megaplasmid of resistance and virulence.
The study identifies multidrug resistance genes such as bla CMY-2, sul2, tet (A), and qnrB19 in a clonal emergent Salmonella Minnesota lineage in Brazil, along with a novel megaplasmid pESM carrying resistance and virulence factors.
Biofilm Formation and Plasmid-Mediated Quinolone Resistance Genes at Varying Quinolone Inhibitory Concentrations in Quinolone-Resistant Bacteria Superinfecting COVID-19 Inpatients.
The study identified plasmid-mediated quinolone resistance genes aac(6')-Ib-cr, qnrB, qnrS, and qnrA in various bacterial isolates from COVID-19 patients, highlighting their role in quinolone resistance and biofilm formation.
Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81.
The study identifies qnrB, qnrS, aac(6')-Ib-cr, and the novel allele qnrB81 as plasmid-mediated quinolone resistance genes in E. coli isolates. Mutations in the QRDRs of gyrA and parC contribute to fluoroquinolone resistance.
Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81.
The study identifies qnrB, qnrS, aac(6')-Ib-cr, and the novel allele qnrB81 as plasmid-mediated quinolone resistance genes in E. coli isolates. Mutations in the QRDRs of gyrA and parC contribute to fluoroquinolone resistance.
Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81.
The study identifies qnrB, qnrS, aac(6')-Ib-cr, and the novel allele qnrB81 as plasmid-mediated quinolone resistance genes in E. coli isolates. Mutations in the QRDRs of gyrA and parC contribute to fluoroquinolone resistance.
Multidrug-resistant ESBL-producing Klebsiella pneumoniae complex in Czech hospitals, wastewaters and surface waters.
The study identified multidrug-resistant Klebsiella pneumoniae complex isolates carrying various beta-lactamase genes such as bla CTX-M-15, bla GES-51, bla OXA-48, bla NDM-1, and bla KPC-3, along with other resistance genes like oqxA, oqxB, sul2, aph(6)-Id, dfr14, qnrB1, and aac(6')-Ib-cr.
Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients.
The study identified multiple AMR genes and mutations in multidrug-resistant Shigella strains, including beta-lactamases, macrolide resistance genes, quinolone resistance genes, and chromosomal mutations contributing to fluoroquinolone resistance.
The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes.
The study characterizes various resistance genes carried by incompatible plasmids in Gram-negative bacteria, highlighting their role in the spread of antibiotic resistance. Key genes include beta-lactamases like bla VIM-1, bla SHV-12, bla TEM-1B, and bla CTX-M-15, as well as sulfonamide resistance genes sul1 and sul2, tetracycline resistance gene tetA, and polymyxin resistance gene mcr-1.
Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307.
The study identifies the colistin resistance gene mcr-8.1 in multidrug-resistant Klebsiella pneumoniae ST307 isolates from Armenia, highlighting the emergence of this gene in the region.
Exploring the genomic and antimicrobial resistance tapestry: comparative insights into Salmonella enterica serotypes Agona, Braenderup, Muenchen, and Panama in Latin American surface waters.
The study identifies several AMR genes, including fosA7.2, qnrB19, aadA1, floR, sat2, tet(B), and tet(A), in Salmonella enterica serotypes Agona, Braenderup, Muenchen, and Panama from Latin American surface waters, highlighting the prevalence of multidrug resistance in these isolates.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Pandemic one health clones of Escherichia coli and Klebsiella pneumoniae producing CTX-M-14, CTX-M-27, CTX-M-55 and CTX-M-65 ESβLs among companion animals in northern Ecuador.
The study identifies CTX-M-55, CTX-M-65, CTX-M-27, and CTX-M-14 ESβL-producing E. coli and K. pneumoniae in companion animals in Ecuador, highlighting their global One Health significance and the need for surveillance programs.
Highly drug resistant clone of Salmonella Kentucky ST198 in clinical infections and poultry in Zimbabwe.
The study identifies multiple AMR genes and mutations in Salmonella Kentucky ST198 strains from Zimbabwe, highlighting their multidrug resistance and the presence of specific resistance mechanisms such as blaCTX-M-14.1 and mutations in gyrA and parC.
Phenotypic and genotypic characterization of antimicrobial resistance and virulence profiles of Salmonella enterica serotypes isolated from necropsied horses in Kentucky.
The study identified several AMR genes in Salmonella enterica isolates from necropsied horses, including beta-lactamase genes (blaTEM, blaCTX-M, blaSHV2, blaOXA-9), aminoglycoside resistance gene (aacA[3]), sulfonamide resistance gene (sul2), amphenicol resistance gene (floR), tetracycline resistance gene (tetB), streptomycin resistance gene (strA), macrolide resistance gene (ermB2), and quinolone resistance gene (qnrB2). These genes were associated with resistance to multiple antibiotics, highlighting the presence of multidrug-resistant Salmonella strains.
Detection of Delafloxacin Resistance Mechanisms in Multidrug-Resistant Klebsiella pneumoniae.
Multiple mutations in quinolone-resistance-determining regions (QRDRs), along with OqxAB and AcrAB efflux pumps, contribute to delafloxacin resistance in multidrug-resistant Klebsiella pneumoniae. Specific mutations in gyrA and parC, as well as plasmid-encoded qnrS1, qnrB1, and aac(6')-Ib-cr, were identified as key resistance mechanisms.
The Difference a Year Can Make: How Antibiotic Resistance Mechanisms in Pseudomonas aeruginosa Have Changed in Northwestern Transylvania.
The study identified an increase in multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates in Northwestern Transylvania, Romania, between 2022 and 2023. Key AMR genes included bla OXA-50, sul1, ermB, mexA, mexB, bla VIM-1, aac(6′)-II, ant(4′)-Ia, aac(3)-I, aac(6′)-Im, aph(2″)-Ib, tetA, tetC, tetK, qnrB, ermC, mphC, fosA, nfsA, nfsB, ampC, and TEM-1.
Assessment of Antibiotic Resistance Among Isolates of Klebsiella spp. and Raoultella spp. in Wildlife and Their Environment from Portugal: A Positive Epidemiologic Outcome.
The study identified a single multidrug-resistant (MDR) and extended-spectrum beta-lactamase (ESBL)-producing K. pneumoniae isolate from soil samples carrying multiple resistance genes, including bla CTX-M-15, bla TEM-1, bla SHV-28, bla OXA-1, qnr B1, oqx A, oqx B19, aac (6′)-Ibcr, sul 2, dfr A14, tet A, aph (6)-Id, aph (3″)-Ib, acr D, cat B3, and Int I1.
Potential links between human bloodstream infection by Salmonella enterica serovar Typhimurium and international transmission to Colombia.
The study identified qnrB19 and floR as key AMR genes in Colombian S. Typhimurium isolates, contributing to quinolone and chloramphenicol resistance, respectively.
Evaluation of the resistome and gut microbiome composition of hospitalized patients in a health unit of southern Brazil coming from a high animal husbandry production region.
The study identified a high prevalence of aminoglycoside and tetracycline resistance genes, including aph(3')-IIIa, ermB, mcr-1, qnrB19, and tetQ, in hospitalized patients from a high animal husbandry region. Unique resistance genes and mutations, such as dfrF and gyrB, were noted at discharge.
Tracing the evolution: the rise of Salmonella Thompson co-resistant to clinically important antibiotics in China, 1997-2020.
The study identifies the IncC plasmid as a major driver of co-resistance to ciprofloxacin, cefotaxime, and azithromycin in Salmonella Thompson isolates in China, with specific resistance genes including qnrS1, qepA4, blaCMY-2, and mph(A).
The rise in domestic shigellosis and the genomic characteristics of Shigella clones linked to men who have sex with men in Taiwan, 2015‒2022.
The study identifies several AMR genes and mutations in Shigella clones associated with men who have sex with men (MSM) in Taiwan, highlighting the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains.
Characterization of Klebsiella pneumoniae Isolates Resistant to Cefiderocol from Hospitals and Outpatient Settings in Croatia.
The study characterizes AMR genes in FDC-resistant K. pneumoniae isolates, identifying bla OXA-48, bla KPC, bla NDM, bla CTX-M, aac(6')-Ib, aadA1, aadA2, qnrB, shv, and tem as significant contributors to resistance.
Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.
This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.
Molecular characterization of resistance and biofilm genes of ESKAPE pathogens isolated from clinical samples: examination of the effect of boric acid on biofilm ability by cell culture method.
The study identified various AMR genes in ESKAPE pathogens, including vanA and vanC for vancomycin resistance, blaKPC and blaOXA-48 for carbapenem resistance, and others related to tetracycline, sulfonamide, quinolone, and aminoglycoside resistance. Additionally, biofilm-related genes such as icaA, icaD, gelE, asa1, and esp were detected in Staphylococcus and Enterococcus spp. Quorum sensing genes LasI and LasR were found in Pseudomonas aeruginosa, and biofilm production genes like mrkA, wbbM, wzm, and luxS were identified in Klebsiella pneumoniae.
Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
The study identified various AMR genes and mutations in Salmonella Enteritidis isolates from Spain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and aminoglycoside resistance genes. Chromosomal mutations in the gyrA gene were also found to contribute to quinolone resistance.
Carbapenem-Resistant, Virulence Plasmid-Harboring Klebsiella pneumoniae, United States.
The study identifies six pVir-CRKP isolates from the United States, highlighting their multidrug resistance and enhanced virulence traits. These isolates exhibit resistance to various antibiotics, including carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, due to the presence of specific AMR genes and mutations.
Whole-Genome Sequencing of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Isolated from Human Bloodstream Infections.
The study identified multiple AMR genes in ESBL-producing K. pneumoniae isolates, including blaCTX-M-15, blaKPC-3, and others conferring resistance to β-lactams, aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and chloramphenicol.
Whole-Genome Sequencing of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Isolated from Human Bloodstream Infections.
The study identified multiple AMR genes in ESBL-producing K. pneumoniae isolates, including blaCTX-M-15, blaKPC-3, and others conferring resistance to β-lactams, aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and chloramphenicol.
Antimicrobial and Metal Resistance Genes in Bacteria Isolated from Mine Water in Austria.
The study identified a variety of antimicrobial and metal resistance genes in bacteria isolated from mine water in Austria, highlighting the prevalence of multidrug efflux pumps and beta-lactamase genes. It also noted the presence of specific metal resistance genes such as ruvB, copA, recGM, and mgtA, as well as co-resistance genes like arsBM, acrD, and the mer operon.
Antimicrobial and Metal Resistance Genes in Bacteria Isolated from Mine Water in Austria.
The study identified a variety of antimicrobial and metal resistance genes in bacteria isolated from mine water in Austria, highlighting the prevalence of multidrug efflux pumps and beta-lactamase genes. It also noted the presence of specific metal resistance genes such as ruvB, copA, recGM, and mgtA, as well as co-resistance genes like arsBM, acrD, and the mer operon.
Polyclonal carbapenemase-producing Escherichia coli in Northern Italy: the emergence of NDM-7.
The study identifies the emergence of NDM-7 in polyclonal carbapenemase-producing E. coli in Northern Italy, highlighting the presence of various carbapenemase genes such as bla KPC-3, bla VIM-1, and bla NDM-7, along with other resistance genes.
Polyclonal carbapenemase-producing Escherichia coli in Northern Italy: the emergence of NDM-7.
The study identifies the emergence of NDM-7 in polyclonal carbapenemase-producing E. coli in Northern Italy, highlighting the presence of various carbapenemase genes such as bla KPC-3, bla VIM-1, and bla NDM-7, along with other resistance genes.
Comprehensive genomic epidemiology and antimicrobial resistance profiles of clinical Klebsiella pneumoniae species complex isolates from a tertiary hospital in Wenzhou, China (2019-2021).
The study identified a variety of antimicrobial resistance genes in clinical Klebsiella pneumoniae species complex isolates, including bla KPC−2, bla CTX−M, bla SHV, aac(6')-Ib, aadA1, aadA2, aph(3')-Ia, oqxAB, qnrB19, qnrS1, tet(A), tet(D), sul1, sul2, sul3, cmlA1, floR, fosA, and fosA3. These genes confer resistance to multiple classes of antibiotics, highlighting the complexity of antimicrobial resistance in these isolates.
Whole-genome-based characterization of Escherichia albertii strains isolated from paediatric diarrhoeal cases in Kolkata, India.
The study identified several antimicrobial resistance genes in Escherichia albertii isolates, including beta-lactamases (bla CTX-M-55, bla TEM-105), quinolone resistance genes (qnrS1, qnrB32), sulfonamide resistance gene (sul2), tetracycline resistance genes (tetA, tetR), and trimethoprim resistance gene (dfrA1).
Genomic Characterization of NDM-1 Harboring Extensively-Drug Resistance Klebsiella pneumoniae Isolate From ICU-Admitted Patient With COVID-19.
The study identified multiple antimicrobial resistance genes in an extensively drug-resistant Klebsiella pneumoniae isolate, including bla NDM-1, armA, msrE, mphE, BRP, bla OXA-1, aadA2, dfrA12, qnrB1, bla CTX-M-15, and cat1, highlighting the complex resistance mechanisms in this isolate.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?
The study identified multiple antibiotic resistance genes in clinical Klebsiella pneumoniae isolates, including bla TEM, bla SHV, bla CTX-M, and bla OXA families, as well as aminoglycoside, fluoroquinolone, and sulfonamide resistance genes. Effluent isolates showed fewer resistance genes and lower resistance levels compared to clinical isolates.
Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?
The study identified multiple antibiotic resistance genes in clinical Klebsiella pneumoniae isolates, including bla TEM, bla SHV, bla CTX-M, and bla OXA families, as well as aminoglycoside, fluoroquinolone, and sulfonamide resistance genes. Effluent isolates showed fewer resistance genes and lower resistance levels compared to clinical isolates.
Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?
The study identified multiple antibiotic resistance genes in clinical Klebsiella pneumoniae isolates, including bla TEM, bla SHV, bla CTX-M, and bla OXA families, as well as aminoglycoside, fluoroquinolone, and sulfonamide resistance genes. Effluent isolates showed fewer resistance genes and lower resistance levels compared to clinical isolates.
The First Case of Antimicrobial-Resistant Salmonella Stanley ST29 Diagnosed Secondary to Acute Cholecystitis.
The study identifies multiple antimicrobial resistance genes in Salmonella Stanley ST29, including beta-lactamases, quinolone resistance genes, macrolide resistance genes, and others, contributing to resistance against various antibiotics.
Mapping Antimicrobial Resistance in Escherichia coli and Klebsiella pneumoniae from Complicated Urinary Tract Infections in Oman: Phenotypic and Genotypic Insights.
The study identified blaDHA-1 as the predominant AmpC gene in E. coli and blaOXA-232 and blaNDM-5 as the primary carbapenemases in K. pneumoniae. Additionally, various other resistance genes such as blaCTX-M-15, blaOXA-1, blaTEM-1B, qnrB4, aac(6')-Ib, and armA were characterized.
Antimicrobial Resistance in Nigeria: A Comprehensive Review of Environmental, Food, and Clinical Impacts
The study identifies several AMR genes, including bla CTX-M-15, floR, and various tetracycline and sulfonamide resistance genes, highlighting the spread of multidrug-resistant bacteria in Nigeria's environment, food supply chain, and clinical settings.
Molecular characterization of multidrug-resistant E. coli recovered from diarrheagenic children under 5 years from Mukuru Informal Settlement, Nairobi, Kenya, based on whole-genome sequencing analysis.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from diarrheagenic children in Nairobi, Kenya, highlighting the presence of blaTEM-1B, blaCTX-M-15, qnrS1, qnrB4, aac(6')-Ib-cr, and other resistance mechanisms.
Rapid whole genome sequencing for AMR surveillance in low- and middle-income countries: Oxford Nanopore Technology reveals multidrug-resistant Enterobacter cloacae complex from dairy farms in Sri Lanka.
The study identified multiple AMR genes in multidrug-resistant Enterobacter isolates from dairy farms in Sri Lanka, including blaCMH-1, blaACT-25, blaCTX-M-15, blaOXA-1, blaTEM-1, blaNDM-4, and blaNDM-15, highlighting the presence of carbapenem-resistant Enterobacterales and the need for improved AMR surveillance in low-resource settings.
Antimicrobial resistance and genetic diversity of Escherichia coli isolated from marine bivalves.
The study identified several AMR genes in E. coli isolates from marine bivalves, including bla TEM, bla CTX-M9, bla SHV, bla CTX-M2, bla CTX-M8/25, qnrS, qnrB, sul1, and sul2. These genes were associated with resistance to various antibiotics, highlighting the role of marine environments in the dissemination of AMR.
Clonal dissemination and persistence of Carbapenem-resistant bla (KPC-2) harbouring Klebsiella pneumoniae ST307 in a Tertiary Hospital in the Republic of Korea.
Prevalence and molecular characterisation of multi-drug resistant ST11 hypervirulent Klebsiella pneumoniae in a teaching hospital.
The study identifies several AMR genes in CRKP strains, including bla KPC-2, bla NDM-1, bla VIM, bla SHV-12, bla TEM-1b, aac(6')-Ib-cr, qnrS, qnrB, rmtB, ant(3'')-I, armA, sul1, sul2, iucA, iutA, iroN, ybtS, mrkD, fimH, and p rmpA. These genes confer resistance to carbapenems, quinolones, aminoglycosides, and sulfonamides. Additionally, the study highlights the transferability of these genes through conjugation.
Multidrug-resistant Klebsiella pneumoniae ST70 harboring bla(NDM) in a migratory Penguin.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Klebsiella pneumoniae ST70 isolate from a Magellanic Penguin, highlighting the potential of migratory penguins as vectors of antimicrobial-resistant microorganisms.
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Plasmid diversity in Klebsiella pneumoniae ST307 co-producing KPC plus NDM recovered during the COVID-19 pandemic.
The study characterizes the plasmid diversity in Klebsiella pneumoniae ST307 isolates co-producing KPC and NDM carbapenemases, identifying multiple resistance genes and plasmid types involved in carbapenem resistance.
Antimicrobial resistance and virulence gene profiles of Escherichia coli isolated from poultry farms using One Health perspective in Abeokuta, Nigeria.
The study identified 30 different resistance determinants in 14 whole genome sequenced E. coli isolates from poultry farms in Abeokuta, Nigeria. These included genes such as blaTEM-1B, blaCARB-2, aph(3'')-Ib, aph(6)-Id, floR, sul1, sul2, tet(A), and tet(B), among others, which conferred resistance to various antimicrobial classes.
Implications of gene expression heterogeneity in the interplay between acquired resistance and bacterial metabolism.
The study identifies and characterizes various AMR genes, including aac(6')-Ib-cr, bla OXA-48, bla KPC-3, qnrB1, and fosA, highlighting their expression heterogeneity influenced by nutrient availability and antimicrobial stress.
Biofilm Formation and Antibiotic Resistance Genes of Escherichia coli From Poultry Farms and Clinical Samples.
The study identified several AMR genes in E. coli isolates from poultry and clinical samples, including blaTEM, gyrA, gyrB, qnrB, qnrB4, qnrS, blaCTX-M, sul1, sul2, tetA, and tetB. These genes conferred resistance to various antibiotics such as beta-lactams, fluoroquinolones, sulfonamides, and tetracyclines. High levels of resistance were observed against tylosin, neomycin, tetracycline, ampicillin, doxycycline, ciprofloxacin, and trimethoprim/sulfamethoxazole.
Biofilm Formation and Antibiotic Resistance Genes of Escherichia coli From Poultry Farms and Clinical Samples.
The study identified several AMR genes in E. coli isolates from poultry and clinical samples, including blaTEM, gyrA, gyrB, qnrB, qnrB4, qnrS, blaCTX-M, sul1, sul2, tetA, and tetB. These genes conferred resistance to various antibiotics such as beta-lactams, fluoroquinolones, sulfonamides, and tetracyclines. High levels of resistance were observed against tylosin, neomycin, tetracycline, ampicillin, doxycycline, ciprofloxacin, and trimethoprim/sulfamethoxazole.
Determination of Phylogroups, Pathotypes and Antibiotic Resistance Profiles of E. coli Isolates from Freshwater and Wastewater in the City of Panama.
The study identified the qnrB19 gene as a major contributor to quinolone resistance in E. coli isolates from the Matasnillo River and detected chromosomal mutations in gyrA, parC, and parE genes in quinolone-resistant isolates from both the river and wastewater treatment plant.
Genomic characterization of a multidrug-resistant Citrobacter portucalensis isolate co-harboring bla (KPC-2) and bla (NDM-1) on distinct plasmids.
The study identifies a multidrug-resistant Citrobacter portucalensis isolate co-harboring bla KPC-2 and bla NDM-1 on distinct plasmids, along with additional resistance genes on the chromosome and plasmids, highlighting the potential for horizontal gene transfer and the need for enhanced surveillance.
Epidemiological and biological characteristics of IncR plasmids as multihost antibiotic resistance carriers.
The study characterizes various AMR genes carried by IncR plasmids, highlighting their role in the dissemination of resistance to carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, and tetracyclines.
Epidemiological and biological characteristics of IncR plasmids as multihost antibiotic resistance carriers.
The study characterizes various AMR genes carried by IncR plasmids, highlighting their role in the dissemination of resistance to carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, and tetracyclines.
Tracking Enterobacteria, microbiomes, and antibiotic resistance genes from waste to soil with repeated compost applications.
The study identifies several AMR genes including bla CTX-M, bla TEM-1B, bla SHV-12, qnr A, qnr B, aac(6')-Ib, sul 1, sul 2, intI 1, and intI 2 in Enterobacteria from composts and raw waste, highlighting their persistence and potential spread in tropical soils.
Stenotrophomonas tuberculopleuritidis sp. nov., a novel pathogenic Stenotrophomonas species isolated from tuberculous pleurisy patient.
The study identifies multiple antibiotic resistance genes in Stenotrophomonas tuberculopleuritidis sp. nov., including beta-lactamases, aminoglycoside resistance genes, and efflux pump genes, highlighting its multidrug-resistant nature and potential clinical significance.
Clonal Dissemination of Pandrug-Resistant Klebsiella pneumoniae ST392KL27 in a Tertiary Care Hospital in Mexico.
The investigation of bacteria in the oral of Trichomonas gallinae infected pigeons and the antibiotic resistance analysis of Klebsiella pneumoniae clinical isolates from farm pigeons in Shandong Province of China.
The study identified multiple antibiotic resistance genes in Klebsiella pneumoniae isolates from farm pigeons in Shandong Province, including bla-SHV, bla-TEM, bla-CTX-M-9, qnrB, tetA, and aac(6')-Ib, highlighting the presence of multidrug-resistant strains.
An NGS-assisted diagnostic workflow for culture-independent detection of bloodstream pathogens and prediction of antimicrobial resistances in sepsis.
The study evaluated the diagnostic performance of PISTE™ technology, an NGS-based workflow for detecting bloodstream pathogens and predicting antimicrobial resistance. It showed high accuracy in identifying pathogens and predicting resistance genes, including beta-lactamases, carbapenemases, aminoglycoside modifying enzymes, tetracycline efflux pumps, and quinolone resistance proteins.
Molecular Characteristics of Epidemiologically Successful Salmonella Enteritidis in Poland.
The study identified several AMR genes and mutations in Salmonella Enteritidis strains, including qnrB19, blaTEM-1, blaTEM-135, tet(A), sul2, and mutations in gyrA (S83Y, D87Y, S83F, S464Y).
Dissemination dynamics of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones.
The study characterizes the dissemination of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones in Enterobacter species, highlighting their co-occurrence with other resistance genes and their global distribution.
Phenotypic and Molecular Study of Multidrug-Resistant Escherichia coli Isolates Expressing Diverse Resistance and Virulence Genes from Broilers in Tunisia.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from broilers in Tunisia, including bla CTX-M-G1, bla TEM, bla SHV, bla OXA-48, bla IMP, mcr-1, aadA-1, aadA-5, aac(6)-Ib-cr, qnrS, and qnrB.
Multidrug-Resistant pESI-Harboring Salmonella enterica Serovar Muenchen Sequence Type 82 in Poultry and Humans, Israel, 2020-2023.
Characteristics of quinolone resistance in Escherichia coli isolated from wildlife in Poland.
Characterization of plasmid-mediated quinolone resistant genes among uropathogenic Escherichia coli isolates in Bushehr, south of Iran.
The study identified qnrS and qnrB genes as significant contributors to quinolone resistance in uropathogenic Escherichia coli isolates from Bushehr, Iran. These genes were associated with resistance to various quinolone antibiotics.
Antibiotic resistance in white stork cloaca and environmental samples
The study identified various antibiotic resistance genes in bacterial isolates from white stork cloaca and environmental samples, highlighting the presence of resistance mechanisms against beta-lactams, aminoglycosides, quinolones, and polymyxins.
Whole-genome sequencing reveals Enterobacter hormaechei as a key bloodstream pathogen in six tertiary care hospitals in southwestern Nigeria.
The study identifies several AMR genes in Enterobacter hormaechei and Enterobacter cloacae, including bla ACT-45, bla CTX-M-15, bla NDM-1, dfrA14, mcr10.1, aac(3)-Ile, aph(3′)-Ib, qnrB1, sul1, sul2, tet(A), catA1, and mphA, highlighting the prevalence of multidrug resistance in these species.
Resistance, virulence and genetic diversity of Salmonella Typhimurium in South Africa (1999-2021).
The study identified several AMR genes in Salmonella Typhimurium isolates from South Africa, including beta-lactamases (bla PSE, bla CMY-2, bla TEM, bla SHV), sulfonamide resistance genes (sul1, sul2, sul3), fluoroquinolone resistance genes (qnrA, qnrB, qnrS), tetracycline resistance genes (tetA, tetB), and trimethoprim resistance genes (dfrXI, dfrXII).
Persistent multispecies dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital.
The study identifies the persistent dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital, highlighting the role of these plasmids in the spread of aminoglycoside resistance.
Analysis of the microbial spectrum of urinary tract infections and antibiotic resistance of UPEC in Central Inner Mongolia, China.
The study identifies mutations in GyrA and ParC genes, along with PMQR genes such as qnrS, qnrB, and qepA, as major contributors to levofloxacin resistance in UPEC strains in Central Inner Mongolia, China.
Surface water as a source of rare Salmonella enterica serovars in semiarid northeastern Brazil.
The study identified several antimicrobial resistance genes in rare Salmonella enterica serovars isolated from surface water in semiarid northeastern Brazil, including mdsA, mdsB, aac(6')-Iaa, parC:p.T57S, qnrB19, and fosA7, which conferred resistance to various antibiotics such as gentamicin, ciprofloxacin, and fosfomycin.
Molecular genetic portrait of virulence and ciprofloxacin resistance genes in clinical Pseudomonas aeruginosa Isolates from Khartoum, Sudan.
The study identified the prevalence of ciprofloxacin resistance genes (gyrA, parC, qnrA, qnrB, qnrS) in Pseudomonas aeruginosa isolates from Khartoum, Sudan, and found a strong association between these genes and ciprofloxacin resistance.
Global genomic survey of Salmonella Kentucky: discovery of a chromosomeborne bla(NDM-5) and the emergence of ST314, an MDR clone mediated by the IncR plasmid.
The study discovered a chromosome-borne bla(NDM-5) gene in Salmonella Kentucky and identified the IncR plasmid as a key mediator of antimicrobial resistance in the MDR clone ST314.
Molecular characterization of extended spectrum beta lactamase producing Escherichia coli in two different wastewater treatment plants in Hatay Province, Türkiye.
The study identified several extended spectrum beta lactamase (ESBL) genes, including bla CTX-M, bla CTX-M-15, bla CTX-M-55, bla CTX-M-1, bla CTX-M-3, bla TEM, and bla CMY-2, in ESBL-producing Escherichia coli isolates from wastewater treatment plants in Hatay Province, Türkiye. Additionally, quinolone resistance genes such as aac(6)-Ib, qnrA, and qnrB, and disinfectant resistance genes like qacEΔ1, ydgE, ydgF, mdfA, emrE, sugE(c), and sugE(p) were also detected.
Pathogenic potential of amoxicillin-clavulanic acid resistant Klebsiella pneumoniae isolated from aquatic environment: a study of multidrug resistance and virulence.
The study identified several AMR genes in AMC-resistant K. pneumoniae isolates from aquatic environments, including bla TEM, bla SHV, bla CTX-M, bla NDM, bla OXA-48, bla CMY, qnr S, qnr B, tet A, tet B, sul 1, dfr A12, intl 1, intl 2, mrk D, ecp A, and iuc C. These genes were associated with resistance to multiple antibiotics, highlighting the complex resistance profiles of these isolates.
Pathogenic potential of amoxicillin-clavulanic acid resistant Klebsiella pneumoniae isolated from aquatic environment: a study of multidrug resistance and virulence.
The study identified several AMR genes in AMC-resistant K. pneumoniae isolates from aquatic environments, including bla TEM, bla SHV, bla CTX-M, bla NDM, bla OXA-48, bla CMY, qnr S, qnr B, tet A, tet B, sul 1, dfr A12, intl 1, intl 2, mrk D, ecp A, and iuc C. These genes were associated with resistance to multiple antibiotics, highlighting the complex resistance profiles of these isolates.
Genetic diversity and antimicrobial resistance profiles of Salmonella enterica in the broiler supply chain in Harare, Zimbabwe: tracking transmission from farm to table.
The study identified several AMR genes and mutations in Salmonella enterica isolates from the broiler supply chain in Zimbabwe, including fosA7.2, qnrB19, aadA1, aph(3'')-Ib, aph(6)-Id, aac(3)-Id, fosA3, sul1, sul3, tetA, cmlA1, blaCMY-2, blaTEM-1B, blaCTX-M-14, and mutations in gyrA and parC. These genes and mutations confer resistance to various antibiotics, including fosfomycin, fluoroquinolones, aminoglycosides, sulfonamides, tetracyclines, chloramphenicol, and beta-lactams.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Assessing the Genomic Landscape of Salmonella enterica Isolated From Cattle Faeces on a Nigerian Farm.
The study identified AMR genes in Salmonella enterica isolates from cattle faeces, including aph(3')-Id, aph(6)-Id, qnrB19, sul2, tet(A), and fosA7, which confer resistance to aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and fosfomycin.
Genomic epidemiology of strains currently and formerly classified as Enterobacter spp. recovered from equine necropsy samples.
The study identified several AMR genes in Enterobacter spp. strains, including beta-lactamases (blaDHA-1, blaOXA-1, blaSHV-12, blaTEM-1B), aminoglycoside resistance genes (aac(6')-ib_cr), quinolone resistance genes (qnrB2, qnrB4), and fosfomycin resistance genes (fosA, fosA2). These genes contribute to resistance against multiple antibiotic classes.
Genomic epidemiology of strains currently and formerly classified as Enterobacter spp. recovered from equine necropsy samples.
The study identified several AMR genes in Enterobacter spp. strains, including beta-lactamases (blaDHA-1, blaOXA-1, blaSHV-12, blaTEM-1B), aminoglycoside resistance genes (aac(6')-ib_cr), quinolone resistance genes (qnrB2, qnrB4), and fosfomycin resistance genes (fosA, fosA2). These genes contribute to resistance against multiple antibiotic classes.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
Genomic characterization of Klebsiella pneumoniae clinical isolates from cancer patients: resistance profiles, virulence factors, and sequence typing.
The study identified several AMR genes in K. pneumoniae isolates from cancer patients, including genes conferring resistance to trimethoprim-sulfamethoxazole, tobramycin, levofloxacin, and carbapenems. Key resistance genes included sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA27, aadA16, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aph(4)-Ia, ACC(3)-IId, ACC(3)-IIV, AAC(6')-Ib-cr, QnrS1, QnrB17, QnrB20, QnrB4, CTX-M, SHV, TEM, DHA-1, LAP-2, bla_kpc-1, bla_ndm-5, and bla_oxa-10.
Genomic characterization of Klebsiella pneumoniae clinical isolates from cancer patients: resistance profiles, virulence factors, and sequence typing.
The study identified several AMR genes in K. pneumoniae isolates from cancer patients, including genes conferring resistance to trimethoprim-sulfamethoxazole, tobramycin, levofloxacin, and carbapenems. Key resistance genes included sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA27, aadA16, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aph(4)-Ia, ACC(3)-IId, ACC(3)-IIV, AAC(6')-Ib-cr, QnrS1, QnrB17, QnrB20, QnrB4, CTX-M, SHV, TEM, DHA-1, LAP-2, bla_kpc-1, bla_ndm-5, and bla_oxa-10.
Genomic characterization of Klebsiella pneumoniae clinical isolates from cancer patients: resistance profiles, virulence factors, and sequence typing.
The study identified several AMR genes in K. pneumoniae isolates from cancer patients, including genes conferring resistance to trimethoprim-sulfamethoxazole, tobramycin, levofloxacin, and carbapenems. Key resistance genes included sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA27, aadA16, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aph(4)-Ia, ACC(3)-IId, ACC(3)-IIV, AAC(6')-Ib-cr, QnrS1, QnrB17, QnrB20, QnrB4, CTX-M, SHV, TEM, DHA-1, LAP-2, bla_kpc-1, bla_ndm-5, and bla_oxa-10.
Multidrug resistant hypervirulent ST307 clone from genomic surveillance of extended spectrum beta-lactamase-producing Klebsiella pneumoniae species complex in East Africa.
The study identifies multiple AMR genes, including blaCTX-M-15, blaTEM-1D, aac(6')-Ib-cr, aadA16, strB, qnrS1, sul2, sul1, catII.2, tet(A), dfrA14, arr-3, and mphA, in ESBL-KpSC isolates from East Africa, highlighting the prevalence of multidrug resistance.
Multidrug resistant hypervirulent ST307 clone from genomic surveillance of extended spectrum beta-lactamase-producing Klebsiella pneumoniae species complex in East Africa.
The study identifies multiple AMR genes, including blaCTX-M-15, blaTEM-1D, aac(6')-Ib-cr, aadA16, strB, qnrS1, sul2, sul1, catII.2, tet(A), dfrA14, arr-3, and mphA, in ESBL-KpSC isolates from East Africa, highlighting the prevalence of multidrug resistance.
Comparative assessment of annotation tools reveals critical antimicrobial resistance knowledge gaps in Klebsiella pneumoniae.
The study identifies various AMR genes and mutations in Klebsiella pneumoniae, highlighting knowledge gaps in existing annotation tools and databases for accurate resistance prediction.
Characterization of Enterobacter cloacae complex clinical isolates: comparative genomics and the role of the efflux pump AcrAB-TolC over-expression and NDM-1 production.
The study characterizes carbapenem-resistant Enterobacter cloacae complex isolates, highlighting the roles of the AcrAB-TolC efflux pump over-expression and the bla NDM-1 carbapenemase in conferring resistance. Multiple resistance genes, including bla NDM-1, acrAB-tolC, and various beta-lactamases, aminoglycoside-modifying enzymes, and sulfonamide resistance genes, were identified and validated.
Genomic characterisation of multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from various sources in Algeria, North Africa.
The study identified multiple AMR genes and chromosomal mutations in multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from Algeria, including bla TEM-1B, bla CTX-M-15, aac(3)-Id, aadA7, sul1, tet(A), mph(A), qnrB19, cmlA1, and floR, along with mutations in gyrA and parC genes that confer resistance to ciprofloxacin.
Genomic analysis of multidrug-resistant Salmonellaenterica Serovar Montevideo isolates in China.
The study identified multiple AMR genes in Chinese S. Montevideo isolates, including beta-lactamases (bla TEM−1B, bla OXA−1, bla LAP−2, bla CTX−M−55, bla CTX−M−65, bla DHA−1), quinolone resistance genes (qnrS2, qnrS1, qnrA1, qnrB6, qnrB4, qepA1), macrolide resistance genes (mphA, mphE, msrE, mphB), tetracycline resistance genes (tetA, tetD, tetB), sulfonamide resistance genes (sul1, sul2, dfrA14, dfrA12, dfrA27, sul3), and chloramphenicol resistance genes (floR, catA2, catB3).
Genomic analysis of multidrug-resistant Salmonellaenterica Serovar Montevideo isolates in China.
The study identified multiple AMR genes in Chinese S. Montevideo isolates, including beta-lactamases (bla TEM−1B, bla OXA−1, bla LAP−2, bla CTX−M−55, bla CTX−M−65, bla DHA−1), quinolone resistance genes (qnrS2, qnrS1, qnrA1, qnrB6, qnrB4, qepA1), macrolide resistance genes (mphA, mphE, msrE, mphB), tetracycline resistance genes (tetA, tetD, tetB), sulfonamide resistance genes (sul1, sul2, dfrA14, dfrA12, dfrA27, sul3), and chloramphenicol resistance genes (floR, catA2, catB3).
A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water.
The study identified multiple antimicrobial resistance genes (ARGs) in Gram-negative bacteria isolated from environmental water samples, including bla NDM-5, bla CTX-M-27, bla DHA-1, and others, indicating the presence of carbapenem-resistant and extended-spectrum beta-lactamase-producing bacteria in the Vietnamese VAC ecosystem.
Unveiling Equine Abortion Pathogens: A One Health Perspective on Prevalence and Resistance in Northwest China.
The study identified multiple antibiotic resistance genes in equine abortion pathogens, including CTX-M, TEM-1, TetM, ermA/B/C, qnrA/B, sul1/2, dfrA1/5, SHV, OXA-1, OXA-23/48/58, mecA/B/C, IMP-1/2, NDM-1, VIM-1/2, and vanA/B/C, highlighting the widespread resistance to various antibiotics among these pathogens.
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