Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
QnrC family quinolone resistance pentapeptide repeat protein
Overview
| C137S | - | - | - | Quinolone | Reslit | Candidate |
| M44T | - | - | - | Quinolone | Reslit | Candidate |
| L38F | - | - | - | Quinolone | Reslit | Candidate |
| L38P | - | - | - | Quinolone | Reslit | Candidate |
| C26S | - | - | - | Quinolone | Reslit | Candidate |
| C133S | - | - | - | Quinolone | Reslit | Candidate |
| I216T | - | - | - | Quinolone | Reslit | Candidate |
| F13S | - | - | - | Quinolone | Reslit | Candidate |
| C84S | - | - | - | Quinolone | Reslit | Candidate |
| C46S | - | - | - | Quinolone | Reslit | Candidate |
| C168S | - | - | - | Quinolone | Reslit | Candidate |
| E50A | - | - | - | Quinolone | Reslit | Candidate |
| C72Y | - | - | - | Quinolone | Reslit | Candidate |
| C31S | - | - | - | Quinolone | Reslit | Candidate |
| C72S | - | - | - | Quinolone | Reslit | Candidate |
| C115S | - | - | - | Quinolone | Reslit | Candidate |
| E50G | - | - | - | Quinolone | Reslit | Candidate |
| A97Y | - | - | - | Quinolone | Reslit | Candidate |
| C36S | - | - | - | Quinolone | Reslit | Candidate |
| C92S | - | - | - | Quinolone | Reslit | Candidate |
| C200S | - | - | - | Quinolone | Reslit | Candidate |
| E55A | - | - | - | Quinolone | Reslit | Candidate |
| L38R | - | - | - | Quinolone | Reslit | Candidate |
| S116P | - | - | - | Quinolone | Reslit | Candidate |
| C57S | - | - | - | Quinolone | Reslit | Candidate |
| C122S | - | - | - | Quinolone | Reslit | Candidate |
| D188V | - | - | - | Quinolone | Reslit | Candidate |
| E55G | - | - | - | Quinolone | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| qnrC | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 15 | QUINOLONE, CIPROFLOXACIN +5 | Proteus mirabilis +17 | China, United States|China|Japan|France|Germany|South Korea|Brazil|Colombia|Canada|Israel|Taiwan|Singapore|Australia|Egypt|Lebanon|Vietnam|Hong Kong, Global, China|Japan|Europe|Denmark|Italy|Spain, India, global, Northern China, Iran, Bangkok|eastern Thailand|Thailand, Azerbaijan, Egypt | 2009, 2010, 2012, 2014, 2022, 2023, 2024 | EU917444.1 | ACK75961.1 |
| qnr C | Reslit | 1 | Ciprofloxacin, Levofloxacin | Escherichia coli | Edo State, Nigeria | 2023 | - | - |
| QnrC | Card Database | 1 | - | Proteus mirabilis | - | - | EU917444.1 | ACK75961.1 |
New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis.
New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis.
New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis.
New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis.
A new plasmid-mediated quinolone resistance gene, qnrC, was identified in a clinical isolate of Proteus mirabilis. The gene encodes a 221-amino-acid pentapeptide repeat protein that confers low-level quinolone resistance.
Plasmid-mediated quinolone resistance: a multifaceted threat.
The paper discusses plasmid-mediated quinolone resistance (PMQR) mechanisms, focusing on qnr genes and other resistance determinants like aac(6')-Ib-cr, oqxAB, and qepA. These genes confer low-level resistance to quinolones, facilitating the selection of higher-level resistant mutants.
A mutational analysis and molecular dynamics simulation of quinolone resistance proteins QnrA1 and QnrC from Proteus mirabilis.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Plasmid-Mediated Quinolone Resistance; Interactions between Human, Animal, and Environmental Ecologies.
The paper discusses plasmid-mediated quinolone resistance (PMQR) mechanisms, including Qnr proteins, the aminoglycoside acetyltransferase AAC(6′)-Ib-cr, and the efflux pumps QepA and OqxAB. These genes contribute to low-level resistance to quinolones and fluoroquinolones, and their presence in various bacterial species highlights the role of environmental and animal reservoirs in the dissemination of PMQR.
Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India.
The study identified a diverse array of antibiotic resistance genes in a polluted lake in India, including sul2, qnrD, aph(6)-Id, aph(3′)-Ib, CMY2, qnrS, ant(3′)-Ia, dfrB1/dfrB5/dfrB6/dfrB8, GES, ere(A)/ere(C), qnrC, mph(E), dfrA1/dfrA15/dfrA25/dfrA30, erm(F), ant(2′)-Ia, cmlA, and tet(39). These genes conferred resistance to various classes of antibiotics, highlighting the significant presence of resistance mechanisms in the polluted environment.
Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance.
The paper discusses the role of qnr genes in mediating low-level quinolone resistance in aquatic environments and their potential contribution to high-level resistance when combined with chromosomal mutations or efflux pumps.
Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae in a Tertiary Hospital in Northern China.
The study identified bla KPC-2, bla GES, bla NDM-1, and bla IMP as the main carbapenemase genes in CRKP isolates. Additionally, various ESBL genes, aminoglycoside resistance genes, and PMQR genes were detected.
Fluoroquinolone-resistance mechanisms and molecular epidemiology of ciprofloxacin-resistant Klebsiella pneumoniae isolates in Iran.
The study identified plasmid-mediated quinolone resistance genes (qnrS, qnrD, qnrB, qnrA, qepA, aac(6')-Ib-cr, and qnrC) and target site mutations in gyrA (S83I) and parC (S129A, A141V) as key mechanisms of ciprofloxacin resistance in Klebsiella pneumoniae isolates in Iran.
Multidrug-resistant extended spectrum β-lactamase (ESBL)-producing Escherichia coli from farm produce and agricultural environments in Edo State, Nigeria.
The study identified various AMR genes in ESBL-producing E. coli isolates from agricultural farms and open markets in Edo State, Nigeria, including blaTEM, blaCTX-M-1, blaCTX-M-15, tetM, tetA, tetB, sul1, sul2, sul3, ant(4')-Ia, aacC(3)-1, qnrA, qnrB, qnrC, qnrS, cat::pC194, cat::pC221, intI1, and intI2. These genes conferred resistance to multiple antibiotics, indicating the presence of multidrug-resistant E. coli in the studied environments.
Incidence, genetic diversity, and antimicrobial resistance profiles of Vibrio parahaemolyticus in seafood in Bangkok and eastern Thailand.
The study identified several antimicrobial resistance genes in Vibrio parahaemolyticus isolates from seafood in Bangkok and eastern Thailand, including blaCARB, tet(34), tet(35), qnrC, dfrA6, and blaCTX-M-55, which confer resistance to various antibiotics such as ampicillin, amoxicillin, piperacillin, tetracycline, doxycycline, ciprofloxacin, and trimethoprim.
Molecular characterization of PMQR carrying bacteriophages in effluent discharge samples of Azerbaijan hospitals.
The study identified PMQR genes (qnrB, qnrD, qnrA, and qnrC) in bacteriophages and bacterial isolates from hospital effluent samples in Azerbaijan, highlighting the role of generalized transduction in the spread of quinolone resistance.
Investigation of plasmid-mediated quinolone resistance among extended-spectrum β-lactamase isolates of E. coli and K. pneumoniae.
The study identified several plasmid-mediated quinolone resistance genes, including qnrS, qnrC, qnrD, qnrB, and qnrVC, in extended-spectrum β-lactamase-producing E. coli and K. pneumoniae isolates.
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