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Explore antimicrobial resistance genes from the literature
quinolone resistance pentapeptide repeat protein QnrVC1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| QnrVC1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 32 | QUINOLONE, CIPROFLOXACIN +4 | Vibrio cholerae |
| Brazil|Vietnam, India|Europe|North America, Kenya, Europe|China|Pakistan|USA, Japan, China, France, Egypt, Singapore, Guangdong, China, Greece, Ghana, India, Norway, Spain, Argentina|Canada|Germany|United States, Thailand |
| 2008, 2011, 2017, 2021, 2022, 2023, 2024, 2025, 2026 |
| EU436855.2 |
| ACC54440.2 |
| qnrVC5 | ResFinder Database | 1 | CIPROFLOXACIN | Vibrio fluvialis | - | 2009 | JN408080 | - |
| QnrVC3 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | Quinolone, QUINOLONE +1 | Vibrio cholerae +2 | Bangladesh | 2010, 2011 | EU436855 | ADI81040.1 |
| qnrVC4 | ResFinder Database | 1 | CIPROFLOXACIN | Aeromonas caviae | - | 2010 | GQ891757 | - |
| QnrVC4 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | Ciprofloxacin, QUINOLONE +3 | Aeromonas punctata +14 | Shandong Province, China, India|Europe|North America, Africa|Asia|Europe|North America|South America|global, Germany, central Adriatic Sea|Croatia|Croatian marine environment, South-West Nigeria, China, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China | 2010, 2013, 2017, 2021, 2022, 2023, 2024 | GQ891757|GQ891754|GQ891755|GQ891756 | ADI55014.1 |
| qnrVC1 | ResFinder Database | 1 | CIPROFLOXACIN | Vibrio cholerae | - | 2011 | EU436855 | - |
| qnrVC3 | ResFinder Database | 1 | CIPROFLOXACIN | Vibrio cholerae non-O1/non-O139 | - | 2011 | HM015626 | - |
| QnrVC7 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | QUINOLONE, CIPROFLOXACIN +2 | Vibrio cholerae +2 | Hong Kong, India|Europe|North America, Thailand | 2013, 2015, 2017, 2025 | KM555152.1 | AJA36815.1 |
| QnrVC6 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | QUINOLONE, CIPROFLOXACIN +3 | Vibrio parahaemolyticus +5 | Hong Kong, India|Europe|North America, Guangdong, China, China, France, Shenzhen|Dapeng | 2013, 2015, 2017, 2022, 2023, 2024, 2025 | KC202804.1 | AGH08253.1 |
| QnrVC5 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | QUINOLONE, CIPROFLOXACIN +5 | Vibrio fluvialis +5 | Hong Kong, Kolkata, India|Europe|North America, India, China|Bangladesh|USA|England|India, Thailand, China|United Kingdom|Argentina|Europe|Americas|Asia|Africa|Australasia|Vietnam|Switzerland|Thailand|Mexico | 2013, 2015, 2016, 2017, 2018, 2022, 2024, 2025 | JN408080.1 | AEM62764.1 |
| qnrVC6 | ResFinder Database | 1 | CIPROFLOXACIN | Vibrio parahaemolyticus | - | 2013 | KC202804 | - |
| qnrVC7 | ResFinder Database | 1 | CIPROFLOXACIN | Vibrio cholerae | - | 2015 | KM555152 | - |
| QnrVC8 | Reference Gene Catalog | 1 | QUINOLONE | Vibrio parahaemolyticus | - | 2018 | MH181806.1 | AXA19787.1 |
| qnrVC | Reslit | 11 | Quinolone, Ciprofloxacin +3 | Photobacterium damselae subsp. damselae +9 | Black Sea, South Africa|various water sources, South Africa, Philippines, global, China, Guangdong, China, Egypt, Bangladesh, Europe | 2020, 2021, 2022, 2023, 2024, 2025 | VAUU02000098.1 | - |
| qnrVC-1 | Reslit | 1 | Fluoroquinolone | Escherichia coli | Europe | 2021 | MT720905|MT441554|MT720906|MT720903|MT720902|MT720904 | - |
| qnrVc | Reslit | 1 | Ciprofloxacin | Vibrio cholerae | Bangladesh | 2022 | PRJNA818081 | - |
| QnrVC10 | Reference Gene Catalog | 1 | QUINOLONE | Vibrio parahaemolyticus | - | - | MH330006.1 | AXI69764.1 |
| QnrVC9 | Reference Gene Catalog | 1 | QUINOLONE | Vibrio mimicus | - | - | VSGV01000051.1 | TXZ06185.1 |
New qnr gene cassettes associated with superintegron repeats in Vibrio cholerae O1.
New qnr gene cassettes associated with superintegron repeats in Vibrio cholerae O1.
New qnr gene cassettes associated with superintegron repeats in Vibrio cholerae O1.
The study identifies two new qnr genes, qnrVC1 and qnrVC2, associated with superintegron repeats in Vibrio cholerae O1, contributing to ciprofloxacin resistance.
New qnr gene cassettes associated with superintegron repeats in Vibrio cholerae O1.
Mechanism of drug resistance in a clinical isolate of Vibrio fluvialis: involvement of multiple plasmids and integrons.
Transferable quinolone resistance in Vibrio cholerae.
The study identifies qnrVC3 as a transferable low-level quinolone resistance gene in Vibrio cholerae, which is part of the SXT integrating conjugative element and contributes to increased ciprofloxacin resistance.
qnrVC-like gene located in a novel complex class 1 integron harboring the ISCR1 element in an Aeromonas punctata strain from an aquatic environment in Shandong Province, China.
qnrVC-like gene located in a novel complex class 1 integron harboring the ISCR1 element in an Aeromonas punctata strain from an aquatic environment in Shandong Province, China.
A novel qnrVC4 gene was identified in a complex class 1 integron in an Aeromonas punctata strain, contributing to quinolone resistance through plasmid-mediated mechanisms.
qnrVC-like gene located in a novel complex class 1 integron harboring the ISCR1 element in an Aeromonas punctata strain from an aquatic environment in Shandong Province, China.
qnrVC-like gene located in a novel complex class 1 integron harboring the ISCR1 element in an Aeromonas punctata strain from an aquatic environment in Shandong Province, China.
qnrVC-like gene located in a novel complex class 1 integron harboring the ISCR1 element in an Aeromonas punctata strain from an aquatic environment in Shandong Province, China.
Spread of the qnrVC quinolone resistance determinant in Vibrio cholerae.
The study confirms that qnrVC1 and qnrVC3 are identical gene cassettes with 100% amino acid identity and highlights their role in quinolone resistance in Vibrio cholerae.
Spread of the qnrVC quinolone resistance determinant in Vibrio cholerae.
Spread of the qnrVC quinolone resistance determinant in Vibrio cholerae.
The study confirms that qnrVC1 and qnrVC3 are identical gene cassettes with 100% amino acid identity and highlights their role in quinolone resistance in Vibrio cholerae.
Presence of qnrVC3 gene cassette in SXT and class 1 integrons of Vibrio cholerae.
QnrVC, a new transferable Qnr-like family.
QnrVC, a new transferable Qnr-like family.
QnrVC, a new transferable Qnr-like family.
Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.
Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.
Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.
Epidemiology of qnrVC alleles and emergence out of the Vibrionaceae family.
Epidemiology of qnrVC alleles and emergence out of the Vibrionaceae family.
Epidemiology of qnrVC alleles and emergence out of the Vibrionaceae family.
Epidemiology of qnrVC alleles and emergence out of the Vibrionaceae family.
Epidemiology of qnrVC alleles and emergence out of the Vibrionaceae family.
Epidemiology of qnrVC alleles and emergence out of the Vibrionaceae family.
Molecular characterisation of a multidrug resistance conjugative plasmid from Vibrio parahaemolyticus.
Identification and characterisation of a novel plasmid-mediated quinolone resistance gene, qnrVC7, in Vibrio cholerae of seafood origin.
The study identifies a novel plasmid-mediated quinolone resistance gene, qnrVC7, in Vibrio cholerae of seafood origin. It also characterizes the resistance mechanisms involving qnrVC7 and other PMQR genes, along with mutations in gyrA and parC.
Identification and characterisation of a novel plasmid-mediated quinolone resistance gene, qnrVC7, in Vibrio cholerae of seafood origin.
Identification and characterisation of a novel plasmid-mediated quinolone resistance gene, qnrVC7, in Vibrio cholerae of seafood origin.
The study identifies a novel plasmid-mediated quinolone resistance gene, qnrVC7, in Vibrio cholerae of seafood origin. It also characterizes the resistance mechanisms involving qnrVC7 and other PMQR genes, along with mutations in gyrA and parC.
Identification and characterisation of a novel plasmid-mediated quinolone resistance gene, qnrVC7, in Vibrio cholerae of seafood origin.
The study identifies a novel plasmid-mediated quinolone resistance gene, qnrVC7, in Vibrio cholerae of seafood origin. It also characterizes the resistance mechanisms involving qnrVC7 and other PMQR genes, along with mutations in gyrA and parC.
Characterization of Vibrio fluvialis qnrVC5 Gene in Native and Heterologous Hosts: Synergy of qnrVC5 with other Determinants in Conferring Quinolone Resistance.
The qnrVC5 gene from Vibrio fluvialis was characterized as a quinolone resistance determinant that increases MIC values of various quinolones in both native and heterologous hosts.
Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets.
The study identifies 20 putatively novel qnr genes from metagenomic data, with six of them experimentally validated to confer resistance to ciprofloxacin when expressed in E. coli.
Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets.
The study identifies 20 putatively novel qnr genes from metagenomic data, with six of them experimentally validated to confer resistance to ciprofloxacin when expressed in E. coli.
Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets.
The study identifies 20 putatively novel qnr genes from metagenomic data, with six of them experimentally validated to confer resistance to ciprofloxacin when expressed in E. coli.
Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets.
The study identifies 20 putatively novel qnr genes from metagenomic data, with six of them experimentally validated to confer resistance to ciprofloxacin when expressed in E. coli.
Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets.
The study identifies 20 putatively novel qnr genes from metagenomic data, with six of them experimentally validated to confer resistance to ciprofloxacin when expressed in E. coli.
A Highly Promiscuous Integron, Plasmids, Extended Spectrum Beta Lactamases and Efflux Pumps as Factors Governing Multidrug Resistance in a Highly Drug Resistant Vibrio fluvialis Isolate BD146 from Kolkata, India.
The study identified several AMR genes and mutations contributing to multidrug resistance in Vibrio fluvialis BD146, including blaOXA10, arr3, aadA1, cmlA, dfrVI, qnrVC5, and BDint, as well as mutations in gyrA and parC.
Molecular Characterization of qnrVC Genes and Their Novel Alleles in Vibrio spp. Isolated from Food Products in China.
Highly Transferable pAQU-Related Plasmids Encoding Multidrug Resistance Are Widespread in the Human and Fish Pathogen Photobacterium damselae subsp. damselae in Aquaculture Areas in the Black Sea.
The study identifies multiple multidrug resistance plasmids in Photobacterium damselae subsp. damselae, including novel versions of pAQU-group plasmids carrying resistance genes such as tetB, floR, sul2, qnrVC, dfrA, and strAB.
Antibiotic Susceptibility Testing (AST) Reports: A Basis for Environmental/Epidemiological Surveillance and Infection Control Amongst Environmental Vibrio cholerae.
The study identified various antibiotic resistance genes in Vibrio cholerae isolates, including blaTEM, NDM-1, AmpC, and ESBL, indicating multidrug resistance in environmental V. cholerae.
Collateral sensitivity associated with antibiotic resistance plasmids.
The study identifies several AMR genes carried by clinically relevant plasmids, including blaOXA-48, qnrS1, blaSHV-12, aac(6')-Ib3, blaVEB-9, qnrVC-1, sul1, tetA', tetC, dfrA1, dfrA23, blaVIM-1, aadA1, qacEΔ1, blaBEL-1, blaGES-5, blaIMP-8, and blaFOX-8. These genes confer resistance to various antibiotics, and the study highlights the collateral sensitivity associated with the acquisition of these plasmids.
Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya.
The study identified various carbapenemase genes (blaNDM-1, blaNDM-5, blaVIM-1, blaVIM-6, blaOXA-23, blaOXA-58, blaOXA-66, blaOXA-69, blaOXA-91, blaOXA-181, blaOXA-50) and other resistance genes (such as armA, rmtC, rmtF, aac(3)-I, aadA1, aph(3')-Ia, aph(3')-VI, aph(3')-Via, aph(6')-Id, mphE, msrE, mphA, ereA, dfrA1, dfrA12, dfrA14, dfrA17, dfrA20, sul1, sul2, tetB, tetD, tetG, tet39, qnrVC1, qnrS1, qnrB4, floR, catA1, catA2, catB3, catB7, cmlA1, cmlA5, arr-3, arr-2, sat2, acrF, mdtM, emrD, mexA, mexE, mexX, kdeA, oxa-10, oxa-395, oxa-396, oxa-846, adc-25, dha-1, act-16, cmY, ctx-m-15, shv-67, tem-1b) in carbapenem non-susceptible clinical isolates of gram-negative bacteria in Kenya, highlighting the diversity and prevalence of multidrug resistance.
A Peek into the Plasmidome of Global Sewage
The study identifies several antimicrobial resistance (AMR) genes in plasmidomes from global sewage samples, highlighting the prevalence of macrolide, lincosamide, streptogramin B, and quinolone resistance genes on plasmids.
Phenotypic and Genotypic Properties of Fluoroquinolone-Resistant, qnr-Carrying Escherichia coli Isolated from the German Food Chain in 2017.
The study identifies qnrS1 as the most prevalent qnr gene in fluoroquinolone-resistant E. coli isolates from the German food chain in 2017. It also detects point mutations in gyrA, parC, and parE genes that contribute to increased fluoroquinolone resistance.
Emergence and Genetic Characterization of Plasmid-Encoded VIM-2-Producing Pseudomonas stutzeri with Novel Integron In1998 Isolated from Cerebrospinal Fluid.
The study identifies a novel plasmid-encoded VIM-2-producing Pseudomonas stutzeri strain, ZDHY95, with a complex genetic arrangement including a novel class I integron In1998 and various resistance genes such as blaVIM-2, aacA3, aadA13, cmlA8, blaOXA-246, arr3, dfrA27, qacEΔ1, sul1, aacA4'-30, aacA4', qnrVC1, catB11, blaCARB-4.
Virulence and Antibiotic Resistance Characteristics of Vibrio Isolates From Rustic Environmental Freshwaters.
The study identified several antibiotic resistance genes in Vibrio isolates from environmental freshwater sources, including aadA, strA, aphA1, catII, ampC, blaTEM, blaGES, blaOXA-48, blaIMP, blaVIM, blaKPC, and qnrVC, indicating a significant risk of antimicrobial resistance in these bacteria.
Genomic surveillance of Pseudomonas aeruginosa in the Philippines, 2013-2014.
The study identified several AMR genes and mutations in Pseudomonas aeruginosa isolates from the Philippines, including bla VIM-2, bla VIM-6, bla NDM-1, bla IMP-26, aac(6')-Ib, aac(6')-Ib4, aac(6')-IIa, aac(6')-31, ant(2")-Ia, aadA1, acc(6')-Ib, qnrVC, gyrA, parC, oprD, nalC, and nalD. These genes and mutations were associated with resistance to carbapenems, aminoglycosides, and fluoroquinolones.
Antimicrobial Resistance and Type III Secretion System Virulotypes of Pseudomonas aeruginosa Isolates from Dogs and Cats in Primary Veterinary Hospitals in Japan: Identification of the International High-Risk Clone Sequence Type 235.
The study identifies various AMR genes and mutations in P. aeruginosa isolates from dogs and cats in Japan, highlighting the presence of high-risk clones like ST235 and the role of genetic factors in carbapenem and fluoroquinolone resistance.
Characterization of a Conjugative Multidrug Resistance IncP-2 Megaplasmid, pPAG5, from a Clinical Pseudomonas aeruginosa Isolate.
The study characterizes a conjugative multidrug resistance IncP-2 megaplasmid, pPAG5, from a clinical Pseudomonas aeruginosa isolate, identifying multiple AMR genes and resistance regions.
A Genomic and Bioinformatics View of the Classification and Evolution of Morganella Species and Their Chromosomal Accessory Genetic Elements Harboring Antimicrobial Resistance Genes.
The study identified 88 acquired antimicrobial resistance genes (ARGs) in 166 Morganella isolates, with a focus on tetracycline, aminoglycoside, sulfonamide, trimethoprim, and beta-lactam resistance genes. Key ARGs included blaKPC-2, blaNDM-1, aacA4, aadA5, dfrA17, catB3, arr-3, blaOXA-1, aacA4cr, mph(A), rmtB, sul2, floR, qnrS1, tetA, and ermB.
Population genomics of the food-borne pathogen Vibrio fluvialis reveals lineage associated pathogenicity-related genetic elements.
The study identified 21 antimicrobial resistance genes in Vibrio fluvialis, with 19 of them predominantly present in VflPop2. The tetracycline resistance gene tet(35) was found in 95% of VflPop2 strains, highlighting its significance in the population. Additionally, the plasmid pBD146 was associated with resistance to trimethoprim-sulfamethoxazole, and the presence of dfr6 gene in pBD146 was linked to this resistance.
Emergence of Carbapenem-Resistant ST244, ST292, and ST2446 Pseudomonas aeruginosa Clones in Burn Patients in Yunnan Province.
Genetic Diversity, Distribution, and Genomic Characterization of Antibiotic Resistance and Virulence of Clinical Pseudomonas aeruginosa Strains in Kenya.
The study identified multiple AMR genes and mutations in P. aeruginosa isolates from Kenya, including carbapenemases (blaNDM-1, blaVIM-6), fluoroquinolone resistance genes (qnrVC1, crpP), aminoglycoside resistance genes (aac(3)-IId, aph(3')-Ib, ant(3'')-Ia), tetracycline resistance genes (tetA, tetG), phenicol resistance genes (floR, cmlA), sulfonamide resistance gene (sul), trimethoprim resistance gene (dfrB), glycopeptide resistance gene (ble), and macrolide resistance gene (EreA). Additionally, mutations in gyrA and parC were associated with fluoroquinolone resistance.
Genetic Diversity, Distribution, and Genomic Characterization of Antibiotic Resistance and Virulence of Clinical Pseudomonas aeruginosa Strains in Kenya.
The study identified multiple AMR genes and mutations in P. aeruginosa isolates from Kenya, including carbapenemases (blaNDM-1, blaVIM-6), fluoroquinolone resistance genes (qnrVC1, crpP), aminoglycoside resistance genes (aac(3)-IId, aph(3')-Ib, ant(3'')-Ia), tetracycline resistance genes (tetA, tetG), phenicol resistance genes (floR, cmlA), sulfonamide resistance gene (sul), trimethoprim resistance gene (dfrB), glycopeptide resistance gene (ble), and macrolide resistance gene (EreA). Additionally, mutations in gyrA and parC were associated with fluoroquinolone resistance.
Submarine Outfalls of Treated Wastewater Effluents are Sources of Extensively- and Multidrug-Resistant KPC- and OXA-48-Producing Enterobacteriaceae in Coastal Marine Environment.
The study identified extensively drug-resistant (XDR) and multidrug-resistant (MDR) KPC- and OXA-48-producing Enterobacteriaceae in coastal marine environments, highlighting the presence of various AMR genes including bla KPC-2, bla OXA-48, and others.
Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance.
The paper discusses the role of qnr genes in mediating low-level quinolone resistance in aquatic environments and their potential contribution to high-level resistance when combined with chromosomal mutations or efflux pumps.
Antimicrobial Resistance and Genetic Diversity of Pseudomonas aeruginosa Strains Isolated from Equine and Other Veterinary Samples.
The study identified several AMR genes in Pseudomonas aeruginosa strains isolated from equine and other veterinary samples, including beta-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes, sulfonamide resistance genes, phenicol resistance genes, tetracycline resistance genes, and efflux pumps. Additionally, genes conferring resistance to quaternary ammonium compounds were detected.
Genome-wide association studies reveal distinct genetic correlates and increased heritability of antimicrobial resistance in Vibrio cholerae under anaerobic conditions.
The study identifies genes associated with antimicrobial resistance in Vibrio cholerae under anaerobic conditions, highlighting the importance of environmental factors in resistance development.
An ST131 clade and a phylogroup A clade bearing an O101-like O-antigen cluster predominate among bloodstream Escherichia coli isolates from South-West Nigeria hospitals.
The study identified several AMR genes and mutations in bloodstream E. coli isolates from South-West Nigeria, including bla CTX-M-15, dfrA, dfrB, and various quinolone resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Epidemiological characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic analysis of Aeromonas caviae isolated from extra-intestinal infections.
The study identified multiple antimicrobial resistance genes in Aeromonas caviae isolates from extra-intestinal infections, including blaMOX, blaPER-3, blaOXA, blaNDM, blaCphA, qnrS2, qnrVC, aac(6')-Ib-cr, tet(A), tet(E), tet(31), dfrA1, dfrA12, dfrA14, dfrA15b, floR, catB3, catII, and catI, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, tetracyclines, trimethoprim, and chloramphenicol.
Genome Analysis of Pseudomonas aeruginosa Strains from Chronically Infected Patients with High Levels of Persister Formation.
The study identified multiple AMR genes and efflux pump systems in P. aeruginosa persister isolates, highlighting their multidrug-resistant phenotype and biofilm-forming capabilities.
Dissemination of Pseudomonas aeruginosa bla(NDM-1)-Positive ST308 Clone in Singapore.
The study identifies multiple antibiotic resistance genes (ARGs) in bla NDM-1 -positive P. aeruginosa ST308 isolates, including aac(3)-Id, aac(6′)-Il, aph(3′)-Iib, bla OXA-488, bla NDM-1, bla PDC-19a, catB7, crpP, fosA, msr(E), qnrVC1, sul2, dfrB5, floR, aadA6, aadA11, and aph(3″)-Ib. These genes confer resistance to various antibiotics such as aminoglycosides, beta-lactams, carbapenems, cephalosporins, chloramphenicol, fluoroquinolones, fosfomycin, macrolides, quinolones, sulfonamides, trimethoprim, and streptomycin.
Epidemiological and Genetic Characteristics of Clinical Carbapenem-Resistant Pseudomonas aeruginosa Strains in Guangdong Province, China.
The study identified blaIMP-45 as a major determinant of meropenem resistance in P. aeruginosa, and mutations in oprD, mexR, nalD, and armR were associated with meropenem resistance.
Whole-genome sequencing reveals high-risk clones of Pseudomonas aeruginosa in Guangdong, China.
The study identified multiple AMR genes, including aac(6')-IIa, aac(6')-Ib4, aac(6')-Ib7, aac(6')-Ib9, aac(6')-Ib10, aac(3)-IId, aadA, aadA2, aadA3, aadA7, aadA13, bla OXA-50-Like, bla OXA-1-Like, bla OXA-10-Like, bla OXA-21-Like, bla VIM-2, bla IMP-9, bla IMP-45, bla KPC-2, bla CTX-M-13, bla CARB-1, bla CARB-3, qnrVC1, qnrVC6, bla PDC-3, and bla PDC-5, in Pseudomonas aeruginosa isolates from Guangdong, China, highlighting the high prevalence of multidrug-resistant and carbapenem-resistant strains.
Whole-genome sequencing reveals high-risk clones of Pseudomonas aeruginosa in Guangdong, China.
The study identified multiple AMR genes, including aac(6')-IIa, aac(6')-Ib4, aac(6')-Ib7, aac(6')-Ib9, aac(6')-Ib10, aac(3)-IId, aadA, aadA2, aadA3, aadA7, aadA13, bla OXA-50-Like, bla OXA-1-Like, bla OXA-10-Like, bla OXA-21-Like, bla VIM-2, bla IMP-9, bla IMP-45, bla KPC-2, bla CTX-M-13, bla CARB-1, bla CARB-3, qnrVC1, qnrVC6, bla PDC-3, and bla PDC-5, in Pseudomonas aeruginosa isolates from Guangdong, China, highlighting the high prevalence of multidrug-resistant and carbapenem-resistant strains.
First Detection and Molecular Characterization of Pseudomonas aeruginosa bla(NDM-1) ST308 in Greece.
The study reports the first detection of blaNDM-1-positive Pseudomonas aeruginosa ST308 in Greece, highlighting the presence of multiple resistance genes including blaNDM-1, blaPAO, blaOXA-10, blaOXA-488, and others, indicating multidrug resistance.
Uncovering the hidden threat: The widespread presence of chromosome-borne accessory genetic elements and novel antibiotic resistance genetic environments in Aeromonas.
The study identifies novel antibiotic resistance genes, including blaVEB-1, tetA(E), and mcr-3.15, in clinical isolates of Aeromonas, highlighting the presence of chromosome-borne accessory genetic elements and new resistance mechanisms.
Prioritization of Critical Factors for Surveillance of the Dissemination of Antibiotic Resistance in Pseudomonas aeruginosa: A Systematic Review.
The study identifies 25 critical mobile antibiotic resistance genes (ARGs) in Pseudomonas aeruginosa, including genes such as sul1, qacEΔ1, aac(6′)-Ib, bla VIM-1, and others, which are associated with various antibiotic classes and are linked to mobile genetic elements (MGEs).
Phenotypic and genomic characterization of Pseudomonas aeruginosa isolates recovered from catheter-associated urinary tract infections in an Egyptian hospital.
The study identified multiple AMR genes and mutations in Pseudomonas aeruginosa isolates from catheter-associated urinary tract infections in Egypt, including beta-lactamases, aminoglycoside-modifying enzymes, quinolone resistance proteins, and efflux pump systems. Additionally, a pBT2436-like megaplasmid was detected, which contributes to multidrug resistance.
Complete genome sequence and comparative analysis of a Vibrio vulnificus strain isolated from a clinical patient.
Characterization of a mobilizable megaplasmid carrying multiple resistance genes from a clinical isolate of Pseudomonas aeruginosa.
The study identifies a 522.5 kb mobilizable megaplasmid, pBJ86, carrying multiple resistance genes including tmexCD-oprJ, blaDIM-1, qnrVC6, and mer operon, which can be transferred via conjugation and contribute to multidrug resistance in Pseudomonas aeruginosa.
Genomic epidemiology and molecular characteristics of bla(NDM-1)-positive carbapenem-resistant Pseudomonas aeruginosa belonging to international high-risk clone ST773 in the Gauteng region, South Africa.
The study identifies bla NDM-1-positive carbapenem-resistant Pseudomonas aeruginosa isolates belonging to the international high-risk clone ST773 in the Gauteng region, South Africa. These isolates harbor various antibiotic resistance genes, including bla NDM-1, aad A11, qnr VC1, flo R2/cml A9, rmt B4, tet G, bla OXA-906, and bla PDC-19b, contributing to their extensive drug resistance.
Development of an in vitro biofilm model for the study of the impact of fluoroquinolones on sewer biofilm microbiota.
The study identified the presence of qnrA, qnrB, qnrD, and qnrS genes in in vitro biofilms, which contribute to fluoroquinolone resistance. Additionally, mutations in gyrA (S83L) and parC (S80I) were observed in response to high concentrations of fluoroquinolones.
Unveiling the microevolution of antimicrobial resistance in selected Pseudomonas aeruginosa isolates from Egyptian healthcare settings: A genomic approach.
The study identified multiple antimicrobial resistance genes and mutations in Pseudomonas aeruginosa isolates from Egyptian healthcare settings, highlighting extensive drug resistance and the role of mobile genetic elements in the spread of resistance.
Investigation of plasmid-mediated quinolone resistance among extended-spectrum β-lactamase isolates of E. coli and K. pneumoniae.
The study identified several plasmid-mediated quinolone resistance genes, including qnrS, qnrC, qnrD, qnrB, and qnrVC, in extended-spectrum β-lactamase-producing E. coli and K. pneumoniae isolates.
Antimicrobial Resistance in Wastewater Samples from Kumasi, Ghana: A Genomic and Metagenomic Analysis
The study identified several AMR genes and mutations in P. aeruginosa and K. pneumoniae isolates from wastewater samples in Kumasi, Ghana, highlighting the presence of multidrug-resistant strains carrying genes such as blaCTX-M-15, blaOXA-488, and qnrVC1, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Molecular Characterization of Pseudomonas aeruginosa Clinical Isolates Through Whole-Genome Sequencing: A Comprehensive Analysis of Biotypes, Sequence Types, and Antimicrobial and Virulence Genes.
The study identified multiple antibiotic resistance genes in Pseudomonas aeruginosa clinical isolates, including bla PDC, bla OXA, and bla VIM, which confer resistance to beta-lactams, as well as aac(6')-Il, aadA10, aph, and others that confer resistance to aminoglycosides. Additionally, genes like catB7, fosA, qnrVC1, and crpP were found to confer resistance to chloramphenicol, fosfomycin, quinolones, and fluoroquinolones, respectively.
Antimicrobial resistance, virulence factors and phylogenetic profiles of Vibrio parahaemolyticus in the eastern coast of Shenzhen.
The study identified several antimicrobial resistance genes in Vibrio parahaemolyticus isolates from Shenzhen, including blaCARB, tet(34), tet(35), qnrVC6, sul2, aph(6)-Id, floR, cat, and blaCTX-M-14. These genes conferred resistance to various antibiotics such as ampicillin, tetracycline, fluoroquinolones, sulfonamides, aminoglycosides, chloramphenicol, and beta-lactams.
Loop-mediated isothermal amplification assays for the detection of antimicrobial resistance elements in Vibrio cholera.
The study presents LAMP assays targeting AMR genes in Vibrio cholerae, including aph(6), varG, floR, qnrVC5, and almG, which confer resistance to aminoglycosides, penicillins/carbapenems, phenicol antibiotics, fluoroquinolones, and polymyxins, respectively.
Import of global high-risk clones is the primary driver of carbapenemase-producing Pseudomonas aeruginosa in Norway.
The study identifies the emergence of carbapenemase-producing Pseudomonas aeruginosa in Norway, primarily linked to international travel and hospitalization, highlighting the importance of genomic surveillance and infection control measures.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Genomic insights into the dynamic antibiotic resistance landscape of Vibrio cholerae during the Cholera outbreak 2022 in Odisha, India.
Ceftazidime-avibactam plus aztreonam cocktail for the treatment of VIM-producing Pseudomonas aeruginosa infections: good enough to have another?
The study characterizes several AMR genes and mutations in VIM-producing P. aeruginosa isolates, including aac(6')-Ib3, aac(6')-Il, aac(6')-Ib-Hangzhou, aadA6, qnrVC1, VIM-2, VIM-1, blaCARB-4, and mutations in mexR and mexB. These genes and mutations contribute to resistance against various antibiotics such as aminoglycosides, quinolones, and beta-lactams.
Vibrio cholerae O47 associated with a cholera-like diarrheal outbreak concurrent with seasonal cholera in Bangladesh.
The study identified multidrug-resistant (MDR) Vibrio cholerae O47 isolates with resistance to azithromycin, ciprofloxacin, erythromycin, tetracycline, ampicillin, and sulfamethoxazole/trimethoprim. Key resistance mechanisms included the efflux pump gene mphA, the quinolone resistance gene qnrVC, and mutations in gyrA (S83) and parC (S85).
Analysis of intrahospital and global dissemination and resistome dynamics of NDM-1-producing ST773 Pseudomonas aeruginosa high-risk clone.
Comparison of virulence and resistance genes in Mannheimia haemolytica and Pasteurella multocida from dairy cattle with and without bovine respiratory disease.
The study identified 22 AMR genes in P. multocida and 12 AMR genes in M. haemolytica, with qnrVC being the only gene identified for fluoroquinolone resistance in both species.
Comparative genomics of Pseudomonas paraeruginosa.
The study identifies various AMR genes and mutations in Pseudomonas paraeruginosa, including carbapenemases like blaVIM-2, blaVIM-6, blaVIM-28, and blaKPC-2, as well as efflux pump genes (mexAB-oprM, mexCD-oprJ, etc.), and mutations in oprD, mexS, mexR, mexZ, lasR, mvfR, and vqsM that contribute to antibiotic resistance.
The genomic configurations driving antimicrobial resistance and virulence in colistin resistant Pseudomonas aeruginosa from an Egyptian Tertiary Oncology Hospital.
The study identified several AMR genes and mutations in colistin-resistant P. aeruginosa isolates, including blaNDM-1, blaOXA-1028, blaOXA-904, and mutations in phoQ and basR genes associated with colistin resistance.
Molecular insights into the persistence and co-occurrence of two different carbapenem-resistant Pseudomonas aeruginosa lineages within a hospital setting.
The study identifies several carbapenem-resistant Pseudomonas aeruginosa lineages with specific resistance genes, including blaOXA-10, blaVIM-2, and others, highlighting the role of plasmids in the spread of resistance.
Molecular insights into the persistence and co-occurrence of two different carbapenem-resistant Pseudomonas aeruginosa lineages within a hospital setting.
The study identifies several carbapenem-resistant Pseudomonas aeruginosa lineages with specific resistance genes, including blaOXA-10, blaVIM-2, and others, highlighting the role of plasmids in the spread of resistance.
Diversity and antimicrobial resistance among bacterial isolates from finfish aquaculture in Thailand.
The study identified high levels of antimicrobial resistance in bacterial isolates from finfish aquaculture in Thailand, with particular emphasis on beta-lactam, tetracycline, and fluoroquinolone resistance in Gram-negative bacteria, and beta-lactam, macrolide, fluoroquinolone, and peptide resistance in Gram-positive bacteria. Unique resistance gene families, such as the SMR efflux pump and OXA beta-lactamase, were found in Aeromonas spp. and V. vulnificus.
Diversity and antimicrobial resistance among bacterial isolates from finfish aquaculture in Thailand.
The study identified high levels of antimicrobial resistance in bacterial isolates from finfish aquaculture in Thailand, with particular emphasis on beta-lactam, tetracycline, and fluoroquinolone resistance in Gram-negative bacteria, and beta-lactam, macrolide, fluoroquinolone, and peptide resistance in Gram-positive bacteria. Unique resistance gene families, such as the SMR efflux pump and OXA beta-lactamase, were found in Aeromonas spp. and V. vulnificus.
Diversity and antimicrobial resistance among bacterial isolates from finfish aquaculture in Thailand.
The study identified high levels of antimicrobial resistance in bacterial isolates from finfish aquaculture in Thailand, with particular emphasis on beta-lactam, tetracycline, and fluoroquinolone resistance in Gram-negative bacteria, and beta-lactam, macrolide, fluoroquinolone, and peptide resistance in Gram-positive bacteria. Unique resistance gene families, such as the SMR efflux pump and OXA beta-lactamase, were found in Aeromonas spp. and V. vulnificus.
Global genomic survey of Salmonella Kentucky: discovery of a chromosomeborne bla(NDM-5) and the emergence of ST314, an MDR clone mediated by the IncR plasmid.
The study discovered a chromosome-borne bla(NDM-5) gene in Salmonella Kentucky and identified the IncR plasmid as a key mediator of antimicrobial resistance in the MDR clone ST314.
Multidrug-resistant gram-negative bacteria in Spanish ICU patients: clinical and microbiological characterization (MURAN-UCI Project).
The study identifies several AMR genes and mutations in multidrug-resistant gram-negative bacteria, including bla VIM-1, bla CTX-M-15, bla OXA-48, and mutations in oprD, mexR, and nalD, contributing to resistance against various antibiotics.
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