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ResLit

rarA

transcriptional regulator

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Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to rarA

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Validation StatusSupported

Overview

Validation Method: cloning and MIC testing
Drug Classes: Chloramphenicol, Tetracycline, Ciprofloxacin, Norfloxacin, Tigecycline, Olaquindox
Organisms: Klebsiella pneumoniae, Escherichia coli
Geographic Location: Chile|Turkey|Germany, Taiwan, United Kingdom
Alleles: 2
Papers: 3
Databases: Reslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
rarA	Reslit	2	Chloramphenicol, Tetracycline +4	Klebsiella pneumoniae +1	Chile\|Turkey\|Germany, Taiwan	2012, 2016	-	-
RarA	Reslit

Papers3

Characterization of RarA, a novel AraC family multidrug resistance regulator in Klebsiella pneumoniae.

PMID 22644028 · 2012

The study identifies RarA, a novel AraC-family transcriptional regulator in Klebsiella pneumoniae, which contributes to multidrug resistance by upregulating the oqxAB efflux pump. Overexpression of RarA leads to increased MICs for multiple antibiotics, including chloramphenicol, tetracycline, ciprofloxacin, norfloxacin, tigecycline, and olaquindox.

Gene Information

Gene Name: rarA
Allele: rarA
Encodes: transcriptional regulator
Source Database: Reslit
Confers Resistance To: ChloramphenicolTetracyclineCiprofloxacinNorfloxacinTigecyclineOlaquindox
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Geographic Location: Chile|Turkey|Germany
Validation Method: cloning and MIC testing

Risk Factors, Outcomes, and Mechanisms of Tigecycline-Nonsusceptible Klebsiella pneumoniae Bacteremia.

PMID 27697759 · 2016

The study identified the overexpression of AcrAB and/or OqxAB efflux pumps, along with the upregulation of RamA and/or RarA, as key mechanisms contributing to tigecycline nonsusceptibility in Klebsiella pneumoniae. Additionally, overexpression of kpgA was noted in some isolates.

Gene Information

Gene Name: rarA
Allele: rarA
Encodes: transcriptional activator
Source Database: Reslit
Confers Resistance To: Tigecycline
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: Taiwan
Validation Method: quantitative reverse transcription-PCR

Clinically Relevant Plasmid-Host Interactions Indicate that Transcriptional and Not Genomic Modifications Ameliorate Fitness Costs of Klebsiella pneumoniae Carbapenemase-Carrying Plasmids.

PMID 29691332 · 2018

The study identified that pKpQIL-UK and pKpQIL-D2 plasmids affect gene expression in K. pneumoniae without causing genomic mutations. These plasmids influence resistance to carbapenems and other antibiotics through the expression of genes like blaKPC and blaTEM, as well as efflux pumps such as acrAB and oqxB.

Gene Information

Gene Name: rarA
Allele: RarA
Encodes: regulator of oqxB
Source Database: Reslit
Confers Resistance To: Olaquindox
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: United Kingdom
Validation Method: RNA sequencing
Sequence Accession: KY798507|KY798506|PRJEB23315