rclA

flavoprotein-disulfide oxidoreductase

Validation StatusCandidate

Overview

Validation Method: enzyme assay, mutant complementation, heterologous expression
Drug Classes: Ciprofloxacin|Kanamycin|Ampicillin
Organisms: Escherichia coli, Limosilactobacillus reuteri, Staphylococcus aureus, Streptococcus pneumoniae, Bacteroides thetaiotaomicron
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R156C	-	-	Escherichia coli	Ciprofloxacin\|Kanamycin\|Ampicillin	Reslit	Candidate

Papers2

Escherichia coli RclA is a highly active hypothiocyanite reductase.

PMID 35867824 · 2022

The study identifies RclA as a highly active hypothiocyanite reductase in Escherichia coli and demonstrates that RclA and its homologs from other bacteria provide protection against hypothiocyanite toxicity through enzymatic reduction of HOSCN to SCN−.

Gene Information

Gene Name: rclA
Allele: rclA
Encodes: flavoprotein-disulfide oxidoreductase
Source Database: Reslit
Organisms Tested In: • Escherichia coli
• Limosilactobacillus reuteri
• Staphylococcus aureus
• Streptococcus pneumoniae
• Bacteroides thetaiotaomicron
Validation Method: enzyme assay, mutant complementation, heterologous expression

Browse AMR Genes

rclA

Mutations

Gene Information