rclR

transcriptional regulator

Validation StatusCandidate

Overview

Mechanism: specifically required for protection against HOCl and HOSCN stress
Validation Method: mutant screen and transcriptional study
Drug Classes: Ciprofloxacin|Kanamycin|Ampicillin
Organisms: Pseudomonas aeruginosa, Escherichia coli
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Y89H	-	-	Escherichia coli	Ciprofloxacin\|Kanamycin\|Ampicillin	Reslit	Candidate

Papers2

Response of Pseudomonas aeruginosa to the Innate Immune System-Derived Oxidants Hypochlorous Acid and Hypothiocyanous Acid.

PMID 33106346 · 2020

The study identifies RclR and RclX as critical for Pseudomonas aeruginosa's protection against hypochlorous acid (HOCl) and hypothiocyanous acid (HOSCN). It also highlights the role of the MexT-regulated mexEF-oprN efflux pump in HOCl resistance.

Gene Information

Gene Name: rclR
Allele: rclR
Encodes: transcriptional regulator
Source Database: Reslit
Mechanism: specifically required for protection against HOCl and HOSCN stress
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: mutant screen and transcriptional study

Browse AMR Genes

rclR

Mutations

Gene Information