recG

RecG helicase

Validation StatusCandidate

Overview

Mechanism: non-synonymous mutation leading to fluoroquinolone resistance
Validation Method: plasmid complementation and MIC testing
Drug Classes: Ciprofloxacin
Organisms: Escherichia coli, Enterococcus lacertideformus, E. coli
Geographic Location: Europe|Christmas Island
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A109T	-	-	E. coli	Ciprofloxacin	Reslit	Candidate

Papers2

Novel Conserved Genotypes Correspond to Antibiotic Resistance Phenotypes of E. coli Clinical Isolates.

PMID 23824211 · 2013

The study identifies novel SNPs in gyrA, mutM, ligB, and recG genes associated with fluoroquinolone resistance in E. coli clinical isolates, demonstrating their role in resistance mechanisms through experimental validation.

Gene Information

Gene Name: recG
Allele: recG
Encodes: RecG helicase
Source Database: Reslit
Mechanism: non-synonymous mutation leading to fluoroquinolone resistance
Confers Resistance To: Ciprofloxacin
Organisms Tested In: • Escherichia coli
Validation Method: plasmid complementation and MIC testing
Sequence Accession: CP000948.1|CP000819.1|CP000970.1|NC_010488.1

Genomic Insights Into the Pathogenicity of a Novel Biofilm-Forming Enterococcus sp. Bacteria (Enterococcus lacertideformus) Identified in Reptiles.

PMID 33737921 · 2021

The study identified several antimicrobial resistance and virulence genes in Enterococcus lacertideformus, including DfrE, EfrB, ClpP, Fss3, and various metal resistance genes such as mgtA, copB, and ziaA. These genes suggest resistance to trimethoprim, macrolides, rifamycins, fluoroquinolones, and heavy metals.

Gene Information

Gene Name: recG
Allele: recG
Encodes: ATP-dependent DNA helicase RecG
Source Database: Reslit
Organisms Tested In: • Enterococcus lacertideformus
Geographic Location: Europe|Christmas Island
Validation Method: screening using EC
Sequence Accession: JADAKE000000000|SRX9763078|SRX9763079|SRX9763080

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recG

Mutations

Gene Information

Gene Information