relJ

antitoxin

Validation StatusCandidate

Overview

Mechanism: mutation in antitoxin relJ gene leads to aspartic acid to asparagine substitution at codon 44
Validation Method: sequencing and protein analysis
Drug Classes: Rifampin
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis
Geographic Location: Iran
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
D44N	-	mutation at codon 44 (aspartic acid to asparagine)	Mycobacterium bovis	Rifampin	Reslit	Candidate

Papers2

Distribution of lineages and type II toxin-antitoxin systems among rifampin-resistant Mycobacterium Tuberculosis Isolates.

PMID 39446830 · 2024

The study identified mutations in the mazF3, relJ, and vapC3 genes of the type II toxin-antitoxin system in rifampin-resistant Mycobacterium tuberculosis isolates. These mutations were found to be associated with rifampin resistance.

Gene Information

Gene Name: relJ
Allele: relJ
Encodes: antitoxin
Source Database: Reslit
Confers Resistance To: Rifampin
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Iran
Validation Method: sequencing and protein analysis
Sequence Accession: OR268987.1|OR268988.1|OR268989.1|OR268990.1|OR268991.1|OR268992.1|OR268993.1|OR268994.1|OR268995.1|OR268996.1|OR268997.1|OR268998.1|OR268999.1|OR269000.1|OR269001.1|OR269002.1|OR269015.1|OR269016.1|OR269017.1|OR269018.1|OR269019.1|OR269020.1|OR269021.1|OR269022.1|OR269023.1|OR269024.1|OR269025.1|OR269026.1|OR269027.1|OR269028.1|OR269029.1|OR269030.1|OR269043.1|OR269044.1|OR269045.1|OR269046.1|OR269047.1|OR269048.1|OR269049.1|OR269050.1|OR269051.1|OR269052.1|OR269053.1|OR269054.1|OR269055.1|OR269056.1|OR269057.1|OR269058.1

Investigation of potential relationship betweenmazEF3, relJK, and vapBC3 genes and antimicrobial resistance inMycobacterium bovis.

PMID 40461986 · 2025

Gene Information

Gene Name: relJ
Allele: relJ
Encodes: antitoxin
Source Database: Reslit
Mechanism: mutation in antitoxin relJ gene leads to aspartic acid to asparagine substitution at codon 44
Confers Resistance To: Rifampin
Organisms Tested In: • Mycobacterium bovis
Validation Method: PCR sequencing and molecular docking analysis

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relJ

Mutations

Gene Information

Gene Information