rfaH

transcription factor

Validation StatusCandidate

Overview

Mechanism: mutated in phage-resistant UPEC strains
Validation Method: whole-genome sequencing and growth assays
Drug Classes: Carbapenem
Organisms: Escherichia coli, Klebsiella pneumoniae
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Q18*	C52T	-	Klebsiella pneumoniae	Carbapenem	Reslit	Candidate

Papers2

Phage Resistance Accompanies Reduced Fitness of Uropathogenic Escherichia coli in the Urinary Environment.

PMID 35920561 · 2022

Phage-resistant UPEC strains exhibited mutations in lipopolysaccharide (LPS) biosynthesis genes, including rfaH, rfaI, waaO, and rfaE, which conferred resistance to phages HP3 and ES17.

Gene Information

Gene Name: rfaH
Allele: rfaH
Encodes: transcription factor
Source Database: Reslit
Mechanism: mutated in phage-resistant UPEC strains
Organisms Tested In: • Escherichia coli
Validation Method: whole-genome sequencing and growth assays

Browse AMR Genes

rfaH

Mutations

Gene Information