rfbE

lipopolysaccharide O-antigen biosynthesis protein

Validation StatusCandidate

Overview

Mechanism: cell envelope modification
Validation Method: transposon insertion mutagenesis and MIC testing
Drug Classes: Ciprofloxacin, Ciprofloxacin|Gentamicin|Meropenem
Organisms: Salmonella enterica serovar Typhi, Salmonella enterica
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
N220Y	-	-	Salmonella enterica	Ciprofloxacin\|Gentamicin\|Meropenem	Reslit	Candidate

Papers2

A whole-genome screen identifies Salmonella enterica serovar Typhi genes involved in fluoroquinolone susceptibility.

PMID 32514543 · 2020

The study identified several genes involved in fluoroquinolone susceptibility in Salmonella enterica serovar Typhi, including efflux pumps (acrA, acrB, tolC), regulatory genes (marA, phoP), and DNA repair genes (uvrD, xseA).

Gene Information

Gene Name: rfbE
Allele: rfbE
Encodes: lipopolysaccharide O-antigen biosynthesis protein
Source Database: Reslit
Mechanism: cell envelope modification
Confers Resistance To: Ciprofloxacin
Organisms Tested In: • Salmonella enterica serovar Typhi
Validation Method: transposon insertion mutagenesis and MIC testing

Browse AMR Genes

rfbE

Mutations

Gene Information