rluD

pseudo uridin synthetase

Validation StatusCandidate

Overview

Mechanism: mutations in rluD are associated with streptomycin resistance
Validation Method: minimum inhibition concentration (MIC) assays and growth curve assays in LB with streptomycin
Drug Classes: Tetracycline|Doxycycline
Organisms: Escherichia coli K-12, Escherichia coli 536, Staphylococcus aureus
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	A29T	-	Staphylococcus aureus	Tetracycline\|Doxycycline	Reslit	Candidate

Papers2

Using long-term experimental evolution to uncover the patterns and determinants of molecular evolution of an Escherichia coli natural isolate in the streptomycin-treated mouse gut.

PMID 27661780 · 2017

The study identifies mutations in the dgoRKADT operon and rluD/gidB genes that enhance growth on D-galactonate and confer streptomycin resistance, respectively, in an E. coli natural isolate adapted to the streptomycin-treated mouse gut.

Gene Information

Gene Name: rluD
Allele: rluD
Encodes: pseudo uridin synthetase
Source Database: Reslit
Mechanism: mutations in rluD are associated with streptomycin resistance
Organisms Tested In: • Escherichia coli K-12
• Escherichia coli 536
Validation Method: minimum inhibition concentration (MIC) assays and growth curve assays in LB with streptomycin

Browse AMR Genes

rluD

Mutations

Gene Information