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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
16S rRNA (guanine(1405)-N(7))-methyltransferase RmtD1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| RmtD1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TOBRAMYCIN, AMINOGLYCOSIDE +6 | Pseudomonas aeruginosa +2 | Brazil |
| 2007, 2013, 2021 |
| DQ914960.2 |
| ABJ53409.1 |
| rmtD | Card DatabaseResFinder DatabaseReslit | 17 | ARBEKACIN, TOBRAMYCIN +9 | Pseudomonas aeruginosa +20 | Brazil, Japan|India|Brazil|United States|China|Saudi Arabia|Europe, India, China, northeast India, Uruguay, Bolivia | 2007, 2013, 2016, 2017, 2018, 2020, 2022, 2023, 2024, 2025 | DQ914960 | ABY64751.1 |
| RmtD2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TOBRAMYCIN, AMINOGLYCOSIDE +8 | Klebsiella aerogenes +3 | Argentina, Brazil | 2011, 2013 | HQ401565.1 | ADW66527.1 |
| rmtD2 | Card DatabaseResFinder Database | 2 | TOBRAMYCIN, AMIKACIN +3 | Klebsiella aerogenes | - | 2011 | HQ401565 | ADW66527.1 |
Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil.
Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil.
Coproduction of novel 16S rRNA methylase RmtD and metallo-β-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil.
The study identifies a novel 16S rRNA methylase, RmtD, and a metallo-β-lactamase, SPM-1, in a panresistant Pseudomonas aeruginosa isolate from Brazil, contributing to resistance against aminoglycosides and β-lactams respectively.
Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil.
Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil.
rmtD2, a new allele of a 16S rRNA methylase gene, has been present in Enterobacteriaceae isolates from Argentina for more than a decade.
rmtD2, a new allele of a 16S rRNA methylase gene, has been present in Enterobacteriaceae isolates from Argentina for more than a decade.
The study identifies rmtD2, a new allele of a 16S rRNA methylase gene, which confers high resistance to all clinically available aminoglycosides in Enterobacteriaceae isolates from Argentina.
rmtD2, a new allele of a 16S rRNA methylase gene, has been present in Enterobacteriaceae isolates from Argentina for more than a decade.
rmtD2, a new allele of a 16S rRNA methylase gene, has been present in Enterobacteriaceae isolates from Argentina for more than a decade.
rmtD2, a new allele of a 16S rRNA methylase gene, has been present in Enterobacteriaceae isolates from Argentina for more than a decade.
Coproduction of 16S rRNA Methyltransferase RmtD or RmtG with KPC-2 and CTX-M Group Extended-Spectrum β-Lactamases in Klebsiella pneumoniae.
The study identifies RmtD1, RmtD2, and a novel 16S rRNA methyltransferase, RmtG, which confer high-level resistance to aminoglycosides in Klebsiella pneumoniae. These genes are often co-produced with KPC-2 and CTX-M group extended-spectrum β-lactamases.
Coproduction of 16S rRNA Methyltransferase RmtD or RmtG with KPC-2 and CTX-M Group Extended-Spectrum β-Lactamases in Klebsiella pneumoniae.
The study identifies RmtD1, RmtD2, and a novel 16S rRNA methyltransferase, RmtG, which confer high-level resistance to aminoglycosides in Klebsiella pneumoniae. These genes are often co-produced with KPC-2 and CTX-M group extended-spectrum β-lactamases.
Indigenous and acquired modifications in the aminoglycoside binding sites of Pseudomonas aeruginosa rRNAs.
The study identifies the rmtD gene, which encodes a methyltransferase that confers high-level resistance to tobramycin in Pseudomonas aeruginosa by methylating the 16S rRNA at position G1405.
Aminoglycoside Resistance: The Emergence of Acquired 16S Ribosomal RNA Methyltransferases.
The paper discusses the emergence and characteristics of acquired 16S ribosomal RNA methyltransferases (16S-RMTases) that confer resistance to aminoglycosides, particularly in gram-negative bacteria. It highlights the importance of these genes in multidrug-resistant organisms and their association with other resistance mechanisms such as carbapenemases.
Intraclonal Genome Stability of the Metallo-β-lactamase SPM-1-producing Pseudomonas aeruginosa ST277, an Endemic Clone Disseminated in Brazilian Hospitals.
The study identifies the blaSPM-1 gene as a key factor in carbapenem resistance in Pseudomonas aeruginosa ST277 isolates, along with other resistance genes in genomic islands.
Occurrence of Acquired 16S rRNA Methyltransferase-Mediated Aminoglycoside Resistance in Clinical Isolates of Enterobacteriaceae within a Tertiary Referral Hospital of Northeast India.
The study identified several 16S rRNA methyltransferase genes (armA, rmtA, rmtB, rmtC, rmtD) responsible for aminoglycoside resistance in Enterobacteriaceae isolates, highlighting their prevalence and association with multidrug resistance.
Characterization of antimicrobial resistance genes in Haemophilus parasuis isolated from pigs in China.
The study identified multiple antimicrobial resistance genes in Haemophilus parasuis isolates from pigs in China, including blaTEM-1, blaROB-1, ermB, ermA, flor, catl, tetB, tetC, rmtB, rmtD, aadA1, aac(3′)-IIc, sul1, and sul2. Additionally, mutations in the gyrA and parC genes were associated with fluoroquinolone resistance.
Expansion of acquired 16S rRNA methytransferases along with CTX-M-15, NDM and OXA-48 within three sequence types of Escherichia coli from northeast India.
The study identified ten different 16S rRNA methyltransferase genes (rmtA, rmtB, rmtC, rmtD, rmtE, rmtF, rmtG, rmtH, armA, npmA) along with CTX-M-15, NDM, and OXA-48 beta-lactamases in three sequence types of Escherichia coli from northeast India.
Characterization of a SPM-1 metallo-beta-lactamase-producing Pseudomonas aeruginosa by comparative genomics and phenotypic analysis.
The study characterizes the multidrug-resistant Pseudomonas aeruginosa isolate CCBH4851, identifying several AMR genes including blaSPM-1, sul1, rmtD, blaOXA-56, aac(6')-I, aadA7, cmx, and bcr, as well as mutations in oprD and mexZ contributing to resistance.
Emergence of rmtD1 gene in clinical isolates of Pseudomonas aeruginosa carrying blaKPC and/or blaVIM-2 genes in Brazil.
The study reports the emergence of the rmtD1 gene in clinical isolates of Pseudomonas aeruginosa carrying blaKPC and/or blaVIM-2 genes in Brazil, highlighting its role in resistance to aminoglycosides.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Genomic features, antimicrobial susceptibility, and epidemiological insights into Burkholderia cenocepacia clonal complex 31 isolates from bloodstream infections in India.
The study identifies several AMR genes and mutations in B. cenocepacia CC31 isolates, including beta-lactamases (OXA-192, PAU-1, TEM162, PME-1), chloramphenicol resistance gene (catB3), disinfectant resistance genes (qacEdelta1, qacL), aminoglycoside methyltransferases (rmtB, rmtD), and mutations in gyrA and 23S rRNA conferring fluoroquinolone and macrolide resistance, respectively.
First Detection of High-Level Aminoglycoside-Resistant Klebsiella pneumoniae and Enterobacter cloacae Isolates Due to 16S rRNA Methyltransferases with and Without bla(NDM) in Uruguay.
The study identifies the first detection of high-level aminoglycoside-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates in Uruguay, carrying 16S rRNA methyltransferases (rmtB, rmtC, rmtD) along with carbapenemase genes (bla NDM-5, bla NDM-1).
Effects of Scutellaria baicalensis, Folium Artemisiae argyi, and Galla Chinensis on the protein expression and resistance genes of Exiguobacterium sp. in response to gentamicin.
The study found that Scutellaria baicalensis, Folium Artemisiae argyi, and Galla Chinensis significantly reduced the abundance of gentamicin resistance genes (armA, rmtB, rmtA, rmtC, rmtD) in Exiguobacterium sp.
Biological cost of aminoglycoside resistance Arm/Kam 16S rRNA methyltransferases from natural antibiotic producers and clinical pathogens.
The study characterizes the biological cost of 16S rRNA methyltransferases (ArmA, RmtA, RmtB, RmtC, RmtD, Sgm, KamB, and NpmA) in Escherichia coli, demonstrating their role in conferring high-level aminoglycoside resistance and their impact on bacterial fitness, translational fidelity, and stress response.
Biological cost of aminoglycoside resistance Arm/Kam 16S rRNA methyltransferases from natural antibiotic producers and clinical pathogens.
The study characterizes the biological cost of 16S rRNA methyltransferases (ArmA, RmtA, RmtB, RmtC, RmtD, Sgm, KamB, and NpmA) in Escherichia coli, demonstrating their role in conferring high-level aminoglycoside resistance and their impact on bacterial fitness, translational fidelity, and stress response.
First nationwide survey on Pseudomonas aeruginosa in Bolivia: susceptibility profiles, resistome, and genomic epidemiology.
The study identified multiple carbapenemases, extended-spectrum beta-lactamases, and 16S rRNA methyltransferases in multidrug-resistant Pseudomonas aeruginosa isolates from Bolivia, highlighting the prevalence of high-risk clones and resistance mechanisms.
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