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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
rifamycin-inactivating phosphotransferase Rph
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| rph | Card DatabaseReference Gene CatalogReslit | 5 | RIFAMYCIN, Aminoglycoside +2 | Streptomyces sp. WAC4747 +3 | Europe|Asia, Lechuguilla Cave, Europe | 2014, 2016, 2022 |
| AIA08936.1 |
| rph-Lm | Reslit | 2 | Rifampin, Rifampicin | Listeria monocytogenes +1 | - | 2016, 2020 | NCBI:WP_011123456|5FBS|5FBT|5FBU | - |
A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria.
A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria.
Rifampin phosphotransferase is an unusual antibiotic resistance kinase.
The study characterizes RPH-Lm, a rifampin phosphotransferase that inactivates rifampin through a two-step phosphotransfer reaction, revealing a unique catalytic mechanism involving a swivel phosphohistidine domain.
Characterization and Comparative Overview of Complete Sequences of the First Plasmids of Pandoraea across Clinical and Non-clinical Strains.
The study characterizes plasmids from various Pandoraea strains, identifying several antibiotic resistance genes including beta-lactamases, tetracycline resistance genes, aminoglycoside resistance genes, fluoroquinolone resistance genes, macrolide resistance genes, chloramphenicol resistance genes, and lincomamide resistance genes.
A diverse intrinsic antibiotic resistome from a cave bacterium.
The study identifies 18 chromosomal resistance elements in Paenibacillus sp. LC231, including five novel determinants and three mechanisms not previously linked to antibiotic resistance. Key genes include bahA, cpaA, mphI, llmA, rph, vatI, vgbC, and catU, which confer resistance to various antibiotics through enzymatic inactivation.
Outer Membrane Disruption Overcomes Intrinsic, Acquired, and Spontaneous Antibiotic Resistance.
The study demonstrates that outer membrane (OM) disruption can overcome intrinsic, acquired, and spontaneous antibiotic resistance in Gram-negative bacteria. Specifically, OM disruption by SPR741 effectively counteracts resistance mediated by macrolide resistance elements (mphA, ermC, mphB, ereA), rifampicin resistance elements (arr, rph-Lm, rpoB), and other resistance mechanisms.
Comparative Analysis of Bacillus cereus Group Isolates' Resistance Using Disk Diffusion and Broth Microdilution and the Correlation between Antimicrobial Resistance Phenotypes and Genotypes.
The study identified several antimicrobial resistance genes in Bacillus cereus group isolates, including beta-lactamase-encoding genes (bla1, blaZ, blaTEM), mph for erythromycin resistance, rph for rifampicin resistance, and fosB for fosfomycin resistance. These genes were detected using ABRIcate and MEGARes 2.0 database, and their association with resistance phenotypes was analyzed.
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